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Research Output

2020

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In : mBio. 11, 1, 6 p., e03187-19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)
2019

MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose

Wong, A., Nejad, C., Gantier, M., Choy, K. W., Doery, J. & Graudins, A., 1 Jun 2019, In : Human and Experimental Toxicology. 38, 6, p. 646-654 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR

Pillman, K. A., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Feb 2019, In : Rna-A Publication of the Rna Society. 25, 2, p. 232-238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)
2018

A guide to miRNAs in inflammation and innate immune responses

Nejad, C., Stunden, H. J. & Gantier, M. P., 24 Apr 2018, In : FEBS Journal. 285, 20, p. 3695-3716 22 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Assessing the cGAS-cGAMP-STING activity of cancer cells

Pépin, G. & Gantier, M. P., 1 Jan 2018, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). New York, NY: Humana Press, p. 257-266 10 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity

Wong, A., Cheung, B., Nejad, C., Gantier, M. & Graudins, A., 3 Oct 2018, In : Clinical Toxicology. 56, 10, p. 904–906 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

miR-222 isoforms are differentially regulated by type-I interferon

Nejad, C., Pillman, K. A., Siddle, K. J., Pépin, G., Anko, M. L., McCoy, C. E., Beilharz, T. H., Quintana-Murci, L., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Mar 2018, In : RNA. 24, 3, p. 332-341 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Modified polyadenylation-based RT-qPCR increases selectivity of amplification of 3'-MicroRNA isoforms

Nejad, C., Pépin, G., Behlke, M. A. & Gantier, M. P., 24 Jan 2018, In : Frontiers in Genetics. 9, JAN, 9 p., 11.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers

Ying, L., Yan, F., Meng, Q., Yu, L., Yuan, X., Gantier, M. P., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Chen, W., Zang, X., Xu, D. & Hu, Y., 20 Feb 2018, In : OncoImmunology. 7, 6, 11 p., e1433520.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The use of CRISPR/Cas9 gene editing to confirm congenic contaminations in host-pathogen interaction studies

Ferrand, J., Croft, N. P., Pépin, G., Diener, K. R., Wu, D., Mangan, N. E., Pedersen, J., Behlke, M. A., Hayball, J. D., Purcell, A. W., Ferrero, R. L. & Gantier, M. P., 19 Mar 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 10 p., 87.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Activation of cGAS-dependent antiviral responses by DNA intercalating agents

Pepin, G., Nejad, C., Thomas, B. J., Ferrand, J., McArthur, K., Bardin, P. G., Williams, B. R. G. & Gantier, M. P., 9 Jan 2017, In : Nucleic Acids Research. 45, 1, p. 198-205 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Assessing the off-target effects of miRNA inhibitors on innate immune toll-like receptors

Pepin, G., Ferrand, J. & Gantier, M. P., 2017, Drug Target miRNA: Methods and Protocols. Schmidt, M. F. (ed.). New York NY USA: Humana Press, Vol. 1517. p. 127-135 9 p. (Methods in Molecular Biology: Springer Protocols; vol. 1517).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

cGAS-STING activation in the tumor microenvironment and its role in cancer immunity

Pépin, G. & Gantier, M. P., 2017, Regulation of Inflammatory Signaling in Health and Disease. Xu, D. (ed.). Singapore: Springer, p. 175-194 20 p. (Advances in Experimental Medicine and Biology; vol. 1024).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

17 Citations (Scopus)

Challenges and opportunities for siRNA-based cancer treatment

Wang, T., Shigdar, S., Shamaileh, H. A., Gantier, M. P., Yin, W., Xiang, D., Wang, L., Zhou, S. F., Hou, Y., Wang, P., Zhang, W., Pu, C. & Duan, W., 28 Feb 2017, In : Cancer Letters. 387, p. 77-83 7 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

36 Citations (Scopus)

Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients

Li, X., Tian, R., Gao, H., Yang, Y., Williams, B. R. G., Gantier, M. P., McMillan, N. A. J., Xu, D., Hu, Y. & Gao, YE., 1 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 16495.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Length does matter for cGAS

Gantier, M. P., 1 Oct 2017, In : EMBO Reports. 18, 10, p. 1675-1676 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

3 Citations (Scopus)

Naturally existing isoforms of miR-222 have distinct functions

Yu, F., Pillman, K. A., Neilsen, C. T., Toubia, J., Lawrence, D. M., Tsykin, A., Gantier, M. P., Callen, D. F., Goodall, G. J. & Bracken, C. P., 1 Jan 2017, In : Nucleic Acids Research. 45, 19, p. 11371-11385 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

Topoisomerase 1 inhibition promotes cyclic GMP-AMP synthase-dependent antiviral responses

Pépin, G., Nejad, C., Ferrand, J., Thomas, B. J., Stunden, H. J., Sanij, E., Foo, C. H., Stewart, C. R., Cain, J. E., Bardin, P. G., Williams, B. R. G. & Gantier, M. P., 1 Sep 2017, In : mBio. 8, 5, 9 p., e01611-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)
2016

Assessing the inhibitory activity of oligonucleotides on TLR7 sensing

Ferrand, J. & Gantier, M. P., 1 Jan 2016, Toll-Like Receptors: Practice and Methods. McCoy, C. E. (ed.). 2nd ed. New York NY USA: Humana Press, p. 79-90 12 p. (Methods in Molecular Biology: Springer Protocols; no. 1390).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

5 Citations (Scopus)

Cre-dependent DNA recombination activates a STING-dependent innate immune response

Pépin, G., Ferrand, J., Höning, K., Jayasekara, W. S. N., Cain, J. E., Behlke, M. A., Gough, D. J., Williams, B. R. G., Hornung, V. & Gantier, M. P., 20 Jun 2016, In : Nucleic Acids Research. 44, 11, p. 5356-5364 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

microRNA Decay: Refining microRNA Regulatory Activity

Pepin, G. & Gantier, M. P., 2016, In : Microrna. 5, 3, p. 167-174 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

6 Citations (Scopus)

Normalization of affymetrix miRNA microarrays for the analysis of cancer samples

Wu, D. & Gantier, M. P., 1 May 2016, Microarray Data Analysis: Methods and Applications. Guzzi, P. H. (ed.). 2nd ed. Humana Press, Vol. 1375. p. 1-10 10 p. (Methods in Molecular Biology; vol. 1375).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)
2015

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler, A. J., Rossello, F. J., Yu, L., Deane, J. A., Yuan, X-L., Wang, D., Irving, A. T., Liaskos, M., Gantier, M. P. M., Ying, H., Yim, H. C. H., Hartland, E. L., Notini, A. J., De Boer, C. M., White, S., Mansell, A. S., Liu, J-P., Watkins, D. N., Gerondakis, S. D., Williams, B. R. G. & 1 others, Xu, D., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1535 - 1540 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

Cancer stem cell targeted therapy: progress amid controversies

Wang, T., Shigdar, S. L., Gantier, M. P. M., Hou, Y., Wang, L., Li, Y., Al Shamaileh, H., Yin, W., Zhou, S-F., Zhao, X. & Duan, W., 2015, In : Oncotarget. 6, 42, p. 44191 - 44206 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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79 Citations (Scopus)

EpCAM aptamer-mediated survivin silencing sensitized cancer stem cells to doxorubicin in a breast cancer model

Wang, T., Gantier, M. P. M., Xiang, D., Bean, A. G., Bruce, M. P., Zhou, S-F., Khasraw, M., Ward, A. C., Wang, L., Wei, M. Q., AlShamaileh, H., Chen, L., She, X., Lin, J., Kong, L., Shigdar, S. L. & Duan, W., 2015, In : Theranostics. 5, 12, p. 1456 - 1472 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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54 Citations (Scopus)

Human blastocyst secreted microRNA regulate endometrial epithelial cell adhesion

Cuman, C., Van Sinderen, M. L., Gantier, M. P. M., Rainczuk, K. E. K., Sorby, K. L., Rombauts, L., Osianlis, T. & Dimitriadis, E., 2015, In : EBioMedicine. 2, 10, p. 1528 - 1535 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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42 Citations (Scopus)

IL-10 regulates Aicda expression through miR-155

Fairfax, K., Gantier, M. P. M., Mackay-Fisson, F., Williams, B. R. G. & McCoy, C., 2015, In : Journal of leukocyte biology. 97, 1, p. 71 - 78 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction

Nold-Petry, C. A., Lo, C. Y-W., Rudloff, I., Elgass, K., Li, S., Gantier, M. P. M., Lotz-Havla, A. S., Gersting, S. W., Cho, S., Lao, C. W. J., Ellisdon, A. M., Rotterd, B., Azam, T., Mangan, N., Rossello, F. J., Whisstock, J., Bufler, P., Garlanda, C., Mantovani, A. A., Dinarello, C. A. & 1 others, Nold, M. F., 2015, In : Nature Immunology. 16, 4, p. 354 - 365 12 p.

Research output: Contribution to journalArticleResearchpeer-review

186 Citations (Scopus)

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

Sarvestani, S., Stunden, H. J., Behlke, M. A., Forster, S., McCoy, C., Tate, M., Ferrand, J. F. P., Lennox, K. A., Latz, E., Williams, B. R. G. & Gantier, M. P. M., 30 Jan 2015, In : Nucleic Acids Research. 43, 2, p. 1177-1188 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)
2014

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8

Sarvestani, S., Tate, M., Moffat, J. M., Jacobi, A. M., Behlke, M. A., Miller, A., Beckham, S. A., McCoy, C., Chen, W., Mintern, J., O'Keeffe, M., John, M., Williams, B. R. G. & Gantier, M. P. M., 2014, In : Journal of Virology. 88, 2, p. 799 - 810 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia

Macintire, K., Tuohey, L., Ye, L., Palmer, K., Gantier, M. P. M., Tong, S. & Kaitu'u-Lino, T. J., 2014, In : Reproduction, Fertility and Development. 26, 2, p. 351 - 357 7 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Processing of double-stranded RNA in Mammalian cells: a direct antiviral role?

Gantier, M. P. M., 2014, In : Journal of Interferon and Cytokine Research. 34, 6, p. 469 - 477 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling

Irving, A. T., Mimuro, H., Kufer, T. A., Lo, C. Y-W., Wheeler, R., Turner, L. J., Thomas, B., Malosse, C., Gantier, M. P. M., Casillas, L. N., Votta, B. J., Bertin, J., Boneca, I. G., Sasakawa, C., Philpott, D., Ferrero, R. L. & Liaskos, M., 2014, In : Cell Host and Microbe. 15, 5, p. 623 - 635 13 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10

Quinn, S. R., Mangan, N., Caffrey, B. E., Gantier, M. P. M., Williams, B. R. G., Hertzog, P. J., McCoy, C. & O'Neill, L. A. J., 2014, In : The Journal of Biological Chemistry. 289, 7, p. 4316 - 4325 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2013

Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling

Ma, Y., Yuan, X., Deng, L., Xu, W., Zheng, Y., Yue, C., Zhang, G., Xie, F., Yang, Y. H., Gantier, M. P. M., Liu, J-P., Xu, D. & Shen, L., 2013, In : PLoS ONE. 8, 8 (art. no. e72804), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

