Projects per year
Associate Professor Gantier is a research group leader, working at the Hudson Institute of medical research in Melbourne, Australia.
The central aim of A/Prof Gantier’s research is to define how nucleic acids (DNA and RNA) modulate immune responses, and how this can be leveraged to develop novel therapies to treat cancer and auto-inflammation.
Over the past decade his research has significantly advanced our understanding of Toll-Like receptor 7 and 8 sensing of RNAs, and cGAS-STING detection of damaged DNA. His laboratory is currently studying next generation TLR7/8 agonists with potential in immunotherapy and vaccination, along with cGAS/STING inhibitors to treat auto-inflammatory (such as lupus) and hyper-inflammatoy disorders (such as sepsis).
In addition, Dr Gantier has made important findings regarding how a class of endogenous small RNAs, known as microRNAs, persist in cells to regulate inflammation. This has led to the identification of microRNA sequence variations, which control microRNA stability and could be used as novel disease biomarkers.
Medicine and Therapeutics, PhD, University College Dublin
1 Sep 2002 → 7 Nov 2005
Award Date: 15 Jun 2006
Research area keywords
- Innate Immunity
- RNA Interference
- Toll-Like Receptor 7 And 8
- DNA damage
- Liver inflammation
- Lung inflammation
- Infection driven inflammation
- Antisense oligonucleotides
1/01/16 → 31/10/18
1/01/15 → 31/12/18
23/07/14 → 22/07/18
1/01/14 → 31/12/16
Gantier, M. P., 2021, (Accepted/In press) In: Respirology.
Research output: Contribution to journal › Letter › Other › peer-reviewOpen Access
Gantier, M. P., 2020, (Accepted/In press) In: Respirology. 3 p.
Research output: Contribution to journal › Comment / Debate › Other › peer-reviewOpen Access
De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In: mBio. 11, 1, 6 p., e03187-19.
Research output: Contribution to journal › Article › Research › peer-reviewOpen AccessFile
Balasubramanian, S., Gantier, M. P., Kunetsky, V., Kracht, M., Schmitz, M. L. & Sträßer, K., 11 Sep 2020, In: Biomolecules. 10, 9, 32 p., 1310.
Research output: Contribution to journal › Review Article › Other › peer-reviewOpen AccessFile
Necrotic cell death increases the release of macrophage migration inhibitory factor by monocytes/macrophagesDankers, W., Hasnat, M. A., Swann, V., Alharbi, A., Lee, J. P. W., Cristofaro, M. A., Gantier, M. P., Jones, S. A., Morand, E. F., Flynn, J. K. & Harris, J., Oct 2020, In: Immunology and Cell Biology. 98, 9, p. 782-790 9 p.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access