19992020

Research output per year

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Research Output

2020

Qualitative formative implementation research to inform introduction of a new essential medicine

Oliver, V. L., Tolera, M., Teklu, A. M., Minaye, A., Lambert, P. & McIntosh, M. P., Apr 2020, In : Research in Social and Administrative Pharmacy. 16, 4, p. 535-543 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats

Haque, S., Feeney, O., Meeusen, E., Boyd, B. J., McIntosh, M. P., Pouton, C. W., Whittaker, M. & Kaminskas, L. M., 10 Aug 2019, In : Journal of Controlled Release. 307, p. 32-43 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Removal of interstitial hyaluronan with recombinant human hyaluronidase improves the systemic and lymphatic uptake of cetuximab in rats

Styles, I. K., Feeney, O. M., Nguyen, T-H., Brundel, D., Kang, D. W., Clift, R., McIntosh, M. P. & Porter, C. J. H., 10 Dec 2019, In : Journal of Controlled Release. 315, p. 85-96 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Temperature stability of oxytocin ampoules labelled for storage at 2°C-8°C and below 25°C: an observational assessment under controlled accelerated and temperature cycling conditions

Nguyen, T-H., Lambert, P., Minhas, R. S., McEvoy, C., Deadman, K., Wright, P., Prankerd, R. J., Mogatle, S. & McIntosh, M. P., 26 Jul 2019, In : BMJ Open. 9, 7, p. 1-7 7 p., e029083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Assessing the operational feasibility and acceptability of an inhalable formulation of oxytocin for improving community-based prevention of postpartum haemorrhage in Myanmar: A qualitative inquiry

Than, K. K., Oliver, V., Mohamed, Y., La, T., Lambert, P., McIntosh, M. & Luchters, S., 1 Oct 2018, In : BMJ Open. 8, 10, 9 p., e022140.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Knowledge, perception and practice towards oxytocin stability and quality: A qualitative study of stakeholders in three resourcelimited countries

Oliver, V. L., Lambert, P. A., Than, K. K., Mohamed, Y., Luchters, S., Verma, S., Yadav, R., Kumar, V., Teklu, A. M., Tolera, M., Minaye, A. & McIntosh, M. P., 1 Sep 2018, In : PLoS ONE. 13, 9, e0203810.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Quality of oxytocin ampoules available in health care facilities in the Democratic Republic of Congo: an exploratory study in five provinces

Lambert, P., Nguyen, T. H., McEvoy, C., Minhas, R. S., Wright, P., Deadman, K., Masururu, L. M. & McIntosh, M. P., 1 Dec 2018, In : Journal of Global Health. 8, 2, p. 1-6 6 p., 020415.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)
3 Citations (Scopus)
2017

Comb poly(oligo(2-ethyl-2-oxazoline)methacrylate)-peptide conjugates prepared by aqueous Cu(0)-mediated polymerization and reductive amination

Collins, J., Wallis, S. J., Simula, A., Whittaker, M. R., McIntosh, M. P., Wilson, P., Davis, T. P., Haddleton, D. M. & Kempe, K., 1 Jan 2017, In : Macromolecular Rapid Communications. 38, 2, 7 p., 1600534.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

Haque, S., McLeod, V. M., Jones, S., Fung, S., Whittaker, M., McIntosh, M., Pouton, C., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 408-418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Safety, Tolerability and Pharmacokinetics of Single Doses of Oxytocin Administered via an Inhaled Route in Healthy Females: Randomized, Single-blind, Phase 1 Study

Fernando, D., Siederer, S., Singh, S., Schneider, I., Gupta, A., Powell, M., Richards, D. B., McIntosh, M. P., Lambert, P. & Fowles, S., 1 Aug 2017, In : EBioMedicine. 22, p. 249-255 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model

Landersdorfer, C., Nguyen, T-H., Lieu, L. T., Nguyen, G., Bischof, R., Meeusen, E., Li, J., Nation, R. & McIntosh, M., 1 Jan 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, 15 p., e01934-16.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: the use of polyol, disaccharide, polysaccharide and synthetic polymer to modify solid-state properties for glassy stabilisation

Sou, T., Forbes, R. T., Gray, J., Prankerd, R. J., Kaminskas, L. M., McIntosh, M. P. & Morton, D. A. V., 1 Jan 2016, In : Powder Technology. 287, p. 248-255 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Disposition and safety of inhaled biodegradable nanomedicines: opportunities and challenges

Haque, S., Whittaker, M. R., McIntosh, M. P., Pouton, C. W. & Kaminskas, L. M., 1 Aug 2016, In : Nanomedicine-Nanotechnology Biology and Medicine. 12, 6, p. 1703-1724 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

Stability enhancing N-terminal PEGylation of oxytocin exploiting different polymer architectures and conjugation approaches

