Projects per year
Personal profile
Biography
Parkinson's disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population worldwide. Multiple lines of evidence place mitochondrial dysfunction as a central player in the pathogenesis of sporadic PD, and studies of genes associated with familial PD demonstrate convergent pathways involving oxidative stress and mitochondrial dysfunction. Two proteins commonly mutated in familial PD, PINK1 and Parkin, play a key role in maintaining mitochondrial integrity by identifying damaged mitochondria and degrading them through a selective form of autophagy termed mitophagy. Our lab investigates the molecular mechanisms of PINK1/Parkin mitophagy and how it works together with the mitochondrial unfolded protein response to maintain healthy mitochondria.
Related Links:
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- mitochondrial biology
- mitophagy mitochondria PINK1 Parkin autophagy
Collaborations and top research areas from the last five years
-
Understanding how cells regulate self-eating in response to starvation and stress
Lazarou, M. (Primary Chief Investigator (PCI))
1/01/20 → 31/12/23
Project: Research
-
How do cells control autophagy during nutrient starvation and stress?
Lazarou, M. (Primary Chief Investigator (PCI))
Australian Research Council (ARC), Monash University
1/01/17 → 31/12/20
Project: Research
-
Mechanisms of mitochondrial damage control by PINK1 and Parkin
Hurley, J. H. (Primary Chief Investigator (PCI)), Holzbaur, E. (Chief Investigator (CI)), Lazarou, M. (Chief Investigator (CI)), Martens, S. (Chief Investigator (CI)) & Park, E. (Chief Investigator (CI))
15/11/20 → 3/01/22
Project: Research
-
Exposure of the inner mitochondrial membrane triggers apoptotic mitophagy
Saunders, T. L., Windley, S. P., Gervinskas, G., Balka, K. R., Rowe, C., Lane, R., Tailler, M., Nguyen, T. N., Ramm, G., Lazarou, M., De Nardo, D., Kile, B. T. & McArthur, K., Mar 2024, In: Cell Death and Differentiation. 31, 3, p. 335-347 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Citations (Scopus) -
Interaction of PINK1 with nucleotides and kinetin
Gan, Z. Y., Callegari, S., Nguyen, T. N., Kirk, N. S., Leis, A., Lazarou, M., Dewson, G. & Komander, D., 19 Jan 2024, In: Science Advances. 10, 3, 12 p., eadj7408.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore
Rao, S., Skulsuppaisarn, M., Strong, L. M., Ren, X., Lazarou, M., Hurley, J. H. & Hummer, G., Feb 2024, In: Science Advances. 10, 6, 12 p., eadj8027.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Development of new tools to study membrane-anchored mammalian Atg8 proteins
Park, S. W., Jeon, P., Yamasaki, A., Lee, H. E., Choi, H., Mun, J. Y., Jun, Y. W., Park, J. H., Lee, S. H., Lee, S. K., Lee, Y. K., Song, H. K., Lazarou, M., Cho, D. H., Komatsu, M., Noda, N. N., Jang, D. J. & Lee, J. A., 4 May 2023, In: Autophagy. 19, 5, p. 1424-1443 20 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus) -
FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors
Nguyen-Dien, G. T., Kozul, K. L., Cui, Y., Townsend, B., Kulkarni, P. G., Ooi, S. S., Marzio, A., Carrodus, N., Zuryn, S., Pagano, M., Parton, R. G., Lazarou, M., Millard, S. S., Taylor, R. W., Collins, B. M., Jones, M. J. K. & Pagan, J. K., 2023, In: The EMBO Journal. 42, 15 p., e112767.Research output: Contribution to journal › Article › Research › peer-review
Open Access38 Citations (Scopus)