Projects per year
Personal profile
Biography
Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.
The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Peptides
- Biomembranes
- Peptide Drugs
- Bionanotechnology
Collaborations and top research areas from the last five years
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Pathogenic membranes as therapeutic drug targets
Aguilar, M., Reid, G. E., Separovic, F., Yarovsky, I., Li, J. & Drummer, H.
1/01/22 → 31/12/25
Project: Research
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ARC Training Centre for Cell and Tissue Engineering Technologies
Meagher, L., Bray, L., Voelcker, N., Risbridger, G., Hutmacher, D. W., Batra, J., Dargaville, T., Elnathan, R., Saifzadeh, S., Heng, T., Aguilar, M., Lim, R., Klein, T. J., Fisher, A., McGovern, J., Dislakis, V., McLellan, A., Dulleck, U., Steck, R., Scott, W., Corrie, S., Thissen, H., Cameron, N., Haupt, L. M., Werner, C., Levett, P., Whyte, S., Forsythe, J., Smith, N., Frith, J., Hicks, C., Rackham, O. J. L., Sohal, A., Polo, J., May, M., Reimers, N., Toh, Y., McKee, J., Adams, M., Obschonka, M., Subramaniam, N., Yambem, S. D., Russell-Bennett, R., Bertram, J., Schierjott, R., Hollands, J., Currie, P., Ball, G., Trapani, J. A., Cadarso Busto, V., Loessner, D., Ecker, R., Boyd, R. L. & Lim, J.
Australian Research Council (ARC), PolVax Pty Ltd, Cartherics Pty Ltd, TissueGUARD GmbH, Peter MacCallum Cancer Centre, TissueGnostics GmbH
13/01/21 → 30/11/27
Project: Research
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Targeting the Angiotensin AT2 Receptor to Treat Cardiac Fibrosis and Heart Failure
Wang, Y., Ferens, D., Salimova, E., Borgo, M., Aguilar, M., Gaspari, T., Nguyen, L., Zhu, L., Xu, P., Denton, K., Wang, M., Samuel, C. & Widdop, R., Aug 2024, In: Heart Lung and Circulation. 33, Supplement 4, p. S486 1 p., 783.Research output: Contribution to journal › Meeting Abstract › peer-review
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A comparison of fixation methods for SEM analysis of self-assembling peptide hydrogel nanoarchitecture
McFetridge, M. L., Kulkarni, K., Hilsenstein, V., Del Borgo, M. P., Aguilar, M. I. & Ricardo, S. D., 21 Jan 2023, In: Nanoscale. 15, 3, p. 1431-1440 10 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Open Access1 Citation (Scopus)
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A switch in N-terminal capping of β-peptides creates novel self-assembled nanoparticles
Chen, Y. K., Simon, I. A., Maslov, I., Oyarce-Pino, I. E., Kulkarni, K., Hopper, D., Aguilar, M. I., Vankadari, N., Broughton, B. RS. & Del Borgo, M. P., 9 Oct 2023, In: RSC Advances. 13, 42, p. 29401-29407 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Differential membrane binding of α/β-peptide foldamers: implications for cellular delivery and mitochondrial targeting
Lee, T. H., Checco, J. W., Malcolm, T., Eller, C. H., Raines, R. T., Gellman, S. H., Lee, E. F., Fairlie, W. D. & Aguilar, M. I., 2023, In: Australian Journal of Chemistry. 76, 8, p. 482–492 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member) & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network