Projects per year
Personal profile
Biography
Associate Professor Menno van Zelm heads the B Cell Differentiation Laboratory in the Department of Immunology and Pathology at AMREP.
Menno van Zelm performed his PhD studies at the Erasmus MC in Rotterdam, the Netherlands on "B cell development and primary antibody deficiencies" under supervision of Jacques van Dongen and Mirjam van der Burg. These studies resulted in new insights on stepwise human B cell differentiation in bone marrow, and on homeostatic and antigen-induced B cell proliferation with the newly developed KREC assay. Furthermore, Menno described the first antibody-deficient patients with CD19 gene defects. Between 2005 and 2007, he spent 18 months in the laboratory of Kees Murre at the University of California San Diego (UCSD) on the structural organization of the Ig heavy chain locus in developing B cells.
In 2008, A/Prof van Zelm returned to Rotterdam for postdoctoral studies on CD19-complex deficiencies and he identified the first CD81 deficiency. From 2009, he headed a research group in the Erasmus MC (since 2013 as associate professor), and works on the regulation of Ig repertoire formation in precursor-B-cell development and the generation of memory B cells and plasma cells. Most studies involve human material to allow direct translation to patient care. Current disease models include antibody deficiencies, Down syndrome, persistent viral infections, auto-inflammatory diseases and IgE-mediated allergies. He moved to Monash University in 2015.
A/Prof van Zelm has received multiple personal grants since 2009, including a Veni Fellowship from the Netherlands Organisation for Scientific Research (NWO). In 2010, he received the Heineken Young Scientists Award from the Royal Netherlands Academy of Sciences (KNAW).
A/Prof van Zelm is an academic editor for the international journals PLoS One, Frontiers in Immunology, and Immunology and Cell Biology. He is vice chair of the IUIS Nomenclature committee and a council member of the Human Cell Differentiation Molecules (HCDM) organisation that assigns new CD nomenclature and currently evaluates expression patterns of previously assigned CD markers in the CDMaps project.
Related Links:
- B cell differentiation laboratory www.med.monash.edu.au/immunology/research/vanzelm-lab.html
- Bibliography (Pubmed) www.ncbi.nlm.nih.gov/pubmed/?term=Van+Zelm+M
External positions
Honorary, Erasmus MC (Erasmus University Medical Center)
1 Aug 2015Research area keywords
- B cell
- adaptive immunity
- immunological memory
- primary immunodeficiencies
- persistent virus
- Immune System
- Immune System Disorders
- Immunogenetics
- Immunology
- Immunopathology
- Immunophysiology
Network
Projects
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Molecular dissection of allergen sensitisation and immunotherapy: direct application to precision medicine in treatment of asthma
van Zelm, M., O'Hehir, R., Wines, B. & Hew, M.
1/01/21 → 31/12/24
Project: Research
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NHMRC equipment grant - BD LSR Fortessa X20 Flow Cytometry system
Tarlinton, D., O'Hehir, R., Cooper, M., Peleg, A., Curtis, D., Dickins, R., van Zelm, M., Plebanski, M., Spencer, A., Hibbs, M., Wei, A., Guthridge, M. A. & Thomas, M.
1/12/16 → 31/12/16
Project: Research
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NHMRC Equipment Grant - Amnis ImageStreamX Mark II Imaging Flow Cytometer (Mark II)
Tarlinton, D., Curtis, D., Guthridge, M. A., Jane, S., Medcalf, R., O'Hehir, R., Plebanski, M., Ting, S. & van Zelm, M.
National Health and Medical Research Council (NHMRC) (Australia)
1/12/15 → 31/12/15
Project: Research
Research output
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A compendium answering 150 questions on COVID-19 and SARS-CoV-2
Riggioni, C., Comberiati, P., Giovannini, M., Agache, I., Akdis, M., Alves-Correia, M., Antó, J. M., Arcolaci, A., Azkur, A. K., Azkur, D., Beken, B., Boccabella, C., Bousquet, J., Breiteneder, H., Carvalho, D., De las Vecillas, L., Diamant, Z., Eguiluz-Gracia, I., Eiwegger, T., Eyerich, S. & 22 others, , Jul 2020, (Accepted/In press) In : Allergy. 39 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile17 Citations (Scopus) -
Associations of Th2, Th17, Treg cells, and IgA+ memory B cells with atopic disease in children: The Generation R Study
Looman, K. I. M., van Meel, E. R., Grosserichter-Wagener, C., Vissers, F. J. M., Klingenberg, J. H., de Jong, N. W., de Jongste, J. C., Pasmans, S. G. M. A., Duijts, L., van Zelm, M. C. & Moll, H. A., 1 Jan 2020, In : Allergy. 75, 1, p. 178-187 10 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency
Edwards, E. S. J., Bosco, J. J., Ojaimi, S., O’Hehir, R. E. & van Zelm, M. C., Aug 2020, (Accepted/In press) In : Cellular and Molecular Immunology. 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile -
Comel-Netherton syndrome: A local skin barrier defect in the absence of an underlying systemic immunodeficiency
Stuvel, K., Heeringa, J. J., Dalm, V. A. S. H., Meijers, R. W. J., van Hoffen, E., Gerritsen, S. A. M., van Zelm, M. C. & Pasmans, S. G. M. A., 1 Jul 2020, In : Allergy. 75, 7, p. 1710-1720 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency
Grosserichter-Wagener, C., Franco-Gallego, A., Ahmadi, F., Moncada-Vélez, M., Dalm, V. A. S. H., Rojas, J. L., Orrego, J. C., Correa Vargas, N., Hammarström, L., Schreurs, M. W. J., Dik, W. A., van Hagen, P. M., Boon, L., van Dongen, J. J. M., van der Burg, M., Pan-Hammarström, Q., Franco, J. L. & van Zelm, M. C., 1 May 2020, In : Clinical & Translational Immunology. 9, 5, 11 p., e1130.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile2 Citations (Scopus)