Projects per year
Personal profile
Biography
Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.
The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.
Keywords
- Peptides
- Biomembranes
- Peptide Drugs
- Bionanotechnology
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2000 2020
Mechanism of Bacterial Membrane Resistance to Antimicrobial Peptides
Aguilar, M. I., Reid, G. & Separovic, F.
1/01/18 → 31/12/20
Project: Research
Elucidating the architecture of fibres formed by designed β-amino acid containing peptides
Serpell, L. C. & Aguilar, M. I.
8/12/17 → 8/12/19
Project: Research
Novel treatments of fibrosis for hypertensive heart disease
Widdop, R. E., Aguilar, M. I. & Denton, K. M.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/20
Project: Research
Research Output 1987 2018
Effect of phosphatidylcholine bilayer thickness and molecular order on the binding of the antimicrobial peptide maculatin 1.1
Lee, T-H., Sani, M. A., Overall, S., Separovic, F. & Aguilar, M-I. 1 Feb 2018 In : Biochimica et Biophysica Acta - Biomembranes. 1860, 2, p. 300-309 10 p.Research output: Contribution to journal › Article › Research › peer-review
Exploring Molecular-Biomembrane Interactions with Surface Plasmon Resonance and Dual Polarization Interferometry Technology: Expanding the Spotlight onto Biomembrane Structure
Lee, T-H., Hirst, D. J., Kulkarni, K., Del Borgo, M. P. & Aguilar, M-I. 13 Jun 2018 In : Chemical Reviews. 118, 11, p. 5392-5487 96 p.Research output: Contribution to journal › Review Article › Research › peer-review
Probing the folding pathway of a consensus serpin using single tryptophan mutants
Yang, L., Irving, J. A., Dai, W., Aguilar, M-I. & Bottomley, S. P. 1 Feb 2018 In : Scientific Reports. 8, 1, 15 p., 2121Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Anti-fibrotic potential of AT2 receptor agonists
Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E. 31 Aug 2017 In : Frontiers in Pharmacology. 8, 7 p., 564Research output: Contribution to journal › Article › Other › peer-review
Open Access
File
A versatile and rapid coating method via a combination of plasma polymerization and surface-initiated SET-LRP for the fabrication of low-fouling surfaces
Shi, Y., Menzies, D. J., Tsang, K. M., Del Borgo, M. P., Easton, C. D., Aguilar, M-I., Perlmutter, P., Truong, V. X. & Forsythe, J. S. 1 Aug 2017 In : Journal of Polymer Science, Part A: Polymer Chemistry. 55, 15, p. 2527-2536 10 p.Research output: Contribution to journal › Article › Research › peer-review