Projects per year
Personal profile
Biography
Dr Miles De Blasio is a Senior Researcher and head of the Cardio-Metabolic Physiology Laboratory and co-head of the Heart Failure Pharmacology Laboratory in the Drug Discovery Biology (DDB) theme at Monash Institute of Pharmaceutical Sciences (MIPS). He holds an Honorary Research Collaborator position at the Baker Heart and Diabetes Institute and is an Honorary Research Fellow of the Department of Pharmacology at Monash Clayton.
Dr De Blasio completed his PhD in 2004 (Uni Adelaide) where he studied the endocrine and metabolic basis of diabetes and obesity after fetal growth restriction. He then spent 4-years in industry with the Australian Pork Cooperative Research Centre (CRC) before moving to the University of Cambridge (UK) to undertake a very successful post-doctoral research project investigating fetal leptin administration on lung and heart development. Dr De Blasio is well-recognised for his contributions to the fetal and postnatal physiology field.
In 2015 he returned to Australia and was recruited to the Baker Heart and Diabetes Institute by Prof Rebecca Ritchie (now Drug Discovery Biology Theme leader at Monash MIPS), to investigate new treatments for diabetic cardiomyopathy in pre-clinical models of diabetes; representing a significant change of research direction. In 2020, he moved to Monash University Institute of Pharmaceutical Sciences (MIPS) Parkville, where he is now the lead researcher investigating new treatments for diabetic cardiomyopathy including the use of pharmacological agents and cardiac-selective gene therapies to target pathways involved in cardioprotection. This includes the hexosamine biosynthesis pathway, particularly O-GlcNAcylation of proteins, and the cardiac adiponectin signalling pathway. He has an overarching vision to make significant contributions to the development of novel therapies for diabetic cardiomyopathy.
His track record to 2015 was investigating the fetal origins of obesity and diabetes in large animal models (sheep) and clinical trials (MiG and ACHOIS RCTs). He has been a CI on 4 NHMRC project grants investigating interventions for insulin resistance, beta-cell plasticity and diabetic cardiomyopathy and has obtained >$7million in funding as CI or named investigator. He has considerable experience with in vivo pre-clinical models of diabetes and metabolic syndrome, and design and administration of pharmaceutical and cardiac-selective gene therapies in vivo and in vitro, having published 68 career papers (43 in last 5 years). His research parameters indicate his research is high impact in the field (>2900 citations, FWCI=2.75, April 2023). He displays outstanding leadership qualities having supervised 10 PhD and 15 Honours students to completion.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Baker Honorary Researcher (Collaborator), Baker Heart and Diabetes Institute
2020 → …
Research area keywords
- Diabetic Complications
- novel therapeutics
- adiponectin
- Pre-clinical studies
- diastolic dysfunction
- Diabetes
- Cardiomyopathies
- Clinical Trials
- myocarditis
Collaborations and top research areas from the last five years
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LIFTING THE VEIL: SEX-SPECIFIC CARDIAC BENEFITS OF NEXT-GENERATION GLUCOSE-LOWERING THERAPY
Ritchie, R. (Primary Chief Investigator (PCI)) & De Blasio, M. (Chief Investigator (CI))
1/01/23 → 30/04/25
Project: Research
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Characterisation of a preclinical mouse model of diabetic cardiomyopathy ready for translational investigations
De Blasio, M. (Primary Chief Investigator (PCI)) & Ritchie, R. (Chief Investigator (CI))
10/03/23 → 9/03/25
Project: Research
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Targeting cardiac adiponectin signalling as a novel treatment for cardiac lipotoxicity.
De Blasio, M. (Primary Chief Investigator (PCI)), Anderson, D. (Chief Investigator (CI)), Ritchie, R. (Chief Investigator (CI)) & Prakoso, D. (Chief Investigator (CI))
3/01/22 → 31/12/22
Project: Research
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Elucidating the transcriptomic profile of impaired glucose metabolism in diabetic female hearts
Prakoso, D. (Primary Chief Investigator (PCI)), Ritchie, R. (Chief Investigator (CI)), Nath, A. P. (Chief Investigator (CI)), De Blasio, M. (Chief Investigator (CI)), Wende, A. (Chief Investigator (CI)) & Gregorevic, P. (Chief Investigator (CI))
18/03/21 → 31/12/21
Project: Research
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Characterising glucose-driven myocardial subproteome in the diabetic human heart and its link to cardiomyopathy phenotype
Ritchie, R. (Primary Chief Investigator (PCI)), Greening, D. W. (Chief Investigator (CI)), De Blasio, M. (Chief Investigator (CI)), Zimmet, A. D. (Associate Investigator (AI)) & Erickson, J. R. (Associate Investigator (AI))
1/01/21 → 31/03/23
Project: Research
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A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
Velagic, A., Li, M., Deo, M., Li, J. C., Kiriazis, H., Donner, D. G., Anderson, D., De Blasio, M. J., Woodman, O. L., Kemp-Harper, B. K., Qin, C. X. & Ritchie, R. H., Feb 2023, In: American Journal of Physiology - Heart and Circulatory Physiology. 324, 2, p. H241-H257 17 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Cardiovascular characterisation of a novel mouse model that combines hypertension and diabetes co-morbidities
Sharma, A., Choi, J. S. Y., Watson, A. M. D., Li, L., Sonntag, T., Lee, M. K. S., Murphy, A. J., De Blasio, M., Head, G. A., Ritchie, R. H. & de Haan, J. B., Dec 2023, In: Scientific Reports. 13, 1, 15 p., 8741.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Current challenges in the treatment of cardiac fibrosis: Recent insights into the sex-specific differences of glucose-lowering therapies on the diabetic heart: IUPHAR Review 33
Sharma, A., De Blasio, M. & Ritchie, R., Nov 2023, In: British Journal of Pharmacology. 180, 22, p. 2916-2933 18 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access9 Citations (Scopus) -
Hypothyroidism impairs development of the gastrointestinal tract in the ovine fetus
Young, R., Lewandowska, D., Long, E., Wooding, F. B. P., De Blasio, M. J., Davies, K. L., Camm, E. J., Sangild, P. T., Fowden, A. L. & Forhead, A. J., 3 Mar 2023, In: Frontiers in Physiology. 14, 14 p., 1124938.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Mapping the cellular and molecular landscape of cardiac non-myocytes in murine diabetic cardiomyopathy
Cohen, C. D., De Blasio, M. J., Farrugia, G. E., Dona, M. S. I., Hsu, I., Prakoso, D., Kiriazis, H., Krstevski, C., Nash, D. M., Li, M., Gaynor, T. L., Deo, M., Drummond, G. R., Ritchie, R. H. & Pinto, A. R., 20 Oct 2023, In: iScience. 26, 10, 21 p., 107759.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus)
Prizes
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Award - Finalist (1 of 6 in Australia) - Novartis Junior Investigator Award
De Blasio, M. (Recipient), 2001
Prize: Prize (including medals and awards)
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Award - Finalist for Ross Wishart Award, Australian Society of Medical Research (ASMR)
De Blasio, M. (Recipient), 2001
Prize: Prize (including medals and awards)
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Award - Second, Oral presentation - IGF Down Under Symposia
De Blasio, M. (Recipient), 2006
Prize: Prize (including medals and awards)
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Award - Second - Oral presentation for GH-IGF International Conference
De Blasio, M. (Recipient), 2004
Prize: Prize (including medals and awards)
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Award - Winner - New Investigator Award, Perinatal Society of Australia and New Zealand (PSANZ)
De Blasio, M. (Recipient), 2002
Prize: Prize (including medals and awards)
Press/Media
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Press release - Publication - Cardiovascular Research
15/03/21
1 item of Media coverage
Press/Media: Research
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Getting to the heart of it - Interview and Editorial
11/09/18
1 item of Media coverage
Press/Media: Profile/Interview
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Press release - Publication - Journal of Physiology
31/01/17
1 Media contribution
Press/Media: Article/Feature
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