Projects per year
Personal profile
Biography
Professor Mike Ryan is the Interim Deputy Vice-Chancellor (Research) and Senior Vice-President at Monash University, providing leadership, direction and advancing the University's research agenda. He is responsible for Monash’s research capability, performance and impact, as well as delivering research services, including funding administration, graduate research programs and research infrastructure.
Prior to this appointment, Professor Ryan was Pro Vice-Chancellor (Research), responsible for leading and supporting Monash’s research agenda, fostering excellence and collaboration and promoting Monash’s research capabilities, global reputation and profile.
Professor Ryan is an award-winning research leader with a background in biochemistry and molecular biology. He heads the Mitochondrial Biology and Disease Laboratory at Monash University’s Biomedical Discovery Institute, with funding from the Australian Research Council (ARC), National Health and Medical Research Council (NHMRC), the Medical Research Future Fund (MRFF) and the Mito Foundation. His research seeks to understand mitochondrial disease pathogenesis and to contribute to the prevention, diagnosis, treatment and cures of mitochondrial disorders. He has published extensively in top-tier publications including Nature and Science, and has served as a member on a number of editorial boards.
Professor Ryan serves as Chair of the Research Grant Committee and Selection Grant Committee of the International Human Frontier Science Program Organisation, based in Strasbourg, France. He is also a Board member for the Mito Foundation and Chair of its Scientific and Medical Advisory Panel.
In 2006, Professor Ryan was awarded the Roche Medal from the Australian Society for Biochemistry and Molecular Biology (ASBMB). In 2015 to 2016, Professor Ryan served as President of ASBMB. In 2023, he was awarded the ASBMB Lemberg Medal. The medal is a recognition of Professor Ryan’s outstanding research in biochemistry and molecular biology, as well as his contributions to the science community and society.
He has also previously held the positions of Academic Director (Research Infrastructure) and Deputy Dean (Research and Research Infrastructure) in Monash’s Faculty of Medicine, Nursing and Health Sciences. Before coming to Monash, Professor Ryan was Head of the Department of Biochemistry at La Trobe University, and was an Alexander von Humboldt Fellow at the University of Freiburg, Germany.
Professor Ryan holds a Bachelor of Science (Honours) and PhD in Biochemistry from La Trobe University.
Research lab webpage: www.monash.edu/discovery-institute/ryan-lab
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Mitochondria
- mitochondrial disease
- mitochondrial dynamics
- mitochondrial fission
- complex I
- mitochondria
- gene-edting
- leigh syndrome
- CRISPR Cas9
- proteomics
- metabolism
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The next great escape – how does mtDNA become extracellular?
McArthur, K. (Primary Chief Investigator (PCI)) & Ryan, M. (Chief Investigator (CI))
1/01/25 → 31/12/27
Project: Research
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MitoHOPE: Introducing Mitochondrial Donation in AustraliaL The MitoHOPE (Healthy Outcomes Pilot and Evaluation) Program
Carroll, J. (Primary Chief Investigator (PCI)), Herbert, M. (Chief Investigator (CI)), Christodoulou, J. (Chief Investigator (CI)), Thorburn, D. R. (Chief Investigator (CI)), Mills, C. (Chief Investigator (CI)), Zander-Fox, D. L. (Chief Investigator (CI)), Robker, R. (Chief Investigator (CI)), Rombauts, L. (Chief Investigator (CI)), Sallevelt, S. (Chief Investigator (CI)), Ludlow, K. (Chief Investigator (CI)), Coman, D. J. (Chief Investigator (CI)), Ellaway, C. (Chief Investigator (CI)), Mackey, D. A. (Chief Investigator (CI)), Delatycki, M. B. (Chief Investigator (CI)), Yau, W. Y. (Chief Investigator (CI)), Tchan, M. C. (Chief Investigator (CI)), Long, J. C. (Chief Investigator (CI)), Hardy, T. (Chief Investigator (CI)), Adhikari, D. (Chief Investigator (CI)), Choudhary, M. (Chief Investigator (CI)), Hyslop, L. A. (Chief Investigator (CI)), Mann, J. (Chief Investigator (CI)), Ryan, M. (Chief Investigator (CI)), Hodges, R. (Chief Investigator (CI)), Hui, L. (Chief Investigator (CI)), Kamien, B. A. (Chief Investigator (CI)), Mallett, A. J. (Chief Investigator (CI)), Semsarian, C. (Chief Investigator (CI)), Wallis, M. J. (Chief Investigator (CI)), Wall, M. (Chief Investigator (CI)), Zoungas, S. (Chief Investigator (CI)), Goranitis, I. (Chief Investigator (CI)), Gyngell, C. (Chief Investigator (CI)), Hammarberg, K. (Chief Investigator (CI)), Sparrow, R. (Chief Investigator (CI)), Warren, N. (Chief Investigator (CI)), Fahey, M. (Chief Investigator (CI)), Stutterd, C. A. (Associate Investigator (AI)), Schweitzer, D. (Associate Investigator (AI)), McGillivray, G. (Associate Investigator (AI)), Savulescu, J. (Associate Investigator (AI)), Panetta, J. (Associate Investigator (AI)), Kava, M. P. (Associate Investigator (AI)), Freckmann, M.