Promotion of Hendra virus replication by microRNA 146a

Stewart, C. R., Marsh, G. A., Jenkins, K. A., Gantier, M. P. M., Tizard, M. L., Middleton, D., Lowenthal, J. W., Haining, J., Izzard, L., Gough, T. J., Deffrasnes, C., Stambas, J., Robinson, R., Heine, H. G., Pallister, J., Foord, A. J., Bean, A. GD. & Wang, L-F., 2013, In : Journal of Virology. 87, 7, p. 3782 - 3791 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

Strategies for designing and validating immunostimulatory siRNAs

Gantier, M. P. M., 2013, In : Methods in Molecular Biology. 942, p. 179 - 191 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The not-so-neutral role of microRNAs in neutrophil biology

Gantier, M. P. M., 2013, In : Journal of leukocyte biology. 94, 4, p. 575 - 583 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease

Wu, D., Hu, Y., Tong, S., Williams, B. R. G., Smyth, G. K. & Gantier, M. P. M., 2013, In : Rna-A Publication of the Rna Society. 19, 7, p. 876 - 888 13 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

X-chromosome-encoded microRNA-19 and -18 are possible modulators of female immunity

Gantier, M. P. M., 2013, In : BioEssays. 35, 8, p. 671 - 671 1 p.

Research output: Contribution to journalLetterOther

3 Citations (Scopus)
2012

A miR-19 regulon that controls NF-{kappa}B signaling

Gantier, M. P. M., Stunden, H. J., McCoy, C., Behlke, M. A., Wang, D., Liaskos, M., Sarvestani, S., Yang, Y. H., Xu, D., Corr, S. C., Morand, E. F. & Williams, B. R. G., 2012, In : Nucleic Acids Research. 40, 16, p. 8048 - 8058 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
120 Citations (Scopus)

An interspecific Nicotiana hybrid as a useful and cost-effective platform for production of animal vaccines

Ling, H-Y., Edwards, A., Gantier, M., DeBoer, K. D., Neale, A., Hamill, J. & Walmsley, A., 2012, In : PLoS ONE. 7, 4, 14 p., e35688.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing

Sarvestani, S., Williams, B. R. G. & Gantier, M. P. M., 2012, In : Journal of Interferon and Cytokine Research. 32, 8, p. 350 - 361 12 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells

Zheng, Y., Wang, Z., Deng, L., Yuan, X-L., Ma, Y-H., Zhang, G., Gantier, M. P. M., Liu, J-P., Shen, L-S. & Xu, D., 2012, In : European Journal of Immunology. 42, 10, p. 2803 - 2814 12 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo

Khairuddin, N., Gantier, M., Blake, S., Wu, S., Behlke, M., Williams, B. & McMillan, N., 2012, In : Immunology and Cell Biology. 90, 2, p. 187 - 196 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2011

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

Gantier, M., McCoy, C., Rusinova, I., Saulep, D., Wang, D., Xu, D., Irving, A., Behlke, M., Hertzog, P., Mackay-Fisson, F. & Williams, B., 2011, In : Nucleic Acids Research. 39, 13, p. 5692 - 5703 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
253 Citations (Scopus)

Making sense of viral RNA sensing

Gantier, M. & Williams, B., 2011, In : Molecular Therapy. 19, 9, p. 1578 - 1581 4 p.

Research output: Contribution to journalLetterOther

6 Citations (Scopus)
2010

Genetic modulation of TLR8 response following bacterial phagocytosis

Gantier, M. P. M., Irving, A. T., Liaskos, M., Xu, D., Evans, V., Cameron, P. U., Bourne, J. A., Ferrero, R. L., John, M., Behlke, M. A. & Williams, B. R. G., 2010, In : Human Mutation. 31, 9, p. 1069 - 1079 11 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Monitoring innate immune recruitment by siRNAs in mammalian cells

Gantier, M. P. M. & Williams, B. R. G., 2010, Methods in Molecular Biology [P]. Min, W-P. & Ichim, T. (eds.). First ed. USA: Humana Press, Vol. 623. p. 21 - 33 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

15 Citations (Scopus)