Projects per year
Personal profile
Biography
Associate Professor Meredith O'Keeffe is an NHMRC Senior Research Fellow and Head of the Laboratory of Dendritic Cell Driven Immunity in Health and Disease. Meredith received her PhD from Monash University in 1998. She has spent the following 16 years investigating dendritic cell biology, with positions at WEHI, Melbourne, Bavarian-Nordic GmbH, Munich, Germany and the Burnet Institute, Melbourne. Meredith's current research interests include investigating the function of dendritic cells in Lupus disease and malaria infection and examining the development and function of dendritic cells in Myelodysplasia.
Dendritic cells are sentinels of the immune system that produce cytokines and interferons upon sensing danger. They are also professional antigen presenting cells, thereby connecting the innate and adaptive immune systems. Our laboratory investigates how pathogens and their products and/or or self-nucleic acids activate dendritic cells. We aim to decipher how this activation influences the function of dendritic cells. We investigate how this process may differ in different body locations, at different ages and in different disease settings. Major aims are to understand the role of dendritic cells in bone marrow malignancies and in autoimmune diseases such as Lupus.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- dendritic cells
- immunity
- cytokines
- interferons
- infection
Network
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Deciphering novel cross-talk between innate cytokine receptors
O'Keeffe, M., De Weerd, N. & Hertzog, P.
Australian Research Council (ARC)
30/06/21 → 30/06/24
Project: Research
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Checkpoint receptors expressed by dendritic cells- do they play a role in immunotherapies?
Cancer Australia, Worldwide Cancer Research
1/02/20 → 31/01/23
Project: Research
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Using the power of cord blood stem cells to humanize mice for effective cancer immunotherapy research
Greenall, S., Watt, A., Ho, G., Segelov, E., O'Keeffe, M. & Jenkin, G.
1/01/20 → 31/12/21
Project: Research
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New generation live-cell imaging microscope (Leica DMi8)
Naderer, T., Lithgow, T., Traven, A., Kile, B., Li, J., Peleg, A., O'Keeffe, M., Heng, T. & Harper, I.
1/01/18 → 31/12/18
Project: Research
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A novel molecular mechanism controlling myelopoiesis
Chong, M., O'Keeffe, M. & Radford, K. J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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Helminth Infection−Induced Increase in Virtual Memory CD8 T Cells Is Transient, Driven by IL-15, and Absent in Aged Mice
Hussain, T., Nguyen, A., Daunt, C., Thiele, D., Pang, E. S., Li, J., Zaini, A., O’Keeffe, M., Zaph, C., Harris, N. L., Quinn, K. M. & La Gruta, N. L., 1 Feb 2023, In: Journal of Immunology. 210, 3, p. 297-309 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations
Pang, E. S., Daraj, G., Balka, K. R., De Nardo, D., Macri, C., Hochrein, H., Masterman, K. A., Tan, P. S., Shoppee, A., Magill, Z., Jahan, N., Bafit, M., Zhan, Y., Kile, B. T., Lawlor, K. E., Radford, K. J., Wright, M. D. & O'Keeffe, M., 25 Feb 2022, In: Frontiers in Immunology. 13, 19 p., 794776.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
In pursuit of biomarkers for predicting susceptibility to activity-based anorexia in adolescent female rats
Milton, L. K., Patton, T., O'Keeffe, M., Oldfield, B. J. & Foldi, C. J., May 2022, In: International Journal of Eating Disorders. 55, 5, p. 664-677 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
The Influence of Antibiotic Resistance on Innate Immune Responses to Staphylococcus aureus Infection
Jahan, N., Patton, T. & O’keeffe, M., May 2022, In: Antibiotics. 11, 5, 22 p., 542.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access -
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development
Tian, L., Tomei, S., Schreuder, J., Weber, T. S., Amann-Zalcenstein, D., Lin, D. S., Tran, J., Audiger, C., Chu, M., Jarratt, A., Willson, T., Hilton, A., Pang, E. S., Patton, T., Kelly, M., Su, S., Gouil, Q., Diakumis, P., Bahlo, M., Sargeant, T., & 6 others , 8 Jun 2021, In: Immunity. 54, 6, p. 1338-1351.e9 24 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus)
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Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member) & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
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Immunology and Cell Biology (Journal)
Meredith O'Keeffe (Editorial board member)
2016 → Dec 2021Activity: Publication peer-review and editorial work types › Editorial responsibility