Projects per year
Personal profile
Biography
Dr Tan has a BBiomedSci (Therapeutics) and a BSci with Honours degree from the University of Melbourne. She completed her PhD at the University of Melbourne in 2011, focussing on novel therapies to inhibit pathological fibrosis in heart and kidney failure. Following her PhD, she received the prestigious Juvenile Diabetes Research Foundation (JDRF) International Postdoctoral Fellowship to continue her work on diabetic complications at the Baker Heart & Diabetes Institute with a special interest in using novel antioxidants to reduce oxidative stress in kidney and eye diseases. In 2016, she was recruited to Monash University's newly established Department of Diabetes where she was a recipient of the JDRF International Advanced Postdoctoral Fellowship to further her work in finding new therapeutic targets for diabetic complications. She recently received a NHMRC Ideas Grant in 2022 to investigate the role of complement in diabetic kidney disease. She is a member of Australian Diabetes Society and Australian and New Zealand Society of Nephrology.
Research interests
- the role of complement in diabetic complications
- inflammation in diabetic kidney disease
- kidney fibrosis and oxidative stress associated with diabetes
- novel therapies to treat diabetic complications
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Diabetes
- Diabetic Kidney Disease (DKD)
- Inflammation
- Oxidative stress
- Fibrosis
- Complement
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 5 Finished
-
Exploring novel strategies to improve insulin sensitivity and secretion in skeletal muscle to combat diabetes
Yeo, W. W. Y. (Primary Chief Investigator (PCI)), Tan, M. (Chief Investigator (CI)), Jaafar, F. (Chief Investigator (CI)) & Ji Wei, T. (Chief Investigator (CI))
1/01/24 → 31/12/24
Project: Research
-
Boosting regulatory T cells with kidney-targeted nanoparticles to treat diabetic kidney disease
Coughlan, M. (Primary Chief Investigator (PCI)), Ooi, J. (Chief Investigator (CI)), Tan, M. (Chief Investigator (CI)) & Gan, P. Y. (Chief Investigator (CI))
1/01/23 → 30/12/23
Project: Research
-
Investigating complement C5a receptor 2 as a therapeutic target for diabetic kidney disease
Tan, M. (Primary Chief Investigator (PCI)), Coughlan, M. (Associate Investigator (AI)), Ekinci, E. (Associate Investigator (AI)), Woodruff, T. M. (Associate Investigator (AI)) & Schittenhelm, R. (Associate Investigator (AI))
1/01/22 → 31/12/24
Project: Research
-
Regulatory T Cells and Kidney Disease Progression in Type 1 Diabetes
Ekinci, E. (Primary Chief Investigator (PCI)), Rojas-Canales, D. (Chief Investigator (CI)), Joglekar, M. V. (Chief Investigator (CI)), Peña, A. S. (Chief Investigator (CI)), Qin, C. H. (Associate Investigator (AI)), Tan, M. (Chief Investigator (CI)), Deliyanti, D. (Chief Investigator (CI)), Glastras, S. (Chief Investigator (CI)), James, S. (Chief Investigator (CI)) & Bansal, A. (Chief Investigator (CI))
17/02/21 → 23/09/22
Project: Research
-
Targeting the C5a-C5aR1 signaling axis in diabetic nephropathy - JDRF Advanced Postdoctoral Fellowship
Tan, M. (Primary Chief Investigator (PCI))
1/01/17 → 31/10/21
Project: Research
-
Therapeutic Potential of Targeting Complement C5a Receptors in Diabetic Kidney Disease
Trambas, I. A. (Leading Author), Coughlan, M. T. & Tan, S. M. (Leading Author), May 2023, In: International Journal of Molecular Sciences. 24, 10, 19 p., 8758.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access10 Citations (Scopus) -
The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease
Tan, S. M., Snelson, M., Ostergaard, J. A. & Coughlan, M. T., Oct 2022, In: Antioxidants and Redox Signaling. 37, 10-12, p. 781-801 21 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access27 Citations (Scopus) -
Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors
Coughlan, M. T., Ziemann, M., Laskowski, A., Woodruff, T. M. & Tan, S. M., Dec 2022, In: Scientific Reports. 12, 1, 10 p., 20278.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Long Term High Protein Diet Feeding Alters the Microbiome and Increases Intestinal Permeability, Systemic Inflammation and Kidney Injury in Mice
Snelson, M., Clarke, R. E., Nguyen, T. V., Penfold, S. A., Forbes, J. M., Tan, S. M. & Coughlan, M. T., Apr 2021, In: Molecular Nutrition & Food Research. 65, 8, 12 p., 2000851.Research output: Contribution to journal › Article › Research › peer-review
42 Citations (Scopus) -
Processed foods drive intestinal barrier permeability and microvascular diseases
Snelson, M., Tan, S. M., Clarke, R. E., de Pasquale, C., Thallas-Bonke, V., Nguyen, T.-V., Penfold, S. A., Harcourt, B. E., Sourris, K. C., Lindblom, R. S. J., Ziemann, M., Steer, D., El-Osta, A., Davies, M. J., Donnellan, L., Deo, P., Kellow, N. J., Cooper, M. E., Woodruff, T. M. & Mackay, C. R. & 2 others, , 31 Mar 2021, In: Science Advances. 7, 14, 15 p., eabe4841.Research output: Contribution to journal › Article › Research › peer-review
Open Access113 Citations (Scopus)
Prizes
-
Australia and New Zealand Society of Nephrology Basic Science Award
Tan, M. (Recipient), 2022
Prize: Prize (including medals and awards)
-
Australian and New Zealand Society of Nephrology Mid-Career Basic Science Award
Tan, M. (Recipient), 2021
Prize: Prize (including medals and awards)
-
Baker Heart & Diabetes Institute Prize for Diabetes Research Poster Award at Alfred Health Week
Tan, M. (Recipient), 2018
Prize: Prize (including medals and awards)
-
Monash FMNHS Exceptional Achievement
Tan, M. (Recipient), 2022
Prize: Prize (including medals and awards)
Activities
- 4 Non-HDR Supervisions
-
Master's Supervision (Master of Biomedical Science and Health Sciences): Mapping the Mitochondrial Signature in Diabetic Kidney Disease
Coughlan, M. (Supervisor) & Tan, M. (Supervisor)
Jul 2022 → Jun 2023Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
-
Honours Supervision (BSc): Characterising the Complement Cascade in Diabetic Kidney Disease
Coughlan, M. (Supervisor) & Tan, M. (Supervisor)
2021Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
-
Honours Supervision (BSc): The Role of Manganese Superoxide Dismutase in Diabetic Kidney Disease
Coughlan, M. (Supervisor) & Tan, M. (Supervisor)
2018Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
-
Honours Supervision (BNutSc): Do Dietary Advanced Glycation End-Products Lead to Changes in Gut Homeostasis?
Coughlan, M. (Supervisor), Tan, M. (Supervisor) & Dordevic, A. (Supervisor)
2015Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions