19942019

Research output per year

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Alpha-toxin of Clostridium perfringens is not an essential virulence factor in necrotic enteritis in chickens

Keyburn, A. L., Sheedy, S. A., Ford, M. E., Williamson, M. M., Awad, M. M., Rood, J. I. & Moore, R. J., 2006, In : Infection and Immunity. 74, 11, p. 6496 - 6500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

152 Citations (Scopus)

Antibiotic resistance, virulence factors and genetics of clostridium sordellii

Vidor, C., Awad, M. M. & Lyras, D., 2015, In : Research in Microbiology. 166, 4, p. 368 - 374 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., Dec 2019, In : Nature Microbiology. 4, p. 2237-2245 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Clostridial gas gangrene: Evidence that α and θ toxins differentially modulate the immune response and induce acute tissue necrosis

Stevens, D. L., Tweten, R. K., Awad, M. M., Rood, J. I. & Bryant, A. E., 1 Jan 1997, In : Journal of Infectious Diseases. 176, 1, p. 189-195 7 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Clostridial gas ganrene: evidence that a and q toxins differentially modulate the immune response and induce acute tissue necrosis

Stevens, D. L., Tweten, R. K., Awad, M. M., Rood, J. I. & Bryant, A. E., 1997, In : Journal of Infectious Diseases. p. 189 - 195 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Clostridium difficile virulence factors: insights into an anaerobic spore-forming pathogen

Awad, M. M., Johanesen, P. A., Carter, G. P., Rose, E. & Lyras, D., 2014, In : Gut Microbes. 5, 5, p. 579 - 593 15 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Clostridium sordellii genome analysis reveals plasmid localized toxin genes encoded within pathogenicity loci

Couchman, E. C., Browne, H. P., Dunn, M., Lawley, T. D., Songer, J. G., Hall, V., Petrovska, L., Vidor, C., Awad, M. M., Lyras, D. & Fairweather, N. F., 16 May 2015, In : BMC Genomics. 16, 1, 13 p., 392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract

Rabi, R., Larcombe, S., Mathias, R., McGowan, S., Awad, M. & Lyras, D., 18 Apr 2018, In : PLoS Pathogens. 14, 4, 25 p., e1007004.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Clostridium sordellii pathogenicity locus plasmid pCS1-1 encodes a novel clostridial conjugation locus

Vidor, C. J., Watts, T. D., Adams, V., Bulach, D., Couchman, E., Rood, J. I., Fairweather, N. F., Awad, M. & Lyras, D., 16 Jan 2018, In : mBio. 9, 1, 14 p., e01761-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Construction and virulence testing of a collagenase mutant of Clostridium perfringens

Awad, M. M., Ellemor, D. M., Bryant, A. E., Matsushita, O., Boyd, R. L., Stevens, D. L., Emmins, J. J. & Rood, J. I., 2000, In : Microbial Pathogenesis. p. 107 - 117 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance

Johanesen, P. A., Mackin, K. E., Hutton, M. L., Awad, M. M., Larcombe, S., Amy, J. M. & Lyras, D., 2015, In : Genes. 6, 4, p. 1347 - 1360 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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35 Citations (Scopus)

Expression of the large clostridial toxins is controlled by conserved regulatory mechanisms

Carter, G. P., Larcombe, S., Li, L., Jayawardena, D., Awad, M. M., Songer, J. G. & Lyras, D., 2014, In : International Journal of Medical Microbiology. 304, 8, p. 1147 - 1159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Functional analysis of an feoB mutant in Clostridium perfringens strain 13

Awad, M. M., Cheung, J. K., Tan, J. E., McEwan, A. G., Lyras, D. & Rood, J. I., Oct 2016, In : Anaerobe. 41, p. 10-17 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Functional analysis of the VirSR phosphorelay from Clostridium perfringens

Cheung, K-L. J., Awad, M. M., McGowan, S. & Rood, J. I., 2009, In : PLoS ONE. 4, 6 (e5849), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens

Lyristis, M., Bryant, A. E., Sloan, J., Awad, M. M., Nisbet, I. T., Stevens, D. L. & Rood, J. I., 1 Jan 1994, In : Molecular Microbiology. 12, 5, p. 761-777 17 p.

