Projects per year
Personal profile
Biography
Our group focuses on peptide-based drug design, membrane biology and biomaterials. We are developing novel compounds that allow us to exploit the potential of peptides as drugs and are currently applying our technology to new compounds for treatments of cardiovascular disease. Our membrane biology projects involve the development of new methods for membrane protein analysis with application to apoptosis, G protein-coupled receptor function and antimicrobial peptide function. We are also applying our recently developed peptide-based materials to the development of new scaffolds for stem cell growth and tissue regeneration.
The long-term aim of these studies is to increase our understanding of the molecular basis of peptide and protein function and allow the rational design of peptide and protein based therapeutics.
Research area keywords
- Peptides
- Biomembranes
- Peptide Drugs
- Bionanotechnology
Network
Projects
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Atomic Scale Precision Engineering of Cell-Material Interfaces
Aguilar, M., Yarovsky, I. & Serpell, L. C.
29/04/19 → 28/04/22
Project: Research
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From a Venom to a Potential Treatment for Alzheimer's Disease
Kuruppu, S., Rajapakse, N., Parkington, H., Smith, I., Aguilar, M. & Martins, R. N.
30/09/18 → 31/05/21
Project: Research
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Research output
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Enhancement of glioblastoma multiforme therapy through a novel Quercetin-Losartan hybrid
Tsiailanis, A. D., Renziehausen, A., Kiriakidi, S., Vrettos, E. I., Markopoulos, G. S., Sayyad, N., Hirmiz, B., Aguilar, M-I., Del Borgo, M. P., Kolettas, E., Widdop, R. E., Mavromoustakos, T., Crook, T., Syed, N. & Tzakos, A. G., 20 Nov 2020, In : Free Radical Biology and Medicine. 160, p. 391-402 12 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Exosome trapping and enrichment using a sound wave activated nano-sieve (SWANS)
Habibi, R., He, V., Ghavamian, S., De Marco, A., Lee, T. H., Aguilar, M. I., Zhu, D., Lim, R. & Neild, A., 28 Aug 2020, In : Lab on a Chip. 20, 19, p. 3633-3643 11 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Peptidomimetic Modulators of BACE1
Juliano, J. P., Small, D. H. & Aguilar, M. I., 2 Mar 2020, In : Australian Journal of Chemistry. 73, 4, p. 366-376 11 p.Research output: Contribution to journal › Article › Research › peer-review
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Renal functional effects of the highly selective AT2R agonist, β-Pro7 Ang III, in normotensive rats
Hilliard Krause, L. M., Kemp, B. A., Tan, A. S. J., Jones, E. S., Del Borgo, M. P., Aguilar, M. I., Denton, K. M., Carey, R. M. & Widdop, R. E., 17 Apr 2020, In : Clinical Science. 134, 7, p. 871-884 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity
Vrettos, E. I., Valverde, I. E., Mascarin, A., Pallier, P. N., Cerofolini, L., Fragai, M., Parigi, G., Hirmiz, B., Bekas, N., Grob, N. M., Stylos, E., Shaye, H., Del Borgo, M., Aguilar, M-I., Magnani, F., Syed, N., Crook, T., Waqif, E., Ghazaly, E., Cherezov, V. & 5 others, , 21 Aug 2020, In : Chemistry - A European Journal. 26, 47, p. 10690-10694 5 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member) & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network