If you made any changes in Pure these will be visible here soon.

Research Output 1998 2018

Filter
Article
2018

Evaluation of Serum Glycoprotein Biomarker Candidates for Detection of Esophageal Adenocarcinoma and Surveillance of Barrett's Esophagus

Shah, A. K., Hartel, G. F., Brown, I., Winterford, C., Na, R., Cao, K. A. L., Spicer, B. A., Dunstone, M. A., Phillips, W. A., Lord, R. V., Barbour, A., Watson, D. I., Joshi, V., Whiteman, D. C. & Hill, M. M., 1 Dec 2018, In : Molecular and Cellular Proteomics. 17, 12, p. 2324-2334 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, B. A., Law, R. H. P., Caradoc-Davies, T. T., Ekkel, S. M., Bayly-Jones, C., Pang, S-S., Conroy, P. J., Ramm, G., Radjainia, M., Venugopal, H., Whisstock, J. C. & Dunstone, M. A., 15 Aug 2018, In : Nature Communications. 9, 1, 7 p., 3266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Real-time visualization of perforin nanopore assembly

Leung, C., Hodel, A. W., Brennan, A. J., Lukoyanova, N., Tran, S., House, C. M., Kondos, S. C., Whisstock, J. C., Dunstone, M. A., Trapani, J. A., Voskoboinik, I., Saibil, H. R. & Hoogenboom, B. W., May 2017, In : Nature Nanotechnology. 12, p. 467-473 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Seminars Editorial: The emerging role of pore forming proteins in cell biology and development

Dunstone, M. A., Dec 2017, In : Seminars in Cell and Developmental Biology. 72, p. 99-100 2 p.

Research output: Contribution to journalArticleOtherpeer-review

2016

Giant MACPF/CDC pore forming toxins: A class of their own

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 1 Mar 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 3, p. 475-486 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of the poly-C9 component of the complement membrane attack complex

Dudkina, N. V., Spicer, B. A., Reboul, C. F., Conroy, P. J., Lukoyanova, N., Elmlund, H., Law, R. HP., Ekkel, S. M., Kondos, S. C., Goode, R. J. A., Ramm, G., Whisstock, J. C., Saibil, H. R. & Dunstone, M. A., 4 Feb 2016, In : Nature Communications. 7, 6 p., 10588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2015

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Lukoyanova, N., Kondos, S. C., Farabella, I., Law, R. H. P., Reboul, C. F., Caradoc-Davies, T. T., Spicer, B., Kleifeld, O., Traore, D. A. K., Ekkel, S. M., Voskoboinik, I., Trapani, J. A., Hatfaludi, T. Z., Oliver, K., Hotze, E. M., Tweten, R. K., Whisstock, J. C., Topf, M., Saibil, H. R. & Dunstone, M. A., 2015, In : PLoS Biology. 13, 2, 15 p., e1002049.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Ellisdon, A. M., Reboul, C. F., Panjikar, S., Huynh, K., Oellig, C. A., Winter, K. L., Dunstone, M. A., Hodgson, W. C., Seymour, J. E., Dearden, P. K., Tweten, R. K., Whisstock, J. C. & McGowan, S., 2015, In : Proceedings of the National Academy of Sciences. 112, 50, p. 15360 - 15365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

A new model for pore formation by cholesterol-dependent cytolysins

Reboul, C. F., Whisstock, J. C. & Dunstone, M. A., 2014, In : PLoS Computational Biology. 10, 8, p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin

Leung, C., Dudkina, N. V., Lukoyanova, N., Hodel, A. W., Farabella, I., Pandurangan, A. P., Jahan, N., Pires Damaso, M., Osmanović, D., Reboul, C. F., Dunstone, M. A., Andrew, P. W., Lonnen, R., Topf, M., Saibil, H. R. & Hoogenboom, B. W., 2014, In : eLife. 3, 17 p., e04247.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The cellular redox environment alters antigen presentation

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. TT., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W., 2014, In : Journal of Biological Chemistry. 289, 40, p. 27979 - 27991 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The perforin pore facilitates the delivery of cationic cargos

Stewart, S. E., Kondos, S., Matthews, A. Y., D'Angelo, M., Dunstone, M. A., Whisstock, J., Trapani, J. A. & Bird, P. I., 2014, In : Journal of Biological Chemistry. 289, 13, p. 9172 - 9181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Structural biology: Torqueing about pores

Whisstock, J. & Dunstone, M. A., 2013, In : Nature Chemical Biology. 9, 10, p. 605 - 606 2 p.

Research output: Contribution to journalArticleOther

2012

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins

Dunstone, M. A. & Tweten, R. K., 2012, In : Current Opinion in Structural Biology. 22, 3, p. 342 - 349 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

D'Angelo, M., Dunstone, M. A., Whisstock, J. C., Trapani, J. & Bird, P. I., 2012, In : BMC Evolutionary Biology. 12, Art. ID: 59, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Predicting giant transmembrane beta-barrel architecture

Reboul, C. F., Mahmood, K., Whisstock, J. C. & Dunstone, M. A., 2012, In : Bioinformatics. 28, 10, p. 1299 - 1302 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE

Hatfaludi, T. Z., Al-Hasani, K., Gong, L., Boyce, J. D., Ford, M., Wilkie, I. W., Quinsey, N. S., Dunstone, M. A., Hoke, D. E. & Adler, B., 2012, In : PLoS ONE. 7, 7, 11 p., e39973.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2010

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition

Theodossis, A., Guillonneau, C., Welland, A. D., Ely, L. K., Clements, C. S., Williamson, N. A., Webb, A. I., Wilce, J. A., Mulder, R. J., Dunstone, M. A., Doherty, P. C., McCluskey, J., Purcell, A. W., Turner, S. J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 12, p. 5534 - 5539 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Perforin: structure, function, and role in human immunopathology

Voskoboinik, I., Dunstone, M. A., Baran, K., Whisstock, J. & Trapani, J. A., 2010, In : Immunological Reviews. 235, 1, p. 35 - 54 20 p.

Research output: Contribution to journalArticleResearchpeer-review

The structural basis for membrane binding and pore formation by lymphocyte perforin

Law, R. H. P., Lukoyanova, N., Voskoboinik, I., Caradoc-Davies, T. T., Baran, K., Dunstone, M. A., D'Angelo, M., Orlova, E. V., Coulibaly, F. J., Verschoor, S., Browne, K. A., Ciccone, A., Kuiper, M. J., Bird, P. I., Trapani, J. A., Saibil, H. R. & Whisstock, J. C., 2010, In : Nature. 468, 7322, p. 447 - 451 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure and function of mammalian membrane-attack complex/perforin-like proteins

Kondos, S., Hatfaludi, T. Z., Voskoboinik, I., Trapani, J. A., Law, R. HP., Whisstock, J. C. & Dunstone, M. A., 2010, In : Tissue Antigens. 76, 5, p. 341 - 351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65

Newton, H. J., Pearson, J. S., Badea, L., Kelly, M., Lucas, M., Holloway, G., Wagstaff, K. M., Dunstone, M. A., Sloan, J., Whisstock, J. C., Kaper, J. B., Robins-Browne, R. M., Jans, D. A., Frankel, G., Phillips, A. D., Coulson, B. S. & Hartland, E. L., 2010, In : PLoS Pathogens. 6, 5 (e1000898), p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Beddoe, T. C., Chen, Z., Clements, C. S., Ely, L. K., Bushell, S. R., Vivian, J. P., Kjer-Nielsen, L., Pang, S. S., Dunstone, M. A., Liu, Y. C., Macdonald, W. A., Perugini, M. A., Wilce, M. C. J., Burrows, S. R., Purcell, A. W., Tiganis, T., Bottomley, S. P., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 6, p. 777 - 788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

Chia, J., Yeo, K. P., Whisstock, J., Dunstone, M. A., Trapani, J. A. & Voskoboinik, I., 2009, In : Proceedings of the National Academy of Sciences. 106, 24, p. 9809 - 9814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The molecular basis for perforin oligomerization and transmembrane pore assembly

Baran, K., Dunstone, M. A., Chia, J., Ciccone, A., Browne, K. A., Clarke, C. J. P., Lukoyanova, N., Saibil, H., Whisstock, J., Voskoboinik, I. & Trapani, J. A., 2009, In : Immunity. 30, 5, p. 684 - 695 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Characterization of TolC efflux pump proteins from Pasteurella multocida

Hatfaludi, T. Z., Al-Hasani, K., Dunstone, M. A., Boyce, J. D. & Adler, B., 2008, In : Antimicrobial Agents and Chemotherapy. 52, 11, p. 4166 - 4171 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: Substrate specificity and requirement for virulence

Sansom, F. M., Riedmaier, P., Newton, H., Dunstone, M. A., Muller, C. E., Stephan, H., Byres, E., Beddoe, T. C., Rossjohn, J., Cowan, P. J., d'Apice, A. J. F., Robson, S. C. & Hartland, E. L., 2008, In : Journal of Biological Chemistry. 283, 19, p. 12909 - 12918 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : PLoS Pathogens. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and biological basis of CTL escape in coronavirus-infected mice

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : Journal of Immunology. 180, 6, p. 3926 - 3937 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The MACPF/CDC family of pore-forming toxins

Rosado, C. J., Kondos, S., Bull, T. E., Kuiper, M., Law, R. H. P., Buckle, A. M., Voskoboinik, I., Bird, P. I., Trapani, J. A., Whisstock, J. & Dunstone, M. A., 2008, In : Cellular Microbiology. 10, 9, p. 1765 - 1774 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

A common fold mediates vertebrate defense and bacterial attack

Rosado, C. J., Buckle, A. M., Law, R. H. P., Butcher, R. E., Kan, W-T., Bird, C. H., Ung, K. S., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J. & 6 othersHartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A. & Whisstock, J., 2007, In : Science. 317, 5844, p. 1548 - 1551 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Specificity on a knife-edge: The alphabeta T cell receptor

Clements, C. S., Dunstone, M. A., Macdonald, W. A., McCluskey, J. & Rossjohn, J., 2006, In : Current Opinion in Structural Biology. 16, 6, p. 787 - 795 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface

Clements, C. S., Kjer-Nielsen, L., Kostenko, L., Hoare, H. L., Dunstone, M. A., Moses, E. K., Freed, K., Brooks, A. G., Rossjohn, J. & McCluskey, J., 2005, In : Proceedings of the National Academy of Sciences. 102, 9, p. 3360 - 3365 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J. & Doherty, P. C., 2005, In : Nature Immunology. 6, 4, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo

Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A. J., Perlmutter, P., McCluskey, J., Aguilar, M-I., Rossjohn, J. & Purcell, A. W., 2005, In : Journal of Immunology. 175, 6, p. 3810 - 3818 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3

Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T. C., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J. & Rossjohn, J., 2004, In : Proceedings of the National Academy of Sciences. 101, 20, p. 7675 - 7680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Webb, A. I., Dunstone, M. A., Chen, W., Aguilar, M. I., Chen, Q., Jackson, H., Chang, L., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Journal of Biological Chemistry. 279, 22, p. 23438 - 23446 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The production and purification of the human T-cell receptors, the CD3and CD3heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425 - 1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 1 Aug 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425-1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance

Webb, A. I., Borg, N. A., Dunstone, M. A., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Carbone, F. R., Bottomley, S. P., Aguilar, M. I., Purcell, A. W. & Rossjohn, J., 2004, In : Journal of Immunology. 173, 1, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Cleaved antitrypsin polymers at atomic resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B. F., Parker, M. W. & Bottomley, S. P., 13 Mar 2000, In : Protein Science. 9, 2, p. 417-420 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cleaved antitrypsin polymers at atominc resolution

Dunstone, M. A., Dai, W., Whisstock, J. C., Rossjohn, J., Pike, R. N., Feil, S. C., Le Bonniec, B., Parker, M. W. & Bottomley, S. P., 2000, In : Protein Science. p. 417 - 420 4 p.

Research output: Contribution to journalArticleResearchpeer-review