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Personal profile

Biography

Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.

The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.

Keywords

  • Peptides
  • Biomembranes
  • Peptide Drugs
  • Bionanotechnology

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Projects 2000 2020

Research Output 1987 2018

Effect of phosphatidylcholine bilayer thickness and molecular order on the binding of the antimicrobial peptide maculatin 1.1

Lee, T-H., Sani, M. A., Overall, S., Separovic, F. & Aguilar, M-I. 1 Feb 2018 In : Biochimica et Biophysica Acta - Biomembranes. 1860, 2, p. 300-309 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the folding pathway of a consensus serpin using single tryptophan mutants

Yang, L., Irving, J. A., Dai, W., Aguilar, M-I. & Bottomley, S. P. 1 Feb 2018 In : Scientific Reports. 8, 1, 15 p., 2121

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E. 31 Aug 2017 In : Frontiers in Pharmacology. 8, 7 p., 564

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

A versatile and rapid coating method via a combination of plasma polymerization and surface-initiated SET-LRP for the fabrication of low-fouling surfaces

Shi, Y., Menzies, D. J., Tsang, K. M., Del Borgo, M. P., Easton, C. D., Aguilar, M-I., Perlmutter, P., Truong, V. X. & Forsythe, J. S. 1 Aug 2017 In : Journal of Polymer Science, Part A: Polymer Chemistry. 55, 15, p. 2527-2536 10 p.

Research output: Contribution to journalArticleResearchpeer-review