Projects per year
Personal profile
Biography
Dr Tan has a BBiomedSci (Therapeutics) and a BSci with Honours degree from the University of Melbourne. She completed her PhD at the University of Melbourne in 2011, focussing on novel therapies to inhibit pathological fibrosis in the heart and kidney failure. Following her PhD, she received the prestigious Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship to continue her work in diabetic complications at Baker Heart & Diabetes Institute with a special interest in the role oxidative stress plays in kidney and eye diseases. In 2014, she joined the Glycation, Nutrition and Metabolism Laboratory led by A/Prof Melinda Coughlan at the Baker Heart & Diabetes Institute and in 2016, she was recruited to Monash University's newly established Department of Diabetes at the Central Clinical School. She is a current recipient of a JDRF Advanced Postdoctoral Fellowship to continue her work on finding new therapeutic targets for diabetic complications. She is a member of Australian Diabetes Society and Australian and New Zealand Society of Nephrology.
Research interests
- the role of complement C5a-C5aR1 signalling in diabetic complications
- inflammation in diabetic kidney disease
- kidney fibrosis and oxidative stress associated with diabetes
- novel therapies to treat diabetic complications
Research area keywords
- Diabetes
- Diabetic Kidney Disease (DKD)
- Inflammation
- Oxidative stress
- Fibrosis
- Complement
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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Targeting the C5a-C5aR1 signaling axis in diabetic nephropathy - JDRF Advanced Postdoctoral Fellowship
1/01/17 → 30/04/20
Project: Research
Research output
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Long Term High Protein Diet Feeding Alters the Microbiome and Increases Intestinal Permeability, Systemic Inflammation and Kidney Injury in Mice
Snelson, M., Clarke, R. E., Nguyen, T. V., Penfold, S. A., Forbes, J. M., Tan, S. M. & Coughlan, M. T., 6 Feb 2021, (Accepted/In press) In : Molecular Nutrition & Food Research. 12 p.Research output: Contribution to journal › Article › Research › peer-review
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Processed foods drive intestinal barrier permeability and microvascular diseases
Snelson, M., Tan, S. M., Clarke, R. E., de Pasquale, C., Thallas-Bonke, V., Nguyen, T-V., Penfold, S. A., Harcourt, B. E., Sourris, K. C., Lindblom, R. S. J., Ziemann, M., Steer, D., El-Osta, A., Davies, M. J., Donnellan, L., Deo, P., Kellow, N. J., Cooper, M. E., Woodruff, T. M., Mackay, C. R. & 2 others, , 31 Mar 2021, In : Science Advances. 7, 14, 15 p., eabe4841.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility
Tan, S. M., Ziemann, M., Thallas-Bonke, V., Snelson, M., Kumar, V., Laskowski, A., Nguyen, T. V., Huynh, K., Clarke, M. V., Libianto, R., Baker, S. T., Skene, A., Power, D. A., MacIsaac, R. J., Henstridge, D. C., Wetsel, R. A., El-Osta, A., Meikle, P. J., Wilson, S. G., Forbes, J. M. & 4 others, , 1 Jan 2020, In : Diabetes. 69, 1, p. 83-98 16 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy
Snelson, M., Tan, S. M., Higgins, G. C., Lindblom, R. S. J. & Coughlan, M. T., 1 Mar 2020, In : American Journal of Physiology-Renal Physiology. 318, 3, p. F835-F842 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile2 Citations (Scopus) -
Lipoxins protect against inflammation in diabetes-associated atherosclerosis
Brennan, E. P., Mohan, M., McClelland, A., De Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., Gray, S. P., Pickering, R., Tan, S. M., Godson-Treacy, M., Sheehan, S., Dowdall, J. F., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P. J. & 4 others, , 1 Dec 2018, In : Diabetes. 67, 12, p. 2657-2667 11 p.Research output: Contribution to journal › Article › Research › peer-review
20 Citations (Scopus)