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Research Output 1999 2019

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2019

Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats

Haque, S., Feeney, O., Meeusen, E., Boyd, B. J., McIntosh, M. P., Pouton, C. W., Whittaker, M. & Kaminskas, L. M., 10 Aug 2019, In : Journal of Controlled Release. 307, p. 32-43 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Elucidation of the pharmacokinetic/pharmacodynamic determinants of fosfomycin activity against Pseudomonas aeruginosa using a dynamic in vitro model

Bilal, H., Peleg, A. Y., McIntosh, M. P., Styles, I. K., Hirsch, E. B., Landersdorfer, C. B. & Bergen, P. J., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1570-1578 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Comb poly(oligo(2-ethyl-2-oxazoline)methacrylate)-peptide conjugates prepared by aqueous Cu(0)-mediated polymerization and reductive amination

Collins, J., Wallis, S. J., Simula, A., Whittaker, M. R., McIntosh, M. P., Wilson, P., Davis, T. P., Haddleton, D. M. & Kempe, K., 1 Jan 2017, In : Macromolecular Rapid Communications. 38, 2, 7 p., 1600534.

Research output: Contribution to journalArticleResearchpeer-review

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

Haque, S., McLeod, V. M., Jones, S., Fung, S., Whittaker, M., McIntosh, M., Pouton, C., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 408-418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Safety, Tolerability and Pharmacokinetics of Single Doses of Oxytocin Administered via an Inhaled Route in Healthy Females: Randomized, Single-blind, Phase 1 Study

Fernando, D., Siederer, S., Singh, S., Schneider, I., Gupta, A., Powell, M., Richards, D. B., McIntosh, M. P., Lambert, P. & Fowles, S., 1 Aug 2017, In : EBioMedicine. 22, p. 249-255 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model

Landersdorfer, C., Nguyen, T-H., Lieu, L. T., Nguyen, G., Bischof, R., Meeusen, E., Li, J., Nation, R. & McIntosh, M., 1 Jan 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, 15 p., e01934-16.

Research output: Contribution to journalArticleResearchpeer-review

Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: the use of polyol, disaccharide, polysaccharide and synthetic polymer to modify solid-state properties for glassy stabilisation

Sou, T., Forbes, R. T., Gray, J., Prankerd, R. J., Kaminskas, L. M., McIntosh, M. P. & Morton, D. A. V., 1 Jan 2016, In : Powder Technology. 287, p. 248-255 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Stability enhancing N-terminal PEGylation of oxytocin exploiting different polymer architectures and conjugation approaches

Collins, J., Kempe, K., Wilson, P., Blindauer, C. A., McIntosh, M. P., Davis, T. P., Whittaker, M. R. & Haddleton, D. M., 8 Aug 2016, In : Biomacromolecules. 17, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticleResearchpeer-review

In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates

Collins, J. S., Tanaka, J., Wilson, P. J., Kempe, K., Davis, T. P., McIntosh, M. P., Whittaker, M. R. & Haddleton, D. M., 2015, In : Bioconjugate Chemistry. 26, 4, p. 633-638 6 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro pharmacodynamics of fosfomycin against clinical isolates of Pseudomonas aeruginosa

Walsh, C. C., McIntosh, M. P., Peleg, A. Y., Kirkpatrick, C. M. & Bergen, P. J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 11, p. 3042-3050 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Spray-dried influenza antigen with trehalose and leucine produces an aerosolizable powder vaccine formulation that induces strong systemic and mucosal immunity after pulmonary administration

Sou, T., Morton, D. A. V., Williamson, M., Meeusen, E. N., Kaminskas, L. M. & McIntosh, M. P., 2015, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 28, 5, p. 361-371 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The effect of intravenous sulfobutylether7-beta-cyclodextrin on the pharmacokinetics of a series of adamantane-containing compounds

Leong, N., Prankerd, R. J., Shackleford, D. & McIntosh, M. P., 2015, In : Journal of Pharmaceutical Sciences. 104, 4, p. 1492 - 1498 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization

Rajapaksa, A. E., Ho, J., Qi, A., Bischof, R., Nguyen, T-H., Tate, M., Piedrafita, D. M., McIntosh, M. P., Yeo, L. Y-M., Meeusen, E. N. T., Coppel, R. L. & Friend, J. R., 2014, In : Respiratory Research. 15, p. 1 - 12 12 p., 60.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: Targeting advantage of inhalational administration

Wickramaratne Senarath Yapa, S., Li, J., Patel, K., Wilson, J. W., Dooley, M. J., George, J., Clark, D., Poole, S. G., Williams, E., Porter, C. J., Nation, R. L. & McIntosh, M. P., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 5, p. 2570 - 2579 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The lymphatic system plays a major role in the intravenous and subcutaneous pharmacokinetics of trastuzumab in rats

Dahlberg, A., Kaminskas, L. M., Smith, A., Nicolazzo, J., Porter, C. J., Bulitta, J. B. & McIntosh, M. P., 2014, In : Molecular Pharmaceutics. 11, p. 496 - 504 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Designing a multicomponent spray-dried formulation platform for pulmonary delivery of biomacromolecules: The effect of polymers on the formation of an amorphous matrix for glassy state stabilization of biomacromolecules

Sou, T., McIntosh, M. P., Kaminskas, L. M., Prankerd, R. J. & Morton, D. A. V., 2013, In : Drying Technology. 31, 13-14, p. 1451 - 1458 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Ontogeny of the adrenal gland in the spiny mouse, with particular reference to production of the steroids cortisol and dehydroepiandrosterone

Quinn, T. A., Ratnayake, U., Dickinson, H., Nguyen, T-H., McIntosh, M. P., Zakhem, M. E., Conley, A. J. & Walker, D. W., 2013, In : Endocrinology. 154, 3, p. 1190 - 1201 12 p.

Research output: Contribution to journalArticleResearchpeer-review

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin

Ryan, G., Kaminskas, L. M., Bulitta, J. B., McIntosh, M. P., Owen, D. J. & Porter, C. J., 2013, In : Journal of Controlled Release. 172, 1, p. 128 - 136 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Population pharmacokinetics of colistin methanesulfonate in rats: Achieving sustained lung concentrations of colistin for targeting respiratory infections

Wickramaratne Senarath Yapa, S., Li, J., Porter, C. J., Nation, R. L., Patel, K. & McIntosh, M. P., 2013, In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 5087 - 5095 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pulmonary administration of PEGylated polylysine dendrimers: Absorption from the lung versus retention within the lung is highly size-dependent

Ryan, G., Kaminskas, L. M., Kelly, B., Owen, D. J., McIntosh, M. P. & Porter, C. J., 2013, In : Molecular Pharmaceutics. 10, 8, p. 2986 - 2995 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Pulmonary delivery of an ultra-fine oxytocin dry powder formulation: Potential for treatment of postpartum haemorrhage in developing countries

Prankerd, R. J., Nguyen, T-H., Ibrahim, J., Bischof, R., Nassta, G., Olerile, L. D., Russell, A. S., Meiser, F., Parkington, H. C., Coleman, H. A., Morton, D. A. V. & McIntosh, M. P., 2013, In : PLoS ONE. 8, 12, 9 p., e82965.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules

Sou, T., Kaminskas, L. M., Nguyen, T-H., Carlberg, R., McIntosh, M. P. & Morton, D. A. V., 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 83, 2, p. 234 - 243 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Hemodynamic profile in rabbits of fospropofol disodium injection relative to propofol emulsion following rapid bolus injection

McIntosh, M. P., Iwasawa, K., Rajewski, R. A., Fujisawa, T. & Goto, H., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3518 - 3525 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems

Anby, M. U., Williams, H. D., McIntosh, M. P., Benameur, H., Edwards, G. A., Pouton, C. W. & Porter, C. J., 2012, In : Molecular Pharmaceutics. 9, 9, p. 2063 - 2079 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing a potential in vivo drug-excipient interaction: Temporal effects of a modified beta-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand

Mannila, A. H., Morizzi, J., Nguyen, T. T., Charman, S. A., McIntosh, M. P. & Shackleford, D., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3381 - 3389 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach

Sou, T., Orlando, L., McIntosh, M. P., Kaminskas, L. & Morton, D., 2011, In : International Journal of Pharmaceutics. 421, 2, p. 220 - 229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

New developments in dry powder pulmonary vaccine delivery

Sou, T., Meeusen, E., de Veer, M. J., Morton, D., Kaminskas, L. & McIntosh, M. P., 2011, In : Trends in Biotechnology. 29, 4, p. 191 - 198 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural influence of cohesive mixtures of salbutamol sulphate and lactose on aerosolisation and de-agglomeration behaviour under dynamic conditions

