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Personal profile

Biography

Dr Tan has a BBiomedSci (Therapeutics) and a BSci with Honours degree from the University of Melbourne. She completed her PhD at the University of Melbourne in 2011, focussing on novel therapies to inhibit pathological fibrosis in the heart and kidney failure. Following her PhD, she received the prestigious Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship to continue her work in diabetic complications at Baker Heart & Diabetes Institute with a special interest in the role oxidative stress plays in kidney and eye diseases. In 2014, she joined the Glycation, Nutrition and Metabolism Laboratory led by A/Prof Melinda Coughlan at the Baker Heart & Diabetes Institute and in 2016, she was recruited to Monash University's newly established Department of Diabetes at the Central Clinical School. She is a current recipient of a JDRF Advanced Postdoctoral Fellowship to continue her work on finding new therapeutic targets for diabetic complications. She is a member of Australian Diabetes Society and Australian and New Zealand Society of Nephrology.

Research interests

  • the role of complement C5a-C5aR1 signalling in diabetic complications
  • inflammation in diabetic kidney disease
  • kidney fibrosis and oxidative stress associated with diabetes
  • novel therapies to treat diabetic complications

Keywords

  • Diabetes
  • Diabetic Kidney Disease (DKD)
  • Inflammation
  • Oxidative stress
  • Fibrosis
  • Complement

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2017 2020

Research Output 2009 2018

Lipoxins protect against inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Mohan, M., McClelland, A., De Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., Gray, S. P., Pickering, R., Tan, S. M., Godson-Treacy, M., Sheehan, S., Dowdall, J. F., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P. J. & 4 othersJandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Dec 2018, In : Diabetes. 67, 12, p. 2657-2667 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease

Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Tasadaque Ali-Shah, S., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1437-1448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Nrf2 activation is a potential therapeutic approach to attenuate diabetic retinopathy

Deliyanti, D., Alrashdi, S. F., Tan, S. M., Meyer, C., Ward, K. W., de Haan, J. B. & Wilkinson-Berka, J. L., 1 Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 815-825 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Use of readily accessible inflammatory markers to predict diabetic kidney disease

Winter, L., Wong, L. A., Jerums, G., Seah, J. M., Clarke, M., Tan, S. M., Coughlan, M. T., MacIsaac, R. J. & Ekinci, E. I., 22 May 2018, In : Frontiers in Endocrinology. 9, MAY, 17 p., 225.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

Coughlan, M. T., Higgins, G. C., Nguyen, T-V., Penfold, S. A., Thallas-Bonke, V., Tan, S. M., Ramm, G., Van Bergen, N. J., Henstridge, D. C., Sourris, K. C., Harcourt, B. E., Trounce, I. A., Robb, P. M., Laskowski, A., McGee, S. L., Genders, A. J., Walder, K., Drew, B. G., Gregorevic, P., Qian, H. & 13 othersThomas, M. C., Jerums, G., Macisaac, R. J., Skene, A., Power, D. A., Ekinci, E. I., Wijeyeratne, X. W., Gallo, L. A., Herman-Edelstein, M., Ryan, M. T., Cooper, M. E., Thorburn, D. R. & Forbes, J. M., Apr 2016, In : Diabetes. 65, 4, p. 1085-1098 14 p.

Research output: Contribution to journalArticleResearchpeer-review