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Personal profile

Biography

Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.

The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.

Keywords

  • Peptides
  • Biomembranes
  • Peptide Drugs
  • Bionanotechnology

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Projects 2000 2020

Research Output 1987 2018

Effect of phosphatidylcholine bilayer thickness and molecular order on the binding of the antimicrobial peptide maculatin 1.1

Lee, T-H., Sani, M. A., Overall, S., Separovic, F. & Aguilar, M-I., 1 Feb 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 2, p. 300-309 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Identifying the Coiled-Coil Triple Helix Structure of β-Peptide Nanofibers at Atomic Resolution

Christofferson, A., Al-Garawi, Z. S., Todorova, N., Turner, J., Del Borgo, M. P., Serpell, L. C., Aguilar, M-I. & Yarovsky, I., 25 Sep 2018, In : ACS Nano. 12, 9, p. 9101-9109 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the folding pathway of a consensus serpin using single tryptophan mutants

Yang, L., Irving, J. A., Dai, W., Aguilar, M-I. & Bottomley, S. P., 1 Feb 2018, In : Scientific Reports. 8, 1, 15 p., 2121.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The use of hydrogels for cell-based treatment of chronic kidney disease

McFetridge, M. L., Del Borgo, M. P., Aguilar, M-I. & Ricardo, S. D., 14 Sep 2018, In : Clinical Science. 132, 17, p. 1977-1994 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review