1991 …2022

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2020

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations

Reutens, A. T., Jandeleit-Dahm, K., Thomas, M., Salim, A., De Livera, A. M., Bach, L. A., Colman, P. G., Davis, T. M. E., Ekinci, E. I., Fulcher, G., Hamblin, P. S., Kotowicz, M. A., MacIsaac, R. J., Morbey, C., Simmons, D., Soldatos, G., Wittert, G., Wu, T., Cooper, M. E. & Shaw, J. E., Mar 2020, In : Contemporary Clinical Trials. 90, 8 p., 105892.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Garg, M., Royce, S. G., Tikellis, C., Shallue, C., Batu, D., Velkoska, E., Burrell, L. M., Patel, S. K., Beswick, L., Jackson, A., Britto, K., Lukies, M., Sluka, P., Wardan, H., Hirokawa, Y., Tan, C. W., Faux, M., Burgess, A. W., Hosking, P., Monagle, S. & 3 others, Thomas, M., Gibson, P. R. & Lubel, J., 1 May 2020, In : Gut. 69, 5, p. 841-851 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The Long-Term Incidence of Hospitalization for Ketoacidosis in Adults with Established T1D-A Prospective Cohort Study

Thomas, M., Harjutsalo, V., Feodoroff, M., Forsblom, C., Gordin, D., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Jan 2020, In : The Journal of Clinical Endocrinology and Metabolism. 105, 1, p. 231-241 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Perspectives on optimizing chronic heart failure care beyond randomised controlled trials - what do we consolidate and how do we plan for the future?

Iyngkaran, P., Thomas, M. & Majoni, S. W., 1 Jan 2019, In : Current Cardiology Reviews. 15, 3, p. 158-160 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

Pickering, R. J., Tikellis, C., Rosado, C. J., Tsorotes, D., Dimitropoulos, A., Smith, M., Huet, O., Seeber, R. M., Abhayawardana, R., Johnstone, E. K. M., Golledge, J., Wang, Y., Jandeleit-Dahm, K. A., Cooper, M. E., Pfleger, K. D. G. & Thomas, M. C., 2 Jan 2019, In : Journal of Clinical Investigation. 129, 1, p. 406-421 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)
2018

Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study

Hughes, J. T., Maple-Brown, L. J., Thomas, M., Lawton, P. D., Sinha, A., Cass, A., Barzi, F., Jones, G. R. D., Jerums, G., MacIsaac, R. J., O'Dea, K. & Hoy, W. E., 1 Jan 2018, In : Nephrology. 23, 1, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Effects of diabetes medications targeting the incretin system on the kidney

Macisaac, R. J. & Thomas, M. C., 7 Feb 2018, In : Clinical Journal of the American Society of Nephrology. 13, 2, p. 321-323 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
4 Citations (Scopus)

Excess mortality in patients with type 1 diabetes without albuminuriadseparating the contribution of early and late risks

Groop, P. H., Thomas, M., Feodoroff, M., Forsblom, C. & Harjutsalo, V., 1 Apr 2018, In : Diabetes Care. 41, 4, p. 748-754 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
8 Citations (Scopus)

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Relationship between plasma 8-OH-deoxyguanosine and cardiovascular disease and survival in type 2 diabetes mellitus: Results from the ADVANCE trial

Thomas, M. C., Woodward, M., Li, Q., Pickering, R., Tikellis, C., Poulter, N., Cooper, M. E., Marre, M., Zoungas, S. & Chalmers, J., 1 Jul 2018, In : Journal of the American Heart Association. 7, 13, 17 p., e008226.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Risk of coronary artery disease and stroke according to sex and presence of diabetic nephropathy in type 1 diabetes

Harjutsalo, V., Thomas, M. C., Forsblom, C., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Dec 2018, In : Diabetes, Obesity and Metabolism. 20, 12, p. 2759-2767 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2017

Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2

Moran, C. S., Biros, E., Krishna, S. M., Wang, Y., Tikellis, C., Morton, S. K., Moxon, J. V., Cooper, M. E., Norman, P. E., Burrell, L. M., Thomas, M. C. & Golledge, J., 2017, In : Arteriosclerosis, Thrombosis and Vascular Biology. 37, 11, p. 2195-2203 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The potential and pitfalls of GLP-1 receptor agonists for renal protection in type 2 diabetes

Thomas, M. C., 1 Apr 2017, In : Diabetes and Metabolism. 43, p. 2S20-2S27 8 p.

