Projects per year
Personal profile
Biography
Parkinson's disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population worldwide. Multiple lines of evidence place mitochondrial dysfunction as a central player in the pathogenesis of sporadic PD, and studies of genes associated with familial PD demonstrate convergent pathways involving oxidative stress and mitochondrial dysfunction. Two proteins commonly mutated in familial PD, PINK1 and Parkin, play a key role in maintaining mitochondrial integrity by identifying damaged mitochondria and degrading them through a selective form of autophagy termed mitophagy. Our lab investigates the molecular mechanisms of PINK1/Parkin mitophagy and how it works together with the mitochondrial unfolded protein response to maintain healthy mitochondria.
Related Links:
Keywords
- mitochondrial biology
- mitophagy mitochondria PINK1 Parkin autophagy
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2014 2020
How do cells control autophagy during nutrient starvation and stress?
Australian Research Council (ARC), Monash University
1/01/17 → 31/12/20
Project: Research
Research Output 2006 2019
LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K. & Lazarou, M., 24 Jan 2019, In : Nature Communications. 10, 1, 13 p., 408.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
Bernardini, J. P., Brouwer, J. M., Tan, I. K. L., Sandow, J. J., Huang, S., Stafford, C. A., Bankovacki, A., Riffkin, C. D., Wardak, A. Z., Czabotar, P. E., Lazarou, M. & Dewson, G., 15 Jan 2019, In : EMBO Journal. 38, 2, 16 p., e99916.Research output: Contribution to journal › Article › Research › peer-review
Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease
Beauchamp, L. C., Chan, J., Hung, L. W., Padman, B. S., Vella, L. J., Liu, X. M., Coleman, B., Bush, A. I., Lazarou, M., Hill, A. F., Jacobson, L. & Barnham, K. J., 5 Jul 2018, In : Acta neuropathologica communications. 6, 1, 12 p., 57.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 others, 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.Research output: Contribution to journal › Article › Research › peer-review
Identification of PSD-95 in the postsynaptic density using miniSOG and Em tomography
Chen, X., Winters, C., Crocker, V., Lazarou, M., Sousa, A. A., Leapman, R. D. & Reese, T. S., 7 Dec 2018, In : Frontiers in Neuroanatomy. 12, 16 p., 107.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File