1994 …2020
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Personal profile

Biography

Associate Professor Meredith O'Keeffe is an NHMRC Senior Research Fellow and Head of the Laboratory of Dendritic Cell Driven Immunity in Health and Disease. Meredith received her PhD from Monash University in 1998. She has spent the following 16 years investigating dendritic cell biology, with positions at WEHI, Melbourne, Bavarian-Nordic GmbH, Munich, Germany and the Burnet Institute, Melbourne. Meredith's current research interests include investigating the function of dendritic cells in Lupus disease and malaria infection and examining the development and function of dendritic cells in Myelodysplasia.

Dendritic cells are sentinels of the immune system that produce cytokines and interferons upon sensing danger. They are also professional antigen presenting cells, thereby connecting the innate and adaptive immune systems. Our laboratory investigates how pathogens and their products and/or or self-nucleic acids activate dendritic cells. We aim to decipher how this activation influences the function of dendritic cells. We investigate how this process may differ in different body locations, at different ages and in different disease settings. Major aims are to understand the role of dendritic cells in bone marrow malignancies and in autoimmune diseases such as Lupus.

Keywords

  • dendritic cells
  • immunity
  • cytokines
  • interferons
  • infection

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Projects 2014 2020

Research Output 1994 2019

Dendritic cell responses and function in malaria

Yap, X. Z., Lundie, R. J., Beeson, J. G. & O'Keeffe, M., Mar 2019, In : Frontiers in Immunology. 10, 25 p., 357.

Research output: Contribution to journalScientific ReviewResearchpeer-review

Open Access
File

Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells

Yap, X. Z., Lundie, R. J., Feng, G., Pooley, J., Beeson, J. G. & O'Keeffe, M., 31 Jan 2019, In : Frontiers in Immunology. 10, 13 p., 32.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Monitoring dendritic cell activation and maturation

Macri, C., Fancke, B., Radford, K. J. & O’Keeffe, M., 31 May 2019, Antigen Processing: Methods and Protocols. van Endert, P. (ed.). 2nd ed. New York, NY: Humana Press, p. 403-418 16 p. (Methods in Molecular Biology; vol. 1988).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection

Bedford, J. G., O’Keeffe, M., Reading, P. C. & Wakim, L. M., 16 Jan 2019, In : PLoS ONE. 14, 1, 12 p., e0210132.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Dendritic cell subsets

Macri, C., Pang, E. S., Patton, T. & O'Keeffe, M., Dec 2018, In : Seminars in Cell and Developmental Biology. 84, p. 11-21 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Activities 2016 2017

  • 1 Editorial responsibility
  • 1 Membership of industry collaboration/ network

Monash Antimicrobial Resistance Group (Event)

Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member), Philip Heraud (Member)
1 Mar 2017

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network

Immunology and Cell Biology (Journal)

Meredith O'Keeffe (Editorial board member)
2016 → …

Activity: Publication peer-review and editorial work typesEditorial responsibility