1994 …2023

Research output per year

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Research Output

  • 66 Article
  • 5 Chapter (Book)
  • 3 Review Article
  • 2 Comment / Debate
2020

Daptomycin-resistant Staphylococcus aureus clinical isolates are poorly sensed by dendritic cells

Patton, T., Jiang, J-H., Lundie, R. J., Bafit, M., Gao, W., Peleg, A. Y. & O'Keeffe, M., Jan 2020, In : Immunology and Cell Biology. 98, 1, p. 42-53 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity

Zhan, Y., Kong, I., Chopin, M., Macri, C., Zhang, J. G., Xie, J., Nutt, S. L., O'Keeffe, M., Hawkins, E. D., Morand, E. F. & Lew, A. M., Mar 2020, In : Immunology and Cell Biology. 98, 3, p. 203-214 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Dendritic cell responses and function in malaria

Yap, X. Z., Lundie, R. J., Beeson, J. G. & O'Keeffe, M., Mar 2019, In : Frontiers in Immunology. 10, 25 p., 357.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Yap, X. Z., Lundie, R. J., Feng, G., Pooley, J., Beeson, J. G. & O'Keeffe, M., 31 Jan 2019, In : Frontiers in Immunology. 10, 13 p., 32.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Monitoring dendritic cell activation and maturation

Macri, C., Fancke, B., Radford, K. J. & O’Keeffe, M., 31 May 2019, Antigen Processing: Methods and Protocols. van Endert, P. (ed.). 2nd ed. New York, NY: Humana Press, p. 403-418 16 p. (Methods in Molecular Biology; vol. 1988).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection

Bedford, J. G., O’Keeffe, M., Reading, P. C. & Wakim, L. M., 16 Jan 2019, In : PLoS ONE. 14, 1, 12 p., e0210132.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)
2018

Dendritic cell subsets

Macri, C., Pang, E. S., Patton, T. & O'Keeffe, M., Dec 2018, In : Seminars in Cell and Developmental Biology. 84, p. 11-21 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

Gavin, A. L., Huang, D., Huber, C., Mårtensson, A., Tardif, V., Skog, P. D., Blane, T. R., Thinnes, T. C., Osborn, K., Chong, H. S., Kargaran, F., Kimm, P., Zeitjian, A., Sielski, R. L., Briggs, M., Schulz, S. R., Zarpellon, A., Cravatt, B., Pang, E. S., Teijaro, J. & 7 others, Torre, J. C. D. L., O’Keeffe, M., Hochrein, H., Damme, M., Teyton, L., Lawson, B. R. & Nemazee, D., 1 Sep 2018, In : Nature Immunology. 19, 9, p. 942-953 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2017

CD14 is not involved in the uptake of synthetic CpG oligonucleotides

Li, J., Ahmet, F., O'Keeffe, M., Lahoud, M. H., Heath, W. R. & Caminschi, I., Jan 2017, In : Molecular Immunology. 81, p. 52-58 7 p.

Research output: Contribution to journalArticleResearchpeer-review

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Nguyen, T. A., Smith, B. R. C., Tate, M. D., Belz, G. T., Barrios, M. H., Elgass, K. D., Weisman, A. S., Baker, P. J., Preston, S. P., Whitehead, L. W., Garnham, A. L., Lundie, R. J., Smyth, G. K., Pellegrini, M., O'Keeffe, M., Wicks, I. P., Masters, S. L., Hunter, C. P. & Pang, K. C., 19 Sep 2017, In : Immunity. 47, 3, p. 498-509 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection

Martinic, M. M., Caminschi, I., O'Keeffe, M., Thinnes, T. C., Grumont, R., Gerondakis, S., McKay, D. B., Nemazee, D. & Gavin, A. L., 1 Apr 2017, In : Journal of Immunology. 198, 7, p. 2649-2660 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2016

A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection

Lundie, R. J., Webb, L. M., Marley, A. K., Phythian-Adams, A. T., Cook, P. C., Jackson-Jones, L. H., Brown, S., Maizels, R. M., Boon, L., O'Keeffe, M. & MacDonald, A. S., 1 Apr 2016, In : Immunology and Cell Biology. 94, 4, p. 400-410 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)

CD117+ dendritic and mast cells are dependent on RasGRP4 to function as accessory cells for optimal natural killer cell-mediated responses to lipopolysaccharide