Research output: Contribution to journalArticleResearchpeer-review

148 Citations (Scopus)

Isolation of a-toxin, q-toxin, k-toxin mutants of Clostridium perfringens by Tn916 mutagenesis

Awad, M. M. & Rood, J. I., 1997, In : Microbial Pathogenesis. p. 275 - 284 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation of α-toxin, θ-toxin and κ-toxin mutants of Clostridium perfringens by Tn916 mutagenesis

Awad, M. M. & Rood, J. I., 1 Jan 1997, In : Microbial Pathogenesis. 22, 5, p. 275-284 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Lectin activity of the TcdA and TcdB toxins of Clostridium difficile

Hartley-Tassell, L. E., Awad, M. M., Seib, K. L., Scarselli, M., Savino, S., Tiralongo, J., Lyras, D., Day, C. J. & Jennings, M. P., 1 Mar 2019, In : Infection and Immunity. 87, 3, 9 p., e00676-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Molecular and cellular basis of microvascular perfusion deficits induced by clostridium perfringens and clostridium septicum

Hickey, M. J., Kwan, R., Awad, M. M., Kennedy, C. L., Young, L. F., Hall, P. H., Cordner, L. M., Lyras, D., Emmins, J. J. & Rood, J. I., 2008, In : PLoS Pathogens. 4, 4, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Necrotic Enteritis in Chickens Associated with Clostridium sordellii

Rimoldi, G., Uzal, F. A., Chin, R. P., Palombo, E. A., Awad, M. M., Lyras, D. & Shivaprasad, H. L., 2015, In : Avian Diseases. 59, 3, p. 447-451 5 p.

Research output: Contribution to journalArticleOtherpeer-review

9 Citations (Scopus)
9 Citations (Scopus)

Opioid analgesics stop the development of clostridial gas gangrene

Chakravorty, A., Awad, M. M., Hiscox, T. J., Cheung, K-L. J., Choo, J. M. F., Lyras, D. & Rood, J. I., 2014, In : Journal of Infectious Diseases. 210, 3, p. 483 - 492 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
Open Access
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pCP13, a representative of a new family of conjugative toxin plasmids in Clostridium perfringens

Watts, T. D., Vidor, C. J., Awad, M. M., Lyras, D., Rood, J. I. & Adams, V., 1 Mar 2019, In : Plasmid. 102, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Perfringolysin O Expression in Clostridium perfringens Is Independent of the Upstream pfoR Gene

Awad, M. M. & Rood, J. I., 2002, In : Journal of Bacteriology. 184, 7, p. 2034 - 2038 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens

Myers, G. S., Rasko, D. A., Cheung, K-L. J., Ravel, J., Seshadri, R., DeBoy, R. T., Ren, Q., Varga, J., Awad, M. M., Brinkac, L. M., Daugherty, S. C., Haft, D. H., Dodson, R. J., Madupu, R., Nelson, W. C., Rasovitz, M. J., Sullivan, S. A., Khouri, H., Dimitrov, G. I., Watkins, K. L. & 14 others, Mulligan, S., Benton, J., Radune, D., Fisher, D. J., Atkins, H. S., Hiscox, T. J., Jost, B. H., Billington, S. J., Songer, J. G., McClane, B. A., Titball, R. W., Rood, J. I., Melville, S. B. & Paulsen, I. T., 2006, In : Genome Research. 16, 8, p. 1031 - 1040 10 p.

