1991 …2022

Research output per year

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Research Output

2020

A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: Protocol and statistical considerations

Reutens, A. T., Jandeleit-Dahm, K., Thomas, M., Salim, A., De Livera, A. M., Bach, L. A., Colman, P. G., Davis, T. M. E., Ekinci, E. I., Fulcher, G., Hamblin, P. S., Kotowicz, M. A., MacIsaac, R. J., Morbey, C., Simmons, D., Soldatos, G., Wittert, G., Wu, T., Cooper, M. E. & Shaw, J. E., Mar 2020, In : Contemporary Clinical Trials. 90, 8 p., 105892.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)

Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?

Garg, M., Royce, S. G., Tikellis, C., Shallue, C., Batu, D., Velkoska, E., Burrell, L. M., Patel, S. K., Beswick, L., Jackson, A., Britto, K., Lukies, M., Sluka, P., Wardan, H., Hirokawa, Y., Tan, C. W., Faux, M., Burgess, A. W., Hosking, P., Monagle, S. & 3 others, Thomas, M., Gibson, P. R. & Lubel, J., 1 May 2020, In : Gut. 69, 5, p. 841-851 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The Heart Failure with Preserved Ejection Fraction Conundrum—Redefining the Problem and Finding Common Ground?

Iyngkaran, P., Thomas, M. C., Neil, C., Jelinek, M., Cooper, M., Horowitz, J. D., Hare, D. L. & Kaye, D. M., 1 Apr 2020, In : Current Heart Failure Reports. 17, 2, p. 34-42 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

The Long-Term Incidence of Hospitalization for Ketoacidosis in Adults with Established T1D-A Prospective Cohort Study

Thomas, M., Harjutsalo, V., Feodoroff, M., Forsblom, C., Gordin, D., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Jan 2020, In : The Journal of Clinical Endocrinology and Metabolism. 105, 1, p. 231-241 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Non-invasive Risk Stratification for Coronary Artery Disease: Is It Time for Subclassifications?

Iyngkaran, P., Noaman, S., Chan, W., Mahadavan, G., Thomas, M. C. & Rajendran, S., 1 Aug 2019, In : Current Cardiology Reports. 21, 8, 10 p., 87.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Perspectives on optimizing chronic heart failure care beyond randomised controlled trials - what do we consolidate and how do we plan for the future?

Iyngkaran, P., Thomas, M. & Majoni, S. W., 1 Jan 2019, In : Current Cardiology Reviews. 15, 3, p. 158-160 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis

Pickering, R. J., Tikellis, C., Rosado, C. J., Tsorotes, D., Dimitropoulos, A., Smith, M., Huet, O., Seeber, R. M., Abhayawardana, R., Johnstone, E. K. M., Golledge, J., Wang, Y., Jandeleit-Dahm, K. A., Cooper, M. E., Pfleger, K. D. G. & Thomas, M. C., 2 Jan 2019, In : Journal of Clinical Investigation. 129, 1, p. 406-421 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)
2018

Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study

Hughes, J. T., Maple-Brown, L. J., Thomas, M., Lawton, P. D., Sinha, A., Cass, A., Barzi, F., Jones, G. R. D., Jerums, G., MacIsaac, R. J., O'Dea, K. & Hoy, W. E., 1 Jan 2018, In : Nephrology. 23, 1, p. 37-45 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Effects of diabetes medications targeting the incretin system on the kidney

Macisaac, R. J. & Thomas, M. C., 7 Feb 2018, In : Clinical Journal of the American Society of Nephrology. 13, 2, p. 321-323 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
4 Citations (Scopus)

Excess mortality in patients with type 1 diabetes without albuminuriadseparating the contribution of early and late risks

Groop, P. H., Thomas, M., Feodoroff, M., Forsblom, C. & Harjutsalo, V., 1 Apr 2018, In : Diabetes Care. 41, 4, p. 748-754 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)
8 Citations (Scopus)

Perspective Review: Type 2 Diabetes and Readmission for Heart Failure

Thomas, M. C., 5 Jun 2018, In : Clinical Medicine Insights: Cardiology. 12, p. 1-7 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
4 Citations (Scopus)