Zhou, S., Tanaka, K., O'Keeffe, M., Qi, M., El-Assaad, F., Weaver, J. C., Chen, G., Weatherall, C., Wang, Y., Giannakopoulos, B. M., Chen, L., Yu, D. M., Hamilton, M. J., Wensing, L. A., Stevens, R. L. & Krilis, S. A., 16 Mar 2016, In : PLoS ONE. 11, 3, 18 p., e0151638.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Contrasting inducible knockdown of the auxiliary PTEX component PTEX88 in P. falciparum and P. berghei unmasks a role in parasite virulence

Chisholm, S. A., McHugh, E., Lundie, R., Dixon, M. W. A., Ghosh, S., O'Keefe, M., Tilley, L., Kalanon, M. & de Koning-Ward, T. F., 17 Feb 2016, In : PLoS ONE. 11, 2, 21 p., e0149296.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Plasmacytoid dendritic cells are short-lived: Reappraising the influence of migration, genetic factors and activation on estimation of lifespan

Zhan, Y., Chow, K. V., Soo, P., Xu, Z., Brady, J. L., Lawlor, K. E., Masters, S. L., O'Keeffe, M., Shortman, K., Zhang, J. G. & Lew, A. M., 26 Apr 2016, In : Scientific Reports. 6, 12 p., 25060.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming

Greyer, M., Whitney, P. G., Stock, A. T., Davey, G. M., Tebartz, C., Bachem, A., Mintern, J. D., Strugnell, R. A., Turner, S. J., Gebhardt, T., O'Keeffe, M., Heath, W. R. & Bedoui, S., 26 Jan 2016, In : Cell Reports. 14, 3, p. 586-597 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
21 Citations (Scopus)
2015

Human dendritic cell subsets and function in health and disease

O'Keeffe, M. A., Mok, W. H. & Radford, K. J., 2015, In : Cellular and Molecular Life Sciences. 72, 22, p. 4309 - 4325 17 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Maintaining dendritic cell viability in culture

Vremec, D., Hansen, J., Strasser, A., Acha-Orbea, H., Zhan, Y., O'Keeffe, M. & Shortman, K., 1 Feb 2015, In : Molecular Immunology. 63, 2, p. 264-267 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2014

Dendritic cells in autoimmune disease

Radford, K. J., Shortman, K. & O'Keeffe, M., 2014, The Autoimmune Diseases. Rose, N. R. & Mackay, I. R. (eds.). 5th ed. USA: Elsevier, p. 175 - 186 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

FLT3-ligand treatment of humanized mice results in the generation of large numbers of CD141+ and CD1c+ dendritic cells in vivo

Ding, Y., Wilkinson, A. R. J., Idris, A., Fancke, B. R., O'Keeffe, M., Khalil, D., Ju, X., Lahoud, M. H., Caminschi, I., Shortman, K., Rodwell, R. L., Vuckovic, S. & Radford, K. J., 2014, In : Journal of Immunology. 192, 4, p. 1982 - 1989 8 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8

Sarvestani, S., Tate, M., Moffat, J. M., Jacobi, A. M., Behlke, M. A., Miller, A., Beckham, S. A., McCoy, C., Chen, W., Mintern, J., O'Keeffe, M., John, M., Williams, B. R. G. & Gantier, M. P. M., 2014, In : Journal of Virology. 88, 2, p. 799 - 810 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)
2013

Monitoring dendritic cell activation and maturation

Fancke, B. & O'Keeffe, M., 2013, Antigen Processing: Methods and Protocols. van Endert, P. (ed.). 1 ed. New York NY USA: Humana Press, p. 359-370 12 p. (Methods in Molecular Biology; vol. 960).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Plasmacytoid dendritic cell development

Shortman, K., Sathe, P., Vremec, D., Naik, S. & O'Keeffe, M., 2013, In : Advances in Immunology. 120, p. 105 - 126 22 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2012

Conventional dendritic cells may be ideal targets for vaccine strategies in the aged

O'Keeffe, M., Aug 2012, In : Immunology and Cell Biology. 90, 7, p. 665-666 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2 Citations (Scopus)

DEC-205 is a cell surface receptor for CpG oligonucleotides

Lahoud, M. H., Ahmet, F., Zhang, J-G., Meuter, S., Policheni, A. N., Kitsoulis, S., Lee, C-N., O'Keeffe, M., Sullivan, L. C., Brooks, A. G., Berry, R., Rossjohn, J., Mintern, J. D., Vega-Ramos, J., Villadangos, J. A., Nicola, N. A., Nussenzweig, M. C., Stacey, K. J., Shortman, K., Heath, W. R. & 1 others, Caminschi, I., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 40, p. 16270 - 16275 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
92 Citations (Scopus)

