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Personal profile

Biography

Mike is Deputy Dean (Research and Research Infrastructure) in the Faculty of Medicine, Nursing and Health Sciences and Head of the Mitochondrial biology and disease laboratory in the Biomedicine Discovery Institute. Mike joined the Department of Biochemistry and Molecular Biology in 2014. Before this he was Head of the Department of Biochemistry at La Trobe University. Mike's research focuses on mitochondrial biology and disease. After undertaking his PhD on molecular chaperones with Peter Hoj (La Trobe/Adelaide), Mike joined the group of Klaus Pfanner (University of Freiburg, Germany) as an Alexander von Humboldt fellow (1997-1999) where he studied protein import mechanisms. His group now uses a variety of techniques including gene editing, proteomics and mouse models to investgate and characterise the gene products involved in mitochondrial disease and dynamics.

Mike was President of the Australian Society for Biochemistry and Molecular Biology. He sits on a variety of university committees and external bodies inlcuding the Scientific and Medical Advisory Panel for the Australian Mitochondrial Disease Foundation (AMDF) and Research Grants panels for the International Human Frontiers Science Program Organisation. His work is funded by the National Health and Medical Research Council, the Australian Research Council and the AMDF.

Research lab webpage: www.ryanlab.org 

Research area keywords

  • Mitochondria
  • mitochondrial disease
  • mitochondrial dynamics
  • mitochondrial fission
  • complex I
  • mitochondria
  • gene-edting
  • leigh syndrome
  • blue native-page
  • proteomics

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Projects

Research Output

The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly

Dibley, M. G., Formosa, L. E., Lyu, B., Reljic, B., McGann, D., Muellner-Wong, L., Kraus, F., Sharpe, A. J., Stroud, D. A. & Ryan, M. T., 1 Jan 2020, In : Molecular & Cellular Proteomics. 19, 1, p. 65-77 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

The 'mitochondrial contact site and cristae organising system' (MICOS) in health and human disease

Eramo, M. J., Lisnyak, V., Formosa, L. E. & Ryan, M. T., Mar 2020, In : Journal of Biochemistry. 167, 3, p. 243-255 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A patient with homozygous nonsense variants in two Leigh syndrome disease genes: Distinguishing a dual diagnosis from a hypomorphic protein-truncating variant

Lake, N. J., Formosa, L. E., Stroud, D. A., Ryan, M. T., Calvo, S. E., Mootha, V. K., Morar, B., Procopis, P. G., Christodoulou, J., Compton, A. G. & Thorburn, D. R., 1 Jul 2019, In : Human Mutation. 40, 7, p. 893-898 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Function of hTim8a in complex IV assembly in neuronal cells provides insight into pathomechanism underlying Mohr-Tranebjærg syndrome

Kang, Y., Anderson, A. J., Jackson, T. D., Palmer, C. S., De Souza, D. P., Fujihara, K. M., Stait, T., Frazier, A. E., Clemons, N. J., Tull, D., Thorburn, D. R., McConville, M. J., Ryan, M. T., Stroud, D. A. & Stojanovski, D., 4 Nov 2019, In : eLife. 8, 32 p., e48828.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Structural and functional characterization of the mitochondrial complex IV assembly factor Coa6

Maghool, S., Cooray, N. D. G., Stroud, D. A., Aragão, D., Ryan, M. T. & Maher, M. J., Oct 2019, In : Life Science Alliance. 2, 5, 12 p., e201900458.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)