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Relationship between plasma 8-OH-deoxyguanosine and cardiovascular disease and survival in type 2 diabetes mellitus: Results from the ADVANCE trial

Thomas, M. C., Woodward, M., Li, Q., Pickering, R., Tikellis, C., Poulter, N., Cooper, M. E., Marre, M., Zoungas, S. & Chalmers, J., 1 Jul 2018, In : Journal of the American Heart Association. 7, 13, 17 p., e008226.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

Risk of coronary artery disease and stroke according to sex and presence of diabetic nephropathy in type 1 diabetes

Harjutsalo, V., Thomas, M. C., Forsblom, C., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Dec 2018, In : Diabetes, Obesity and Metabolism. 20, 12, p. 2759-2767 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The actions of SGLT2 inhibitors on metabolism, renal function and blood pressure

Thomas, M. C. & Cherney, D. Z. I., 1 Oct 2018, In : Diabetologia. 61, 10, p. 2098-2107 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
56 Citations (Scopus)
2017

Resveratrol inhibits growth of experimental abdominal aortic aneurysm associated with upregulation of angiotensin-converting enzyme 2

Moran, C. S., Biros, E., Krishna, S. M., Wang, Y., Tikellis, C., Morton, S. K., Moxon, J. V., Cooper, M. E., Norman, P. E., Burrell, L. M., Thomas, M. C. & Golledge, J., 2017, In : Arteriosclerosis, Thrombosis and Vascular Biology. 37, 11, p. 2195-2203 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The potential and pitfalls of GLP-1 receptor agonists for renal protection in type 2 diabetes

Thomas, M. C., 1 Apr 2017, In : Diabetes and Metabolism. 43, p. 2S20-2S27 8 p.

Research output: Contribution to journalArticleOtherpeer-review

19 Citations (Scopus)
2016

A review of the external validity of clinical trials with beta-blockers in heart failure

Iyngkaran, P., Toukhsati, S. R., Thomas, M. C., Jelinek, M. V., Hare, D. L. & Horowitz, J. D., 12 Oct 2016, In : Clinical Medicine Insights: Cardiology. 10, p. 163-171 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease

Thomas, M. C., Cooper, M. E. & Zimmet, P., 1 Feb 2016, In : Nature Reviews Nephrology. 12, 2, p. 73-81 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

131 Citations (Scopus)

Contextualizing genetics for regional heart failure care

Iyngkaran, P., Thomas, M. C., Johnson, R., French, J. R. J., Ilton, M., McDonald, P., Hare, D. L. & Fatkin, D., 1 Aug 2016, In : Current Cardiology Reviews. 12, 3, p. 231-242 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

Coughlan, M. T., Higgins, G. C., Nguyen, T-V., Penfold, S. A., Thallas-Bonke, V., Tan, S. M., Ramm, G., Van Bergen, N. J., Henstridge, D. C., Sourris, K. C., Harcourt, B. E., Trounce, I. A., Robb, P. M., Laskowski, A., McGee, S. L., Genders, A. J., Walder, K., Drew, B. G., Gregorevic, P., Qian, H. & 13 others, Thomas, M. C., Jerums, G., Macisaac, R. J., Skene, A., Power, D. A., Ekinci, E. I., Wijeyeratne, X. W., Gallo, L. A., Herman-Edelstein, M., Ryan, M. T., Cooper, M. E., Thorburn, D. R. & Forbes, J. M., Apr 2016, In : Diabetes. 65, 4, p. 1085-1098 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Dietary sodium and cardiovascular disease risk

O'Donnell, M., Mann, J. F. E., Schutte, A. E., Staessen, J. A., Lopez-Jaramillo, P., Thomas, M., Mente, A., Saulnier, P. J. & Yusuf, S., 15 Dec 2016, In : The New England Journal of Medicine. 375, 24, p. 2404-2406 3 p.

Research output: Contribution to journalLetterOtherpeer-review

Epigenetic Mechanisms in Diabetic Kidney Disease

Thomas, M. C., 1 Mar 2016, In : Current Diabetes Reports. 16, 3, 8 p., 31.

