20002020

Research output per year

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Research Output

  • 50 Article
  • 2 Comment / Debate
  • 1 Chapter (Book)
  • 1 Review Article
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Article
2020

Defining the Progression of Diabetic Cardiomyopathy in a Mouse Model of Type 1 Diabetes

De Blasio, M. J., Huynh, N., Deo, M., Dubrana, L. E., Walsh, J., Willis, A., Prakoso, D., Kiriazis, H., Donner, D. G., Chatham, J. C. & Ritchie, R. H., 20 Feb 2020, In : Frontiers in Physiology. 11, 16 p., 124.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes

Prakoso, D., De Blasio, M. J., Tate, M., Kiriazis, H., Donner, D. G., Qian, H., Nash, D., Deo, M., Weeks, K. L., Parry, L. J., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., Apr 2020, In : American Journal of Physiology - Heart and Circulatory Physiology. 318, 4, p. H840-H852 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Thyroid Deficiency Before Birth Alters the Adipose Transcriptome to Promote Overgrowth of White Adipose Tissue and Impair Thermogenic Capacity

Harris, S. E., De Blasio, M. J., Zhao, X., Ma, M., Davies, K. L., Wooding, F. B. P., Hamilton, R. S., Blache, D., Meredith, D., Murray, A. J., Fowden, A. L. & Forhead, A. J., 1 Jun 2020, In : Thyroid. 30, 6, p. 794-805 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2019

Characterising an Alternative Murine Model of Diabetic Cardiomyopathy

Tate, M., Prakoso, D., Willis, A. M., Peng, C., Deo, M., Qin, C. X., Walsh, J. L., Nash, D. M., Cohen, C. D., Rofe, A. K., Sharma, A., Kiriazis, H., Donner, D. G., De Haan, J. B., Watson, A. M. D., De Blasio, M. J. & Ritchie, R. H., 14 Nov 2019, In : Frontiers in Physiology. 10, 15 p., 1395.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart

Tate, M., Higgins, G., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garz, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. & Ritchie, R. H., Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 669-674 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
2018

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chandramouli, C., Reichelt, M. E., Curl, C. L., Varma, U., Bienvenu, L. A., Koutsifeli, P., Raaijmakers, A. J. A., De Blasio, M. J., Qin, C. X., Jenkins, A. J., Ritchie, R. H., Mellor, K. M. & Delbridge, L. M. D., 1 Dec 2018, In : Scientific Reports. 8, 1, 13 p., 2346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Ovine uteroplacental and fetal metabolism during and after fetal cortisol overexposure in late gestation

Vaughan, O. R., De Blasio, M. J. & Fowden, A. L., 4 Jun 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 6, p. R791-R801 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Sex-and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus

De Blasio, M. J., Lanham, S. A., Blache, D., Oreffo, R. O. C., Fowden, A. L. & Forhead, A. J., 4 Jun 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 6, p. R781-R790 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation

Spallotta, F., Cencioni, C., Atlante, S., Garella, D., Cocco, M., Mori, M., Mastrocola, R., Kuenne, C., Guenther, S., Nanni, S., Azzimato, V., Zukunft, S., Kornberger, A., Sürün, D., Schnütgen, F., Von Melchner, H., Di Stilo, A., Aragno, M., Braspenning, M., Van Criekinge, W. & 13 others, De Blasio, M. J., Ritchie, R. H., Zaccagnini, G., Martelli, F., Farsetti, A., Fleming, I., Braun, T., Beiras-Fernandez, A., Botta, B., Collino, M., Bertinaria, M., Zeiher, A. M. & Gaetano, C., 5 Jan 2018, In : Circulation Research. 122, 1, p. 31-46 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
18 Citations (Scopus)
2017

Effects of induced placental and fetal growth restriction, size at birth and early neonatal growth on behavioural and brain structural lateralization in sheep

Hunter, D. S., Hazel, S. J., Kind, K. L., Liu, H., Marini, D., Giles, L. C., De Blasio, M. J., Owens, J. A., Pitcher, J. B. & Gatford, K. L., 3 Sep 2017, In : Laterality. 22, 5, p. 560-589 30 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice in Vivo

Qin, C. X., Finlayson, S. B., Ai-Sharea, A., Tate, M., De Blasio, M. J., Deo, M., Rosli, S., Prakoso, D., Thomas, C. J., Kiriazis, H., Gould, E., Yang, Y. H., Morand, E. F., Perretti, M., Murphy, A. J., Du, X. J., Gao, X. M. & Ritchie, R. H., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16615.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation

Harris, S. E., De Blasio, M. J., Davis, M. A., Kelly, A. C., Davenport, H. M., Wooding, F. B. P., Blache, D., Meredith, D., Anderson, M., Fowden, A. L., Limesand, S. W. & Forhead, A. J., 1 Jun 2017, In : Journal of Physiology. 595, 11, p. 3331-3343 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications

Qin, C. X., Sleaby, R., Davidoff, A. J., Bell, J. R., De Blasio, M. J., Delbridge, L. M., Chatham, J. C. & Ritchie, R. H., 1 Feb 2017, In : Pharmacological Research. 116, p. 45-56 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Maternal methyl donor and cofactor supplementation in late pregnancy increases β-cell numbers at 16 days of life in growth-restricted twin lambs

Sulaiman, S. A., De Blasio, M. J., Harland, M. L., Gatford, K. L. & Owens, J. A., 1 Oct 2017, In : American Journal of Physiology - Endocrinology and Metabolism. 313, 4, p. E381-E390 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Prakoso, D., De Blasio, M. J., Qin, C., Rosli, S., Kiriazis, H., Qian, H., Du, X-J., Weeks, K. L., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., 7 Jun 2017, In : Clinical Science. 131, 12, p. 1345-1360 16 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart

Vranas, S., Heinemann, G. K., Liu, H., De Blasio, M. J., Owens, J. A., Gatford, K. L. & Black, M. J., Oct 2017, In : Journal of Developmental Origins of Health and Disease. 8, 5, p. 618-625 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2016

A physiological increase in maternal cortisol alters uteroplacental metabolism in the pregnant ewe

Vaughan, O. R., Davies, K. L., Ward, J. W., de Blasio, M. J. & Fowden, A. L., 1 Nov 2016, In : Journal of Physiology. 594, 21, p. 6407-6418 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)

Leptin matures aspects of lung structure and function in the ovine fetus

De Blasio, M. J., Boije, M., Kempster, S. L., Smith, G. C. S., Charnock-Jones, D. S., Denyer, A., Hughes, A., Wooding, F. B. P., Blache, D., Fowden, A. L. & Forhead, A. J., 1 Jan 2016, In : Endocrinology. 157, 1, p. 395-404 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)
2015

Developmental expression and glucocorticoid control of the leptin receptor in fetal ovine lung

De Blasio, M. J., Boije, M., Vaughan, O. R., Bernstein, B. S., Davies, K. L., Plein, A., Kempster, S. L., Smith, G. C. S., Charnock-Jones, D. S., Blache, D., Wooding, F. B. P., Giussani, D. A., Fowden, A. L. & Forhead, A. J., 19 Aug 2015, In : PLoS ONE. 10, 8, 15 p., e0136115.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Effect of placental restriction and neonatal exendin-4 treatment on postnatal growth, adult body composition, and in vivo glucose metabolism in the sheep

Liu, H., Schultz, C. G., De Blasio, M. J., Peura, A. M., Heinemann, G. K., Harryanto, H., Hunter, D. S., Wooldridge, A. L., Kind, K. L., Giles, L. C., Simmons, R. A., Owens, J. A. & Gatford, K. L., 15 Sep 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 309, 6, p. E589-E600 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

Maternal dexamethasone treatment alters tissue and circulating components of the renin-angiotensin system in the pregnant ewe and fetus

Forhead, A. J., Jellyman, J. K., De Blasio, M. J., Johnson, E., Giussani, D. A., Pipkin, F. B. & Fowden, A. L., 1 Aug 2015, In : Endocrinology. 156, 8, p. 3038-3046 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Placental and fetal growth restriction, size at birth and neonatal growth alter cognitive function and behaviour in sheep in an age- and sex-specific manner

Hunter, D. S., Hazel, S. J., Kind, K. L., Liu, H., Marini, D., Giles, L. C., De Blasio, M. J., Owens, J. A., Pitcher, J. B. & Gatford, K. L., 1 Dec 2015, In : Physiology and Behavior. 152, p. 1-10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110alpha) signaling

De Blasio, M. J., Huynh, K. N. N., Qin, C. H., Rosli, S., Kiriazis, H., Ayer, A., Cemerlang, N., Stocker, R., Du, X-J., McMullen, J. R. & Ritchie, R. H., 2015, In : Free Radical Biology and Medicine. 87, (Art. No:12407), p. 137 - 147 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2013

Determinants of maternal triglycerides in women with gestational diabetes mellitus in themetformin in gestational diabetes (MiG) study

Barrett, H. L., Nitert, M. D., Jones, L., O'Rourke, P., Lust, K., Gatford, K. L., De Blasio, M. J., Coat, S., Owens, J. A., Hague, W. M., McIntyre, H. D., Callaway, L. & Rowan, J., 28 Oct 2013, In : Diabetes Care. 36, 7, p. 1941-1946 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Maternal and neonatal circulating markers of metabolic and cardiovascular risk in the Metformin in Gestational diabetes (MiG) trial

Barrett, H. L., Gatford, K. L., Houda, C. M., De Blasio, M. J., Mcintyre, H. D., Callaway, L. K., Nitert, M. D., Coat, S., Owens, J. A., Hague, W. M. & Rowan, J. A., 1 Mar 2013, In : Diabetes Care. 36, 3, p. 529-536 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Neonatal Exendin-4 Reduces Growth, Fat Deposition and Glucose Tolerance during Treatment in the Intrauterine Growth-Restricted Lamb

Gatford, K. L., Sulaiman, S. A., Mohammad, S. N. B., De Blasio, M. J., Harland, M. L., Simmons, R. A. & Owens, J. A., 12 Feb 2013, In : PLoS ONE. 8, 2, e56553.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

Fullston, T., Teague, E. M. C. O., Palmer, N. O., Deblasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A. & Lane, M., 1 Oct 2013, In : The FASEB Journal. 27, 10, p. 4226-4243 18 p.

Research output: Contribution to journalArticleResearchpeer-review

298 Citations (Scopus)
2012

Increased placental nutrient transporter expression at midgestation after maternal growth hormone treatment in pigs: a placental mechanism for increased fetal growth.

Tung, E., Roberts, C. T., Heinemann, G. K., De Blasio, M. J., Kind, K. L., van Wettere, W. H. E. J., Owens, J. A. & Gatford, K. L., 1 Jan 2012, In : Biology of Reproduction. 87, 5

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Maternal low-dose porcine somatotropin treatment in late gestation increases progeny weight at birth and weaning in sows but not in gilts

Gatford, K. L., Smits, R. J., Collins, C. L., de Blasio, M. J., Roberts, C. T., Nottle, M. B., van Wettere, W. H. E. J., Kind, K. L. & Owens, J. A., 1 May 2012, In : Journal of Animal Science. 90, 5, p. 1428-1435 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Placental restriction reduces insulin sensitivity and expression of insulin signaling and glucose transporter genes in skeletal muscle, but not liver, in young sheep

De Blasio, M. J., Gatford, K. L., Harland, M. L., Robinson, J. S. & Owens, J. A., 1 May 2012, In : Endocrinology. 153, 5, p. 2142-2151 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
35 Citations (Scopus)

Testing the plasticity of insulin secretion and β-cell function in vivo: Responses to chronic hyperglycaemia in the sheep

Gatford, K. L., De Blasio, M. J., How, T. A., Harland, M. L., Summers-Pearce, B. L. & Owens, J. A., 1 Jan 2012, In : Experimental Physiology. 97, 5, p. 663-675 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2010

Maternal responses to daily maternal porcine somatotropin injections during early-mid pregnancy or early-late pregnancy in sows and gilts

Gatford, K. L., Smits, R. J., Collins, C. L., Argent, C., de Blasio, M. J., Roberts, C. T., Nottle, M. B., Kind, K. L. & Owens, J. A., 1 Apr 2010, In : Journal of Animal Science. 88, 4, p. 1365-1378 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Placental restriction increases adipose leptin gene expression and plasma leptin and alters their relationship to feeding activity in the young lamb

De Blasio, M. J., Blache, D., Gatford, K. L., Robinson, J. S. & Owens, J. A., 1 Jun 2010, In : Pediatric Research. 67, 6, p. 603-608 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Review: Placental Programming of Postnatal Diabetes and Impaired Insulin Action after IUGR

Gatford, K. L., Simmons, R. A., De Blasio, M. J., Robinson, J. S. & Owens, J. A., 1 Mar 2010, In : Placenta. 31, SUPPL.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)
2009

Responses to maternal GH or ractopamine during early-mid pregnancy are similar in primiparous and multiparous pregnant pigs

Gatford, K. L., De Blasio, M. J., Roberts, C. T., Nottle, M. B., Kind, K. L., Van Wettere, W. H. E. J., Smits, R. J. & Owens, J. A., 1 Oct 2009, In : Journal of Endocrinology. 203, 1, p. 143-154 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)
2008

Effect of Variable Long-Term Maternal Feed Allowance on the Development of the Ovine Placenta and Fetus

Quigley, S. P., Kleemann, D. O., Walker, S. K., Speck, P. A., Rudiger, S. R., Nattrass, G. S., DeBlasio, M. J. & Owens, J. A., 1 Jun 2008, In : Placenta. 29, 6, p. 539-548 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Impaired β-cell function and inadequate compensatory increases in β-cell mass after intrauterine growth restriction in sheep

Gatford, K. L., Mohammad, S. N. B., Harland, M. L., De Blasio, M. J., Fowden, A. L., Robinson, J. S. & Owens, J. A., 1 Oct 2008, In : Endocrinology. 149, 10, p. 5118-5127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)

Improved lactational nutrition and postnatal growth ameliorates impairment of glucose tolerance by uteroplacental insufficiency in male rat offspring

Siebel, A. L., Mibus, A., De Blasio, M. J., Westcott, K. T., Morris, M. J., Prior, L., Owens, J. A. & Wlodek, M. E., 1 Jun 2008, In : Endocrinology. 149, 6, p. 3067-3076 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
60 Citations (Scopus)
2007

Maternal exposure to dexamethasone or cortisol in early pregnancy differentially alters insulin secretion and glucose homeostasis in adult male sheep offspring

De Blasio, M. J., Dodic, M., Jefferies, A. J., Moritz, K. M., Wintour-Coghlan, M. & Owens, J. A., 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 293, 1, p. E75 - E82 8 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Mild gestational diabetes in pregnancy and the adipoinsular axis in babies born to mothers in the ACHOIS randomised controlled trial

Pirc, L. K., Owens, J. A., Crowther, C. A., Willson, K., De Blasio, M. J. & Robinson, J. S., 12 Apr 2007, In : BMC Pediatrics. 7, 18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

Placental restriction of fetal growth increases insulin action, growth, and adiposity in the young lamb

De Blasio, M. J., Gatford, K. L., McMillen, I. C., Robinson, J. S. & Owens, J. A., 1 Mar 2007, In : Endocrinology. 148, 3, p. 1350-1358 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
100 Citations (Scopus)
84 Citations (Scopus)

Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth

Owens, J. A., Gatford, K. L., De Blasio, M. J., Edwards, L. J., McMillen, I. C. & Fowden, A. L., 1 Nov 2007, In : Journal of Physiology. 584, 3, p. 935-949 15 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep

Owens, J. A., Thavaneswaran, P., De Blasio, M. J., McMillen, I. C., Robinson, J. S. & Gatford, K. L., 1 Jun 2007, In : American Journal of Physiology - Endocrinology and Metabolism. 292, 6

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)
2006

Placental restriction alters circulating thyroid hormone in the young lamb postnatally

De Blasio, M. J., Gatford, K. L., Robinson, J. S. & Owens, J. A., 9 Oct 2006, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 291, 4

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2004

Postnatal ontogeny of glucose homeostasis and insulin action in sheep

Gatford, K. L., De Blasio, M. J., Thavaneswaran, P., Robinson, J. S., McMillen, I. C. & Owens, J. A., 1 Jun 2004, In : American Journal of Physiology - Endocrinology and Metabolism. 286, 6 49-6

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)
2003

Variable maternal nutrition and growth hormone treatment in the second quarter of pregnancy in pigs alter semitendinosus muscle in adolescent progeny

Gatford, K. L., Ekert, J. E., Blackmore, K., De Blasio, M. J., Boyce, J. M., Owens, J. A., Campbell, R. G. & Owens, P. C., 1 Aug 2003, In : British Journal of Nutrition. 90, 2, p. 283-292 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)
2000

Differential timing for programming of glucose homoeostasis, sensitivity to insulin and blood pressure by in utero exposure to dexamethasone in sheep

Gatford, K. L., Wintour, E. M., De Blasio, M. J., Owens, J. A. & Dodic, M., 1 Jan 2000, In : Clinical Science. 98, 5, p. 553-560 8 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Treatment of underfed pigs with GH throughout the second quarter of pregnancy increases fetal growth

Gatford, K. L., Owens, J. A., Campbell, R. G., Boyce, J. M., Grant, P. A., De Blasio, M. J. & Owens, P. C., 1 Jan 2000, In : Journal of Endocrinology. 166, 1, p. 227-234 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)