Projects per year
Personal profile
Biography
As a Research Fellow at the Department of Biochemistry and Molecular Biology Dr. Uckelmann studies the relationship between epigenetic modifiers, chromatin structure and transcription. He addresses these topics through an integrated structural biology approach, combining high resolution structure determination of macromolecular complexes (cryo-EM) with mass spectrometry, enzymology and genetic pertubations in cellular reporter systems.
His research on basic mechanisms of transcriptional regulation impacts on different fields, such as developmental biology, stem cell differentiation and cancer biology.
Dr. Uckelmann undertook his PhD studies at the Netherlands Cancer Institute (NKI) in Amsterdam, where he investigated structure and function relationship of epigenetic enzymes in the response to DNA damage. He moved to Monash University in 2018.
Research interests
- Epigenetic regulation of transcription
- Chromatin structure and function
- Enzymolgy of epigenetic modifiers
- Polycomb group proteins
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 2 Active
-
Rewriting the dogma of chromatin compaction: a new pathway for polycomb-mediated gene repression in development and disease
Davidovich, C., Uckelmann, M., Zhang, Q., de Marco, A. & Das, P.
1/01/22 → 31/12/24
Project: Research
-
Polycomb Group Proteins - Shaping Chromatin Architecture to Silence Genes
Australian Research Council (ARC)
14/01/21 → 13/01/24
Project: Research
-
Not just a writer: PRC2 as a chromatin reader
Uckelmann, M. & Davidovich, C., Jun 2021, In: Biochemical Society Transactions. 49, 3, p. 1159-1170 12 p.Research output: Contribution to journal › Review Article › Other › peer-review
Open Access8 Citations (Scopus) -
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis
Zhang, Q., Agius, S. C., Flanigan, S. F., Uckelmann, M., Levina, V., Owen, B. M. & Davidovich, C., Dec 2021, In: Nature Communications. 12, 1, 18 p., 4592.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Quantitative analysis of USP activity in vitro
Dharadhar, S., Kim, R. Q., Uckelmann, M. & Sixma, T. K., 2019, Ubiquitin and Ubiquitin-like Protein Modifiers. Hochstrasser, M. (ed.). Cambridge, MA: Academic Press, Vol. 618. p. 281-319 39 p. (Methods in Enzymology).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
3 Citations (Scopus) -
Structural basis of specific H2A K13/K15 ubiquitination by RNF168
Horn, V., Uckelmann, M., Zhang, H., Eerland, J., Aarsman, I., le Paige, U. B., Davidovich, C., Sixma, T. K. & van Ingen, H., 15 Apr 2019, In: Nature Communications. 10, 12 p., 1751.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile25 Citations (Scopus) -
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
Uckelmann, M., Densham, R. M., Baas, R., Winterwerp, H. H. K., Fish, A., Sixma, T. K. & Morris, J. R., 15 Jan 2018, In: Nature Communications. 9, 1, 16 p., 229.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile57 Citations (Scopus)