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

Heart failure in minority populations - Impediments to optimal treatment in Australian aborigines

Iyngkaran, P., Kangaharan, N., Zimmet, H., Arstall, M., Minson, R., Thomas, M. C., Bergin, P., Atherton, J., MacDonald, P. B., Hare, D. L., Horowitz, J. D. & Ilton, M., 1 Aug 2016, In : Current Cardiology Reviews. 12, 3, p. 166-179 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Management of patients with diabetes and CKD: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

Perkovic, V., Agarwal, R., Fioretto, P., Hemmelgarn, B. R., Levin, A., Thomas, M. C., Wanner, C., Kasiske, B. L., Wheeler, D. C., Groop, P-H. & for Conference Participants, 1 Dec 2016, In : Kidney International. 90, 6, p. 1175-1183 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
48 Citations (Scopus)

Phase 4 studies in heart failure - What is done and what is needed?

Iyngkaran, P., Liew, D., McDonald, P., Thomas, M. C., Reid, C., Chew, D. & Hare, D. L., 1 Aug 2016, In : Current Cardiology Reviews. 12, 3, p. 216-230 15 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Systematic Literature Review of DPP-4 Inhibitors in Patients with Type 2 Diabetes Mellitus and Renal Impairment

Thomas, M. C., Paldánius, P. M., Ayyagari, R., Ong, S. H. & Groop, P. H., 1 Sep 2016, In : Diabetes Therapy. 7, 3, p. 439-454 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
21 Citations (Scopus)

Type 2 diabetes and heart failure: Challenges and solutions

Thomas, M. C., 1 Aug 2016, In : Current Cardiology Reviews. 12, 3, p. 249-255 7 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)
2015

ACE2 deficiency shifts energy metabolism towards glucose utilization

Bernardi, S., Tikellis, C., Candido, R., Tsorotes, D., Pickering, R. J., Bossi, F., Carretta, R., Fabris, B., Cooper, M. E. & Thomas, M. C., 1 Mar 2015, In : Metabolism. 64, 3, p. 406-415 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

AT2R agonist, compound 21, is reno-protective against type 1 diabetic nephropathy

Koulis, C., Chow, B. SM., Mckelvey, M., Steckelings, U. M., Unger, T., Thallas-Bonke, V., Thomas, M. C., Cooper, M. E., Jandeleit-Dahm, K. A. M. & Allen, T. J., 2015, In : Hypertension. 65, 5, p. 1073 - 1081 9 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Bedside–to-bench translational research for chronic heart failure: Creating an agenda for clients who do not meet trial enrollment criteria

Iyngkaran, P. & Thomas, M., 25 Mar 2015, In : Clinical Medicine Insights: Cardiology. 9, p. 121-132 12 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
4 Citations (Scopus)

Diabetic kidney disease

Thomas, M. C., Brownlee, M., Susztak, K., Sharma, S. K., Jandeleit-Dahm, K. A. M., Zoungas, S., Rossing, P., Groop, P-H. & Cooper, M. E., 30 Jul 2015, In : Nature Reviews Disease Primers. 1, 15018.

Research output: Contribution to journalReview ArticleResearchpeer-review

88 Citations (Scopus)

Northern Territory Perspectives on Heart Failure with Comorbidities - Understanding Trial Validity and Exploring Collaborative Opportunities to Broaden the Evidence Base

Iyngkaran, P., Majoni, W., Cass, A., Sanders, P., Ronco, C., Brady, S., Kangaharan, N., Ilton, M., Hare, D. L. & Thomas, M. C., 1 Jun 2015, In : Heart Lung and Circulation. 24, 6, p. 536-543 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Relationship between levels of advanced glycation end products and their soluble receptor and adverse outcomes in adults with type 2 diabetes

Thomas, M. C., Woodward, M., Neal, B., Li, Q., Pickering, R., Marre, M., Williams, B., Perkovic, V., Cooper, M. E., Zoungas, S., Chalmers, J., Hillis, G. S. & ADVANCE Collaborative Group, 1 Oct 2015, In : Diabetes Care. 38, 10, p. 1891-1897 7 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
2014

