Projects per year
Personal profile
Biography
Parkinson's disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population worldwide. Multiple lines of evidence place mitochondrial dysfunction as a central player in the pathogenesis of sporadic PD, and studies of genes associated with familial PD demonstrate convergent pathways involving oxidative stress and mitochondrial dysfunction. Two proteins commonly mutated in familial PD, PINK1 and Parkin, play a key role in maintaining mitochondrial integrity by identifying damaged mitochondria and degrading them through a selective form of autophagy termed mitophagy. Our lab investigates the molecular mechanisms of PINK1/Parkin mitophagy and how it works together with the mitochondrial unfolded protein response to maintain healthy mitochondria.
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Research area keywords
- mitochondrial biology
- mitophagy mitochondria PINK1 Parkin autophagy
Network
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Understanding how cells regulate self-eating in response to starvation and stress
17/04/20 → 31/12/22
Project: Research
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How do cells control autophagy during nutrient starvation and stress?
Australian Research Council (ARC), Monash University
1/01/17 → 31/12/20
Project: Research
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Mechanisms of mitochondrial damage control by PINK1 and Parkin
Hurley, J. H., Holzbaur, E., Lazarou, M., Martens, S. & Park, E.
15/11/20 → 3/01/22
Project: Research
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Quality Control: Maintaining molecular order and preventing cellular chaos
Neal, S., Ohtake, F., Cuervo, A. M., Hegde, R. S., Jakob, U., Lazarou, M., Gilbert, W. V., Chen, Z. J., Tooze, S. A., Haber, J. E., Walters, K. J. & Hartl, F. U., 21 Apr 2022, In: Molecular Cell. 82, 8, p. 1390-1397 8 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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A human apolipoprotein L with detergent-like activity kills intracellular pathogens
Gaudet, R. G., Zhu, S., Halder, A., Kim, B. H., Bradfield, C. J., Huang, S., Xu, D., Mamiñska, A., Nguyen, T. N., Lazarou, M., Karatekin, E., Gupta, K. & MacMicking, J. D., 16 Jul 2021, In: Science. 373, 6552, 14 p., eabf8113.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system
Nguyen, T. N., Padman, B. S., Zellner, S., Khuu, G., Uoselis, L., Lam, W. K., Skulsuppaisarn, M., Lindblom, R. S. J., Watts, E. M., Behrends, C. & Lazarou, M., 6 May 2021, In: Molecular Cell. 81, 9, p. 2013-e9 27 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
ATG4s: above and beyond the Atg8-family protein lipidation system
Nguyen, T. N., Padman, B. S. & Lazarou, M., 2021, In: Autophagy. 17, 9, p. 2648-2650 3 p.Research output: Contribution to journal › Article › Research › peer-review
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Defective lysosome reformation during autophagy causes skeletal muscle disease
McGrath, M. J., Eramo, M. J., Gurung, R., Sriratana, A., Gehrig, S. M., Lynch, G. S., Lourdes, S. R., Koentgen, F., Feeney, S. J., Lazarou, M., McLean, C. A. & Mitchell, C. A., 4 Jan 2021, In: Journal of Clinical Investigation. 131, 1, 16 p., e135124.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus)