Projects per year
Personal profile
Biography
Associate Professor Gantier is a research group leader, working at the Hudson Institute of medical research in Melbourne, Australia.
The central aim of A/Prof Gantier’s research is to define how nucleic acids (DNA and RNA) modulate immune responses, and how this can be leveraged to develop novel therapies to treat cancer and auto-inflammation.
Over the past decade his research has significantly advanced our understanding of Toll-Like receptor 7 and 8 sensing of RNAs, and cGAS-STING detection of damaged DNA. His laboratory is currently studying next generation TLR7/8 agonists and inhibitors with can be used to improve mRNA-based vaccinations, along with cGAS/STING inhibitors to treat auto-inflammatory (such as lupus) and hyper-inflammatoy disorders.
In addition, Dr Gantier has made important findings regarding how a class of endogenous small RNAs, known as microRNAs, persist in cells to regulate inflammation. This has led to the identification of microRNA sequence variations, which control microRNA stability and could be used as novel disease biomarkers.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine and Therapeutics, PhD, University College Dublin
1 Sep 2002 → 7 Nov 2005
Award Date: 15 Jun 2006
Research area keywords
- Innate Immunity
- MicroRNAs
- RNA Interference
- SiRNAs
- Toll-Like Receptor 7 And 8
- cGAS-STING
- DNA damage
- mRNA vaccines
- Lung inflammation
- Infection driven inflammation
- Antisense oligonucleotides
Network
Projects
- 6 Finished
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Critical regulators of endometrial receptivity
Dimitriadis, E., Gantier, M., Menkhorst, E. & Rombauts, L.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/10/18
Project: Research
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Defining a role for TLR7/8 in Helicobacter pylori infection
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/18
Project: Research
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Uncovering microRNA decay regulation in mammalian cells
Australian Research Council (ARC)
23/07/14 → 22/07/18
Project: Research
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Targeting small RNA technologies
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 31/12/16
Project: Research
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Deficiency in coatomer complex I causes aberrant activation of STING signalling
Steiner, A., Hrovat-Schaale, K., Prigione, I., Yu, C. H., Laohamonthonkul, P., Harapas, C. R., Low, R. R. J., De Nardo, D., Dagley, L. F., Mlodzianoski, M. J., Rogers, K. L., Zillinger, T., Hartmann, G., Gantier, M. P., Gattorno, M., Geyer, M., Volpi, S., Davidson, S. & Masters, S. L., 28 Apr 2022, In: Nature Communications. 13, 1, 16 p., 2321.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Citations (Scopus) -
Genistein Targets STING-Driven Antiviral Responses
Ullah, T. R., Balka, K. R., Ambrose, R. L., Pépin, G., Wilce, M. C. J., Wilce, J. A., Thomas, B. J., De Nardo, D., Williams, B. R. G. & Gantier, M. P., Jul 2022, In: mBio. 13, 4, 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly
Ziemann, M., Lim, S. C., Kang, Y., Samuel, S., Sanchez, I. L., Gantier, M., Stojanovski, D. & McKenzie, M., 30 Jan 2022, In: Journal of Molecular Biology. 434, 2, 16 p., 167361.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Pharmacological Targeting of STING-Dependent IL-6 Production in Cancer Cells
Al-Asmari, S. S., Rajapakse, A., Ullah, T. R., Pépin, G., Croft, L. V. & Gantier, M. P., 11 Jan 2022, In: Frontiers in Cell and Developmental Biology. 9, 11 p., 709618.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Powering on cGAMP mini factories
Gantier, M. P., 5 Jan 2022, In: EMBO Reports. 23, 1, 3 p., e54231.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Prizes
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Milstein Young investigator award
Gantier, Michael (Recipient), 2010
Prize: Prize (including medals and awards)
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OTS Young Investigator Award
Gantier, Michael (Recipient), Oct 2014
Prize: National/international honour
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Outstanding Young investigator award
Gantier, Michael (Recipient), 2012
Prize: Prize (including medals and awards)