Projects per year
Personal profile
Biography
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Projects
- 4 Finished
-
Mechanism of secretion of large clostridial toxins
Lyras, D. (Primary Chief Investigator (PCI)), McGowan, S. (Chief Investigator (CI)) & Awad, M. (Chief Investigator (CI))
Australian Research Council (ARC)
1/01/21 → 31/12/23
Project: Research
-
The role of host proteases in exacerbating enteric infectious disease
Lyras, D. (Primary Chief Investigator (PCI)), Srikhanta, Y. (Chief Investigator (CI)), Awad, M. (Chief Investigator (CI)) & Hutton, M. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/21 → 31/12/24
Project: Research
-
The role of Clostridium difficile spore surface structures in initiating gastrointestinal infection and disease
Lyras, D. (Primary Chief Investigator (PCI)), Awad, M. (Chief Investigator (CI)) & Rood, J. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/15
Project: Research
-
Host-pathogen interactions in clostrudial myonecrosis
Rood, J. (Primary Chief Investigator (PCI)), Awad, M. (Chief Investigator (CI)) & Lyras, D. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/11 → 31/12/14
Project: Research
-
A Clostridioides difficile endolysin modulates toxin secretion without cell lysis
Awad, M. M., Suraweera, C. D., Vidor, C. J., Ye-Lin, A. Y., Williams, G. C., Mileto, S. J., Barlow, C. K., McGowan, S. & Lyras, D., Dec 2024, In: Communications Biology. 7, 1, 12 p., 1044.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome
Mathur, A., Kay, C., Xue, Y., Pandey, A., Lee, J., Jing, W., Enosi Tuipulotu, D., Lo Pilato, J., Feng, S., Ngo, C., Zhao, A., Shen, C., Rug, M., Miosge, L. A., Atmosukarto, I. I., Price, J. D., Ali, S. A., Gardiner, E. E., Robertson, A. A. B. & Awad, M. M. & 3 others, , 2023, In: EMBO Reports. 24, 6, 20 p., e54600.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
A Highly Specific Holin-Mediated Mechanism Facilitates the Secretion of Lethal Toxin TcsL in Paeniclostridium sordellii
Vidor, C. J., Hamiot, A., Wisniewski, J., Mathias, R. A., Dupuy, B., Awad, M. & Lyras, D., Feb 2022, In: Toxins. 14, 2, 19 p., 124.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins
Jing, W., Pilato, J. L., Kay, C., Feng, S., Tuipulotu, D. E., Mathur, A., Shen, C., Ngo, C., Zhao, A., Miosge, L. A., Ali, S. A., Gardiner, E. E., Awad, M. M., Lyras, D., Robertson, A. A. B., Kaakoush, N. O. & Man, S. M., May 2022, In: Science Immunology. 7, 71, 17 p., eabm1803.Research output: Contribution to journal › Article › Research › peer-review
28 Citations (Scopus) -
Chromosome Segregation and Peptidoglycan Remodeling Are Coordinated at a Highly Stabilized Septal Pore to Maintain Bacterial Spore Development
Mohamed, A., Chan, H., Luhur, J., Bauda, E., Gallet, B., Morlot, C., Cole, L., Awad, M., Crawford, S., Lyras, D., Rudner, D. Z. & Rodrigues, C. D. A., 11 Jan 2021, In: Developmental Cell. 56, 1, p. 36-51.e5 21 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus)
Activities
- 1 Patents
-
PCT/AU2018/051007 (Event)
Yogi Srikhanta (Inventor), Melanie Hutton (Inventor), Milena Awad (Inventor), Julie Singleton (Inventor), Nyssa Drinkwater (Inventor), Sheena McGowan (Inventor) & Dena Lyras (Inventor)
14 Sept 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent