• 23 Innovation Walk, Building 77

    3800 Clayton

    Australia

Accepting PhD Students

20062020
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Parkinson's disease (PD) is one of the most common of the neurodegenerative disorders, affecting 1-2% of the population worldwide. Multiple lines of evidence place mitochondrial dysfunction as a central player in the pathogenesis of sporadic PD, and studies of genes associated with familial PD demonstrate convergent pathways involving oxidative stress and mitochondrial dysfunction. Two proteins commonly mutated in familial PD, PINK1 and Parkin, play a key role in maintaining mitochondrial integrity by identifying damaged mitochondria and degrading them through a selective form of autophagy termed mitophagy. Our lab investigates the molecular mechanisms of PINK1/Parkin mitophagy and how it works together with the mitochondrial unfolded protein response to maintain healthy mitochondria.

Related Links:

Keywords

  • mitochondrial biology
  • mitophagy mitochondria PINK1 Parkin autophagy

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2020

Research Output 2006 2019

  • 30 Article
  • 2 Review Article
  • 1 Chapter (Book)
  • 1 Comment / Debate

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Padman, B. S., Nguyen, T. N., Uoselis, L., Skulsuppaisarn, M., Nguyen, L. K. & Lazarou, M., 24 Jan 2019, In : Nature Communications. 10, 1, 13 p., 408.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy

Bernardini, J. P., Brouwer, J. M., Tan, I. K. L., Sandow, J. J., Huang, S., Stafford, C. A., Bankovacki, A., Riffkin, C. D., Wardak, A. Z., Czabotar, P. E., Lazarou, M. & Dewson, G., 15 Jan 2019, In : EMBO Journal. 38, 2, 16 p., e99916.

Research output: Contribution to journalArticleResearchpeer-review

Ablation of tau causes an olfactory deficit in a murine model of Parkinson's disease

Beauchamp, L. C., Chan, J., Hung, L. W., Padman, B. S., Vella, L. J., Liu, X. M., Coleman, B., Bush, A. I., Lazarou, M., Hill, A. F., Jacobson, L. & Barnham, K. J., 5 Jul 2018, In : Acta neuropathologica communications. 6, 1, 12 p., 57.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., Chin, H. S., Lane, R. M., Dramicanin, M., Saunders, T. L., Sugiana, C., Lessene, R., Osellame, L. D., Chew, T. L., Dewson, G., Lazarou, M., Ramm, G. & 5 othersLessene, G., Ryan, M. T., Rogers, K. L., Van Delft, M. F. & Kile, B. T., 23 Feb 2018, In : Science. 359, 6378, 12 p., eaao6047.

Research output: Contribution to journalArticleResearchpeer-review

Identification of PSD-95 in the postsynaptic density using miniSOG and Em tomography

Chen, X., Winters, C., Crocker, V., Lazarou, M., Sousa, A. A., Leapman, R. D. & Reese, T. S., 7 Dec 2018, In : Frontiers in Neuroanatomy. 12, 16 p., 107.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File