Added value of soluble tumor necrosis factor-α receptor 1 as a biomarker of ESRD risk in patients with type 1 diabetes

Forsblom, C., Moran, J., Harjutsalo, V., Loughman, T., Wadén, J., Tolonen, N., Thorn, L., Saraheimo, M., Gordin, D., Groop, P. H., Thomas, M. C. & On Behalf of the FinnDiane Study Group, 1 Jan 2014, In : Diabetes Care. 37, 8, p. 2334-2342 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
26 Citations (Scopus)

Angiotensin-converting enzyme 2 mediates hyperfiltration associated with diabetes

Tikellis, C., Brown, R., Head, G. A., Cooper, M. E. & Thomas, M. C., 1 Apr 2014, In : American Journal of Physiology-Renal Physiology. 306, 7, p. F773 - F780 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Beyond Glycosuria: Exploring the intrarenal effects of SGLT-2 inhibition in diabetes

Thomas, M. C., Jandeleit-Dahm, K. & Bonnet, F., 1 Dec 2014, In : Diabetes and Metabolism. 40, 6, p. S17-S22 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
48 Citations (Scopus)

Glycemic exposure, glycemic control, and metabolic karma in diabetic complications

Thomas, M. C., 2014, In : Advances in Chronic Kidney Disease. 21, 3, p. 311 - 317 7 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Origin of the Y chromosome influences intrarenal vascular responsiveness to angiotensin I and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats

Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Head, G. A., Thomas, M. C., Chin-Dusting, J. P. F., Dominiczak, A. F. & Jennings, G. L., 2014, In : Hypertension. 64, 6, p. 1376-1383 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Osteopontin is a strong predictor of incipient diabetic nephropathy, cardiovascular disease, and all-cause mortality in patients with type 1 diabetes

Gordin, D., Forsblom, C., Panduru, N. M., Thomas, M. C., Bjerre, M., Soro-Paavonen, A., Tolonen, N., Sandholm, N., Flyvbjerg, A., Harjutsalo, V., Groop, P. H. & On Behalf of the FinnDiane Study Group, 1 Jan 2014, In : Diabetes Care. 37, 9, p. 2593-2600 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
29 Citations (Scopus)

Osteoprotegerin increases in metabolic syndrome and promotes adipose tissue proinflammatory changes

Bernardi, S., Fabris, B., Thomas, M., Toffoli, B., Tikellis, C., Candido, R., Catena, C., Mulatero, P., Barbone, F., Radillo, O., Zauli, G. & Secchiero, P., 25 Aug 2014, In : Molecular and Cellular Endocrinology. 394, 1-2, p. 13-20 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice

Watson, A. M. D., Li, J., Samijono, D., Bierhaus, A., Thomas, M. C., Jandeleit-Dahm, K. A. M. & Cooper, M. E., 2014, In : Atherosclerosis. 235, 2, p. 444 - 448 5 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Relationship between urinary sodium excretion over time and mortality in type 2 diabetes

Ekinci, E. I., Moran, J. L., Thomas, M. C., Cheong, K., Clarke, S., Chen, A., Dobson, M., Leong, A., MacIsaac, R. J. & Jerums, G., 1 Jan 2014, In : Diabetes Care. 37, 4, 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Open Access
10 Citations (Scopus)

Renal effects of dapagliflozin in patients with type 2 diabetes

Thomas, M. C., 1 Jan 2014, In : Therapeutic Advances in Endocrinology and Metabolism. 5, 3, p. 53-61 9 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

39 Citations (Scopus)

Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b

Wang, B., Jha, J. C., Hagiwara, S., Mcclelland, A. D., Jandeleit-Dahm, K., Thomas, M. C., Cooper, M. E. & Kantharidis, P., Feb 2014, In : Kidney International. 85, 2, p. 352-361 10 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)
2013

Angiotensin converting enzyme 2 and atherosclerosis

Wang, Y., Tikellis, C., Thomas, M. C. & Golledge, J., Jan 2013, In : Atherosclerosis. 226, 1, p. 3-8 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

35 Citations (Scopus)