Dendritic cell subsets and immune regulation

O'Keeffe, M., Lahoud, M. H., Caminschi, I. & Wu, L., 1 Jan 2012, Innate Immune Regulation and Cancer Immunotherapy. Springer, p. 89-119 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Nonplasmacytoid, high IFN-a-producing, bone marrow dendritic cells

O'Keeffe, M., Fanche, B., Suter, M., Ramm, G., Clark, J. M., Wu, L. & Hochrein, H., 2012, In : Journal of Immunology. 188, 8, p. 3774 - 3783 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

Gugasyan, R., Horat, E., Kinkel, S., Ross, F., Grigoriadis, G., Gray, D., O'Keeffe, M., Berzins, S., Belz, G., Grumont, R., Banerjee, A., Strasser, A., Godfrey, D., Tsichlis, P. & Gerondakis, S., 2012, In : The EMBO Journal. 31, 3, p. 692 - 706 15 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2011

Factors determining the spontaneous activation of splenic dendritic cells in culture

Vremec, D., O'Keeffe, M., Wilson, A., Ferrero, I., Koch, U., Radtke, F., Scott, B., Hertzog, P., Villadangos, J. & Shortman, K., 2011, In : Innate Immunity. 17, 3, p. 338 - 352 15 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2010

CD8+, CD8-, and plasmacytoid dendritic cell generation in vitro using flt3 ligand.

Naik, S. H., O'Keeffe, M., Proietto, A., Shortman, H. H. K. & Wu, L., 2010, In : Methods in Molecular Biology. 595, p. 167-176 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Mouse CD8alpha{+} DCs and human BDCA3{+} DCs are major producers of IFN-lambda in response to poly IC

Lauterbach, H., Bathke, B., Gilles, S., Traidl-Hoffmann, C., Luber, C. A., Fejer, G., Freudenberg, M. A., Davey, G. M., Vremec, D., Kallies, A., Wu, L., Shortman, K., Chaplin, P., Suter, M., O'Keeffe, M. & Hochrein, H., 2010, In : Journal of Experimental Medicine. 207, 12, p. 2703 - 2717 15 p.

Research output: Contribution to journalArticleResearchpeer-review

180 Citations (Scopus)

Quantitative Proteomics Reveals Subset-Specific Viral Recognition in Dendritic Cells

Luber, C. A., Cox, J., Lauterbach, H., Fancke, B., Selbach, M., Tschopp, J., Akira, S., Wiegand, M., Hochrein, H., O'Keeffe, M. & Mann, M., 26 Feb 2010, In : Immunity. 32, 2, p. 279-289 11 p.

Research output: Contribution to journalArticleResearchpeer-review

367 Citations (Scopus)

The generation of plasmacytoid and conventional dendritic cells with M-CSF.

O'Keeffe, M., Fancke, B. & Hochrein, H., 2010, In : Methods in Molecular Biology. 595, p. 187-193 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2008

Dendritic cell subsets and toll-like receptors

Hochrein, H. & O'Keeffe, M., 2008, Toll-Like Receptors (TLRs) and Innate Immunity. Vol. 183. p. 153-179 27 p. (Handbook of Experimental Pharmacology; vol. 183).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

30 Citations (Scopus)

Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells

Young, L. J., Wilson, N. S., Schnorrer, P., Proietto, A. I., ten Broeke, T., Matsuki, Y., Mount, A. M., Belz, G. T., O'Keeffe, M., Ohmura-Hoshino, M., Ishido, S., Stoorvogel, W., Heath, W. R., Shortman, K. & Villadangos, J. A., 2008, In : Nature Immunology. 9, 11, p. 1244-1252 9 p.

Research output: Contribution to journalArticleResearchpeer-review

158 Citations (Scopus)

M-CSF: A novel plasmacytoid and conventional dendritic cell poietin

Fancke, B., Suter, M., Hochrein, H. & O'Keeffe, M., 1 Jan 2008, In : Blood. 111, 1, p. 150-159 10 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection

Samuelsson, C., Hausmann, J., Lauterbach, H., Schmidt, M., Akira, S., Wagner, H., Chaplin, P., Suter, M., O'Keeffe, M. & Hochrein, H., 1 May 2008, In : Journal of Clinical Investigation. 118, 5, p. 1776-1784 9 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)
2007

Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

Naik, S. H., Sathe, P., Park, H. Y., Metcalf, D., Proietto, A. I., Dakic, A., Carotta, S., O'Keeffe, M., Bahlo, M., Papenfuss, A., Kwak, J. Y., Wu, L. & Shortman, K., Nov 2007, In : Nature Immunology. 8, 11, p. 1217-1226 10 p.

