Projects per year
Personal profile
Biography
Dr Tan has a BBiomedSci (Therapeutics) and a BSci with Honours degree from the University of Melbourne. She completed her PhD at the University of Melbourne in 2011, focussing on novel therapies to inhibit pathological fibrosis in heart and kidney failure. Following her PhD, she received the prestigious Juvenile Diabetes Research Foundation (JDRF) International Postdoctoral Fellowship to continue her work on diabetic complications at the Baker Heart & Diabetes Institute with a special interest in using novel antioxidants to reduce oxidative stress in kidney and eye diseases. In 2016, she was recruited to Monash University's newly established Department of Diabetes where she was a recipient of the JDRF International Advanced Postdoctoral Fellowship to further her work in finding new therapeutic targets for diabetic complications. She recently received a NHMRC Ideas Grant in 2022 to investigate the role of complement in diabetic kidney disease. She is a member of Australian Diabetes Society and Australian and New Zealand Society of Nephrology.
Research interests
- the role of complement in diabetic complications
- inflammation in diabetic kidney disease
- kidney fibrosis and oxidative stress associated with diabetes
- novel therapies to treat diabetic complications
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Diabetes
- Diabetic Kidney Disease (DKD)
- Inflammation
- Oxidative stress
- Fibrosis
- Complement
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigating complement C5a receptor 2 as a therapeutic target for diabetic kidney disease
Tan, M., Coughlan, M., Ekinci, E., Woodruff, T. M. & Schittenhelm, R.
1/01/22 → 31/12/24
Project: Research
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Regulatory T Cells and Kidney Disease Progression in Type 1 Diabetes
Ekinci, E., Rojas-Canales, D., Joglekar, M. V., Peña, A., Qin, C. H., Tan, M., Deliyanti, D., Glastras, S., James , S. & Bansal, A.
17/02/21 → 23/09/22
Project: Research
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Targeting the C5a-C5aR1 signaling axis in diabetic nephropathy - JDRF Advanced Postdoctoral Fellowship
1/01/17 → 30/04/20
Project: Research
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The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease
Tan, S. M., Snelson, M., Ostergaard, J. A. & Coughlan, M. T., 7 Feb 2022, (Accepted/In press) In: Antioxidants and Redox Signaling. 22 p.Research output: Contribution to journal › Review Article › Research › peer-review
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Long Term High Protein Diet Feeding Alters the Microbiome and Increases Intestinal Permeability, Systemic Inflammation and Kidney Injury in Mice
Snelson, M., Clarke, R. E., Nguyen, T. V., Penfold, S. A., Forbes, J. M., Tan, S. M. & Coughlan, M. T., Apr 2021, In: Molecular Nutrition & Food Research. 65, 8, 12 p., 2000851.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Processed foods drive intestinal barrier permeability and microvascular diseases
Snelson, M., Tan, S. M., Clarke, R. E., de Pasquale, C., Thallas-Bonke, V., Nguyen, T-V., Penfold, S. A., Harcourt, B. E., Sourris, K. C., Lindblom, R. S. J., Ziemann, M., Steer, D., El-Osta, A., Davies, M. J., Donnellan, L., Deo, P., Kellow, N. J., Cooper, M. E., Woodruff, T. M., Mackay, C. R. & 2 others, , 31 Mar 2021, In: Science Advances. 7, 14, 15 p., eabe4841.Research output: Contribution to journal › Article › Research › peer-review
Open Access23 Citations (Scopus) -
Targeted deletion of nicotinamide adenine dinucleotide phosphate oxidase 4 from proximal tubules is dispensable for diabetic kidney disease development
Thallas-Bonke, V., Tan, S. M., Lindblom, R. S., Snelson, M., Granata, C., Jha, J. C., Sourris, K. C., Laskowski, A., Watson, A., Tauc, M., Rubera, I., Zheng, G., Shah, A. M., Harris, D. C. H., Elbatreek, M. H., Kantharidis, P., Cooper, M. E., Jandeleit-Dahm, K. & Coughlan, M. T., 27 May 2021, In: Nephrology Dialysis Transplantation. 36, 6, p. 988-997 10 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Targeting methylglyoxal in diabetic kidney disease using the mitochondria-targeted compound mitogamide
Tan, S. M., Lindblom, R. S. J., Ziemann, M., Laskowski, A., Granata, C., Snelson, M., Thallas-Bonke, V., El-Osta, A., Baeza-Garza, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Cooper, M. E., Murphy, M. P. & Coughlan, M. T., 5 Apr 2021, In: Nutrients. 13, 5, 14 p., 1457.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Prizes
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ANZSN Mid-Career Basic Science Award
Tan, Min (Recipient), 2021
Prize: Prize (including medals and awards)