Projects per year
Personal profile
Biography
Position
Professor
Faculty of Pharmacy and Pharmaceutical Sciences
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Prof McIntosh is a pharmaceutical scientist with an international reputation in the fields of pulmonary delivery and global health. Her research is aimed at improving drug delivery systems with an emphasis on translational research projects aiming to improve patient healthcare outcomes.
Michelle completed her undergraduate and PhD studies at Monash University before moving in 1999 to the University of Kansas, Center for Drug Delivery Research. In 2006 she returned to Monash University to continue her research at the Monash Institute of Pharmaceutical Sciences, Drug Delivery, Disposition and Dynamics.
Michelle’s research has focused on improving access to life saving medications in the developing world by developing a novel aerosol delivery system for oxytocin. In 2015 this research was recognised by the Saving Lives at Birth program as the innovation most likely to be transformational in maternal and neonatal healthcare. In 2017 Michelle was co-awarded the John Dixon Hughes Medal for Medical Research Innovation and in 2014 was acknowledged at the highest level of the University when she was awarded the Vice-Chancellor’s award for Excellence in Research Impact (Economic and Social Impact). In 2013 Michelle and her team received the Australian Innovation Challenge award.
Other current research areas, include
- the development of a medicinal cannabis formulation for the treatment of paediatric patients suffering from intractable epilepsy;
- investigations into the targeted delivery of antibiotics in the treatment of respiratory infections; and
- the evaluation of modified cyclodextrins as formulation excipients to enhance drug solubility and stability.
Michelle has served on a WHO expert panel on the use of uterotonics in developing countries (2011) and was a member of a technical advisory group focused on innovations for the UN Commission on Life Saving Commodities for Women and Children (2013–2014).
Since 2014 Michelle has been the founding Director of the HMSTrust Laboratory, an open access analytical laboratory at Monash Institute of Pharmaceutical Sciences. She is also the Director of the newly formed Medicines Manufacturing Innovation Centre (MMIC) which is a joint initiative of the Victorian State Government, Monash University and industry partners to advance manufacturing innovations in Victorian based pharmaceutical and allied industries. Through both the HMSTrust Laboratory and the MMIC, she maintains a strong focus on cultivating the next generation talent by providing opportunities for emerging scientist to develop highly valued specialist skills. To date her research activities have attracted over $15,000,000 in government, industry and philanthropic grants.
In 2015 Michelle became the Course Director of the Bachelor of Pharmaceutical Sciences at Monash’s Faculty of Pharmacy and Pharmaceutical Sciences and in 2016 she and her team received a Vice Chancellor’s Citation for Outstanding Contribution to Student Learning.
Monash teaching commitment
- Course Director, Bachelor of Pharmaceutical Science
- PSC2041 (Biopharmaceutics) lecturer in pharmacokinetics, drug absorption, drug delivery, drug dissolution
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PAC2232 (Drug Delivery) lecturer in pharmacokinetics, drug absorption, bioequivalence
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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Quality of Medicines Hub - Cornerstone funding by the Ripple Foundation
1/03/23 → 1/03/25
Project: Research
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Inhaled Oxytocin for Improved Maternal Health in Australia & Globally
McIntosh, M., Lambert, P. & Kirkpatrick, C.
1/01/22 → 31/12/23
Project: Research
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HMST Lab - Oxytocin Ampoule quality testing for the WHO in Senegal and Ivory Coast
22/04/21 → 19/05/21
Project: Research
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Clinical Proof of Concept for an Innovative Inhaled Oxytocin Product to Address the Leading Cause of Global Maternal Mortality
McIntosh, M., Lambert, P., Kirkpatrick, C., Palmer, K. & Kruger, N.