Research output: Contribution to journalArticleResearchpeer-review

503 Citations (Scopus)

Erratum: Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo (Nature Immunology (2007) 10.1038/ni1522)

Naik, S. H., Sathe, P., Park, H. Y., Metcalf, D., Proietto, A. I., Dakic, A., Carotta, S., O'Keeffe, M., Bahlo, M., Papenfuss, A., Kwak, J. Y., Wu, L. & Shortman, K., Nov 2007, In : Nature Immunology. 8, 11

Research output: Contribution to journalComment / DebateOtherpeer-review

Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells

Vremec, D., O'Keeffe, M., Hochrein, H., Fuchsberger, M., Caminschi, I., Lahoud, M. & Shortman, K., 1 Feb 2007, In : Blood. 109, 3, p. 1165-1173 9 p.

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells

Caminschi, I., Ahmet, F., Heger, K., Brady, J., Nutt, S. L., Vremec, D., Pietersz, S., Lahoud, M. H., Schofield, L. D., Hansen, D. S., O'Keeffe, M., Smyth, M. J., Bedoui, S., Davey, G. M., Villadangos, J. A., Heath, W. R. & Shortman, K., 29 Oct 2007, In : Journal of Experimental Medicine. 204, 11, p. 2579-2590 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)
2006

Adenovirus efficiently transduces plasmacytoid dendritic cells resulting in TLR9-dependent maturation and IFN-α production

Basner-Tschakarjan, E., Gaffal, E., O'Keeffe, M., Tormo, D., Limmer, A., Wagner, H., Hochrein, H. & Tüting, T., Nov 2006, In : Journal of Gene Medicine. 8, 11, p. 1300-1306 7 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes

Naik, S. H., Metcalf, D., van Nieuwenhuijze, A., Wicks, I., Wu, L., O'Keeffe, M. & Shortman, K., Jun 2006, In : Nature Immunology. 7, 6, p. 663-671 9 p.

Research output: Contribution to journalArticleResearchpeer-review

446 Citations (Scopus)

Signal regulatory protein molecules are differentially expressed, by CD8- dendritic cells

Lahoud, M. H., Proietto, A. I., Gartlan, K., Kitsoulis, S., Curtis, J., Wettenhall, J., Sofi, M., Daunt, C. P., O'Keeffe, M., Caminschi, I., Satterley, K., Rizzitelli, A., Schnorrer, P., Hinohara, A., Yamaguchi, Y., Wu, L., Smyth, G. K., Handman, E., Shortman, K. & Wright, M. D., 2006, In : Journal of Immunology. 177, 1, p. 372 - 382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

The long-term but not the short-term antiviral effect of IFN-α depends on Flt3 ligand and pDC

Vollstedt, S., O'Keeffe, M., Ryf, B., Glanzmann, B., Hochrein, H. & Suter, M., May 2006, In : European Journal of Immunology. 36, 5, p. 1231-1240 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2005

Activation of plasmacytoid dendritic cells

Fuchsberger, M., Hochrein, H. & O'Keeffe, M., Oct 2005, In : Immunology and Cell Biology. 83, 5, p. 571-577 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

32 Citations (Scopus)

Cutting edge: Generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures

Naik, S. H., Proietto, A. I., Wilson, N. S., Dakic, A., Schnorrer, P., Fuchsberger, M., Lahoud, M. H., O'Keeffe, M., Shao, Q. X., Chen, W. F., Villadangos, J. A., Shortman, K. & Wu, L., 1 Jun 2005, In : Journal of Immunology. 174, 11, p. 6592-6597 6 p.

Research output: Contribution to journalArticleResearchpeer-review

355 Citations (Scopus)

Distinct roles for the NF-κB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals

O'Keeffe, M., Grumont, R. J., Hochrein, H., Fuchsberger, M., Gugasyan, R., Vremec, D., Shortman, K. & Gerondakis, S., 15 Nov 2005, In : Blood. 106, 10, p. 3457-3464 8 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development

O'Keeffe, M., Brodnicki, T. C., Fancke, B., Vremec, D., Morahan, G., Maraskovsky, E., Steptoe, R. J., Harrison, L. C. & Shortman, K., Mar 2005, In : International Immunology. 17, 3, p. 307-314 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Protective CD8 T cell immunity triggered by CpG-protein conjugates competes with the efficacy of live vaccines

Heit, A., Schmitz, F., O'Keeffe, M., Staib, C., Busch, D. H., Wagner, H. & Huster, K. M., 1 Apr 2005, In : Journal of Immunology. 174, 7, p. 4373-4380 8 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)