Research output per year

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Personal profile


As a Research Fellow at the Department of Biochemistry and Molecular Biology Dr. Uckelmann studies the relationship between epigenetic modifiers, chromatin structure and transcription. He addresses these topics through an integrated structural biology approach, combining high resolution structure determination of macromolecular complexes (cryo-EM) with mass spectrometry, enzymology and genetic pertubations in cellular reporter systems.

His research on basic mechanisms of transcriptional regulation impacts on different fields, such as developmental biology, stem cell differentiation and cancer biology.

Dr. Uckelmann undertook his PhD studies at the Netherlands Cancer Institute (NKI) in Amsterdam, where he investigated structure and function relationship of epigenetic enzymes in the response to DNA damage. He moved to Monash University in 2018.  

Research interests

  • Epigenetic regulation of transcription
  • Chromatin structure and function
  • Enzymolgy of epigenetic modifiers
  • Polycomb group proteins

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Research Output

Quantitative analysis of USP activity in vitro

Dharadhar, S., Kim, R. Q., Uckelmann, M. & Sixma, T. K., 2019, Ubiquitin and Ubiquitin-like Protein Modifiers. Hochstrasser, M. (ed.). Cambridge, MA: Academic Press, Vol. 618. p. 281-319 39 p. (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Structural basis of specific H2A K13/K15 ubiquitination by RNF168

Horn, V., Uckelmann, M., Zhang, H., Eerland, J., Aarsman, I., le Paige, U. B., Davidovich, C., Sixma, T. K. & van Ingen, H., 15 Apr 2019, In : Nature Communications. 10, 12 p., 1751.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

Uckelmann, M., Densham, R. M., Baas, R., Winterwerp, H. H. K., Fish, A., Sixma, T. K. & Morris, J. R., 15 Jan 2018, In : Nature Communications. 9, 1, 16 p., 229.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Histone ubiquitination in the DNA damage response

Uckelmann, M. & Sixma, T. K., 1 Aug 2017, In : DNA Repair. 56, p. 92-101 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
37 Citations (Scopus)

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

Thorslund, T., Ripplinger, A., Hoffmann, S., Wild, T., Uckelmann, M., Villumsen, B., Narita, T., Sixma, T. K., Choudhary, C., Bekker-Jensen, S. & Mailand, N., 19 Nov 2015, In : Nature. 527, 7578, p. 389-393 5 p.

Research output: Contribution to journalArticleResearchpeer-review

170 Citations (Scopus)