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Research Output 2005 2019

2019
2 Citations (Scopus)

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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GRK mediates µ-opioid receptor plasma membrane reorganization

Gondin, A. B., Halls, M. L., Canals, M. & Briddon, S. J., 1 May 2019, In : Frontiers in Molecular Neuroscience. 12, 14 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Localised GPCR signalling as revealed by FRET biosensors

Halls, M. L., 1 Apr 2019, In : Current Opinion in Cell Biology. 57, p. 48-56 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Signalling in response to sub-picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

Civciristov, S. & Halls, M. L., Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2382-2401 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2018
4 Citations (Scopus)

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling

Halls, M. L. & Canals, M., 1 Feb 2018, In : Trends in Pharmacological Sciences. 39, 2, p. 148-157 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Fletcher, M. M., Halls, M. L., Zhao, P., Clydesdale, L., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Oct 2018, In : Biochemical Pharmacology. 156, p. 406-419 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid -opioid receptor desensitization

Miess, E., Gondin, A. B., Yousuf, A., Steinborn, R., Mösslein, N., Yang, Y., Göldner, M., Ruland, J. G., Bünemann, M., Krasel, C., Christie, M. J., Halls, M. L., Schulz, S. & Canals, M., 17 Jul 2018, In : Science Signaling. 11, 539, 15 p., eaas9609.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

Civciristov, S., Ellisdon, A. M., Suderman, R., Pon, C. K., Evans, B. A., Kleifeld, O., Charlton, S. J., Hlavacek, W. S., Canals, M. & Halls, M. L., 9 Oct 2018, In : Science Signaling. 11, 551, 22 p., eaan1188.

Research output: Contribution to journalArticleResearchpeer-review

File
18 Citations (Scopus)

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 others, Scheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
14 Citations (Scopus)

Adenylyl cyclase signalling complexes - pharmacological challenges and opportunities

Halls, M. L. & Cooper, D. M. F., Apr 2017, In : Pharmacology and Therapeutics. 172, p. 171-180 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File
6 Citations (Scopus)

Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease

Lucato, C. M., Lupton, C. J., Halls, M. L. & Ellisdon, A. M., 5 May 2017, In : Journal of Molecular Biology. 429, 9, p. 1289-1304 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

File
18 Citations (Scopus)

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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34 Citations (Scopus)

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

Ercole, F., Whittaker, M. R., Halls, M. L., Boyd, B. J., Davis, T. P. & Quinn, J. F., 2017, In : Chemical Communications. 53, 57, p. 8030-8033 4 p.

Research output: Contribution to journalArticleResearchpeer-review

File
40 Citations (Scopus)

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

Ang, S. Y., Hutchinson, D. S., Patil, N., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J. & Kocan, M., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 1077-1089 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
19 Citations (Scopus)

Compartmentalization of GPCR signalling controls unique cellular responses

Ellisdon, A. M. & Halls, M. L., 15 Apr 2016, In : Biochemical Society Transactions. 44, 2, p. 562-567 6 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Ligand-dependent modulation of G protein conformation alters drug efficacy

Furness, S. G. B., Liang, Y-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D. & Sexton, P. M., 20 Oct 2016, In : Cell. 167, 3, p. 739-749 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Macromolecular hydrogen sulfide donors trigger spatiotemporally confined changes in cell signaling

Ercole, F., Mansfeld, F. M., Kavallaris, M., Whittaker, M. R., Quinn, J. F., Halls, M. L. & Davis, T. P., 11 Jan 2016, In : Biomacromolecules. 17, 1, p. 371-383 13 p.

Research output: Contribution to journalArticleResearchpeer-review

File
32 Citations (Scopus)

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Halls, M., Yeatman, H. R., Nowell, C. J., Thompson, G. L., Gondin, A. B., Civciristov, S., Bunnett, N. W., Lambert, N. A., Poole, D. P. & Canals, M., 9 Feb 2016, In : Science Signaling. 9, 414, p. 1-13 13 p., ra16.

Research output: Contribution to journalArticleResearchpeer-review

File
5 Citations (Scopus)

The complexity of signalling mediated by the glucagon-like peptide-1 receptor

Fletcher, M. M., Halls, M. L., Christopoulos, A., Sexton, P. M. & Wootten, D., 15 Apr 2016, In : Biochemical Society Transactions. 44, 2, p. 582-588 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The β2-adrenoceptor activates a positive cAMP-calcium feedforward loop to drive breast cancer cell invasion

Pon, C., Lane, J. R. D., Sloan, E. K. & Halls, M., 2016, In : FASEB Journal. 30, 3, p. 1144-1154 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

β2-adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer

Chang, A., Le, C. P., Walker, A. K., Creed, S. J., Pon, C. K., Albold, S., Carroll, D., Halls, M. L., Lane, J. R., Riedel, B., Ferrari, D. & Sloan, E. K., 1 Oct 2016, In : Brain, Behavior, and Immunity. 57, p. 106-115 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
13 Citations (Scopus)

Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging

Halls, M. L., Poole, D. P., Ellisdon, A. M., Nowell, C. & Canals, M., 2015, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols. Filizola, M. (ed.). 2 ed. New York NY USA: Springer, Vol. 1335. p. 131-161 31 p. (Methods in Molecular Biology; vol. 1335, no. 2).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Open Access
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17 Citations (Scopus)

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)
27 Citations (Scopus)
Open Access
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28 Citations (Scopus)

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Creed, S. J., Le, C. P., Hassan, M., Pon, C. K., Albold, S., Chan, K. T., Berginski, M. E., Huang, Z., Bear, J. E., Lane, J. R., Halls, M. L., Ferrari, D., Nowell, C. J. & Sloan, E. K., 2015, In : Breast Cancer Research. 17, 1, 12 p., 145.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014
12 Citations (Scopus)

Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Jensen, D. D., Halls, M. L., Murphy, J. E., Canals, M., Cattaruzza, F., Poole, D. P., Lieu, T. M., Koon, H-W., Pothoulakis, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 29, p. 20283 - 20294 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
245 Citations (Scopus)

Relaxin family peptides and their receptors

Bathgate, R., Halls, M. L., van der Westhuizen, E. T., Callander, G., Kocan, M. & Summers, R. J., 2013, In : Physiological Reviews. 93, 1, p. 405 - 480 76 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
20 Citations (Scopus)

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu

Ayling, L. J., Briddon, S. J., Halls, M. L., Hammond, G. R. V., Vaca, L., Pacheco, J., Hill, S. J. & Cooper, D. M. F., 2012, In : Journal of Cell Science. 125, 4, p. 869 - 886 18 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

A key phosphorylation site in AC8 mediates regulation of Ca2+-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex

Willoughby, D., Halls, M. L., Everett, K. L., Ciruela, A., Skroblin, P., Klussmann, E. & Cooper, D. M. F., 2012, In : Journal of Cell Science. 125, 23, p. 5850 - 5859 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Constitutive formation of an RXFP1-signalosome: A novel paradigm in GPCR function and regulation

Halls, M. L., 2012, In : British Journal of Pharmacology. 165, 6, p. 1644 - 1658 15 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling

Willoughby, D., Everett, K. L., Halls, M. L., Pacheco, J., Skroblin, P., Vaca, L., Klussmann, E. & Cooper, D. M. F., 2012, In : Science Signaling. 5, 219, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Muscarinic receptors stimulate AC2 by novel phosphorylation sites, whereas G-beta-gamma subunits exert opposing effects depending on the G-protein source

Shen, J. X., Wachten, S., Halls, M. L., Everett, K. L. & Cooper, D. M. F., 2012, In : Biochemical Journal. 447, 3, p. 393 - 405 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Insulin-like peptide 3 (INSL3)

Halls, M., 2011, xPharm: The Comprehensive Pharmacology Reference. Enna, S. J. & Bylund, D. B. (eds.). Amsterdam Netherlands: Academic Press, p. 1-9 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

69 Citations (Scopus)

Regulation by Ca2+-signaling pathways of adenylyl cyclases

Halls, M. L. & Cooper, D. M. F., 2011, In : Cold Spring Harbor Perspectives in Biology. 3, 1, p. a004143 - a004143 22 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
56 Citations (Scopus)

AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems

Willoughby, D., Masada, N., Wachten, S., Pagano, M., Halls, M., Everett, K., Ciruela, A. & Cooper, D., 2010, In : Journal of Biological Chemistry. 285, 26, p. 20328 - 20342 15 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

Halls, M. & Cooper, D., 2010, In : EMBO Journal. 29, 16, p. 2772 - 2787 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
7 Citations (Scopus)

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

Samuel, C. S., Mookerjee, I., Halls, M. L., Summers, R. J., Chew, E., Bathgate, R. A. D., Tregear, G. W. & Hewitson, T. D., 2009, In : Annals of the New York Academy of Sciences. 1160, p. 294 - 299 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Relaxin activates multiple cAMP signaling pathway profiles in different target cells

Halls, M. L., Hewitson, T. D., Moore, X-L., Du, X-J., Bathgate, R. A. D. & Summers, R. J., 2009, In : Annals of the New York Academy of Sciences. 1160, p. 108 - 111 4 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Relaxin family peptide receptor (RXFP1) coupling to Galphai3, involves the C-terminal Arg752 and localization within membrane raft microdomains

Halls, M. L., van der Westhuizen, E. T., Wade, J. D., Evans, B. A., Bathgate, R. A. D. & Summers, R. J., 2009, In : Molecular Pharmacology. 75, 2, p. 415 - 428 14 p.

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

Mookerjee, I., Hewitson, T. D., Halls, M. L., Summers, R. J., Mathai, M. L., Bathgate, R., Tregear, G. W. & Samuel, C. S., 2009, In : FASEB Journal. 23, p. 1219 - 1229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3

Summers, R. J., Bathgate, R. A. D., Wade, J. D., van der Westhuizen, E. T. & Halls, M. L., 2009, In : Annals of the New York Academy of Sciences. 1160, p. 99 - 104 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

RXFP1 couples to the Galphai3-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail

Halls, M. L., Papaioannou, M., Wade, J. D., Evans, B. A., Bathgate, R. A. D. & Summers, R. J., 2009, In : Annals of the New York Academy of Sciences. 1160, p. 117 - 120 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
50 Citations (Scopus)

Relaxin family peptide receptors - from orphans to therapeutic targets

van der Westhuizen, E. T., Halls, M. L., Samuel, C. S., Bathgate, R., Unemori, E. N., Sutton, S. W. & Summers, R. J., 2008, In : Drug Discovery Today. 13, 15-16, p. 640 - 651 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
43 Citations (Scopus)

Comparison of signaling pathways activated by the relaxin family peptide receptors, RXFP1 and RXFP2, using reporter genes

Halls, M. L., Bathgate, R. & Summers, R. J., 2007, In : Journal of Pharmacology and Experimental Therapeutics. 320, 1, p. 281 - 290 10 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Relaxin family peptide receptors - Former orphans reunite with their parent ligands to activate multiple signalling pathways

Halls, M. L., van der Westhuizen, E. T., Bathgate, R. & Summers, R. J., 2007, In : British Journal of Pharmacology. 150, 6, p. 677 - 691 15 p.

Research output: Contribution to journalArticleResearchpeer-review