Projects per year
Personal profile
Biography
Mike is Pro Vice-Chancellor Research at Monash University. He also heads the Mitochondrial Biology and Disease Laboratory in the Monash Biomedicine Discovery Institute. Mike joined the Department of Biochemistry and Molecular Biology in 2014 and served as Deputy Dean (Research and Research Infrastructure) in the Faculty of Medicine, Nursing and Health Sciences before becoming Academic Director Research Infrastructure. Before this he was Head of the Department of Biochemistry at La Trobe University. Mike's research focuses on mitochondrial biology and disease. After undertaking his PhD on molecular chaperones with Peter Hoj (La Trobe/Adelaide), Mike joined the group of Klaus Pfanner (University of Freiburg, Germany) as an Alexander von Humboldt fellow (1997-1999) where he studied protein import mechanisms. His group now uses a variety of techniques including gene editing, proteomics and mouse models to investgate and characterise the gene products involved in mitochondrial disease and dynamics.
Mike was President of the Australian Society for Biochemistry and Molecular Biology. He sits on a variety of university committees and external bodies inlcuding the Scientific and Medical Advisory Panel for the Australian Mitochondrial Disease Foundation (AMDF), Research Grants panels for the International Human Frontiers Science Program Organisation and board memberships. His work is funded by the National Health and Medical Research Council, the Australian Research Council, MRFF and the AMDF.
Research lab webpage: www.monash.edu/discovery-institute/ryan-lab
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Mitochondria
- mitochondrial disease
- mitochondrial dynamics
- mitochondrial fission
- complex I
- mitochondria
- gene-edting
- leigh syndrome
- blue native-page
- proteomics
Network
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Advanced lattice light sheet microscope optimised for biological imaging
Lieschke, G., Currie, P., Mitchell, C., Ryan, M., Zenker, J., Hogan, B. M., Smith, K. A. & Poon, I.
6/05/22 → 5/05/23
Project: Research
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Mechanisms maintaining mitochondrial copper homeostasis
Maher, M., Newstead, S. & Ryan, M.
1/01/22 → 31/12/24
Project: Research
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Molecular mechanisms underlying the pathogenesis of complex I dysfunction and mitochondrial disease
Ryan, M. & Reljic, B.
1/01/22 → 31/12/25
Project: Research
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Mitochondrial Diagnostic Network for Genomics and Omics
Thorburn, D. R., Sue, C., Filipovska, A., Ryan, M., Stroud, D. A., Stojanovski, D., Coman, D. J., Murray, S., Davis, R., Christodoulou , J., Lamont, P. J., Sallevelt, S., Ghaoui, R., Simons, C., Siira, S., Balasubramaniam, S., Compton, A. G. & Macarthur, D.
1/06/21 → 31/05/25
Project: Research
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Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response
McMahon, K. A., Stroud, D. A., Gambin, Y., Tillu, V. A., Bastiani, M., Sierecki, E., Polinkovsky, M., Hall, T. E., Gomez, G. A., Wu, Y., Parat, M. O., Martel, N., Lo, H. P., Khanna, K. K., Alexandrov, K., Daly, R., Yap, A. S., Ryan, M. T. & Parton, R. G., Jun 2021, In: eLife. 10, 35 p., e61407.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus
Frazier, A. E., Compton, A. G., Kishita, Y., Hock, D. H., Welch, A. E., Amarasekera, S. S. C., Rius, R., Formosa, L. E., Imai-Okazaki, A., Francis, D., Wang, M., Lake, N. J., Tregoning, S., Jabbari, J. S., Lucattini, A., Nitta, K. R., Ohtake, A., Murayama, K., Amor, D. J., McGillivray, G. & 25 others, , 15 Jan 2021, In: Med. 2, 1, p. 49-73.e10 35 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Function and regulation of the divisome for mitochondrial fission
Kraus, F., Roy, K., Pucadyil, T. J. & Ryan, M. T., 4 Feb 2021, In: Nature. 590, 7844, p. 57-66 10 p.Research output: Contribution to journal › Review Article › Research › peer-review
35 Citations (Scopus) -
Mitochondrial dynamics in health and disease
Yapa, N. M. B., Lisnyak, V., Reljic, B. & Ryan, M. T., Apr 2021, In: FEBS Letters. 595, 8, p. 1184-1204 21 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access23 Citations (Scopus) -
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells
Sun, X., Cao, B., Naval-Sanchez, M., Pham, T., Sun, Y. B. Y., Williams, B., Heazlewood, S. Y., Deshpande, N., Li, J., Kraus, F., Rae, J., Nguyen, Q., Yari, H., Schröder, J., Heazlewood, C. K., Fulton, M., Hatwell-Humble, J., Das Gupta, K., Kapetanovic, R., Chen, X. & 6 others, , Dec 2021, In: Nature Communications. 12, 1, 17 p., 2665.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus)