Melissa Southey

Accepting PhD Students

PhD projects

<a href="https://www.monash.edu/medicine/research/supervisorconnect" onclick="target='_blank';">https://www.monash.edu/medicine/research/supervisorconnect</a>

Research activity per year

Biography

Professor Melissa C. Southey, BSc (Hons, Pathology) PhD (Medicine), GradDip (Law), is a molecular geneticist (FHGSA) and a Founding Fellow of the Faculty of Science, Royal College of Pathologists of Australasia (FFSc, RCPA). She is Chair of Precision Medicine, School of Clinical Sciences at Monash Health, Director of Monash University’s new Biobanking Victoria initiative, based at the Monash Health Translation Precinct and Research Director of the Monash Partners Comprehensive Cancer Consortium.

Professor Southey’s research program has a population-based focus that has been pivotal to the establishment of large genetic epidemiological research resources that are now being utilized to address key questions in cancer research. Melissa is best known for her work with multiple-case cancer families and heritable risk factors that has provided the evidence base for best practice guidelines for the clinical management of individuals at high risk of the disease.

Professor Southey has led multidisciplinary teams in diagnostic and research settings in Australia and internationally, supported by programmatic awards from the European Commission, the National Institutes of Health (USA), NHMRC and The National Breast Cancer Foundation. She has co-authored more than 520 peer reviewed publications and has been namedin the Clarivate 2018 Highly Cited Researchers, ranking in the top 1% of researchers over the last 10 years. She actively participates on a number of national and international scientific advisory, governance and editorial bodies.

Biography

Please see Southeylab.org

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

External positions

Honorary Professorial Fellow, University of Melbourne

1 Jan 2019 → …

Senior Honorary Research Associate, Cancer Council Victoria

1 Jan 2013 → …

Research area keywords

Precision Medicine
Oncology
Familial Cancer
Epidemiology
Genomics
Biobanking

12 Active
23 Finished

Classification of SMAD4 pathogenic variants
Rosenbluh, S. (Primary Chief Investigator (PCI)), Southey, M. (Chief Investigator (CI)), Buchanan, D. (Chief Investigator (CI)) & Thompson, B. A. (Chief Investigator (CI))
Australian Functional Genomics Network
1/02/25 → 1/02/26
Project: Research
Integrating genetic and epigenetic data for prediction of prostate cancer aggressiveness and outcomes
Dugue, P.-A. (Primary Chief Investigator (PCI)), Southey, M. (Chief Investigator (CI)), Azad, A. (Chief Investigator (CI)), Giles, G. (Chief Investigator (CI)), Maclnnis, R. (Chief Investigator (CI)), Barlee, A. (Partner Investigator (PI)) & Cavill, S. (Partner Investigator (PI))
1/01/24 → 31/12/27
Project: Research
The One Water Consortium
Henry, R. (Primary Chief Investigator (PCI)), McCarthy, D. (Chief Investigator (CI)), Barker, F. (Chief Investigator (CI)), Powell, D. (Chief Investigator (CI)), Southey, M. (Chief Investigator (CI)), Leder, K. (Chief Investigator (CI)), Cottam, D. (Partner Investigator (PI)), Crosbie, N. (Partner Investigator (PI)), Poon, R. (Partner Investigator (PI)) & Sprink, T. (Partner Investigator (PI))
Monash University, Environment Protection Authority (trading as EPA Victoria) , Melbourne Water Corporation (MWC) (trading as Melbourne Water) (Victoria), Department of Health (DH) (Victoria)
30/06/23 → 6/09/28
Project: Research
Trial Integration of Polygenic Scores for Common Cancers into Standard Clinical Care
James, P. (Primary Chief Investigator (PCI)), Young, M. A. (Chief Investigator (CI)), Yanes, T. (Chief Investigator (CI)), Chenevix-Trench, G. (Chief Investigator (CI)), Fox, S. (Chief Investigator (CI)), Best, S. (Chief Investigator (CI)), Taylor, N. (Chief Investigator (CI)), Jackson, V. (Chief Investigator (CI)), Marfan, H. (Chief Investigator (CI)), Blackburn, J. (Chief Investigator (CI)), Willis, A. M. (Chief Investigator (CI)), Goranitis, I. (Chief Investigator (CI)), Terrill, B. N. (Chief Investigator (CI)), McLanders, M. (Chief Investigator (CI)) & Southey, M. (Chief Investigator (CI))
1/06/23 → 31/05/27
Project: Research
Determination of “actionable vaccine targets” for breast cancer immunotherapy
Faridi, P. (Primary Chief Investigator (PCI)), Dolcetti, R. (Chief Investigator (CI)), Purcell, A. (Associate Investigator (AI)), Mazzieri, R. (Associate Investigator (AI)) & Southey, M. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research

636 Article
22 Letter
20 Comment / Debate
15 Review Article
More

Body Size, Diet Quality, and Epigenetic Aging: Cross-Sectional and Longitudinal Analyses
Li, D. L., Hodge, A. M., Cribb, L., Southey, M. C., Giles, G. G., Milne, R. L. & Dugué, P. A., Apr 2024, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 79, 4, 10 p., glae026.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

10 Citations (Scopus)
Breast and bowel cancers diagnosed in people ‘too young to have cancer’: A blueprint for research using family and twin studies
Hopper, J. L., Li, S., MacInnis, R. J., Dowty, J. G., Nguyen, T. L., Bui, M., Dite, G. S., Esser, V. F. C., Ye, Z., Makalic, E., Schmidt, D. F., Goudey, B., Alpen, K., Kapuscinski, M., Win, A. K., Dugué, P. A., Milne, R. L., Jayasekara, H., Brooks, J. D. & Malta, S. & 11 others, Calais-Ferreira, L., Campbell, A. C., Young, J. T., Nguyen-Dumont, T., Sung, J., Giles, G. G., Buchanan, D., Winship, I., Terry, M. B., Southey, M. C. & Jenkins, M. A., Dec 2024, In: Genetic Epidemiology. 48, 8, p. 433-447 15 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
Causation and familial confounding as explanations for the associations of polygenic risk scores with breast cancer: Evidence from innovative ICE FALCON and ICE CRISTAL analyses
Li, S., Dite, G. S., MacInnis, R. J., Bui, M., Nguyen, T. L., Esser, V. F. C., Ye, Z., Dowty, J. G., Makalic, E., Sung, J., Giles, G. G., Southey, M. C. & Hopper, J. L., Dec 2024, In: Genetic Epidemiology. 48, 8, p. 401-413 13 p.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

2 Citations (Scopus)
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Chen, Z., Guo, X., Tao, R., Huyghe, J. R., Law, P. J., Fernandez-Rozadilla, C., Ping, J., Jia, G., Long, J., Li, C., Shen, Q., Xie, Y., Timofeeva, M. N., Thomas, M., Schmit, S. L., Díez-Obrero, V., Devall, M., Moratalla-Navarro, F., Fernandez-Tajes, J. & Palles, C. & 185 others, Sherwood, K., Briggs, S. E. W., Svinti, V., Donnelly, K., Farrington, S. M., Blackmur, J., Vaughan-Shaw, P. G., Shu, X. O., Lu, Y., Broderick, P., Studd, J., Harrison, T. A., Conti, D. V., Schumacher, F. R., Melas, M., Rennert, G., Obón-Santacana, M., Martín-Sánchez, V., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S. S., Shin, M. H., Shin, A., Ahn, Y. O., Kim, D. H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y. T., Jia, W. H., Hopper, J. L., Jenkins, M. A., Win, A. K., Pai, R. K., Figueiredo, J. C., Haile, R. W., Gallinger, S., Woods, M. O., Newcomb, P. A., Duggan, D., Cheadle, J. P., Kaplan, R., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, J. P., Jousilahti, P., Knekt, P., Aaltonen, L. A., Rissanen, H., Pukkala, E., Eriksson, J. G., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Männistö, S., Albanes, D., Weinstein, S. J., Ruiz-Narvaez, E., Palmer, J. R., Buchanan, D. D., Platz, E. A., Visvanathan, K., Ulrich, C. M., Siegel, E., Brezina, S., Gsur, A., Campbell, P. T., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M. L., Potter, J. D., Tsilidis, K. K., Schulze, M. B., Gunter, M. J., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Bishop, D. T., Giles, G. G., Southey, M. C., Idos, G. E., McDonnell, K. J., Abu-Ful, Z., Greenson, J. K., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y. R., Steinfelder, R., Keku, T. O., van Guelpen, B., Hudson, T. J., Hampel, H., Pearlman, R., Berndt, S. I., Hayes, R. B., Martinez, M. E., Thomas, S. S., Pharoah, P. D. P., Larsson, S. C., Yen, Y., Lenz, H. J., White, E., Li, L., Doheny, K. F., Pugh, E., Shelford, T., Chan, A. T., Cruz-Correa, M., Lindblom, A., Hunter, D. J., Joshi, A. D., Schafmayer, C., Scacheri, P. C., Kundaje, A., Schoen, R. E., