Projects per year
Personal profile
Biography
My research and knowledge focus on sensitive periods of brain development and puberty using longitudinal and multi-method data. Neurobiological development related to social processing and self-identity during puberty is critical for healthy development. Peer social-evaluative stress related to self-identity (i.e., “self-social stress”) shows observable neural, hormonal, and immune (i.e., neurobiological) responses. Adolescents with more reactive neurobiological systems to self-social stress may be more at risk for developing depression. Conversely, there are factors such as high levels of social support, that may protect against this risk. My PhD and postdoctoral training focused examining these associations in adolescent girls. My current program of research at Monash focuses on LGBTIQA+ adolescents and youth, because there are salient issues specific to LGBTIQA+ adolescent development of self-identity and social relationships that occur during puberty. The aim is to work with LGBTIQA+ communities and allies in a co-design framework and eventually provide evidence to inform public policy and education. This evidence should motivate us, as a broader society, to function in a more inclusive and less violent way, and ultimately reduce mental health disparities in this community.
Current Projects:
Social Stress and Puberty in Gender and Sexual Diverse Youth
Gender and sexual diverse youth experience a number of health disparities, including mental health. They also are one group of young people that experience a specific type of social (and self-identity) stressor at puberty – understanding, realizing, and announcing what their gender identity or sexual orientation is, can be stressful. For example, research shows that sexual minority-specific victimization significantly mediates the effect of sexual minority status on depressive symptoms. But this may depend on the level and quality of peer and family social support that they experience as they go through puberty and on individual differences in pubertal development. Yet, this community does not have a psychosocial puberty study of their own where their voices and stories of development can be heard. This pilot study will provide preliminary data showing if the association between social stress and mental health depends on puberty and social support specifically in sexual and gender diverse youth. We will then aim to develop a proposal for large-scale longitudinal cohort study following only gender and sexual diverse youth throughout adolescence and early adulthood to look at trajectories and the onset of mental health disorders in that community.
Identifying Brain Networks Associated with Immunoendocrine Reactivity to Social Stress and Depression During Puberty
Puberty is an important life phase where neurobiological development related to social processing is critical for healthy development. Peer social-evaluative stress becomes especially important during this time, because as children transition to adolescence, they become more concerned with how their peers think of them. One important step is to investigate how the functioning of brain networks necessary for social processing is associated with both endocrine and immune system responses to peer social-evaluative stress and how this, in turn, is associated with depression during adolescence, a sensitive developmental period for social learning. The aim of the proposed study is to determine if brain activity, hormonal and immune reactivity to social-evaluative stress, and depression are related in adolescent girls, and if early pubertal timing may be a risk factor for dysregulated neurobiological responses to social stress and depression. This study will provide unique and comprehensive insight into how brain and biological development in the context of social stress is associated with risk for adolescent depression in girls. It will fundamentally contribute to early intervention and preventative efforts for depression in adolescent girls.
The role of brain activity and connectivity in the association between immune function and depressive symptoms, and the effect of pubertal timing: A longitudinal study of adolescent girls
Recently, researchers have found that the functioning of the immune system, including chronic inflammation, is related to mental disorders such as depression, but the reasons for this are not clear. Because brain and pubertal development during early adolescence might play particularly important roles in this link, this study will look at how puberty, the immune system, brain development, and depression are related across time. Ultimately, this study will help us to understand how levels of inflammation during important times of adolescence can affect mental and physical health, so that we can intervene at the right time to ensure good health outcomes for all children.
Teaching:
PSY3062 - Research Methods and Theory - S2 2020, 2021, 2022
PSY4210 –Statistics and Data Science for Psychology - S1 2021, 2022
PSY4130 – Developmental psychology and clinical neuroscience - S2 2021
Recent Publications
Multimethod assessment of pubertal timing and associations with internalizing psychopathology in early adolescent girls: https://pubmed.ncbi.nlm.nih.gov/34941314/
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Psychoneuroimmunology
- Psychoneuroendocrinology
- Depression
- Adolescence
- Puberty
- Developmental Social Neuroscience
- Mental health
- Brain development
- Longitudinal designs and analyses
- Inflammation
- LGBTIQA+
Collaborations and top research areas from the last five years
Projects
- 8 Finished
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ABCD Workshop on Brain Development in Relation to Mental Health
Byrne, M., Mills, K. L. & Fair, D. A.
1/06/19 → 31/05/20
Project: Research
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Identifying brain networks associated with immunoendocrine reactivity to social stress and depression during puberty
15/01/19 → 14/01/22
Project: Research
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Modeling Developmental Change: Practical Integration of Advanced Neuroimaging and Statistical Methods
Byrne, M., Sabb, F., Mills, K. L., Allen, N. B. & Pfeifer, J. H.
1/06/17 → 31/05/18
Project: Research
-
Interactions of abuse and mental illness in the development of girls’ immune health
1/04/17 → 30/06/18
Project: Research
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Insomnia is a key risk factor for persistent anxiety and depressive symptoms: A 12-month longitudinal cohort study during the COVID-19 pandemic
Meaklim, H., Saunders, W. J., Byrne, M. L., Junge, M. F., Varma, P., Finck, W. A. & Jackson, M. L., 1 Feb 2023, In: Journal of Affective Disorders. 322, p. 52-62 11 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
A Researcher’s Guide to the Measurement and Modeling of Puberty in the ABCD Study® at Baseline
Cheng, T. W., Magis-Weinberg, L., Guazzelli Williamson, V., Ladouceur, C. D., Whittle, S. L., Herting, M. M., Uban, K. A., Byrne, M. L., Barendse, M. E. A., Shirtcliff, E. A. & Pfeifer, J. H., 5 May 2021, In: Frontiers in Endocrinology. 12, 9 p., 608575.Research output: Contribution to journal › Article › Research › peer-review
Open Access18 Citations (Scopus) -
Maternal parenting behavior and functional connectivity development in children: A longitudinal fMRI study
Pozzi, E., Vijayakumar, N., Byrne, M. L., Bray, K. O., Seal, M., Richmond, S., Zalesky, A. & Whittle, S. L., Apr 2021, In: Developmental Cognitive Neuroscience. 48, 8 p., 100946.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
Adrenarcheal Timing Longitudinally Predicts Anxiety Symptoms via Amygdala Connectivity During Emotion Processing
Barendse, M. E. A., Simmons, J. G., Patton, G., Mundy, L., Byrne, M. L., Seal, M. L., Allen, N. B. & Whittle, S., Jun 2020, In: Journal of the American Academy of Child and Adolescent Psychiatry. 59, 6, p. 739-748 10 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
Corrigendum to ‘Acute phase protein and cytokine levels in serum and saliva: A comparison of detectable levels and correlations in a depressed and healthy adolescent sample’ [Brain Behav. Immun. 34 (2013) 164–175] (Brain, Behavior, and Immunity (2013) 34 (164–175), (S0889159113004212), (10.1016/j.bbi.2013.08.010))
Byrne, M. L., O'Brien-Simpson, N. M., Reynolds, E. C., Walsh, K. A., Laughton, K., Waloszek, J. M., Woods, M. J., Trinder, J. & Allen, N. B., Oct 2020, In: Brain, Behavior, and Immunity. 89, p. 696-697 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access1 Citation (Scopus)