Projects per year
Personal profile
Biography
Associate Professor Meredith O'Keeffe is an NHMRC Senior Research Fellow and Head of the Laboratory of Dendritic Cell Driven Immunity in Health and Disease. Meredith received her PhD from Monash University in 1998. She has spent the following 16 years investigating dendritic cell biology, with positions at WEHI, Melbourne, Bavarian-Nordic GmbH, Munich, Germany and the Burnet Institute, Melbourne. Meredith's current research interests include investigating the function of dendritic cells in Lupus disease and malaria infection and examining the development and function of dendritic cells in Myelodysplasia.
Dendritic cells are sentinels of the immune system that produce cytokines and interferons upon sensing danger. They are also professional antigen presenting cells, thereby connecting the innate and adaptive immune systems. Our laboratory investigates how pathogens and their products and/or or self-nucleic acids activate dendritic cells. We aim to decipher how this activation influences the function of dendritic cells. We investigate how this process may differ in different body locations, at different ages and in different disease settings. Major aims are to understand the role of dendritic cells in bone marrow malignancies and in autoimmune diseases such as Lupus.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- dendritic cells
- immunity
- cytokines
- interferons
- infection
Network
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Deciphering novel cross-talk between innate cytokine receptors
O'Keeffe, M., De Weerd, N. & Hertzog, P.
Australian Research Council (ARC)
4/06/21 → 3/06/24
Project: Research
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Checkpoint receptors expressed by dendritic cells- do they play a role in immunotherapies?
O'Keeffe, M. & Shackleton, M.
Cancer Australia, Worldwide Cancer Research
1/02/20 → 31/01/23
Project: Research
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Using the power of cord blood stem cells to humanize mice for effective cancer immunotherapy research
Greenall, S., Watt, A., Ho, G., Segelov, E., O'Keeffe, M. & Jenkin, G.
1/01/20 → 31/12/21
Project: Research
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A novel molecular mechanism controlling myelopoiesis
Chong, M., O'Keeffe, M. & Radford, K. J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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NHMRC Equipment Grant - FACSAria Fusion with Biosafety Cabinet
Risbridger, G., Azad, A., Daly, R., O'Keeffe, M., Taylor, R. & Watt, M.
National Health and Medical Research Council (NHMRC) (Australia)
1/12/15 → 31/12/15
Project: Research
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Discordance in STING-Induced Activation and Cell Death Between Mouse and Human Dendritic Cell Populations
Pang, E. S., Daraj, G., Balka, K. R., De Nardo, D., Macri, C., Hochrein, H., Masterman, K. A., Tan, P. S., Shoppee, A., Magill, Z., Jahan, N., Bafit, M., Zhan, Y., Kile, B. T., Lawlor, K. E., Radford, K. J., Wright, M. D. & O'Keeffe, M., 25 Feb 2022, In: Frontiers in Immunology. 13, 19 p., 794776.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
In pursuit of biomarkers for predicting susceptibility to activity-based anorexia in adolescent female rats
Milton, L. K., Patton, T., O'Keeffe, M., Oldfield, B. J. & Foldi, C. J., May 2022, In: International Journal of Eating Disorders. 55, 5, p. 664-677 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development
Tian, L., Tomei, S., Schreuder, J., Weber, T. S., Amann-Zalcenstein, D., Lin, D. S., Tran, J., Audiger, C., Chu, M., Jarratt, A., Willson, T., Hilton, A., Pang, E. S., Patton, T., Kelly, M., Su, S., Gouil, Q., Diakumis, P., Bahlo, M., Sargeant, T. & 6 others, , 8 Jun 2021, In: Immunity. 54, 6, p. 1338-1351.e9 24 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Daptomycin-resistant Staphylococcus aureus clinical isolates are poorly sensed by dendritic cells
Patton, T., Jiang, J-H., Lundie, R. J., Bafit, M., Gao, W., Peleg, A. Y. & O'Keeffe, M., Jan 2020, In: Immunology and Cell Biology. 98, 1, p. 42-53 12 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation
Garcias López, A., Bekiaris, V., Müller Luda, K., Hütter, J., Ulmert, I., Getachew Muleta, K., Nakawesi, J., Kotarsky, K., Malissen, B., O'Keeffe, M., Holzmann, B., Winston Agace, W. & Lahl, K., Oct 2020, In: European Journal of Immunology. 50, 10, p. 1525-1536 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)
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Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member) & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
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Immunology and Cell Biology (Journal)
Meredith O'Keeffe (Editorial board member)
2016 → Dec 2021Activity: Publication peer-review and editorial work types › Editorial responsibility