Research output: Contribution to journalArticleOtherpeer-review

19 Citations (Scopus)
2016

Contextualizing genetics for regional heart failure care

Iyngkaran, P., Thomas, M. C., Johnson, R., French, J. R. J., Ilton, M., McDonald, P., Hare, D. L. & Fatkin, D., 1 Aug 2016, In : Current Cardiology Reviews. 12, 3, p. 231-242 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

Coughlan, M. T., Higgins, G. C., Nguyen, T-V., Penfold, S. A., Thallas-Bonke, V., Tan, S. M., Ramm, G., Van Bergen, N. J., Henstridge, D. C., Sourris, K. C., Harcourt, B. E., Trounce, I. A., Robb, P. M., Laskowski, A., McGee, S. L., Genders, A. J., Walder, K., Drew, B. G., Gregorevic, P., Qian, H. & 13 others, Thomas, M. C., Jerums, G., Macisaac, R. J., Skene, A., Power, D. A., Ekinci, E. I., Wijeyeratne, X. W., Gallo, L. A., Herman-Edelstein, M., Ryan, M. T., Cooper, M. E., Thorburn, D. R. & Forbes, J. M., Apr 2016, In : Diabetes. 65, 4, p. 1085-1098 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Management of patients with diabetes and CKD: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Perkovic, V., Agarwal, R., Fioretto, P., Hemmelgarn, B. R., Levin, A., Thomas, M. C., Wanner, C., Kasiske, B. L., Wheeler, D. C., Groop, P-H. & for Conference Participants, 1 Dec 2016, In : Kidney International. 90, 6, p. 1175-1183 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
48 Citations (Scopus)

Phase 4 studies in heart failure - What is done and what is needed?

Iyngkaran, P., Liew, D., McDonald, P., Thomas, M. C., Reid, C., Chew, D. & Hare, D. L., 1 Aug 2016, In : Current Cardiology Reviews. 12, 3, p. 216-230 15 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Type 2 diabetes and heart failure: Challenges and solutions

Thomas, M. C., 1 Aug 2016, In : Current Cardiology Reviews. 12, 3, p. 249-255 7 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)
2015

ACE2 deficiency shifts energy metabolism towards glucose utilization

Bernardi, S., Tikellis, C., Candido, R., Tsorotes, D., Pickering, R. J., Bossi, F., Carretta, R., Fabris, B., Cooper, M. E. & Thomas, M. C., 1 Mar 2015, In : Metabolism. 64, 3, p. 406-415 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy

Koulis, C., Chow, B. SM., Mckelvey, M., Steckelings, U. M., Unger, T., Thallas-Bonke, V., Thomas, M. C., Cooper, M. E., Jandeleit-Dahm, K. A. M. & Allen, T. J., 2015, In : Hypertension. 65, 5, p. 1073 - 1081 9 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Relationship between levels of advanced glycation end products and their soluble receptor and adverse outcomes in adults with type 2 diabetes

Thomas, M. C., Woodward, M., Neal, B., Li, Q., Pickering, R., Marre, M., Williams, B., Perkovic, V., Cooper, M. E., Zoungas, S., Chalmers, J., Hillis, G. S. & ADVANCE Collaborative Group, 1 Oct 2015, In : Diabetes Care. 38, 10, p. 1891-1897 7 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
2014

Added value of soluble tumor necrosis factor-α receptor 1 as a biomarker of ESRD risk in patients with type 1 diabetes