Department of Jobs, Skills, Industry and Regions (DJSIR) (Victoria), Janssen Pharmaceutical (Yardley, Pennsylvania, United States of America)
1/01/21 → 31/12/21
Project: Research
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Depolymerization of hyaluronan using PEGylated human recombinant hyaluronidase promotes nanoparticle tumor penetration
Brundel, D. H. S., Feeney, O. M., Nowell, C. J., Suys, E. J. A., Gracia, G., Kaminskas, L. M., McIntosh, M. M., Kang, D. W. & Porter, C. J. H., 9 Feb 2021, In: Nanomedicine. 16, 4, p. 275-292 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus) -
Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system
Gigante, V., Pauletti, G. M., Kopp, S., Xu, M., Gonzalez-Alvarez, I., Merino, V., McIntosh, M. P., Wessels, A., Lee, B. J., Rezende, K. R., Scriba, G. K. E., P.S.Jadaun, G. & Bermejo, M., 1 Jan 2021, In: ADMET and DMPK. 9, 1, p. 23-39 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
A Phase 1, Randomised, Placebo-Controlled, Dose Escalation Study to Investigate the Safety, Tolerability and Pharmacokinetics of Cannabidiol in Fed Healthy Volunteers
Perkins, D., Butler, J., Ong, K., Nguyen, T. H., Cox, S., Francis, B., Mcintosh, M. & Lilley, B., 1 Oct 2020, In: European Journal of Drug Metabolism and Pharmacokinetics. 45, 5, p. 575-586 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Cost-effectiveness of inhaled oxytocin for prevention of postpartum haemorrhage: a modelling study applied to two high burden settings
Carvalho, N., Hoque, M. E., Oliver, V. L., Byrne, A., Kermode, M., Lambert, P., McIntosh, M. P. & Morgan, A., 28 Jul 2020, In: BMC Medicine. 18, 1, 18 p., 201.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Oxytocin quality: evidence to support updated global recommendations on oxytocin for postpartum hemorrhage
Lambert, P., McIntosh, M. P., Widmer, M., Evans, L., Rauscher, M., Kuwana, R., Theunissen, F., Yeager, B. & Petach, H., Dec 2020, In: Journal of Pharmaceutical Policy and Practice. 13, 1, 13 p., 14.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access8 Citations (Scopus)
Prizes
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Faculty of Pharmacy and Pharmaceutical Sciences Award for Technological Innovation in Learning and Teaching
Yuriev, Elizabeth (Recipient), McIntosh, Michelle (Recipient), Thomas, Trayder (Recipient) & Dingjan, Tamir Yaakov (Recipient), 2019
Prize: Prize (including medals and awards)
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Faculty of Pharmacy and Pharmaceutical Sciences Excellence in Research Award for Research Impact (Economic and Social)
McIntosh, Michelle (Recipient), 2014
Prize: Prize (including medals and awards)
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Faculty of Pharmacy and Pharmaceutical Sciences Teaching Citation for Outstanding Contributions to Student Learning
McIntosh, Michelle (Recipient), 2011
Prize: Prize (including medals and awards)
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Impact7 ‘Innovation with greatest potential impact’
McIntosh, Michelle (Recipient), 2017
Prize: Prize (including medals and awards)
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John Dixon Huges Medal for Medical Research Innovation
McIntosh, Michelle (Recipient), 2017
Prize: Prize (including medals and awards)
Activities
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Course Director, Bachelor of Pharmaceutical Sciences
Michelle McIntosh (Speaker)
1 Jan 2015Activity: Other Teaching Engagements and non-HDR Supervisions › Executive education programs
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Drug Delivery, Disposition and Dynamics
Michelle McIntosh (Member)
29 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries
Press/Media
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Medtech manufacturing leads Victorian export boom
Michelle McIntosh & Paul Wynne
26/09/19
1 item of Media coverage
Press/Media: Article/Feature
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Pharmaceutical and Medtech export growth soars
Michelle McIntosh & Paul Wynne
23/09/19
1 item of Media coverage
Press/Media: Article/Feature
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Mum’s the word: saving women’s lives in childbirth
12/09/19
1 item of Media coverage
Press/Media: Article/Feature
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J&J joins forces with Monash University to advance novel technology
22/03/19
1 item of Media coverage
Press/Media: Article/Feature
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Johnson & Johnson joins forces with Monash University-led partnership to advance novel technology aimed at saving lives of women in child birth
21/03/19
1 item of Media coverage
Press/Media: Article/Feature
Equipment
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HMSTrust Analytical Laboratory
David Rudd (Manager) & Michelle McIntosh (Other)
Drug Delivery Disposition & DynamicsFacility/equipment: Facility