Projects per year
Personal profile
Biography
Associate Professor Meredith O'Keeffe is an NHMRC Senior Research Fellow and Head of the Laboratory of Dendritic Cell Driven Immunity in Health and Disease. Meredith received her PhD from Monash University in 1998. She has spent the following 16 years investigating dendritic cell biology, with positions at WEHI, Melbourne, Bavarian-Nordic GmbH, Munich, Germany and the Burnet Institute, Melbourne. Meredith's current research interests include investigating the function of dendritic cells in Lupus disease and malaria infection and examining the development and function of dendritic cells in Myelodysplasia.
Dendritic cells are sentinels of the immune system that produce cytokines and interferons upon sensing danger. They are also professional antigen presenting cells, thereby connecting the innate and adaptive immune systems. Our laboratory investigates how pathogens and their products and/or or self-nucleic acids activate dendritic cells. We aim to decipher how this activation influences the function of dendritic cells. We investigate how this process may differ in different body locations, at different ages and in different disease settings. Major aims are to understand the role of dendritic cells in bone marrow malignancies and in autoimmune diseases such as Lupus.
Keywords
- dendritic cells
- immunity
- cytokines
- interferons
- infection
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Projects 2014 2020
A novel molecular mechanism controlling myelopoiesis
Chong, M., O'Keeffe, M. A. & Radford, K. J.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/20
Project: Research
Exploring the innate immune system of bone marrow
National Health & Medical Research Council (NHMRC)
1/01/15 → 31/12/19
Project: Research
Investigating dendritic cells of bone marrow in healthy and myelodysplastic states
O'Keeffe, M. A., Lucas, M. & Radford, K.
1/10/15 → 31/12/16
Project: Research
Exploring the contribution of interferon-lambda to autoimmune disease
O'Keeffe, M. A., Radford, K. & Lucas, M.
National Health & Medical Research Council (NHMRC)
1/01/15 → 31/12/17
Project: Research
Research Output 1994 2018
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing
Gavin, A. L., Huang, D., Huber, C., Mårtensson, A., Tardif, V., Skog, P. D., Blane, T. R., Thinnes, T. C., Osborn, K., Chong, H. S., Kargaran, F., Kimm, P., Zeitjian, A., Sielski, R. L., Briggs, M., Schulz, S. R., Zarpellon, A., Cravatt, B., Pang, E. S., Teijaro, J. & 7 others, 13 Aug 2018, (Accepted/In press) In : Nature Immunology. 14 p.Research output: Contribution to journal › Article › Research › peer-review
CD14 is not involved in the uptake of synthetic CpG oligonucleotides
Li, J., Ahmet, F., O'Keeffe, M., Lahoud, M. H., Heath, W. R. & Caminschi, I., Jan 2017, In : Molecular Immunology. 81, p. 52-58 7 p.Research output: Contribution to journal › Article › Research › peer-review
Dendritic cell subsets
Macri, C., Pang, E. S., Patton, T. & O'Keeffe, M., 23 Dec 2017, (Accepted/In press) In : Seminars in Cell and Developmental Biology.Research output: Contribution to journal › Review Article › Research › peer-review
SIDT2 Transports Extracellular dsRNA into the Cytoplasm for Innate Immune Recognition
Nguyen, T. A., Smith, B. R. C., Tate, M. D., Belz, G. T., Barrios, M. H., Elgass, K. D., Weisman, A. S., Baker, P. J., Preston, S. P., Whitehead, L. W., Garnham, A. L., Lundie, R. J., Smyth, G. K., Pellegrini, M., O'Keeffe, M., Wicks, I. P., Masters, S. L., Hunter, C. P. & Pang, K. C., 19 Sep 2017, In : Immunity. 47, 3, p. 498-509 12 p.Research output: Contribution to journal › Article › Research › peer-review
The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection
Martinic, M. M., Caminschi, I., O'Keeffe, M., Thinnes, T. C., Grumont, R., Gerondakis, S., McKay, D. B., Nemazee, D. & Gavin, A. L., 1 Apr 2017, In : Journal of Immunology. 198, 7, p. 2649-2660 12 p.Research output: Contribution to journal › Article › Research › peer-review
Activities 2016 2017
Monash Biomedicine Discovery Institute (Organisational unit)
Trevor Lithgow (Inventor), Matthew James Belousoff (Member), Meredith Anne O'Keeffe (Member), Max Cryle (Member), Ana Traven (Member), John Dallas Boyce (Member), Julian Ian Rood (Member), Fasseli Joseph Coulibaly (Member), Anton Yariv Peleg (Member), Sheena McGowan (Member), Dena Lyras (Member), Philip Robert Heraud (Member)2017 → 2018
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
Immunology and Cell Biology (Journal)
Meredith O'Keeffe (Editorial board member)2016 → …
Activity: Publication peer-review and editorial work types › Editorial responsibility