Personal profile
Biography
Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.
The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.
Research area keywords
- Peptides
- Biomembranes
- Peptide Drugs
- Bionanotechnology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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26th European Peptide Symposium, Montpellier, France
Aguilar, M. (Primary Chief Investigator (PCI))
16/10/00 → …
Project: Research
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Membrane proteomics
Aguilar, M. (Primary Chief Investigator (PCI))
Agilent Technologies (Australia)
Project: Research
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A Digital Instruments NanoScope Atomic Force (Scanning Probe) Microscope (AFM) System and an Agilent High Performance Liquid Chromatography - Mass Spectrometer (LCMS) system
Aguilar, M. (Primary Chief Investigator (PCI))
Project: Research
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Pathogenic membranes as therapeutic drug targets
Aguilar, M. (Primary Chief Investigator (PCI)), Reid, G. E. (Chief Investigator (CI)), Separovic, F. (Chief Investigator (CI)), Yarovsky, I. (Chief Investigator (CI)), Li, J. (Associate Investigator (AI)) & Drummer, H. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
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Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R. (Primary Chief Investigator (PCI)), Davidovich, C. (Chief Investigator (CI)), Purcell, A. (Chief Investigator (CI)), Ellisdon, A. (Chief Investigator (CI)), Li, J. (Chief Investigator (CI)), Aguilar, M. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Stone, M. (Chief Investigator (CI)), Lithgow, T. (Chief Investigator (CI)) & Zhang, Q. (Chief Investigator (CI))
1/10/21 → 31/12/22
Project: Research
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Accurate quantitation of antibiotic penetration through staphylococcal biofilms
Bin, L. (Leading Author), McGiffin, D., Nguyen, T., Wang, L., Sun, Y., Ye, L., Han, M., Sheng, C., Lee, T.-H., Aguilar, M.-I., Peleg, A. Y. & Qu, Y. (Leading Author), Dec 2025, In: Biofilm. 10, 100316, 9 p., 100316.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
Atomic Scale Structure of Self-Assembled Lipidated Peptide Nanomaterials
Williams-Noonan, B. J., Kulkarni, K., Todorova, N., Franceschi, M., Wilde, C., Borgo, M. P. D., Serpell, L. C., Aguilar, M. I. & Yarovsky, I., 13 Jun 2024, In: Advanced Materials. 36, 24, 16 p., 2311103.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Link opens in a new tab Citations (Scopus) -
Decoding the role of mycobacterial lipid remodelling and membrane dynamics in antibiotic tolerance
Menon, A. P., Lee, T. H., Aguilar, M. I. & Kapoor, S., 2024, In: Chemical Science. 15, p. 19084-19093 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Link opens in a new tab Citations (Scopus) -
Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements
Simm, C., Lee, T. H., Weerasinghe, H., Walsh, D., Nakou, I. T., Shankar, M., Tse, W. C., Zhang, Y., Inman, R., Mulder, R. J., Harrison, F., Aguilar, M. I., Challis, G. L. & Traven, A., 13 Nov 2024, In: mBio. 15, 11, 19 p., e0261124.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Quest for New Generation Biocompatible Materials: Tailoring β-Peptide Structure and Interactions via Synergy of Experiments and Modelling
Aguilar, M. I. & Yarovsky, I., 1 Nov 2024, In: Journal of Molecular Biology. 436, 21, 14 p., 168646.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Monash Antimicrobial Resistance Group (Event)
Lithgow, T. (Chair/Co-Chair), Cryle, M. (Member), Tuck, K. (Member), Traven, A. (Member), Naderer, T. (Member), Rood, J. (Member), Lyras, D. (Member), Peleg, A. (Member), Aguilar, M. (Member), Coulibaly, F. (Member), McGowan, S. (Member), Okeeffe, M. A. (Member), Belousoff, M. (Member) & Heraud, P. (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
Press/Media
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Fight Parkinson’s announces the inaugural recipients of the Seed Research Grant Program
Forsythe, J., Aguilar, M. & Kulkarni, K.
13/08/25
1 item of Media coverage
Press/Media: Blogs, Podcasts and Social Media › Social Media Article