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Parkinson's disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population worldwide. Multiple lines of evidence place mitochondrial dysfunction as a central player in the pathogenesis of sporadic PD, and studies of genes associated with familial PD demonstrate convergent pathways involving oxidative stress and mitochondrial dysfunction. Two proteins commonly mutated in familial PD, PINK1 and Parkin, play a key role in maintaining mitochondrial integrity by identifying damaged mitochondria and degrading them through a selective form of autophagy termed mitophagy. Our lab investigates the molecular mechanisms of PINK1/Parkin mitophagy and how it works together with the mitochondrial unfolded protein response to maintain healthy mitochondria.

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Research area keywords

  • mitochondrial biology
  • mitophagy mitochondria PINK1 Parkin autophagy

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Projects 2014 2020

Research Output 2006 2019

  • 31 Article
  • 2 Review Article
  • 1 Chapter (Book)
  • 1 Comment / Debate
8 Citations (Scopus)

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K. & Lazarou, M., 24 Jan 2019, In : Nature Communications. 10, 1, 13 p., 408.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs

Gu, Y., Princely Abudu, Y., Kumar, S., Bissa, B., Choi, S. W., Jia, J., Lazarou, M., Eskelinen, E. L., Johansen, T. & Deretic, V., 15 Nov 2019, In : The EMBO journal. 38, 22, 22 p., e101994.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Bernardini, J. P., Brouwer, J. M., Tan, I. K. L., Sandow, J. J., Huang, S., Stafford, C. A., Bankovacki, A., Riffkin, C. D., Wardak, A. Z., Czabotar, P. E., Lazarou, M. & Dewson, G., 15 Jan 2019, In : EMBO Journal. 38, 2, 16 p., e99916.

Research output: Contribution to journalArticleResearchpeer-review

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Beauchamp, L. C., Chan, J., Hung, L. W., Padman, B. S., Vella, L. J., Liu, X. M., Coleman, B., Bush, A. I., Lazarou, M., Hill, A. F., Jacobson, L. & Barnham, K. J., 5 Jul 2018, In : Acta neuropathologica communications. 6, 1, 12 p., 57.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
54 Citations (Scopus)

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 others, Lessene, G., Ryan, M. T., Rogers, K. L., Van Delft, M. F. & Kile, B. T., 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.

Research output: Contribution to journalArticleResearchpeer-review