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Research Output 1993 2019

2019

Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection

Harpur, C. M., Kato, Y., Dewi, S. T., Stankovic, S., Johnson, D. N., Bedoui, S., Whitney, P. G., Lahoud, M. H., Caminschi, I., Heath, W. R., Brooks, A. G. & Gebhardt, T., 1 Feb 2019, In : Journal of Immunology. 202, 3, p. 653-663 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8+ T cell development

Caminschi, I., Lahoud, M. H., Pizzolla, A. & Wakim, L. M., 21 Jan 2019, In : Mucosal Immunology. 12, p. 403-412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver

Holz, L. E., Prier, J. E., Freestone, D., Steiner, T. M., English, K., Johnson, D. N., Mollard, V., Cozijnsen, A., Davey, G. M., Godfrey, D. I., Yui, K., Mackay, L. K., Lahoud, M. H., Caminschi, I., McFadden, G. I., Bertolino, P., Fernandez-Ruiz, D. & Heath, W. R., 2 Oct 2018, In : Cell Reports. 25, 1, p. 68-79 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Self-adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen-specific immunotherapy

Zeng, B., Middelberg, A. P. J., Gemiarto, A., MacDonald, K. P. A., Baxter, A. G., Talekar, M., Moi, D., Tullett, K. M., Caminschi, I., Lahoud, M. H., Mazzieri, R., Dolcetti, R. & Thomas, R., 1 May 2018, In : Journal of Clinical Investigation. 128, 5, p. 1971-1984 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Antibody-mediated targeting of antigen to C-type lectin-like receptors Clec9A and Clec12A elicits different vaccination outcomes

Macri, C., Dumont, C., Panozza, S., Lahoud, M. H., Caminschi, I., Villadangos, J. A., Johnston, A. P. R. & Mintern, J. D., Jan 2017, In : Molecular Immunology. 81, p. 143-150 8 p.

Research output: Contribution to journalArticleResearchpeer-review

CD14 is not involved in the uptake of synthetic CpG oligonucleotides

Li, J., Ahmet, F., O'Keeffe, M., Lahoud, M. H., Heath, W. R. & Caminschi, I., Jan 2017, In : Molecular Immunology. 81, p. 52-58 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancing vaccine antibody responses by targeting Clec9A on dendritic cells

Park, H-Y., Tan, P. S., Kavishna, R., Ker, A., Lu, J., Chan, C. E. Z., Hanson, B. J., MacAry, P. A., Caminschi, I., Shortman, K., Alonso, S. & Lahoud, M. H., 1 Dec 2017, In : npj Vaccines. 2, 1, 11 p., 33.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Local Modulation of Antigen-Presenting Cell Development after Resolution of Pneumonia Induces Long-Term Susceptibility to Secondary Infections

Roquilly, A., McWilliam, H. E. G., Jacqueline, C., Tian, Z., Cinotti, R., Rimbert, M., Wakim, L., Caminschi, I., Lahoud, M. H., Belz, G. T., Kallies, A., Mintern, J. D., Asehnoune, K. & Villadangos, J. A., 18 Jul 2017, In : Immunity. 47, 1, p. 135-147.e5 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Differential uptake and cross-presentation of soluble and necrotic cell antigen by human DC subsets

Chiang, M-C., Tullett, K. M., Lee, Y. S., Idris, A., Ding, Y., McDonald, K. J., Kassianos, A., Leal Rojas, I. M., Jeet, V., Lahoud, M. & Radford, K. J., Feb 2016, In : European Journal of Immunology. 46, 2, p. 329-339 11 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-12p40/IL-10 producing preCD8/Clec9A+ dendritic cells are induced in neonates upon listeria monocytogenes infection

Torres, D., Kohler, A., Delbauve, S., Caminschi, I., Lahoud, M. H., Shortman, K. & Flamand, V., 13 Apr 2016, In : PLoS Pathogens. 12, 4, 21 p., 1005561.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Liver-resident memory CD8+ T cells rorm a front-line defense against malaria liver-stage infection

Fernandez-Ruiz, D., Ng, W. Y., Holz, L. E., Ma, J. Z., Zaid, A., Wong, Y. C., Lau, L. S., Mollard, V., Cozijnsen, A., Collins, N., Li, J., Davey, G. M., Kato, Y., Devi, S., Skandari, R., Pauley, M., Manton, J. H., Godfrey, D. I., Braun, A., Tay, S. S. & 13 othersTan, P. S., Bowen, D. G., Koch-Nolte, F., Rissiek, B., Carbone, F. R., Crabb, B. S., Lahoud, M., Cockburn, I. A., Mueller, S. N., Bertolino, P., McFadden, G. I., Caminschi, I. & Heath, W. R., 18 Oct 2016, In : Immunity. 45, 4, p. 889-902 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition

Tullett, K. M., Leal Rojas, I. M., Minoda, Y., Tan, P. S., Zhang, J-G., Smith, C., Khanna, R., Shortman, K., Caminschi, I., Lahoud, M. H. & Radford, K. J., 19 May 2016, In : JCI Insight. 1, 7, 12 p., e87102.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates

Li, J., Ahmet, F., Sullivan, L. C., Brooks, A. G., Kent, S. J., De Rose, R., Salazar, A. M., Reis e Sousa, C., Shortman, K., Lahoud, M. H., Heath, W. R. & Caminschi, I., 2015, In : European Journal of Immunology. 45, 3, p. 854 - 864 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

Wakim, L., Smith, J. R., Caminschi, I., Lahoud, M. H. & Villadangos, J. A., 2015, In : Mucosal Immunology. 8, 5, p. 1060 - 1071 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting antigen to Clec9A primes follicular Th cell memory responses capable of robust recall

Kato, Y., Zaid, A., Davey, G. M., Mueller, S. N., Nutt, S. L., Zotos, D., Tarlinton, D., Shortman, K., Lahoud, M. H., Heath, W. R. & Caminschi, I., 2015, In : Journal of Immunology. 195, 3, p. 1006 - 1014 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Dendritic cells and cancer immunotherapy

Radford, K. J., Tullett, K. M. & Lahoud, M. H., 2014, In : Current Opinion in Immunology. 27, 1, p. 26 - 32 7 p.

Research output: Contribution to journalArticleResearchpeer-review

FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo

Ding, Y., Wilkinson, A. R. J., Idris, A., Fancke, B. R., O'Keeffe, M., Khalil, D., Ju, X., Lahoud, M. H., Caminschi, I., Shortman, K., Rodwell, R. L., Vuckovic, S. & Radford, K. J., 2014, In : Journal of Immunology. 192, 4, p. 1982 - 1989 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapy

Tullett, K. M., Lahoud, M. H. & Radford, K. J., 2014, In : Frontiers in Immunology. 5, p. 1 - 4 4 p., 239.

Research output: Contribution to journalComment / DebateResearchpeer-review

Open Access
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2013

Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model

Brady, J. L., Sutherland, R. M., Hancock, M. S., Kitsoulis, S., Lahoud, M. H., Phillips, P. M., Hawthorne, W. J., d'Apice, A. JF., Cowan, P. J., Harrison, L., O'Connell, P. J. & Lew, A. M., 2013, In : Xenotransplantation. 20, 2, p. 100 - 109 10 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats

Wang, Y., Wang, Y. M., Wang, Y., Zheng, G., Zhang, G. Y., Zhou, J. J., Tan, T. K., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Lahoud, M. H., Caminschi, I., Harris, D. C. & Alexander, S. I., Feb 2013, In : Kidney International. 83, 2, p. 223-232 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Evolution of B cell responses to Clec9A-targeted antigen

Park, H-Y., Light, A., Lahoud, M., Caminschi, I., Tarlinton, D. M. & Shortman, K., 2013, In : Journal of Immunology. 191, 10, p. 4919 - 4925 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: Potential therapeutic implications

Gagné, V., Marois, L., Levesque, J. M., Galarneau, H., Lahoud, M. H., Caminschi, I., Naccache, P. H., Tessier, P. & Fernandes, M. J. G., 9 Jul 2013, In : Arthritis Research and Therapy. 15, 4, 15 p., R73.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Receptor-specific delivery of protein antigen to dendritic cells by a nanoemulsion formed using top-down non-covalent click self-assembly

Zeng, B. J., Chuan, Y. P., O'Sullivan, B., Caminschi, I., Lahoud, M. H., Thomas, R. & Middelberg, A. P. J., 25 Nov 2013, In : Small. 9, 22, p. 3736-3742 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3-/- mice

Caminschi, I., Vremec, D., Ahmet, F., Lahoud, M. H., Villadangos, J. A., Murphy, K. M., Heath, W. R. & Shortman, K., Feb 2012, In : Molecular Immunology. 50, 1-2, p. 9-17 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Co-sedimentation assay for the detection of direct binding to F-actin

Wong, W., Baum, J., Lahoud, M. H. & Shortman, K., 5 Oct 2012, In : Bio-protocol. 2, 19, 4 p., e270.

