Projects per year
Personal profile
Biography
Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.
The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Peptides
- Biomembranes
- Peptide Drugs
- Bionanotechnology
Network
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Pathogenic membranes as therapeutic drug targets
Aguilar, M., Reid, G., Separovic, F., Yarovsky, I., Li, J. & Drummer, H.
1/01/22 → 31/12/25
Project: Research
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Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R., Davidovich, C., Purcell, A., Ellisdon, A., Li, J., Aguilar, M., Cryle, M., Stone, M., Lithgow, T. & Zhang, Q.
1/10/21 → 31/12/22
Project: Research
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A comparison of fixation methods for SEM analysis of self-assembling peptide hydrogel nanoarchitecture
McFetridge, M. L., Kulkarni, K., Hilsenstein, V., Del Borgo, M. P., Aguilar, M. I. & Ricardo, S. D., 21 Jan 2023, In: Nanoscale. 15, 3, p. 1431-1440 10 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Multi-Omic Analysis to Characterize Metabolic Adaptation of the E. coli Lipidome in Response to Environmental Stress
Kralj, T., Nuske, M., Hofferek, V., Sani, M. A., Lee, T. H., Separovic, F., Aguilar, M. I. & Reid, G. E., Feb 2022, In: Metabolites. 12, 2, 16 p., 171.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Mutually Exclusive Interactions of Rifabutin with Spatially Distinct Mycobacterial Cell Envelope Membrane Layers Offer Insights into Membrane-Centric Therapy of Infectious Diseases
Menon, A. P., Dong, W., Lee, T. H., Aguilar, M. I., Duan, M. & Kapoor, S., 17 Aug 2022, In: ACS Bio & Med Chem Au. 2, 4, p. 395-408 14 p.Research output: Contribution to journal › Article › Research › peer-review
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The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice
Wang, Y., Yodgee, J., Del Borgo, M., Spizzo, I., Nguyen, L., Aguilar, M. I., Denton, K. M., Samuel, C. S. & Widdop, R. E., Nov 2022, In: International Journal of Molecular Sciences. 23, 22, 12 p., 14039.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
An active site inhibitor induces conformational penalties for ACE2 recognition by the spike protein of SARS-CoV-2
Williams-Noonan, B. J., Todorova, N., Kulkarni, K., Aguilar, M. I. & Yarovsky, I., 18 Mar 2021, In: Journal of Physical Chemistry B. 125, 10, p. 2533-2550 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member) & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network