Behara, S., Kippax, P., McIntosh, M. P., Morton, D., Larson, I. & Stewart, P., 2011, In : European Journal of Pharmaceutical Sciences. 42, 3, p. 210 - 219 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE7-beta-CD on the disposition of chlorpromazine in the rat

McIntosh, M. P., Leong, N., Katneni, K., Morizzi, J., Shackleford, D. M. & Prankerd, R. J., 2010, In : Journal of Pharmaceutical Sciences. 99, 7, p. 2999 - 3008 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in biabetic mice

Urban, M., Li, C., Yu, C., Lu, Y., Krise, J., McIntosh, M. P., Rajewski, R. A., Blagg, B. & Dobrowsky, R. T., 2010, In : ASN Neuro. 2, 4, p. 189 - 199 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7m-beta-cyclodextrin or a co-solvent system

Koltun, M., Morizzi, J., Katneni, K., Charman, S. A., Shackleford, D. & McIntosh, M. P., 2010, In : Biopharmaceutics and Drug Disposition. 31, 8-9, p. 450 - 454 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623)

Trevaskis, N., McEvoy, C. L., McIntosh, M. P., Edwards, G. A., Shanker, R., Charman, W. N. & Porter, C. J., 2010, In : Pharmaceutical Research. 27, p. 878 - 893 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Ultrasonic nebulization platforms for pulmonary drug delivery

Yeo, L., Friend, J., McIntosh, M. P., Meeusen, E. & Morton, D., 2010, In : Expert Opinion on Drug Delivery. 7, 6, p. 663 - 679 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization

Qi, A., Friend, J., Yeo, L. Y-M., Morton, D. A. V., McIntosh, M. P. & Spiccia, L., 2009, In : Lab on a Chip. 9, p. 2184 - 2193 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Evaluation of mean arterial blood pressure, heart rate, and sympathetic nerve activity in rabbits after administration of two formulations of etomidate

McIntosh, M. P., Narita, H., Kameyama, Y., Rajewski, R. A. & Goto, H., 2007, In : Veterinary Anaesthesia and Analgesia. 34, 3, p. 149 - 156 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Single quadrupole mass spectrometry for pre-clinical pharmacokinetic analysis: Quantitation of carvedilol in dog plasma

McIntosh, M. P., Carlson, B. J., Schorno, K. S. & Rajewski, R. A., 2007, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 852, p. 665 - 668 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Ongoing In Vivo Studies with Cytoskeletal Drugs in Tau Transgenic Mice

Georg, G., McIntosh, M. P., Rajewski, R. A. & Telikepalli, H., 2006, In : Current Alzheimer Research. 3, 3, p. 215 - 219 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Preliminary evaluation of polymer-based drug composite microparticle production by coacervate desolvation with supercritical carbon dioxide

Yasuji, T., Haslam, J., Kajiyama, A., McIntosh, M. P. & Rajewski, R. A., 2006, In : Journal of Pharmaceutical Sciences. 95, 3, p. 581 - 588 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Preparation and purification of desethylamiodarone hydrochloride

Lucas, A. N., Tanol, M., McIntosh, M. P. & Rajewski, R. A., 2006, In : Synthetic Communications. 36, April, p. 3371 - 3376 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

In vitro and in vivo evaluation of a sulfobutyl ether beta-cyclodextrin enabled etomidate formulation

McIntosh, M. P., Schwarting, N. & Rajewski, R. A., 2004, In : Journal of Pharmaceutical Sciences. 93, 10, p. 2585 - 2594 10 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro and in vivo evaluation of a sulfobutyl ether β-cyclodextrin enabled etomidate formulation

McIntosh, M. P., Schwarting, N. & Rajewski, R. A., 1 Jan 2004, In : Journal of Pharmaceutical Sciences. 93, 10, p. 2585-2594 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Desbutylhalofantrine: evaluation of QT prolongation and other cardiovascular effects after intravenous administration in vivo

McIntosh, M. P., Batey, A. J., Porter, C. J. H., Charman, W. N. & Coker, S. J., 2003, In : Journal of Cardiovascular Pharmacology. 41, 3, p. 406 - 413 8 p.

Research output: Contribution to journalArticleResearchpeer-review