Projects per year
Personal profile
Biography
Associate Professor Meredith O'Keeffe is an NHMRC Senior Research Fellow and Head of the Laboratory of Dendritic Cell Driven Immunity in Health and Disease. Meredith received her PhD from Monash University in 1998. She has spent the following 16 years investigating dendritic cell biology, with positions at WEHI, Melbourne, Bavarian-Nordic GmbH, Munich, Germany and the Burnet Institute, Melbourne. Meredith's current research interests include investigating the function of dendritic cells in Lupus disease and malaria infection and examining the development and function of dendritic cells in Myelodysplasia.
Dendritic cells are sentinels of the immune system that produce cytokines and interferons upon sensing danger. They are also professional antigen presenting cells, thereby connecting the innate and adaptive immune systems. Our laboratory investigates how pathogens and their products and/or or self-nucleic acids activate dendritic cells. We aim to decipher how this activation influences the function of dendritic cells. We investigate how this process may differ in different body locations, at different ages and in different disease settings. Major aims are to understand the role of dendritic cells in bone marrow malignancies and in autoimmune diseases such as Lupus.
Research area keywords
- dendritic cells
- immunity
- cytokines
- interferons
- infection
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Checkpoint receptors expressed by dendritic cells- do they play a role in immunotherapies?
Cancer Australia, Worldwide Cancer Research
1/02/20 → 31/01/23
Project: Research
Using the power of cord blood stem cells to humanize mice for effective cancer immunotherapy research
Greenall, S., Watt, A., Ho, G., Segelov, E., O'Keeffe, M. & Jenkin, G.
1/01/20 → 31/12/20
Project: Research
A novel molecular mechanism controlling myelopoiesis
Chong, M., O'Keeffe, M. & Radford, K. J.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/20
Project: Research
NHMRC Equipment Grant - FACSAria Fusion with Biosafety Cabinet
Risbridger, G., Azad, A., Daly, R., O'Keeffe, M., Taylor, R. & Watt, M.
National Health & Medical Research Council (NHMRC)
1/12/15 → 31/12/15
Project: Research
Investigating dendritic cells of bone marrow in healthy and myelodysplastic states
O'Keeffe, M., Radford, K. & Lucas, M.
1/10/15 → 31/12/16
Project: Research
Research Output
Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity
Zhan, Y., Kong, I., Chopin, M., Macri, C., Zhang, J. G., Xie, J., Nutt, S. L., O'Keeffe, M., Hawkins, E. D., Morand, E. F. & Lew, A. M., 9 Jan 2020, (Accepted/In press) In : Immunology and Cell Biology. 12 p.Research output: Contribution to journal › Article › Research › peer-review
Daptomycin-resistant Staphylococcus aureus clinical isolates are poorly sensed by dendritic cells
Patton, T., Jiang, J-H., Lundie, R. J., Bafit, M., Gao, W., Peleg, A. Y. & O'Keeffe, M., 26 Sep 2019, (Accepted/In press) In : Immunology and Cell Biology. 12 p.Research output: Contribution to journal › Article › Research › peer-review
Dendritic cell responses and function in malaria
Yap, X. Z., Lundie, R. J., Beeson, J. G. & O'Keeffe, M., Mar 2019, In : Frontiers in Immunology. 10, 25 p., 357.Research output: Contribution to journal › Scientific Review › Research › peer-review
Open Access
File
Different Life Cycle Stages of Plasmodium falciparum Induce Contrasting Responses in Dendritic Cells
Yap, X. Z., Lundie, R. J., Feng, G., Pooley, J., Beeson, J. G. & O'Keeffe, M., 31 Jan 2019, In : Frontiers in Immunology. 10, 13 p., 32.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Monitoring dendritic cell activation and maturation
Macri, C., Fancke, B., Radford, K. J. & O’Keeffe, M., 31 May 2019, Antigen Processing: Methods and Protocols. van Endert, P. (ed.). 2nd ed. New York, NY: Humana Press, p. 403-418 16 p. (Methods in Molecular Biology; vol. 1988).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
Activities
Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member), Philip Heraud (Member)1 Mar 2017 → 1 Jan 2019
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
Immunology and Cell Biology (Journal)
Meredith O'Keeffe (Editorial board member)2016 → …
Activity: Publication peer-review and editorial work types › Editorial responsibility