Collins, J., Kempe, K., Wilson, P., Blindauer, C. A., McIntosh, M. P., Davis, T. P., Whittaker, M. R. & Haddleton, D. M., 8 Aug 2016, In : Biomacromolecules. 17, 8, p. 2755-2766 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates

Collins, J. S., Tanaka, J., Wilson, P. J., Kempe, K., Davis, T. P., McIntosh, M. P., Whittaker, M. R. & Haddleton, D. M., 2015, In : Bioconjugate Chemistry. 26, 4, p. 633-638 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
38 Citations (Scopus)

In vitro pharmacodynamics of fosfomycin against clinical isolates of Pseudomonas aeruginosa

Walsh, C. C., McIntosh, M. P., Peleg, A. Y., Kirkpatrick, C. M. & Bergen, P. J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 11, p. 3042-3050 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Spray-dried influenza antigen with trehalose and leucine produces an aerosolizable powder vaccine formulation that induces strong systemic and mucosal immunity after pulmonary administration

Sou, T., Morton, D. A. V., Williamson, M., Meeusen, E. N., Kaminskas, L. M. & McIntosh, M. P., 2015, In : Journal of Aerosol Medicine and Pulmonary Drug Delivery. 28, 5, p. 361-371 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The effect of intravenous sulfobutylether7-beta-cyclodextrin on the pharmacokinetics of a series of adamantane-containing compounds

Leong, N., Prankerd, R. J., Shackleford, D. & McIntosh, M. P., 2015, In : Journal of Pharmaceutical Sciences. 104, 4, p. 1492 - 1498 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
2014

Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization

Rajapaksa, A. E., Ho, J., Qi, A., Bischof, R., Nguyen, T-H., Tate, M., Piedrafita, D. M., McIntosh, M. P., Yeo, L. Y-M., Meeusen, E. N. T., Coppel, R. L. & Friend, J. R., 2014, In : Respiratory Research. 15, p. 1 - 12 12 p., 60.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: Targeting advantage of inhalational administration

Wickramaratne Senarath Yapa, S., Li, J., Patel, K., Wilson, J. W., Dooley, M. J., George, J., Clark, D., Poole, S. G., Williams, E., Porter, C. J., Nation, R. L. & McIntosh, M. P., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 5, p. 2570 - 2579 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
83 Citations (Scopus)

The lymphatic system plays a major role in the intravenous and subcutaneous pharmacokinetics of trastuzumab in rats

Dahlberg, A., Kaminskas, L. M., Smith, A., Nicolazzo, J., Porter, C. J., Bulitta, J. B. & McIntosh, M. P., 2014, In : Molecular Pharmaceutics. 11, p. 496 - 504 9 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2013

Designing a multicomponent spray-dried formulation platform for pulmonary delivery of biomacromolecules: The effect of polymers on the formation of an amorphous matrix for glassy state stabilization of biomacromolecules

Sou, T., McIntosh, M. P., Kaminskas, L. M., Prankerd, R. J. & Morton, D. A. V., 2013, In : Drying Technology. 31, 13-14, p. 1451 - 1458 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Effect of freezing on oxytocin ampules

Nassta, G. C., Prankerd, R. J. & McIntosh, M. P., 30 May 2013, In : The New England Journal of Medicine. 368, 22, p. 2145-2146 2 p.

Research output: Contribution to journalLetterOtherpeer-review

4 Citations (Scopus)

Ontogeny of the adrenal gland in the spiny mouse, with particular reference to production of the steroids cortisol and dehydroepiandrosterone

Quinn, T. A., Ratnayake, U., Dickinson, H., Nguyen, T-H., McIntosh, M. P., Zakhem, M. E., Conley, A. J. & Walker, D. W., 2013, In : Endocrinology. 154, 3, p. 1190 - 1201 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin

Ryan, G., Kaminskas, L. M., Bulitta, J. B., McIntosh, M. P., Owen, D. J. & Porter, C. J., 2013, In : Journal of Controlled Release. 172, 1, p. 128 - 136 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Population pharmacokinetics of colistin methanesulfonate in rats: Achieving sustained lung concentrations of colistin for targeting respiratory infections

Wickramaratne Senarath Yapa, S., Li, J., Porter, C. J., Nation, R. L., Patel, K. & McIntosh, M. P., 2013, In : Antimicrobial Agents and Chemotherapy. 57, 10, p. 5087 - 5095 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Pulmonary administration of PEGylated polylysine dendrimers: Absorption from the lung versus retention within the lung is highly size-dependent

Ryan, G., Kaminskas, L. M., Kelly, B., Owen, D. J., McIntosh, M. P. & Porter, C. J., 2013, In : Molecular Pharmaceutics. 10, 8, p. 2986 - 2995 10 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Pulmonary delivery of an ultra-fine oxytocin dry powder formulation: Potential for treatment of postpartum haemorrhage in developing countries

