Projects per year
Personal profile
Biography
Associate Professor Gantier is a research group leader, working at the Hudson Institute of medical research in Melbourne, Australia.
The central aim of A/Prof Gantier’s research is to define how nucleic acids (DNA and RNA) modulate immune responses, and how this can be leveraged to develop novel therapies to treat cancer and auto-inflammation.
Over the past decade his research has significantly advanced our understanding of Toll-Like receptor 7 and 8 sensing of RNAs, and cGAS-STING detection of damaged DNA. His laboratory is currently studying next generation TLR7/8 agonists and inhibitors with can be used to improve mRNA-based vaccinations, along with cGAS/STING inhibitors to treat auto-inflammatory (such as lupus) and hyper-inflammatoy disorders.
In addition, Dr Gantier has made important findings regarding how a class of endogenous small RNAs, known as microRNAs, persist in cells to regulate inflammation. This has led to the identification of microRNA sequence variations, which control microRNA stability and could be used as novel disease biomarkers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine and Therapeutics, PhD, RNAi in mammalian cells: studying the emerging roles of double stranded RNAs, University College Dublin
1 Sept 2002 → 7 Nov 2005
Award Date: 15 Jun 2006
Research area keywords
- Innate Immunity
- MicroRNAs
- RNA Interference
- SiRNAs
- Toll-Like Receptor 7 And 8
- cGAS-STING
- DNA damage
- mRNA vaccines
- Lung inflammation
- Infection driven inflammation
- Antisense oligonucleotides
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 6 Finished
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Attenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-B activity
Bardin, P. (Primary Chief Investigator (PCI)), Gantier, M. (Chief Investigator (CI)), Elias, J. (Chief Investigator (CI)) & Loveland, K. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/21
Project: Research
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Critical regulators of endometrial receptivity
Dimitriadis, E. (Primary Chief Investigator (PCI)), Gantier, M. (Chief Investigator (CI)), Menkhorst, E. (Chief Investigator (CI)) & Rombauts, L. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/10/18
Project: Research
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Defining a role for TLR7/8 in Helicobacter pylori infection
Gantier, M. & Ferrero, R.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/18
Project: Research
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Uncovering microRNA decay regulation in mammalian cells
Australian Research Council (ARC)
23/07/14 → 22/07/18
Project: Research
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Targeting small RNA technologies
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/16
Project: Research
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Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation
El-Mortada, F., Landelouci, K., Bertrand-Perron, S., Aubé, F. A., Poirier, A., Bidias, A., Jourdi, G., Welman, M., Gantier, M. P., Hamilton, J. R., Kile, B., Lordkipanidzé, M. & Pépin, G., 1 Feb 2024, In: Life Science Alliance. 7, 2, 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival
Bichet, M. C., Adderley, J., Avellaneda-Franco, L., Magnin-Bougma, I., Torriero-Smith, N., Gearing, L. J., Deffrasnes, C., David, C., Pepin, G., Gantier, M. P., Lin, R. C., Patwa, R., Moseley, G. W., Doerig, C. & Barr, J. J., 1 Oct 2023, In: PLoS Biology. 21, 10, p. e3002341 21 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection
Ullah, T. R. (Leading Author), Johansen, M. D. (Leading Author), Balka, K. R., Ambrose, R. L., Gearing, L. J., Roest, J., Vivian, J. P., Sapkota, S., Jayasekara, W. S. N., Wenholz, D. S., Aldilla, V. R., Zeng, J., Miemczyk, S., Nguyen, D. H., Hansbro, N. G., Venkatraman, R., Kang, J. H., Pang, E. S., Thomas, B. J. & Alharbi, A. S. & 13 others, , Dec 2023, In: Nature Communications. 14, 1, 13 p., 5666.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Selecting Therapeutic Antisense Oligonucleotides with Gene Targeting and TLR8 Potentiating Bifunctionality
Sapkota, S. & Gantier, M. P., 2023, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). 2nd ed. New York NY USA: Humana Press, Vol. 2691. p. 225-234 10 p. (Methods in Molecular Biology; vol. 2691).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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Deficiency in coatomer complex I causes aberrant activation of STING signalling
Steiner, A., Hrovat-Schaale, K., Prigione, I., Yu, C. H., Laohamonthonkul, P., Harapas, C. R., Low, R. R. J., De Nardo, D., Dagley, L. F., Mlodzianoski, M. J., Rogers, K. L., Zillinger, T., Hartmann, G., Gantier, M. P., Gattorno, M., Geyer, M., Volpi, S., Davidson, S. & Masters, S. L., 28 Apr 2022, In: Nature Communications. 13, 1, 16 p., 2321.Research output: Contribution to journal › Article › Research › peer-review
Open Access58 Citations (Scopus)
Prizes
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Milstein Young investigator award
Gantier, Michael (Recipient), 2010
Prize: Prize (including medals and awards)
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Outstanding Young investigator award
Gantier, Michael (Recipient), 2012
Prize: Prize (including medals and awards)