Forsblom, C., Moran, J., Harjutsalo, V., Loughman, T., Wadén, J., Tolonen, N., Thorn, L., Saraheimo, M., Gordin, D., Groop, P. H., Thomas, M. C. & On Behalf of the FinnDiane Study Group, 1 Jan 2014, In : Diabetes Care. 37, 8, p. 2334-2342 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

Angiotensin-converting enzyme 2 mediates hyperfiltration associated with diabetes

Tikellis, C., Brown, R., Head, G. A., Cooper, M. E. & Thomas, M. C., 1 Apr 2014, In : American Journal of Physiology-Renal Physiology. 306, 7, p. F773 - F780 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Beyond Glycosuria: Exploring the intrarenal effects of SGLT-2 inhibition in diabetes

Thomas, M. C., Jandeleit-Dahm, K. & Bonnet, F., 1 Dec 2014, In : Diabetes and Metabolism. 40, 6, p. S17-S22 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
48 Citations (Scopus)

Glycemic exposure, glycemic control, and metabolic karma in diabetic complications

Thomas, M. C., 2014, In : Advances in Chronic Kidney Disease. 21, 3, p. 311 - 317 7 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Origin of the Y chromosome influences intrarenal vascular responsiveness to angiotensin I and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats

Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Head, G. A., Thomas, M. C., Chin-Dusting, J. P. F., Dominiczak, A. F. & Jennings, G. L., 2014, In : Hypertension. 64, 6, p. 1376-1383 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Osteopontin is a strong predictor of incipient diabetic nephropathy, cardiovascular disease, and all-cause mortality in patients with type 1 diabetes

Gordin, D., Forsblom, C., Panduru, N. M., Thomas, M. C., Bjerre, M., Soro-Paavonen, A., Tolonen, N., Sandholm, N., Flyvbjerg, A., Harjutsalo, V., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Jan 2014, In : Diabetes Care. 37, 9, p. 2593-2600 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
29 Citations (Scopus)

Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes

Bernardi, S., Fabris, B., Thomas, M., Toffoli, B., Tikellis, C., Candido, R., Catena, C., Mulatero, P., Barbone, F., Radillo, O., Zauli, G. & Secchiero, P., 25 Aug 2014, In : Molecular and Cellular Endocrinology. 394, 1-2, p. 13-20 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice

Watson, A. M. D., Li, J., Samijono, D., Bierhaus, A., Thomas, M. C., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2014, In : Atherosclerosis. 235, 2, p. 444 - 448 5 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b

Wang, B., Jha, J. C., Hagiwara, S., Mcclelland, A. D., Jandeleit-Dahm, K., Thomas, M. C., Cooper, M. E. & Kantharidis, P., Feb 2014, In : Kidney International. 85, 2, p. 352-361 10 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)
2013

Association of dietary sodium intake with atherogenesis in experimental diabetes and with cardiovascular disease in patients with Type 1 diabetes

Tikellis, C., Pickering, R., Tsorotes, D., Harjutsalo, V., Thorn, L., Ahola, A., Waden, J., Tolonen, N., Saraheimo, M., Gordin, D., Forsblom, C., Groop, P-H., Cooper, M. E., Moran, J. L. & Thomas, M. C., 2013, In : Clinical Science. 124, 10, p. 617 - 626 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Coeliac disease, gluten-free diet and the development and progression of albuminuria in children with type 1 diabetes

Gopee, E., van den Oever, E. L., Cameron, F. & Thomas, M. C., 1 Sep 2013, In : Pediatric Diabetes. 14, 6, p. 455-458 4 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Does a nephron deficit exacerbate the renal and cardiovascular effects of obesity?

Gurusinghe, S., Brown, R. D., Cai, X., Samuel, C. S., Ricardo, S. D., Thomas, M. C. & Kett, M. M., 2013, In : PLoS ONE. 8, 9, 8 p., e73095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury

Chai, Z-L., Dai, A., Tu, Y., Li, J., Wu, T., Wang, Y., Hale, L. J., Koentgen, F., Thomas, M. C. & Cooper, M. E., 2013, In : Journal of the American Society of Nephrology. 24, 11, p. 1782-1792 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Osteoprotegerin is an independent predictor of vascular events in finnish adults with type 1 diabetes

Gordin, D., Soro-Paavonen, A., Thomas, M. C., Harjutsalo, V., Saraheimo, M., Bjerre, M., Forsblom, C., Flyvbjerg, A. & Groop, P. H., 28 Oct 2013, In : Diabetes Care. 36, 7, p. 1827-1833 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

SGLT2 inhibition with dapagliflozin: A novel approach for the management of type 2 diabetes

Kilov, G., Leow, S. & Thomas, M., 25 Oct 2013, In : Australian Family Physician. 42, 10, p. 706-710 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2012

Activation of the renin-angiotensin system mediates the effects of dietary salt intake on atherogenesis in the apolipoprotein E knockout mouse

Tikellis, C., Pickering, R. J., Tsorotes, D., Huet, O., Chin-Dusting, J., Cooper, M. E. & Thomas, M. C., Jul 2012, In : Hypertension. 60, 1, p. 98-105 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models

Low, H., Hoang, A., Forbes, J., Thomas, M., Lyons, J., Nestel, P., Bach, L. A. & Sviridov, D., 2012, In : Diabetologia. 55, 9, p. 2513 - 2521 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice

Watson, A. M. D., Gray, S. P., Jiaze, L., Soro-Paavonen, A., Wong, B., Cooper, M. E., Bierhaus, A., Pickering, R., Tikellis, C., Tsorotes, D., Thomas, M. C. & Jandeleit-Dahm, K. A. M., Aug 2012, In : Diabetes. 61, 8, p. 2105-2113 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Angiotensin-converting enzyme 2 regulates renal atrial natriuretic peptide through angiotensin-(1-7)

Bernardi, S., Burns, W. C., Toffoli, B., Pickering, R., Sakoda, M., Tsorotes, D., Grixti, E., Velkoska, E., Burrell, L. M., Johnston, C., Thomas, M. C., Fabris, B. & Tikellis, C., Jul 2012, In : Clinical Science. 123, 1, p. 29-37 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications

Soro-Paavonen, A., Gordin, D., Forsblom, C., Rosengard-Barlund, M., Waden, J., Thorn, L., Sandholm, N., Thomas, M. C. & Groop, P. H., 1 Feb 2012, In : Journal of Hypertension. 30, 2, p. 375-383 9 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Distinguishing hyperglycemic changes by set7 in vascular endothelial cells

Okabe, J., Orlowski, C., Balcerczyk, A., Tikellis, C., Thomas, M. C., Cooper, M. E. & El-Osta, A., 2012, In : Circulation Research. 110, 8, p. 1067 - 1076 10 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

High nephron endowment protects against salt-induced hypertension

Walker, K. A., Cai, X., Caruana, G., Thomas, M. C., Bertram, J. F. & Kett, M. M., 2012, In : American Journal of Physiology-Renal Physiology. 303, 2, p. F253 - F258 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage.

Bernardi, S., Toffoli, B., Zennaro, C., Tikellis, C., Monticone, S., Losurdo, P., Bellini, G., Thomas, M. C., Fallo, F., Veglio, F., Johnston, C. I. & Fabris, B., May 2012, In : Nephrology Dialysis Transplantation. 27, 5, p. 1793-1800 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Hyperfiltration in type 1 diabetes: Does it exist and does it matter for nephropathy?

Thomas, M. C., Moran, J. L., Harjutsalo, V., Thorn, L., Wadén, J., Saraheimo, M., Tolonen, N., Leiviskä, J., Jula, A., Forsblom, C. & Groop, H., 1 May 2012, In : Diabetologia. 55, 5, p. 1505-1513 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes

Tikellis, C., Pickering, R., Tsorotes, D., Du, X. J., Kiriazis, H., Nguyen-Huu, T-P., Head, G. A., Cooper, M. E. & Thomas, M. C., 1 Oct 2012, In : Clinical Science. 123, 8, p. 519-529 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)