Projects per year
Personal profile
Biography
Mike is Pro Vice-Chancellor Research at Monash University. He also heads the Mitochondrial Biology and Disease Laboratory in the Monash Biomedicine Discovery Institute. Mike joined the Department of Biochemistry and Molecular Biology in 2014 and served as Deputy Dean (Research and Research Infrastructure) in the Faculty of Medicine, Nursing and Health Sciences before becoming Academic Director Research Infrastructure. Before this he was Head of the Department of Biochemistry at La Trobe University. Mike's research focuses on mitochondrial biology and disease. After undertaking his PhD on molecular chaperones with Peter Hoj (La Trobe/Adelaide), Mike joined the group of Klaus Pfanner (University of Freiburg, Germany) as an Alexander von Humboldt fellow (1997-1999) where he studied protein import mechanisms. His group now uses a variety of techniques including gene editing, proteomics and mouse models to investgate and characterise the gene products involved in mitochondrial disease and dynamics.
Mike was President of the Australian Society for Biochemistry and Molecular Biology. He sits on a variety of university committees and external bodies inlcuding the Scientific and Medical Advisory Panel for the Australian Mitochondrial Disease Foundation (AMDF), Research Grants panels for the International Human Frontiers Science Program Organisation and board memberships. His work is funded by the National Health and Medical Research Council, the Australian Research Council, MRFF and the AMDF.
Research lab webpage: www.monash.edu/discovery-institute/ryan-lab
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Mitochondria
- mitochondrial disease
- mitochondrial dynamics
- mitochondrial fission
- complex I
- mitochondria
- gene-edting
- leigh syndrome
- CRISPR Cas9
- proteomics
- metabolism
Collaborations and top research areas from the last five years
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MitoHOPE: Introducing Mitochondrial Donation in AustraliaL The MitoHOPE (Healthy Outcomes Pilot and Evaluation) Program
Carroll, J., Herbert, M., Christodoulou , J., Thorburn, D. R., Mills, C., Zander-Fox, D. L., Robker, R., Rombauts, L., Sallevelt, S., Ludlow, K., Coman, D. J., Ellaway, C. J., Mackey, D. A., Delatycki, M., Yau, W. Y., Tchan, M. C., Long, J. C., Hardy, T., Adhikari, D., CHOUDHARY, M., Hyslop, L., Mann, J., Ryan, M., Hodges, R., Hui, L., Kamien, B. A., Mallett, A., Semsarian, C., Wallis, M. J., Wall, M., Zoungas, S., Goranitis, I., Gyngell, C., Hammarberg, K., Sparrow, R., Warren, N., Fahey, M., Stutterd, C. A., Schweitzer, D., McGillivray, G., Savulescu, J., Panetta, J., Kava, M. P., Freckmann, M., Lynch, M., Lamont, P. J., Scott, R., Ware, T., Mowat, D., Jones, K. J., Green, S., Wolfe, R., Hackett, A. & Bratkovic, D.
Monash University – Internal Faculty Contribution
1/06/23 → 31/05/28
Project: Research
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Molecular mechanisms underlying the pathogenesis of complex I dysfunction and mitochondrial disease
Ryan, M. & Reljic, B.
1/01/22 → 31/12/25
Project: Research
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Mechanisms maintaining mitochondrial copper homeostasis
Maher, M., Newstead, S. & Ryan, M.
1/01/22 → 31/12/24
Project: Research
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Mitochondrial Diagnostic Network for Genomics and Omics
Thorburn, D. R., Sue, C., Filipovska, A., Ryan, M., Stroud, D. A., Stojanovski, D., Coman, D. J., Murray, S., Davis, R., Christodoulou , J., Lamont, P. J., Sallevelt, S., Ghaoui, R., Simons, C., Siira, S., Balasubramaniam, S., Compton, A. G. & Macarthur, D.
1/06/21 → 31/05/25
Project: Research
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High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production
Heazlewood, S. Y., Ahmad, T., Cao, B., Cao, H., Domingues, M., Sun, X., Heazlewood, C. K., Li, S., Williams, B., Fulton, M., White, J. F., Nebl, T., Nefzger, C. M., Polo, J. M., Kile, B. T., Kraus, F., Ryan, M. T., Sun, Y. B., Choong, P. F. M., Ellis, S. L., & 2 others , Dec 2023, In: Nature Communications. 14, 1, 18 p., 2099.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
The African killifish: A short-lived vertebrate model to study the biology of sarcopenia and longevity
Ruparelia, A. A., Salavaty, A., Barlow, C. K., Lu, Y., Sonntag, C., Hersey, L., Eramo, M. J., Krug, J., Reuter, H., Schittenhelm, R. B., Ramialison, M., Cox, A., Ryan, M. T., Creek, D. J., Englert, C. & Currie, P. D., May 2023, (Accepted/In press) In: Aging Cell. 22 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5
Salscheider, S. L., Gerlich, S., Cabrera-Orefice, A., Peker, E., Rothemann, R. A., Murschall, L. M., Finger, Y., Szczepanowska, K., Ahmadi, Z. A., Guerrero-Castillo, S., Erdogan, A., Becker, M., Ali, M., Habich, M., Petrungaro, C., Burdina, N., Schwarz, G., Klußmann, M., Neundorf, I., Stroud, D. A., & 4 others , 1 Sept 2022, In: The EMBO Journal. 41, 17, 21 p., e110784.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Biallelic pathogenic variants in COX11 are associated with an infantile-onset mitochondrial encephalopathy
Rius, R., Bennett, N. K., Bhattacharya, K., Riley, L. G., Yüksel, Z., Formosa, L. E., Compton, A. G., Dale, R. C., Cowley, M. J., Gayevskiy, V., Al Tala, S. M., Almehery, A. A., Ryan, M. T., Thorburn, D. R., Nakamura, K. & Christodoulou, J., Dec 2022, In: Human Mutation. 43, 12, p. 1970-1978 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly
Formosa, L. E., Maghool, S., Sharpe, A. J., Reljic, B., Muellner-Wong, L., Stroud, D. A., Ryan, M. T. & Maher, M. J., 24 Feb 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, 10 p., e2110357119.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)