Projects per year
Personal profile
Biography
Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.
The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Peptides
- Biomembranes
- Peptide Drugs
- Bionanotechnology
Network
-
Pathogenic membranes as therapeutic drug targets
Aguilar, M., Reid, G., Separovic, F., Yarovsky, I., Li, J. & Drummer, H.
1/01/22 → 31/12/25
Project: Research
-
Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R., Davidovich, C., Purcell, A., Ellisdon, A., Li, J., Aguilar, M., Cryle, M., Stone, M., Lithgow, T. & Zhang, Q.
1/10/21 → 31/12/22
Project: Research
-
-
-
An active site inhibitor induces conformational penalties for ACE2 recognition by the spike protein of SARS-CoV-2
Williams-Noonan, B. J., Todorova, N., Kulkarni, K., Aguilar, M. I. & Yarovsky, I., 18 Mar 2021, In: Journal of Physical Chemistry B. 125, 10, p. 2533-2550 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Self-assembly of trifunctional tripeptides to form neural scaffolds
Kulkarni, K., Kelderman, J., Coleman, H., Aguilar, M-I., Parkington, H. & Del Borgo, M., 14 Jun 2021, In: Journal of Materials Chemistry B. 9, 22, p. 4475-4479 5 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Staphylococcus aureus entanglement in self-assembling β-peptide nanofibres decorated with vancomycin
Payne, J. A. E., Kulkarni, K., Izore, T., Fulcher, A. J., Peleg, A. Y., Aguilar, M. I., Cryle, M. J. & Del Borgo, M. P., 7 May 2021, In: Nanoscale Advances. 3, 9, p. 2607-2616 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
The impact of antibacterial peptides on bacterial lipid membranes depends on stage of growth
Lee, T. H., Hofferek, V., Sani, M. A., Separovic, F., Reid, G. E. & Aguilar, M. I., 1 Dec 2021, In: Faraday Discussions. 232, p. 399-418 20 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Using conformational constraints at position 6 of Angiotensin II to generate compounds with enhanced AT2R selectivity and proteolytic stability
Tourwé, D., Tsiailanis, A. D., Parisis, N., Hirmiz, B., Del Borgo, M., Aguilar, M. I., Van der Poorten, O., Ballet, S., Widdop, R. E. & Tzakos, A. G., 1 Jul 2021, In: Bioorganic and Medicinal Chemistry Letters. 43, 5 p., 128086.Research output: Contribution to journal › Article › Research › peer-review
Activities
- 1 Membership of industry collaboration/ network
-
Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member) & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network