Michael Uckelmann

Dr

20102021

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Personal profile

Biography

As a Research Fellow at the Department of Biochemistry and Molecular Biology Dr. Uckelmann studies the relationship between epigenetic modifiers, chromatin structure and transcription. He addresses these topics through an integrated structural biology approach, combining high resolution structure determination of macromolecular complexes (cryo-EM) with mass spectrometry, enzymology and genetic pertubations in cellular reporter systems.

His research on basic mechanisms of transcriptional regulation impacts on different fields, such as developmental biology, stem cell differentiation and cancer biology.

Dr. Uckelmann undertook his PhD studies at the Netherlands Cancer Institute (NKI) in Amsterdam, where he investigated structure and function relationship of epigenetic enzymes in the response to DNA damage. He moved to Monash University in 2018.  

Research interests

  • Epigenetic regulation of transcription
  • Chromatin structure and function
  • Enzymolgy of epigenetic modifiers
  • Polycomb group proteins

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