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Personal profile


Dr Mitchell Lawrence is a Research Fellow in the Department of Anatomy and Developmental Biology and Biomedicine Discovery Institute, Monash University. He graduated with a PhD from Queensland University of Technology in 2009 before joining the Prostate Cancer Research Group at Monash University. His expertise includes the use of patient-derived xenografts of prostate cancer as preclinical models for studying tumour biology and testing novel therapies. His research also focusses on the tumour microenvironment of prostate cancer, particularly the features of cancer-associated fibroblasts. For these multidisciplinary studies, Dr Lawrence works with a diverse team of collaborators, including urologists, oncologists, pathologists, bioinformaticians and patient advocates.

Dr Lawrence is the recipient of funding from the National Health and Medical Research Council (Early Career Fellowship, project grants), the Victorian Government through the Victorian Cancer Agency (Early Career Seed Grant, Mid-Career Fellowship), the Prostate Cancer Foundation of Australia (Movember Young Investigator Grant) and several philanthropic organisations.

Research area keywords

  • Prostate cancer
  • Tumour microenvironment
  • Patient-derived models
  • Preclinical testing

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Projects 2012 2023

Research Output 2005 2019

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 others, Huglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Enduring epigenetic landmarks define the cancer microenvironment

Pidsley, R., Lawrence, M. G., Zotenko, E., Niranjan, B., Statham, A., Song, J., Chabanon, R. M., Qu, W., Wang, H., Richards, M., Nair, S. S., Armstrong, N., Nim, H. T., Papargiris, M., Balanathan, P., French, H., Peters, T., Norden, S., Ryan, A., Pedersen, J. & 9 others, Kench, J. G., Daly, R. J., Horvath, L., Stricker, P., Frydenberg, M., Taylor, R. A., Stirzaker, C., Risbridger, G. P. & Clark, S. J., 1 May 2018, In : Genome Research. 28, 5, p. 625-638 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Systematic Review Links the Prevalence of Intraductal Carcinoma of the Prostate to Prostate Cancer Risk Categories

Porter, L. H., Lawrence, M. G., Ilic, D., Clouston, D., Bolton, D. M., Frydenberg, M., Murphy, D. G., Pezaro, C., Risbridger, G. P. & Taylor, R. A., Oct 2017, In : European Urology. 72, 4, p. 492-495 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Patient-derived Xenografts Reveal that Intraductal Carcinoma of the Prostate Is a Prominent Pathology in BRCA2 Mutation Carriers with Prostate Cancer and Correlates with Poor Prognosis

Risbridger, G. P., Taylor, R. A., Clouston, D., Sliwinski, A., Thorne, H. J., Hunter, S. M., Li, J., Mitchell, G. W. E., Murphy, D. G. M., Frydenberg, M., Pook, D. W., Pedersen, J. S., Toivanen, R., Wang, H., Papargiris, M., Lawrence, M. G. & Bolton, D. M., 1 Mar 2015, In : European Urology. 67, 3, p. 496 - 503 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A preclinical xenograft model of prostate cancer using human tumors

Lawrence, M. G., Taylor, R. A., Toivanen, R., Pedersen, J. S., Norden, S., Pook, D. W., Frydenberg, M., Australian Prostate Cancer BioResource, Papargiris, M., Niranjan, B., Richards, M. G., Wang, H., Collins, A. T., Maitland, N. J. & Risbridger, G. P., 2013, In : Nature Protocols. 8, 5, p. 836 - 848 13 p.

Research output: Contribution to journalArticleResearchpeer-review