Personal profile

Biography

Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.

The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.

Keywords

  • Peptides
  • Biomembranes
  • Peptide Drugs
  • Bionanotechnology

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Projects 2000 2020

Research Output 1987 2017

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E. 31 Aug 2017 In : Frontiers in Pharmacology. 8, 7 p., 564

Research output: Contribution to journalArticle

Open Access
File

Mitochondrial outer membrane permeabilization: a focus on the role of mitochondrial membrane structural organization

Suhaili, S. H., Karimian, H., Stellato, M., Lee, T-H. & Aguilar, M-I. 1 Aug 2017 In : Biophysical Reviews. 9, 4, p. 443-457 15 p.

Research output: Contribution to journalReview Article