Projects per year
Personal profile
Biography
Associate Professor Menno van Zelm heads the B Cell Differentiation Laboratory in the Department of Immunology and Pathology at AMREP.
Menno van Zelm performed his PhD studies at the Erasmus MC in Rotterdam, the Netherlands on "B cell development and primary antibody deficiencies" under supervision of Jacques van Dongen and Mirjam van der Burg. These studies resulted in new insights on stepwise human B cell differentiation in bone marrow, and on homeostatic and antigen-induced B cell proliferation with the newly developed KREC assay. Furthermore, Menno described the first antibody-deficient patients with CD19 gene defects. Between 2005 and 2007, he spent 18 months in the laboratory of Kees Murre at the University of California San Diego (UCSD) on the structural organization of the Ig heavy chain locus in developing B cells.
In 2008, A/Prof van Zelm returned to Rotterdam for postdoctoral studies on CD19-complex deficiencies and he identified the first CD81 deficiency. From 2009, he headed a research group in the Erasmus MC (since 2013 as associate professor), and works on the regulation of Ig repertoire formation in precursor-B-cell development and the generation of memory B cells and plasma cells. Most studies involve human material to allow direct translation to patient care. Current disease models include antibody deficiencies, Down syndrome, persistent viral infections, auto-inflammatory diseases and IgE-mediated allergies. He moved to Monash University in 2015.
A/Prof van Zelm has received multiple personal grants since 2009, including a Veni Fellowship from the Netherlands Organisation for Scientific Research (NWO). In 2010, he received the Heineken Young Scientists Award from the Royal Netherlands Academy of Sciences (KNAW).
A/Prof van Zelm is an academic editor for the international journals PLoS One, Frontiers in Immunology, and Immunology and Cell Biology. He is vice chair of the IUIS Nomenclature committee and a council member of the Human Cell Differentiation Molecules (HCDM) organisation that assigns new CD nomenclature and currently evaluates expression patterns of previously assigned CD markers in the CDMaps project.
Related Links:
- B cell differentiation laboratory www.med.monash.edu.au/immunology/research/vanzelm-lab.html
- Bibliography (Pubmed) www.ncbi.nlm.nih.gov/pubmed/?term=Van+Zelm+M
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary, Erasmus MC (Erasmus University Medical Center)
1 Aug 2015
Research area keywords
- B cell
- adaptive immunity
- immunological memory
- primary immunodeficiencies
- persistent virus
- Immune System
- Immune System Disorders
- Immunogenetics
- Immunology
- Immunopathology
- Immunophysiology
Network
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Molecular dissection of allergen sensitisation and immunotherapy: direct application to precision medicine in treatment of asthma
van Zelm, M., O'Hehir, R., Wines, B. & Hew, M.
1/01/21 → 31/12/24
Project: Research
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NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system
Tarlinton, D., O'Hehir, R., Cooper, M., Peleg, A., Curtis, D., Dickins, R., van Zelm, M., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.
1/12/16 → 31/12/16
Project: Research
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NHMRC Equipment Grant - Amnis ImageStreamX Mark II Imaging Flow Cytometer (Mark II)
Tarlinton, D., Curtis, D., Guthridge, M. A., Jane, S., Medcalf, R., O'Hehir, R., Plebanski, M., Ting, S. & van Zelm, M.
National Health and Medical Research Council (NHMRC) (Australia)
1/12/15 → 31/12/15
Project: Research
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Advances in allergen-specific immune cell measurements for improved detection of allergic sensitization and immunotherapy responses
van Zelm, M. C., McKenzie, C. I., Varese, N., Rolland, J. M. & O’Hehir, R. E., Nov 2021, In: Allergy. 76, 11, p. 3374-3382 9 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency
Edwards, E. S. J., Bosco, J. J., Ojaimi, S., O’Hehir, R. E. & van Zelm, M. C., Mar 2021, In: Cellular & Molecular Immunology. 18, 3, p. 588-603 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access6 Citations (Scopus) -
Case Report: Infantile-Onset Fulminant Type 1 Diabetes Mellitus Caused by Novel Compound Heterozygous LRBA Variants
Totsune, E., Nakano, T., Moriya, K., Sato, D., Suzuki, D., Miura, A., Katayama, S., Niizuma, H., Kanno, J., van Zelm, M. C., Imai, K., Kanegane, H., Sasahara, Y. & Kure, S., 12 Apr 2021, In: Frontiers in Immunology. 12, 8 p., 677572.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Cell-density independent increased lymphocyte production and loss rates post-autologous hsct
Baliu-Piqué, M., van Hoeven, V., Drylewicz, J., van der Wagen, L. E., Janssen, A., Otto, S. A., van Zelm, M. C., de Boer, R. J., Kuball, J., Borghans, J. A. M. & Tesselaar, K., Feb 2021, In: eLife. 10, 22 p., e59775.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
CytoBas: Precision component-resolved diagnostics for allergy using flow cytometric staining of basophils with recombinant allergen tetramers
McKenzie, C. I., Varese, N., Aui, P. M., Wines, B. D., Hogarth, P. M., Thien, F., Hew, M., Rolland, J. M., O’Hehir, R. E. & van Zelm, M. C., Oct 2021, In: Allergy. 76, 10, p. 3028-3040 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)