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Personal profile


Mike is Associate Dean (Research Strategy) in the faculty of Medicine, Nursing and Helath Sciences and Head of the Mitochondrial biology and disease laboratory in the Biomedicine Discovery Institute. Mike joined the Department of Biochemistry and Molecular Biology in 2014. Before this he was Head of the Department of Biochemistry at La Trobe University. Mike's research focuses on mitochondrial biology and disease. After undertaking his PhD on molecular chaperones with Peter Hoj (La Trobe/Adelaide), Mike joined the group of Klaus Pfanner (University of Freiburg, Germany) as an Alexander von Humboldt fellow (1997-1999) where he studied protein import mechanisms. His group now uses a variety of techniques including gene editing, proteomics and mouse models to investgate and characterise the gene products involved in mitochondrial disease and dynamics.

Mike was President of the Australian Society for Biochemistry and Molecular Biology. He is a member of the Scientific and Medical Advisory Panel for the Australian Mitochondrial Disease Foundation (AMDF), the National Committee for Biomedical Science and is on the Grants panel for the Human Frontier Scrience Program. His work is funded by the National Health and Medical Research Council, the Australian Research Council and the AMDF.

Research lab webpage: www.ryanlab.org 


  • Mitochondria
  • mitochondrial disease
  • mitochondrial dynamics
  • mitochondrial fission
  • complex I
  • mitochondria
  • gene-edting
  • leigh syndrome
  • blue native-page
  • proteomics

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Projects 2013 2022

Research Output 1993 2019

A patient with homozygous nonsense variants in two Leigh syndrome disease genes: Distinguishing a dual diagnosis from a hypomorphic protein-truncating variant

Lake, N. J., Formosa, L. E., Stroud, D. A., Ryan, M. T., Calvo, S. E., Mootha, V. K., Morar, B., Procopis, P. G., Christodoulou, J., Compton, A. G. & Thorburn, D. R., 1 Jul 2019, In : Human Mutation. 40, 7, p. 893-898 6 p.

Research output: Contribution to journalArticleResearchpeer-review

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 othersLessene, G., Ryan, M. T., Rogers, K. L., Van Delft, M. F. & Kile, B. T., 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.

Research output: Contribution to journalArticleResearchpeer-review

Bi-allelic Mutations in NDUFA6 Establish Its Role in Early-Onset Isolated Mitochondrial Complex I Deficiency

Alston, C. L., Heidler, J., Dibley, M. G., Kremer, L. S., Taylor, L. S., Fratter, C., French, C. E., Glasgow, R. I. C., Feichtinger, R. G., Delon, I., Pagnamenta, A. T., Dolling, H., Lemonde, H., Aiton, N., Bjørnstad, A., Henneke, L., Gärtner, J., Thiele, H., Tauchmannova, K., Quaghebeur, G. & 11 othersHoustek, J., Sperl, W., Raymond, F. L., Prokisch, H., Mayr, J. A., McFarland, R., Poulton, J., Ryan, M. T., Wittig, I., Henneke, M. & Taylor, R. W., 4 Oct 2018, In : American Journal of Human Genetics. 103, 4, p. 592-601 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Building a complex complex: Assembly of mitochondrial respiratory chain complex I

Formosa, L. E., Dibley, M. G., Stroud, D. A. & Ryan, M. T., Apr 2018, In : Seminars in Cell and Developmental Biology. 76, p. 154-162 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission

Kamerkar, S. C., Kraus, F., Sharpe, A. J., Pucadyil, T. J. & Ryan, M. T., 7 Dec 2018, In : Nature Communications. 9, 1, 15 p., 5239.

Research output: Contribution to journalArticleResearchpeer-review

Open Access