Michael Gantier

Adj Assoc Prof

Accepting PhD Students

PhD projects

https://www.monash.edu/medicine/research/supervisorconnect

20062023

Research activity per year

Personal profile

Biography

Associate Professor Gantier is a research group leader, working at the Hudson Institute of medical research in Melbourne, Australia. 

The central aim of A/Prof Gantier’s research is to define how nucleic acids (DNA and RNA) modulate immune responses, and how this can be leveraged to develop novel therapies to treat cancer and auto-inflammation.

Over the past decade his research has significantly advanced our understanding of Toll-Like receptor 7 and 8 sensing of RNAs, and cGAS-STING detection of damaged DNA. His laboratory is currently studying next generation TLR7/8 agonists and inhibitors with can be used to improve mRNA-based vaccinations, along with cGAS/STING inhibitors to treat auto-inflammatory (such as lupus) and hyper-inflammatoy disorders.

In addition, Dr Gantier has made important findings regarding how a class of endogenous small RNAs, known as microRNAs, persist in cells to regulate inflammation. This has led to the identification of microRNA sequence variations, which control microRNA stability and could be used as novel disease biomarkers.

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Medicine and Therapeutics, PhD, RNAi in mammalian cells: studying the emerging roles of double stranded RNAs, University College Dublin

1 Sept 20027 Nov 2005

Award Date: 15 Jun 2006

Research area keywords

  • Innate Immunity
  • MicroRNAs
  • RNA Interference
  • SiRNAs
  • Toll-Like Receptor 7 And 8
  • cGAS-STING
  • DNA damage
  • mRNA vaccines
  • Lung inflammation
  • Infection driven inflammation
  • Antisense oligonucleotides

Collaborations and top research areas from the last five years

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