-L. (Associate Investigator (AI)), Lynch, M. (Associate Investigator (AI)), Lamont, P. J. (Associate Investigator (AI)), Scott, R. (Associate Investigator (AI)), Ware, T. (Associate Investigator (AI)), Mowat, D. (Associate Investigator (AI)), Jones, K. J. (Associate Investigator (AI)), Green, S. (Associate Investigator (AI)), Wolfe, R. (Associate Investigator (AI)), Hackett, A. (Associate Investigator (AI)), Bratkovic, D. (Associate Investigator (AI)), Horton, A. (Associate Investigator (AI)) & Blok, R. (Project Manager)
Monash University – Internal Faculty Contribution, Australian Genomics, Centenary Institute of Cancer Medicine & Cell Biology, James Cook University, Lyons Eye Institute Limited, Macquarie University, Murdoch Children's Research Institute, Australian Mitochondrial Disease Foundation Limited (trading as Mito Foundation), Monash IVF Group Limited, Perron Institute for Neurological and Translational Science Limited, Queensland Children's Hosptial , Tasmanian Clinical Genetics Service, University of Adelaide, Victorian Assisted Reproductive Treatment Authority (VARTA) (Victoria), Women's and Children's Health Care Network Incorporated, Western Sydney Local Health District (WSLHD)
1/06/23 → 31/05/29
Project: Research
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Molecular mechanisms underlying the pathogenesis of complex I dysfunction and mitochondrial disease
Ryan, M. (Primary Chief Investigator (PCI)) & Reljic, B. (Chief Investigator (CI))
1/01/22 → 31/12/25
Project: Research
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Advanced lattice light sheet microscope optimised for biological imaging
Lieschke, G. (Primary Chief Investigator (PCI)), Currie, P. (Chief Investigator (CI)), Mitchell, C. (Chief Investigator (CI)), Ryan, M. (Chief Investigator (CI)), Zenker, J. (Chief Investigator (CI)), Hogan, B. (Chief Investigator (CI)), Smith, K. A. (Chief Investigator (CI)) & Poon, I. (Chief Investigator (CI))
6/05/22 → 31/12/22
Project: Research
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Dynamics of mitochondrial cristae in life and death
Ryan, M. (Primary Chief Investigator (PCI)) & McArthur, K. (Chief Investigator (CI))
21/02/22 → 20/02/25
Project: Research
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Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA
McArthur, K. & Ryan, M. T., 20 Mar 2025, In: Nature. 639, 8055, p. 582-584 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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The African killifish: A short-lived vertebrate model to study the biology of sarcopenia and longevity
Ruparelia, A. A., Salavaty, A., Barlow, C. K., Lu, Y., Sonntag, C., Hersey, L., Eramo, M. J., Krug, J., Reuter, H., Schittenhelm, R. B., Ramialison, M., Cox, A., Ryan, M. T., Creek, D. J., Englert, C. & Currie, P. D., Jan 2024, In: Aging Cell. 23, 1, 22 p., e13862.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2
Wu, Y., Lim, Y.-W., Stroud, D. A., Martel, N., Hall, T. E., Lo, H. P., Ferguson, C., Ryan, M. T., McMahon, K.-A. & Parton, R. G., 13 Mar 2023, In: Developmental Cell. 58, 5, p. 376-397.e1-4 27 p.Research output: Contribution to journal › Article › Research › peer-review
22 Citations (Scopus) -
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production
Heazlewood, S. Y., Ahmad, T., Cao, B., Cao, H., Domingues, M., Sun, X., Heazlewood, C. K., Li, S., Williams, B., Fulton, M., White, J. F., Nebl, T., Nefzger, C. M., Polo, J. M., Kile, B. T., Kraus, F., Ryan, M. T., Sun, Y. B., Choong, P. F. M. & Ellis, S. L. & 2 others, , Dec 2023, In: Nature Communications. 14, 1, 18 p., 2099.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV
Anderson, A. J., Crameri, J. J., Ang, C.-S., Malcolm, T. R., Kang, Y., Baker, M. J., Palmer, C. S., Sharpe, A. J., Formosa, L. E., Ganio, K., Baker, M. J., McDevitt, C. A., Ryan, M. T., Maher, M. J. & Stojanovski, D., 3 Aug 2023, In: EMBO Reports. 8, 23 p., e56430.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus)