Projects per year
Personal profile
Biography
Parkinson's disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population worldwide. Multiple lines of evidence place mitochondrial dysfunction as a central player in the pathogenesis of sporadic PD, and studies of genes associated with familial PD demonstrate convergent pathways involving oxidative stress and mitochondrial dysfunction. Two proteins commonly mutated in familial PD, PINK1 and Parkin, play a key role in maintaining mitochondrial integrity by identifying damaged mitochondria and degrading them through a selective form of autophagy termed mitophagy. Our lab investigates the molecular mechanisms of PINK1/Parkin mitophagy and how it works together with the mitochondrial unfolded protein response to maintain healthy mitochondria.
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Research area keywords
- mitochondrial biology
- mitophagy mitochondria PINK1 Parkin autophagy
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Projects
Understanding how cells regulate self-eating in response to starvation and stress
17/04/20 → 31/12/22
Project: Research
How do cells control autophagy during nutrient starvation and stress?
Australian Research Council (ARC), Monash University
1/01/17 → 31/12/20
Project: Research
Research Output
Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I
Formosa, L. E., Muellner-Wong, L., Reljic, B., Sharpe, A. J., Jackson, T. D., Beilharz, T. H., Stojanovski, D., Lazarou, M., Stroud, D. A. & Ryan, M. T., 21 Apr 2020, In : Cell Reports. 31, 3, 14 p., 107541.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K. & Lazarou, M., 24 Jan 2019, In : Nature Communications. 10, 1, 13 p., 408.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
21
Citations
(Scopus)
Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs
Gu, Y., Princely Abudu, Y., Kumar, S., Bissa, B., Choi, S. W., Jia, J., Lazarou, M., Eskelinen, E. L., Johansen, T. & Deretic, V., 15 Nov 2019, In : The EMBO Journal. 38, 22, 22 p., e101994.Research output: Contribution to journal › Article › Research › peer-review
5
Citations
(Scopus)
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
Bernardini, J. P., Brouwer, J. M., Tan, I. K. L., Sandow, J. J., Huang, S., Stafford, C. A., Bankovacki, A., Riffkin, C. D., Wardak, A. Z., Czabotar, P. E., Lazarou, M. & Dewson, G., 15 Jan 2019, In : The EMBO Journal. 38, 2, 16 p., e99916.Research output: Contribution to journal › Article › Research › peer-review
8
Citations
(Scopus)
Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease
Beauchamp, L. C., Chan, J., Hung, L. W., Padman, B. S., Vella, L. J., Liu, X. M., Coleman, B., Bush, A. I., Lazarou, M., Hill, A. F., Jacobson, L. & Barnham, K. J., 5 Jul 2018, In : Acta neuropathologica communications. 6, 1, 12 p., 57.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File