If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

My research intially focuses on investigating respiratory syncytial virus (RSV) infection, a leading cause of acute respiratory illness in infants, immunosuppressed adults and the elderly. Using high-resolution quantitative imaging, bioenergetics measurements and infectious assays, RSV's unque ability to co-opt host cell mitochondria to facilitate viral infection has been revealed. Agents that inhibit virus-induced changes on mitochondria strongly suppresses RSV virus production, including in a mouse model with reduced virus-induced lung inflammation. These findings establish the RSV-mitochondrial interface for the first time as a viable target for therapeutic intervention.

My research is now expanding to develop novel antiviral comouds targeting host factors from high-throughput screening as potential therapeutics for infectious diseases caused by lethal viruses (e.g., Dengue virus, Zika virus, west nile virus and other flaviviruses).  

Education/Academic qualification

Biochemistry and Molecular Biology, PhD, University of Melbourne

3 Nov 201412 Apr 2019

Biomedical Science, Masters, University of Melbourne

11 Mar 20116 Dec 2012

Science, Bachelor , University of Melbourne

8 Mar 200812 Dec 2010

Research area keywords

  • virus infection
  • host cell mitochondria
  • anti-viral

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2013 2019

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

Hu, M., Schulze, K. E., Ghildyal, R., Henstridge, D. C., Kolanowski, J. L., New, E. J., Hong, Y., Hsu, A. C., Hansbro, P. M., Wark, P. A., Bogoyevitch, M. A. & Jans, D. A., 27 Jun 2019, In : eLife. 8, 30 p., e42448.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production

Hu, M., Li, H-M., Bogoyevitch, M. A. & Jans, D. A., 5 Aug 2017, In : Biochemical and Biophysical Research Communications. 489, 4, p. 460-465 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival

Hu, M., Crawford, S. A., Henstridge, D. C., Ng, I. H. W., Boey, E. JH., Xu, Y., Febbraio, M. A., Jans, D. A. & Bogoyevitch, M. A., 2013, In : Biochemical Journal. 453, 3, p. 381-391 11 p.

Research output: Contribution to journalArticleResearchpeer-review