Research output: Contribution to journalArticleResearchpeer-review

184 Citations (Scopus)

Structural characterization of Clostridium sordellii spores of diverse human, animal, and environmental origin and comparison to Clostridium difficile spores

Rabi, R., Turnbull, L., Whitchurch, C. B., Awad, M. & Lyras, D., 1 Sep 2017, In : mSphere. 2, 5, 12 p., e00343-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene

Awad, M. M., Ellemor, D. M., Boyd, R. L., Emmins, J. J. & Rood, J. I., 2001, In : Infection and Immunity. 69, 12, p. 7904 - 7910 7 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)

TcsL Is an Essential Virulence Factor in Clostridium sordellii ATCC 9714

Carter, G. P., Awad, M. M., Hao, Y., Thelen, T., Bergin, I. L., Howarth, P. M., Seemann, T., Rood, J. I., Aronoff, D. M. & Lyras, D., 2011, In : Infection and Immunity. 79, 3, p. 1025 - 1032 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

The alpha-toxin of Clostridium septicum is essential for virulence

Kennedy, C. L., Krejany, E. O., Young, L. F., O'Connor, J. R., Awad, M. M., Boyd, R. L., Emmins, J. J., Lyras, D. & Rood, J. I., 2005, In : Molecular Microbiology. 57, 5, p. 1357 - 1366 10 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

The cysteine protease alpha-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis

Chakravorty, A., Awad, M., Hiscox, T., Cheung, K-L., Carter, G., Choo, J., Lyras, D. & Rood, J., 2011, In : PLoS ONE. 6, 7, 7 p., e22762.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)
16 Citations (Scopus)

The level of expression of α-toxin by different strains of Clostridium perfringens is dependent on differences in promoter structure and genetic background

Bullifent, H. L., Moir, A., Awad, M. M., Scott, P. T., Rood, J. I. & Titball, R. W., 1 Jan 1996, In : Anaerobe. 2, 6, p. 365-371 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence

Chiarezza, M., Lyras, D., Pidot, S. J., Flores-Diaz, M., Awad, M. M., Kennedy, C. L., Cordner, L. M., Das, T. P., Poon, R., Hughes, M. L., Emmins, J. J., Alape-Giron, A. & Rood, J. I., 2009, In : Infection and Immunity. 77, 10, p. 4421 - 4428 8 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

The NEAT domain-containing proteins of Clostridium perfringens bind heme

Choo, J. M., Cheung, J. K., Wisniewski, J. A., Steer, D. L., Bulach, D. M., Hiscox, T. J., Chakravorty, A., Smith, A. I., Gell, D. A., Rood, J. I. & Awad, M. M., 16 Sep 2016, In : PLoS ONE. 11, 9, 26 p., 0162981.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

The pore-forming alpha-toxin from clostridium septicum activates the MAPK pathway in a Ras-c-Raf-dependent and independent manner

Chakravorty, A., Awad, M. M., Cheung, J. K. T., Hiscox, T. J., Lyras, D. & Rood, J. I., 2015, In : Toxins. 7, 2, p. 516 - 534 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

The Sialidase NanS enhances non-TcsL mediated cytotoxicity of Clostridium sordellii

Awad, M. M., Singleton, J. & Lyras, D., 17 Jun 2016, In : Toxins. 8, 6, 15 p., 189.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease

Uzal, F. A., Freedman, J. C., Shrestha, A., Theoret, J. R., Garcia, J. P., Awad, M. M., Adams, V. M., Moore, R. J., Rood, J. I. & McClane, B. A., 2014, In : Future Microbiology. 9, 3, p. 361 - 377 17 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)

Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia

Draxler, D. F., Awad, M. M., Hanafi, G., Daglas, M., Ho, H., Keragala, C., Galle, A., Roquilly, A., Lyras, D., Sashindranath, M. & Medcalf, R. L., 1 Dec 2019, In : Journal of Neurotrauma. 36, 23, p. 3297-3308 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Use of genetically manipulated strains of "Clostridium perfringens" reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene

Ellemor, D. M., Baird, R. N., Awad, M. M., Boyd, R. L., Rood, J. I. & Emmins, J. J., 1999, In : Infection and Immunity. p. 4902 - 4907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Utility of the clostridial site-specific recombinase TnpX to clone toxic-product-encoding genes and selectively remove genomic DNA fragments

Adams, V., Bantwal, R., Stevenson, L., Cheung, K-L. J., Awad, M. M., Nicholson, A. J., Carter, G. P., Mackin, K. E., Rood, J. I. & Lyras, D., 2014, In : Applied and Environmental Microbiology. 80, 12, p. 3597-3603 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)
243 Citations (Scopus)