Personal profile
Biography
Professor Gantier is a research group leader, working at the Hudson Institute of medical research in Melbourne, Australia.
The central aim of Prof. Gantier’s research is to define how nucleic acids (DNA and RNA) modulate immune responses, and how this can be leveraged to develop novel therapies to treat cancer and auto-inflammation.
Over the past decade his research has significantly advanced our understanding of Toll-Like receptor 7 and 8 sensing of RNAs, and cGAS-STING detection of damaged DNA. His laboratory is currently studying next generation TLR7/8 agonists and inhibitors with can be used to improve mRNA-based vaccinations, along with cGAS/STING inhibitors to treat auto-inflammatory (such as lupus) and hyper-inflammatoy disorders.
In addition, Prof. Gantier has made important findings regarding how a class of endogenous small RNAs, known as microRNAs, persist in cells to regulate inflammation. This has led to the identification of microRNA sequence variations, which control microRNA stability and could be used as novel disease biomarkers.
Education/Academic qualification
Medicine and Therapeutics, PhD, RNAi in mammalian cells: studying the emerging roles of double stranded RNAs, University College Dublin
1 Sept 2002 → 7 Nov 2005
Award Date: 15 Jun 2006
Research area keywords
- Innate Immunity
- MicroRNAs
- RNA Interference
- SiRNAs
- Toll-Like Receptor 7 And 8
- cGAS-STING
- DNA damage
- mRNA vaccines
- Lung inflammation
- Infection driven inflammation
- Antisense oligonucleotides
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Projects
- 6 Finished
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Attenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-B activity
Bardin, P. (Primary Chief Investigator (PCI)), Gantier, M. (Chief Investigator (CI)), Elias, J. (Chief Investigator (CI)) & Loveland, K. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/17 → 31/12/21
Project: Research
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Critical regulators of endometrial receptivity
Dimitriadis, E. (Primary Chief Investigator (PCI)), Gantier, M. (Chief Investigator (CI)), Menkhorst, E. (Chief Investigator (CI)) & Rombauts, L. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/16 → 31/10/18
Project: Research
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Defining a role for TLR7/8 in Helicobacter pylori infection
Gantier, M. (Primary Chief Investigator (PCI)) & Ferrero, R. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/15 → 31/12/18
Project: Research
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Uncovering microRNA decay regulation in mammalian cells
Gantier, M. (Primary Chief Investigator (PCI))
ARC - Australian Research Council
23/07/14 → 22/07/18
Project: Research
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Targeting small RNA technologies
Gantier, M. (Primary Chief Investigator (PCI)) & Williams, B. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/16
Project: Research
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Pirfenidone Mitigates Transforming Growth Factor-β-induced Inflammation after Viral Infection
Thomas, B. J., Kan-O, K., Gantier, M. P., Simpson, I., Chitty, J. G., Lam, M., Dousha, L., Gottschalk, T. A., Lawlor, K. E., Tate, M. D., Ruwanpura, S., Seow, H. J., Loveland, K. L., Deshpande, S., Li, X., Hamza, K., King, P. T., Elias, J. A., Vlahos, R. & Bourke, J. E. & 1 others, , Oct 2025, In: American Journal of Respiratory Cell and Molecular Biology. 73, 4, p. 545-558 14 p.Research output: Contribution to journal › Article › Research › peer-review
5 Link opens in a new tab Citations (Scopus) -
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
Guanizo, A. C., Luong, Q., Jayasekara, W. S. N., de Geus, E. D., Inampudi, C., Xue, V. S., Chen, J., de Weerd, N. A., Matthews, A. Y., Gantier, M. P., Balic, J. J., Arulananda, S., Garama, D. J., Hertzog, P. J., Ganju, V., Watkins, D. N., Cain, J. E. & Gough, D. J., Dec 2024, In: Nature Immunology. 25, 12, p. 2259-2269 11 p.Research output: Contribution to journal › Article › Research › peer-review
15 Link opens in a new tab Citations (Scopus) -
Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation
El-Mortada, F., Landelouci, K., Bertrand-Perron, S., Aubé, F. A., Poirier, A., Bidias, A., Jourdi, G., Welman, M., Gantier, M. P., Hamilton, J. R., Kile, B., Lordkipanidzé, M. & Pépin, G., 1 Feb 2024, In: Life Science Alliance. 7, 2, 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
UNCovering new causes of monogenic systemic lupus erythematosus
Ellyard, J. I. & Gantier, M. P., Sept 2024, In: Immunology and Cell Biology. 102, 8, p. 651-654 4 p.Research output: Contribution to journal › Article › Other › peer-review
2 Link opens in a new tab Citations (Scopus) -
Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival
Bichet, M. C., Adderley, J., Avellaneda-Franco, L., Magnin-Bougma, I., Torriero-Smith, N., Gearing, L. J., Deffrasnes, C., David, C., Pepin, G., Gantier, M. P., Lin, R. C., Patwa, R., Moseley, G. W., Doerig, C. & Barr, J. J., 1 Oct 2023, In: PLoS Biology. 21, 10, p. e3002341 21 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access32 Link opens in a new tab Citations (Scopus)
Prizes
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Milstein Young investigator award
Gantier, M. (Recipient), 2010
Prize: Prize (including medals and awards)
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Outstanding Young investigator award
Gantier, M. (Recipient), 2012
Prize: Prize (including medals and awards)