• Level 5, Block E, Monash Medical Centre, 246 Clayton Rd

    3168 Clayton, Vic.


Accepting PhD Students

1989 …2023

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile


Michael Hickey undertook his B.Sc. (Hons) and PhD at the University of Melbourne, examining the inflammatory mechanisms of ischaemia/reperfusion injury in skeletal muscle. He subsequently undertook postdoctoral training in the laboratory of Dr. Paul Kubes at the University of Calgary in Canada, where he learnt how to use intravital microscopy to investigate mechanisms of leukocyte recruitment. He returned to Australia in late 1999, initially to the Baker Medical Research Institute, where he initiated a research program examining mechanisms of leukocyte recruitment in autoimmune disease. He subsequently joined the Centre for Inflammatory Diseases at Monash University in 2001 and was awarded NHMRC Senior Research Fellowships in 2008, 2013 & 2018.

Research interests

“Caught in the act” – imaging white blood cells while they cause inflammatory injury

Professor Michael Hickey says leukocytes, or white blood cells, are both the good and bad guys of our immune system. While these cells are critical to our ability to fight infections and heal our tissues after injury, they are also responsible for some of the most debilitating inflammatory diseases, including rheumatoid arthritis, asthma, multiple sclerosis and inflammatory kidney disease. Michael’s laboratory investigates the behaviour of leukocytes in inflamed tissues and the blood vessels that supply them, using highly advanced microscopes to visualise white blood cells in tissues. The overall approach of the laboratory stems from the idea that only by directly visualising white blood cells in action can we aim to understand how they contribute to inflammatory diseases, and thereby identify new ways to tackle these conditions.

Leukocytes circulate in the blood vessels and migrate into tissues when they detect signs of infection or tissue damage. Inflammatory diseases occur when this response is excessive or inappropriately targeted. Michael’s research examines the process whereby the cells stick to blood vessel walls in order to leave the bloodstream and enter the inflammatory site.

'We investigate the dynamic process of how white blood cells move out of blood vessels' Michael says. 'It sounds simple but it's very diverse because the mechanisms of this process can be different in different organs and for different types of white blood cells. The strategy we use in my lab is to directly visualise these cells in specific tissues during inflammatory responses, with the aim of identifying the molecules involved in leukocyte accumulation in tissues,' he says.

While inappropriate inflammation can affect every tissue in the body, the main focus of Michael's current research is white blood cell-mediated inflammatory injury of the kidney, a major cause of kidney failure.

'The part of the kidney that filters the blood - the glomerulus - can be a target of various life-threatening inflammatory diseases,' Michael says. ‘We're one of the few labs in the world using microscopy to look specifically at this part of the kidney. We are using this approach to investigate the mechanisms whereby white blood cells are attracted to the glomerulus and to understand their behaviour once they get there. We've discovered some unique aspects whereby white blood cells injure this component of the kidney.

'We are also examining inflammatory disease of the skin,' he says. 'We've been studying a very rare kind of white blood cell – the regulatory T cell - that dampens down skin inflammation, examining the process whereby these cells get into the skin and identifying new processes whereby they control inflammation.'

The ultimate aim of this work is to develop a detailed molecular understanding of the mechanisms whereby leukocytes cause or alternatively control injury in inflamed tissues.

Professor Hickey's research has been supported by funding from the National Health & Medical Research Council, National Institutes of Health (US), the Heart Foundation of Australia, ANZ Trustees and the Rebecca L Cooper Foundation.



Education/Academic qualification

B.Sc. (Hons), University of Melbourne

PhD, University of Melbourne

Research area keywords

  • Inflammation
  • Leukocyte trafficking
  • Glomerulonephritis
  • Immune System
  • imaging
  • Microscopy
  • Neutrophils
  • skin inflammation

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


Research Output

Memory regulatory T cells home to the lung and control influenza A virus infection

Lu, C., Zanker, D., Lock, P., Jiang, X., Deng, J., Duan, M., Liu, C., Faou, P., Hickey, M. J. & Chen, W., 22 May 2019, (Accepted/In press) In : Immunology and Cell Biology. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Platelet retention in inflamed glomeruli occurs via selective prolongation of interactions with immune cells

Finsterbusch, M., Norman, M. U., Hall, P., Kitching, A. R. & Hickey, M. J., 1 Feb 2019, In : Kidney International. 95, 2, p. 363-374 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Activation of the sympathetic nervous system modulates neutrophil function

Nicholls, A. J., Wen, S. W., Hall, P., Hickey, M. J. & Wong, C. H. Y., 1 Feb 2018, In : Journal of leukocyte biology. 103, 2, p. 295-309 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

CD39 and CD73 activity are protective in a mouse model of antiphospholipid antibody-induced miscarriages

Samudra, A. N., Dwyer, K. M., Selan, C., Freddi, S., Murray-Segal, L., Nikpour, M., Hickey, M. J., Peter, K., Robson, S. C., Sashindranath, M., Cowan, P. J. & Nandurkar, H. H., Mar 2018, In : Journal of Autoimmunity. 88, p. 131-138 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)


  • 1 Contribution to conference
  • 1 Editorial responsibility
  • 1 Non-HDR Supervisions

World Congress of Inflammation 2019

Michael Hickey (Organiser)

Activity: Participating in or organising an event typesContribution to conference

John Wiley & Sons (Publisher)

Michael Hickey (Associate editor)

Activity: Publication peer-review and editorial work typesEditorial responsibility

Honours student supervision

Michael Hickey (Supervisor)

Activity: Other Teaching Engagements and non-HDR SupervisionsNon-HDR Supervisions