Projects per year
Personal profile
Biography
Professor Menno van Zelm heads the Allergy and Clinical Immunology Laboratory in the Department of Immunology and Pathology at the Alfred Research Alliance (ARA) precinct.
Menno van Zelm performed his PhD studies at the Erasmus MC in Rotterdam, the Netherlands on "B cell development and primary antibody deficiencies" under supervision of Jacques van Dongen and Mirjam van der Burg. These studies resulted in new insights on stepwise human B cell differentiation in bone marrow, and on homeostatic and antigen-induced B cell proliferation with the newly developed KREC assay. Furthermore, Menno described the first antibody-deficient patients with CD19 gene defects. Between 2005 and 2007, he spent 18 months in the laboratory of Kees Murre at the University of California San Diego (UCSD) on the structural organization of the Ig heavy chain locus in developing B cells.
In 2008, Prof van Zelm returned to Rotterdam for postdoctoral studies on CD19-complex deficiencies and he identified the first CD81 deficiency. From 2009, he headed a research group in the Erasmus MC (since 2013 as Associate Professor and since 2022 as Full Professor), and works on the regulation of Ig repertoire formation in precursor-B-cell development and the generation of memory B cells and plasma cells. Most studies involve human material to allow direct translation to patient care. Current disease models include antibody deficiencies, vacination for viral infections (COVID19, influenza) and IgE-mediated allergies. He moved to Monash University in 2015.
Prof van Zelm has received multiple personal grants since 2009, including a Veni Fellowship from the Netherlands Organisation for Scientific Research (NWO). In 2010, he received the Heineken Young Scientists Award from the Royal Netherlands Academy of Sciences (KNAW).
Prof van Zelm is an academic editor for the international journals PLoS One, Frontiers in Immunology, and Immunotherapy Advances. He is chair of the IUIS Nomenclature committee and incoming president of the Human Cell Differentiation Molecules (HCDM) organisation that assigns new CD nomenclature and currently evaluates expression patterns of previously assigned CD markers in the CDMaps project.
Related Links:
- Allergy and Clinical Immunology laboratory www.med.monash.edu.au/immunology/research/vanzelm-lab.html
- Bibliography (Pubmed) www.ncbi.nlm.nih.gov/pubmed/?term=Van+Zelm+M
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary, Erasmus MC (Erasmus University Medical Center)
1 Aug 2015
Research area keywords
- B cell
- adaptive immunity
- immunological memory
- primary immunodeficiencies
- persistent virus
- Immune System
- Immune System Disorders
- Immunogenetics
- Immunology
- Immunopathology
- Immunophysiology
Network
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Development and standardization of assays for the functional validation of genetic variants in inborn errors of immunity
Edwards, E., Bosco, J. J., Ojaimi, S., Fok, J., Wong, N., van Zelm, M. & Hambleton, S.
17/04/23 → 16/04/25
Project: Research
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Quantification of antibody levels to SARS-CoV-2 in immunoglobulin replacement therapy products, and their capacity to augment immunity in immunodeficient patients.
Edwards, E., van Zelm, M., Ojaimi, S., Bosco, J. J., O'Hehir, R., Drummer, H., Hogarth, M., Daly, J. & Murphy, J.
Allergy and Immunology Foundation of Australasia
1/10/22 → 30/09/24
Project: Research
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Molecular dissection of allergen sensitisation and immunotherapy: direct application to precision medicine in treatment of asthma
van Zelm, M., O'Hehir, R., Wines, B. & Hew, M.
1/01/21 → 31/12/24
Project: Research
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Establishing a Jeffrey Modell Center in Melbourne, Australia.
van Zelm, M., Choo, S., Bosco, J. J., Slade, C., Bryant, V., Ojaimi, S., Barnes, S., Holdsworth, S., Gowdie, P., Douglass, J., Unglik, G., Richards, S., Smart, J. M., Mehr, S., Akikusa, J. D., Allen, R., Cole, T., Taranto, M., Stirling, R., Cameron, P. U., O'Hehir, R., Gugasyan, R., Masters, S. L. & Moghaddas, F.
19/10/17 → 19/10/23
Project: Research
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Clinical and Genetic Characterization of Patients with Artemis Deficiency in Japan
Inoue, K., Miyamoto, S., Tomomasa, D., Adachi, E., Azumi, S., Horikoshi, Y., Ishihara, T., Osone, S., Kawahara, Y., Kudo, K., Kato, Z., Ohnishi, H., Kashimada, K., Imai, K., Ohara, O., van Zelm, M. C., Cowan, M. J., Morio, T. & Kanegane, H., Apr 2023, In: Journal of Clinical Immunology. 43, 3, p. 585–594 10 p.Research output: Contribution to journal › Article › Research › peer-review
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Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2(Front. Immunol., (2022), 13, (889372), 10.3389/fimmu.2022.889372)
Wines, B. D., Kurtovic, L., Trist, H. M., Esparon, S., Lopez, E., Chappin, K., Chan, L. J., Mordant, F. L., Lee, W. S., Gherardin, N. A., Patel, S. K., Hartley, G. E., Pymm, P., Cooney, J. P., Beeson, J. G., Godfrey, D. I., Burrell, L. M., van Zelm, M. C., Wheatley, A. K., Chung, A. W., & 4 others , 10 Jan 2023, In: Frontiers in Immunology. 13, 2 p., 1122516.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Early increase in serum specific IgG2 upon allergen immunotherapy with a 300 IR sublingual house dust mite tablet
Berjont, N., Floch, V. B. L., O'Hehir, R. E., Canonica, W. G., van Zelm, M. C., Batard, T. & Mascarell, L., 2023, (Accepted/In press) In: Allergy. 4 p.Research output: Contribution to journal › Letter › Other › peer-review
Open Access -
Multiple sclerosis risk variants influence the peripheral B-cell compartment early in life in the general population
de Mol, C. L., van Luijn, M. M., Kreft, K. L., Looman, K. I. M., van Zelm, M. C., White, T., Moll, H. A., Smolders, J. & Neuteboom, R. F., Feb 2023, In: European Journal of Neurology. 30, 2, p. 434-442 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Altered leukocyte subsets and immune proteome indicate proinflammatory mechanisms in mastocytosis
Hermans, M. A. W., Heeringa, J. J., Swagemakers, S. G. A., Schrijver, B., van Daele, P. L. A., van der Spek, P. J., van Hagen, P. M., van Zelm, M. C. & Dik, W. A., 1 Jul 2022, In: The Journal of Allergy and Clinical Immunology. 150, 1, p. 146-156 21 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
Press/Media
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Multi-institutional consortium attracts $6.3 million MRFF grant to profile COVID-19 vaccine responses in our most vulnerable patient populations across the lifespan.
Gabriela Khoury, Menno van Zelm, Heidi Drummer, Benjamin Rogers & James McMahon
1/09/22
1 item of Media coverage
Press/Media: Profile/Interview