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Personal profile

Biography

Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.

The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.

Keywords

  • Peptides
  • Biomembranes
  • Peptide Drugs
  • Bionanotechnology

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Projects 2000 2021

Research Output 1987 2019

A comment by Prof. Mibel Aguilar—2018 recipient of the Australian Society for Biophysics’ McAulay-Hope Prize for Original Biophysics

Aguilar, M-I., 1 Jun 2019, In : Biophysical Reviews. 11, 3, p. 271-272 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Novel materials from the supramolecular self-assembly of short helical β3-peptide foldamers

Kulkarni, K., Habila, N., Del Borgo, M. P. & Aguilar, M-I., 15 Feb 2019, In : Frontiers in Chemistry. 7, 12 p., 70.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

Hong, A., Aguilar, M-I., Del Borgo, M. P., Sobey, C. G., Broughton, B. R. S. & Forsythe, J. S., 2019, In : Journal of Materials Chemistry B. 7, 25, p. 3927-3943 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The role of bacterial lipid diversity and membrane properties in modulating antimicrobial peptide activity and drug resistance

Lee, T-H., Hofferek, V., Separovic, F., Reid, G. E. & Aguilar, M-I., 1 Oct 2019, In : Current Opinion in Chemical Biology. 52, p. 85-92 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Effect of phosphatidylcholine bilayer thickness and molecular order on the binding of the antimicrobial peptide maculatin 1.1

Lee, T-H., Sani, M. A., Overall, S., Separovic, F. & Aguilar, M-I., 1 Feb 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 2, p. 300-309 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2017 2017

  • 1 Membership of industry collaboration/ network

Monash Antimicrobial Resistance Group (Event)

Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member), Philip Heraud (Member)
1 Mar 2017

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network