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Personal profile

Biography

Dr Gantier is an Australian Research Council (ARC) Future Fellow, working at the Hudson Institute of medical research in Melbourne, Australia. 

The central aim of Dr Michael Gantier’s research is to define how nucleic acids (DNA and RNA) modulate immune responses. Following on his PhD studies on RNA interference in Dublin (Ireland), he joined the laboratory of Prof Bryan Williams in 2006, to define the interaction of small RNAs with the innate immune system. This led to the discovery of structural determinants of RNAs which underlie their capacity to activate, or inhibit immune responses, resulting in the rational design of molecules with potential therapeutic application in cancer and autoinflammatory diseases. More recently, his laboratory discovered how immune responses could be engaged in damaged cells, with implications in infection, immunity and cancer.

 

In addition, Dr Gantier made important findings regarding how a class of endogenous small RNAs, known as microRNAs, persist in cells to regulate inflammation. This has led to the identification of microRNA sequence variations, which control microRNA stability and could be used as novel disease biomarkers.

In 2015, following the award of an ARC Future Fellowship and several NHMRC project grants, he was promoted to lead his own research group in the Hudson Institute of Medical Research.

Keywords

  • Innate Immunity
  • MicroRNAs
  • RNA Interference
  • SiRNAs
  • Toll-Like Receptor 7 And 8
  • cGAS-STING
  • DNA damage

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Projects 2012 2020

Research Output 2006 2019

MicroRNA from a 12-h versus 20-h acetylcysteine infusion for paracetamol overdose

Wong, A., Nejad, C., Gantier, M., Choy, K. W., Doery, J. & Graudins, A., 1 Jun 2019, In : Human and Experimental Toxicology. 38, 6, p. 646-654 9 p.

Research output: Contribution to journalArticleResearchpeer-review

miRNA length variation during macrophage stimulation confounds the interpretation of results: implications for miRNA quantification by RT-qPCR

Pillman, K. A., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Feb 2019, In : Rna-A Publication of the Rna Society. 25, 2, p. 232-238 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A guide to miRNAs in inflammation and innate immune responses

Nejad, C., Stunden, H. J. & Gantier, M. P., 24 Apr 2018, In : FEBS Journal. 285, 20, p. 3695-3716 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Assessing the cGAS-cGAMP-STING activity of cancer cells

Pépin, G. & Gantier, M. P., 1 Jan 2018, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). New York, NY: Humana Press, p. 257-266 10 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Hepatotoxicity after paracetamol overdose in a patient with cystic fibrosis despite early acetylcysteine and utility of microRNA to predict hepatotoxicity

Wong, A., Cheung, B., Nejad, C., Gantier, M. & Graudins, A., 3 Oct 2018, In : Clinical Toxicology. 56, 10, p. 904–906 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Prizes

Best Paper Prize

Michael Gantier (Recipient), 2011

Prize: Prize (including medals and awards)

Milstein Young investigator award

Michael Gantier (Recipient), 2010

Prize: Prize (including medals and awards)

Next Big Idea Award

Michael Gantier (Recipient), 2018

Prize: Prize (including medals and awards)

OTS Young Investigator Award

Michael Gantier (Recipient), Oct 2014

Prize: National/international honour

Outstanding Young investigator award

Michael Gantier (Recipient), 2012

Prize: Prize (including medals and awards)