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Personal profile

Biography

Dr Gantier is a research group leader, working at the Hudson Institute of medical research in Melbourne, Australia. 

The central aim of Dr Gantier’s research is to define how nucleic acids (DNA and RNA) modulate immune responses, and how this can be leveraged to develop novel therapies to treat cancer and auto-inflammation.

Over the past decade his research has significantly advanced our understanding of Toll-Like receptor 7 and 8 sensing of RNAs, and cGAS-STING detection of damaged DNA. His laboratory is currently studying next generation TLR7/8 agonists with potential in immunotherapy and vaccination, along with cGAS/STING inhibitors to treat auto-inflammatory (such as lupus) and hyper-inflammatoy disorders (such as sepsis).

In addition, Dr Gantier has made important findings regarding how a class of endogenous small RNAs, known as microRNAs, persist in cells to regulate inflammation. This has led to the identification of microRNA sequence variations, which control microRNA stability and could be used as novel disease biomarkers.

 

Education/Academic qualification

Medicine and Therapeutics, PhD, University College Dublin

1 Sep 20027 Nov 2005

Award Date: 15 Jun 2006

Research area keywords

  • Innate Immunity
  • MicroRNAs
  • RNA Interference
  • SiRNAs
  • Toll-Like Receptor 7 And 8
  • cGAS-STING
  • DNA damage
  • Liver inflammation
  • Lung inflammation
  • Infection driven inflammation
  • Antisense oligonucleotides

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Projects

Research Output

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In : mBio. 11, 1, 6 p., e03187-19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose

Wong, A., Nejad, C., Gantier, M., Choy, K. W., Doery, J. & Graudins, A., 1 Jun 2019, In : Human and Experimental Toxicology. 38, 6, p. 646-654 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR

Pillman, K. A., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Feb 2019, In : Rna-A Publication of the Rna Society. 25, 2, p. 232-238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

A guide to miRNAs in inflammation and innate immune responses

Nejad, C., Stunden, H. J. & Gantier, M. P., 24 Apr 2018, In : FEBS Journal. 285, 20, p. 3695-3716 22 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Assessing the cGAS-cGAMP-STING activity of cancer cells

Pépin, G. & Gantier, M. P., 1 Jan 2018, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). New York, NY: Humana Press, p. 257-266 10 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Prizes

Best Paper Prize

Gantier, Michael (Recipient), 2011

Prize: Prize (including medals and awards)

Milstein Young investigator award

Gantier, Michael (Recipient), 2010

Prize: Prize (including medals and awards)

Next Big Idea Award

Gantier, Michael (Recipient), 2018

Prize: Prize (including medals and awards)

OTS Young Investigator Award

Gantier, Michael (Recipient), Oct 2014

Prize: National/international honour

Outstanding Young investigator award

Gantier, Michael (Recipient), 2012

Prize: Prize (including medals and awards)