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Research output per year

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Personal profile


Parkinson's disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population worldwide. Multiple lines of evidence place mitochondrial dysfunction as a central player in the pathogenesis of sporadic PD, and studies of genes associated with familial PD demonstrate convergent pathways involving oxidative stress and mitochondrial dysfunction. Two proteins commonly mutated in familial PD, PINK1 and Parkin, play a key role in maintaining mitochondrial integrity by identifying damaged mitochondria and degrading them through a selective form of autophagy termed mitophagy. Our lab investigates the molecular mechanisms of PINK1/Parkin mitophagy and how it works together with the mitochondrial unfolded protein response to maintain healthy mitochondria.

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Research area keywords

  • mitochondrial biology
  • mitophagy mitochondria PINK1 Parkin autophagy

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Research Output

  • 32 Article
  • 2 Review Article
  • 1 Chapter (Book)
  • 1 Comment / Debate

Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

Formosa, L. E., Muellner-Wong, L., Reljic, B., Sharpe, A. J., Jackson, T. D., Beilharz, T. H., Stojanovski, D., Lazarou, M., Stroud, D. A. & Ryan, M. T., 21 Apr 2020, In : Cell Reports. 31, 3, 14 p., 107541.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K. & Lazarou, M., 24 Jan 2019, In : Nature Communications. 10, 1, 13 p., 408.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs

Gu, Y., Princely Abudu, Y., Kumar, S., Bissa, B., Choi, S. W., Jia, J., Lazarou, M., Eskelinen, E. L., Johansen, T. & Deretic, V., 15 Nov 2019, In : The EMBO Journal. 38, 22, 22 p., e101994.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Bernardini, J. P., Brouwer, J. M., Tan, I. K. L., Sandow, J. J., Huang, S., Stafford, C. A., Bankovacki, A., Riffkin, C. D., Wardak, A. Z., Czabotar, P. E., Lazarou, M. & Dewson, G., 15 Jan 2019, In : The EMBO Journal. 38, 2, 16 p., e99916.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Beauchamp, L. C., Chan, J., Hung, L. W., Padman, B. S., Vella, L. J., Liu, X. M., Coleman, B., Bush, A. I., Lazarou, M., Hill, A. F., Jacobson, L. & Barnham, K. J., 5 Jul 2018, In : Acta neuropathologica communications. 6, 1, 12 p., 57.

Research output: Contribution to journalArticleResearchpeer-review

Open Access