Research output: Contribution to journalArticleOtherpeer-review

DEC-205 is a cell surface receptor for CpG oligonucleotides

Lahoud, M. H., Ahmet, F., Zhang, J-G., Meuter, S., Policheni, A. N., Kitsoulis, S., Lee, C-N., O'Keeffe, M., Sullivan, L. C., Brooks, A. G., Berry, R., Rossjohn, J., Mintern, J. D., Vega-Ramos, J., Villadangos, J. A., Nicola, N. A., Nussenzweig, M. C., Stacey, K. J., Shortman, K., Heath, W. R. & 1 othersCaminschi, I., 2012, In : Proceedings of the National Academy of Sciences. 109, 40, p. 16270 - 16275 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Dendritic cell subsets and immune regulation

O'Keeffe, M., Lahoud, M. H., Caminschi, I. & Wu, L., 1 Jan 2012, Innate Immune Regulation and Cancer Immunotherapy. Springer, p. 89-119 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

Zhang, J-G., Czabotar, P. E., Policheni, A. N., Caminschi, I., Wan, S. S., Kitsoulis, S., Tullett, K. M., Robin, A. Y., Brammananth, R., van Delft, M. F., Lu, J., O'Reilly, L. A., Josefsson, E. C., Kile, B. T., Chin, W. J., Mintern, J. D., Olshina, M. A., Wong, W., Baum, J., Wright, M. D. & 7 othersHuang, D. C. S., Mohandas, N., Coppel, R. L., Colman, P. M., Nicola, N. A., Shortman, K. & Lahoud, M. H., 2012, In : Immunity. 36, 4, p. 646-657 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen

Desch, A. N., Randolph, G. J., Murphy, K. M., Gautier, E. L., Kedl, R. M., Lahoud, M. H., Caminschi, I., Shortman, K., Henson, P. M. & Jakubzick, C. V., 29 Aug 2011, In : Journal of Experimental Medicine. 208, 9, p. 1789-1797 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

Idoyaga, J., Lubkin, A., Fiorese, C., Lahoud, M. H., Caminschi, I., Huang, Y., Rodriguez, A., Clausen, B. E., Park, C. G., Trumpfheller, C. & Steinmana, R. M., 8 Feb 2011, In : Proceedings of the National Academy of Sciences. 108, 6, p. 2384-2389 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma

Prato, S., Mintern, J. D., Lahoud, M. H., Huang, D. C. S. & Villadangos, J. A., Jul 2011, In : Immunology and Cell Biology. 89, 5, p. 595-603 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype

Lahoud, M. H., Ahmet, F., Kitsoulis, S., Wan, S. S., Vremec, D., Lee, C-N., Phipson, B., Shi, W., Smyth, G. K., Lew, A. M., Kato, Y., Mueller, S. N., Davey, G. M., Heath, W. R., Shortman, K. & Caminschi, I., 15 Jul 2011, In : Journal of Immunology. 187, 2, p. 842-850 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases

van Delft, M. F., Smith, D. P., Lahoud, M. H., Huang, D. C. S. & Adams, J. M., May 2010, In : Cell Death and Differentiation. 17, 5, p. 821-832 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Distinct functional capacities of mouse thymic and splenic dendritic cell populations (Immunology and Cell Biology (2007) 86, (700-708) DOI: 10.1038/icb.2008.63)

Proietto, A. I., Lahoud, M. H. & Wu, L., Feb 2009, In : Immunology and Cell Biology. 87, 2, p. 190 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Enhancing immune responses by targeting antigen to DC

Caminschi, I., Lahoud, M. H. & Shortman, K., 2009, In : European Journal of Immunology. 39, 4, p. 931-938 8 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Erratum: Dendritic cells in the thymus contribute to T-regulatory cell induction (Proceedings of the National Academy of Sciences of the United States of America (2008)105: (19869-19874) DOI: 10.1073/pnas.0810268105))

Proietto, A. I., van Dommelen, S. LH., Zhou, P., Rizzitelli, A., D'Amico, A., Steptoe, R. J., Naik, S. H., Lahoud, M. H., Liu, Y., Zheng, P., Shortman, K. & Wu, L., 3 Feb 2009, In : Proceedings of the National Academy of Sciences. 106, 5, p. 1679 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Improving vaccines by targeting antigens to dendritic cells

Shortman, K., Lahoud, M. H. & Caminschi, I., 28 Feb 2009, In : Experimental and Molecular Medicine. 41, 2, p. 61-66 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses

Lahoud, M., Proietto, A. I., Ahmet, F., Kitsoulis, S., Eidsmo, L., Wu, L., Sathe, P., Pietersz, S., Chang, H-W., Walker, I., Maraskovsky, E., Braley, H., Lew, A. M., Wright, M. D., Heath, W. R., Shortman, K. & Caminschi, I., 2009, In : Journal of Immunology. 182, 12, p. 7587 - 7594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Dendritic cells in the thymus contribute to T-regulatory cell induction

Proietto, A. I., van Dommelen, S. LH., Zhou, P., Rizzitelli, A., D'Amico, A., Steptoe, R. J., Naik, S. H., Lahoud, M. H., Liu, Y., Zheng, P., Shortman, K. & Wu, L., 16 Dec 2008, In : Proceedings of the National Academy of Sciences. 105, 50, p. 19869-19874 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct functional capacities of mouse thymic and splenic dendritic cell populations

Proietto, A. I., Lahoud, M. H. & Wu, L., Nov 2008, In : Immunology and Cell Biology. 86, 8, p. 700-708 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement

Caminschi, I., Proietto, A. I., Ahmet, F., Kitsoulis, S., Teh, J. S., Lo, J. C. Y., Rizzitelli, A., Wu, L., Vremec, D., van Dommelen, S. LH., Campbell, I. K., Maraskovsky, E., Braley, H., Davey, G. M., Mottram, P. L., van de Velde, N. C., Jensen, K., Lew, A. M., Wright, M. D., Heath, W. R. & 2 othersShortman, K. & Lahoud, M. H., 2008, In : Blood. 112, 8, p. 3264 - 3273 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells

Vremec, D., O'Keeffe, M., Hochrein, H., Fuchsberger, M., Caminschi, I., Lahoud, M. & Shortman, K., 1 Feb 2007, In : Blood. 109, 3, p. 1165-1173 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

Caminschi, I., Ahmet, F., Heger, K., Brady, J., Nutt, S. L., Vremec, D., Pietersz, S., Lahoud, M. H., Schofield, L. D., Hansen, D. S., O'Keeffe, M., Smyth, M. J., Bedoui, S., Davey, G. M., Villadangos, J. A., Heath, W. R. & Shortman, K., 29 Oct 2007, In : Journal of Experimental Medicine. 204, 11, p. 2579-2590 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN

Caminschi, I., Corbett, A., Zahra, C., Lahoud, M., Lucas, K., Sofi, M., Vremec, D., Gramberg, T., Pohlmann, S., Curtis, J., Handman, E., van Dommelen, S. LH., Fleming, P., Degli-Esposti, M., Shortman, K. & Wright, M. D., 2006, In : International Immunology. 18, 5, p. 741 - 753 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE

Caminschi, I., Vandenabeele, S., Sofi, M., McKnight, A. J., Ward, N., Brodnicki, T. C., Toy, T., Lahoud, M., Maraskovsky, E., Shortman, K. & Wright, M. D., 2006, In : Dna Sequence. 17, 1, p. 8 - 14 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Signal regulatory protein molecules are differentially expressed, by CD8- dendritic cells

Lahoud, M. H., Proietto, A. I., Gartlan, K., Kitsoulis, S., Curtis, J., Wettenhall, J., Sofi, M., Daunt, C. P., O'Keeffe, M., Caminschi, I., Satterley, K., Rizzitelli, A., Schnorrer, P., Hinohara, A., Yamaguchi, Y., Wu, L., Smyth, G. K., Handman, E., Shortman, K. & Wright, M. D., 2006, In : Journal of Immunology. 177, 1, p. 372 - 382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting antigen to dendritic cells

Caminschi, I., Corbett, A. J., Lahoud, M. & Lew, A. M., 2006, In : Modern Aspects of Immunobiology. 20, p. 10-11 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2005

Cutting edge: Generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures

Naik, S. H., Proietto, A. I., Wilson, N. S., Dakic, A., Schnorrer, P., Fuchsberger, M., Lahoud, M. H., O'Keeffe, M., Shao, Q. X., Chen, W. F., Villadangos, J. A., Shortman, K. & Wu, L., 1 Jun 2005, In : Journal of Immunology. 174, 11, p. 6592-6597 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Differential production of inflammatory chemokines by murine dendritic cell subsets

Proietto, A. I., O'Keeffe, M., Gartlan, K., Wright, M. D., Shortman, K., Wu, L. & Lahoud, M., 2004, In : Immunobiology. 209, 1-2, p. 163 - 172 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Choice of mouse strains for gene targeting

Lahoud, M. H., Wilson, T. J. & Hertzog, P. J., 2001, Methods in Molecular Biology: Gene Knockout Protocols. Tymms, M. J. & Kola, I. (eds.). Totowa New Jersey USA: Humana Press, p. 107 - 119 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review