Projects per year
Personal profile
Biography
Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.
The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.
Keywords
- Peptides
- Biomembranes
- Peptide Drugs
- Bionanotechnology
Network
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Projects 2000 2021
Atomic Scale Precision Engineering of Cell-Material Interfaces
Aguilar, M., Yarovsky, I. & Serpell, L. C.
1/01/19 → 31/12/21
Project: Research
From a Venom to a Potential Treatment for Alzheimer's Disease
Kuruppu, S., Rajapakse, N., Parkington, H., Smith, I., Aguilar, M. & Martins, R. N.
30/09/18 → 31/05/20
Project: Research
Mechanism of Bacterial Membrane Resistance to Antimicrobial Peptides
Aguilar, M., Reid, G. & Separovic, F.
1/01/18 → 31/12/20
Project: Research
Elucidating the architecture of fibres formed by designed β-amino acid containing peptides
Serpell, L. C. & Aguilar, M.
8/12/17 → 8/12/19
Project: Research
Research Output 1987 2018
Effect of phosphatidylcholine bilayer thickness and molecular order on the binding of the antimicrobial peptide maculatin 1.1
Lee, T-H., Sani, M. A., Overall, S., Separovic, F. & Aguilar, M-I., 1 Feb 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 2, p. 300-309 10 p.Research output: Contribution to journal › Article › Research › peer-review
Exploring Molecular-Biomembrane Interactions with Surface Plasmon Resonance and Dual Polarization Interferometry Technology: Expanding the Spotlight onto Biomembrane Structure
Lee, T-H., Hirst, D. J., Kulkarni, K., Del Borgo, M. P. & Aguilar, M-I., 13 Jun 2018, In : Chemical Reviews. 118, 11, p. 5392-5487 96 p.Research output: Contribution to journal › Review Article › Research › peer-review
Identifying the Coiled-Coil Triple Helix Structure of β-Peptide Nanofibers at Atomic Resolution
Christofferson, A., Al-Garawi, Z. S., Todorova, N., Turner, J., Del Borgo, M. P., Serpell, L. C., Aguilar, M-I. & Yarovsky, I., 25 Sep 2018, In : ACS Nano. 12, 9, p. 9101-9109 9 p.Research output: Contribution to journal › Article › Research › peer-review
Probing the folding pathway of a consensus serpin using single tryptophan mutants
Yang, L., Irving, J. A., Dai, W., Aguilar, M-I. & Bottomley, S. P., 1 Feb 2018, In : Scientific Reports. 8, 1, 15 p., 2121.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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The use of hydrogels for cell-based treatment of chronic kidney disease
McFetridge, M. L., Del Borgo, M. P., Aguilar, M-I. & Ricardo, S. D., 14 Sep 2018, In : Clinical Science. 132, 17, p. 1977-1994 18 p.Research output: Contribution to journal › Review Article › Research › peer-review