Prankerd, R. J., Nguyen, T-H., Ibrahim, J., Bischof, R., Nassta, G., Olerile, L. D., Russell, A. S., Meiser, F., Parkington, H. C., Coleman, H. A., Morton, D. A. V. & McIntosh, M. P., 2013, In : PLoS ONE. 8, 12, 9 p., e82965.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules

Sou, T., Kaminskas, L. M., Nguyen, T-H., Carlberg, R., McIntosh, M. P. & Morton, D. A. V., 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 83, 2, p. 234 - 243 10 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)
2012
12 Citations (Scopus)

Hemodynamic profile in rabbits of fospropofol disodium injection relative to propofol emulsion following rapid bolus injection

McIntosh, M. P., Iwasawa, K., Rajewski, R. A., Fujisawa, T. & Goto, H., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3518 - 3525 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems

Anby, M. U., Williams, H. D., McIntosh, M. P., Benameur, H., Edwards, G. A., Pouton, C. W. & Porter, C. J., 2012, In : Molecular Pharmaceutics. 9, 9, p. 2063 - 2079 17 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Probing a potential in vivo drug-excipient interaction: Temporal effects of a modified beta-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand

Mannila, A. H., Morizzi, J., Nguyen, T. T., Charman, S. A., McIntosh, M. P. & Shackleford, D., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3381 - 3389 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2011

Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach

Sou, T., Orlando, L., McIntosh, M. P., Kaminskas, L. & Morton, D., 2011, In : International Journal of Pharmaceutics. 421, 2, p. 220 - 229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

New developments in dry powder pulmonary vaccine delivery

Sou, T., Meeusen, E., de Veer, M. J., Morton, D., Kaminskas, L. & McIntosh, M. P., 2011, In : Trends in Biotechnology. 29, 4, p. 191 - 198 8 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Particle engineering of a mannitol-based powder formulation for delivery of biomolecules to the lung

Sou, T., Nassta, G., Kaminskas, L., McIntosh, M. P., Prankerd, R., Orlando, L. & Morton, D., 2011, p. 52 - 55. 4 p.

Research output: Contribution to conferenceOther

Probing the role of self-assembly in spray dried powder formulations

Morton, D., McIntosh, M. P., Olerile, L. & Prankerd, R., 2011, Respiratory Drug Delivery 2011. Dalby, R. N., Byron, P. R., Peart, J., Suman, J. D. & Young, P. M. (eds.). USA: VCU Respiratory Drug Delivery, p. 363 - 366 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Structural influence of cohesive mixtures of salbutamol sulphate and lactose on aerosolisation and de-agglomeration behaviour under dynamic conditions

Behara, S., Kippax, P., McIntosh, M. P., Morton, D., Larson, I. & Stewart, P., 2011, In : European Journal of Pharmaceutical Sciences. 42, 3, p. 210 - 219 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2010

Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE7-beta-CD on the disposition of chlorpromazine in the rat

McIntosh, M. P., Leong, N., Katneni, K., Morizzi, J., Shackleford, D. M. & Prankerd, R. J., 2010, In : Journal of Pharmaceutical Sciences. 99, 7, p. 2999 - 3008 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in biabetic mice

Urban, M., Li, C., Yu, C., Lu, Y., Krise, J., McIntosh, M. P., Rajewski, R. A., Blagg, B. & Dobrowsky, R. T., 2010, In : ASN Neuro. 2, 4, p. 189 - 199 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7m-beta-cyclodextrin or a co-solvent system

Koltun, M., Morizzi, J., Katneni, K., Charman, S. A., Shackleford, D. & McIntosh, M. P., 2010, In : Biopharmaceutics and Drug Disposition. 31, 8-9, p. 450 - 454 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623)

Trevaskis, N., McEvoy, C. L., McIntosh, M. P., Edwards, G. A., Shanker, R., Charman, W. N. & Porter, C. J., 2010, In : Pharmaceutical Research. 27, p. 878 - 893 16 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Ultrasonic nebulization platforms for pulmonary drug delivery

Yeo, L., Friend, J., McIntosh, M. P., Meeusen, E. & Morton, D., 2010, In : Expert Opinion on Drug Delivery. 7, 6, p. 663 - 679 17 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)
2009

Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization

Qi, A., Friend, J., Yeo, L. Y-M., Morton, D. A. V., McIntosh, M. P. & Spiccia, L., 2009, In : Lab on a Chip. 9, p. 2184 - 2193 10 p.

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)

Ongoing in vivo studies with cytoskeletal drugs in tau transgenic mice (Current Alzheimer Research 3, 3, (215-219))

Michaelis, M. L., Georg, G., Telikepalli, H., McIntosh, M. & Rajewski, R. A., Jun 2009, In : Current Alzheimer Research. 6, 3, p. 320 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review