1994 …2020
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Personal profile

Biography

Associate Professor Meredith O'Keeffe is an NHMRC Senior Research Fellow and Head of the Laboratory of Dendritic Cell Driven Immunity in Health and Disease. Meredith received her PhD from Monash University in 1998. She has spent the following 16 years investigating dendritic cell biology, with positions at WEHI, Melbourne, Bavarian-Nordic GmbH, Munich, Germany and the Burnet Institute, Melbourne. Meredith's current research interests include investigating the function of dendritic cells in Lupus disease and malaria infection and examining the development and function of dendritic cells in Myelodysplasia.

Dendritic cells are sentinels of the immune system that produce cytokines and interferons upon sensing danger. They are also professional antigen presenting cells, thereby connecting the innate and adaptive immune systems. Our laboratory investigates how pathogens and their products and/or or self-nucleic acids activate dendritic cells. We aim to decipher how this activation influences the function of dendritic cells. We investigate how this process may differ in different body locations, at different ages and in different disease settings. Major aims are to understand the role of dendritic cells in bone marrow malignancies and in autoimmune diseases such as Lupus.

Keywords

  • dendritic cells
  • immunity
  • cytokines
  • interferons
  • infection

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Projects 2014 2020

Research Output 1994 2018

  • 60 Article
  • 4 Chapter (Book)
  • 2 Comment / Debate
  • 2 Review Article

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

Gavin, A. L. , Huang, D. , Huber, C. , Mårtensson, A. , Tardif, V. , Skog, P. D. , Blane, T. R. , Thinnes, T. C. , Osborn, K. , Chong, H. S. , Kargaran, F. , Kimm, P. , Zeitjian, A. , Sielski, R. L. , Briggs, M. , Schulz, S. R. , Zarpellon, A. , Cravatt, B. , Pang, E. S. , Teijaro, J. & 7 others Torre, J. C. D. L., O’Keeffe, M., Hochrein, H., Damme, M., Teyton, L., Lawson, B. R. & Nemazee, D. 13 Aug 2018 (Accepted/In press) In : Nature Immunology. 14 p.

Research output: Contribution to journalArticleResearchpeer-review

CD14 is not involved in the uptake of synthetic CpG oligonucleotides

Li, J., Ahmet, F., O'Keeffe, M., Lahoud, M. H., Heath, W. R. & Caminschi, I. Jan 2017 In : Molecular Immunology. 81, p. 52-58 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Dendritic cell subsets

Macri, C., Pang, E. S., Patton, T. & O'Keeffe, M. 23 Dec 2017 (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalReview ArticleResearchpeer-review

SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition

Nguyen, T. A., Smith, B. R. C., Tate, M. D., Belz, G. T., Barrios, M. H., Elgass, K. D., Weisman, A. S., Baker, P. J., Preston, S. P., Whitehead, L. W., Garnham, A. L., Lundie, R. J., Smyth, G. K., Pellegrini, M., O'Keeffe, M., Wicks, I. P., Masters, S. L., Hunter, C. P. & Pang, K. C. 19 Sep 2017 In : Immunity. 47, 3, p. 498-509 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection

Martinic, M. M., Caminschi, I., O'Keeffe, M., Thinnes, T. C., Grumont, R., Gerondakis, S., McKay, D. B., Nemazee, D. & Gavin, A. L. 1 Apr 2017 In : Journal of Immunology. 198, 7, p. 2649-2660 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Activities 2016 2017

  • 1 Editorial responsibility
  • 1 Membership of industry collaboration/ network

Monash Biomedicine Discovery Institute (Organisational unit)

Lithgow, T. J. (Inventor), Belousoff, M. J. (Member), O'Keeffe, M. A. (Member), Cryle, M. (Member), Traven, A. (Member), Boyce, J. D. (Member), Rood, J. I. (Member), Coulibaly, F. J. (Member), Peleg, A. Y. (Member), McGowan, S. (Member), Lyras, D. (Member), Heraud, P. R. (Member)
20172018

Activity: Membership of industry collaboration/ network

Immunology and Cell Biology (Journal)

O'Keeffe, M. A. (Editorial board member)
2016 → …

Activity: Editorial responsibility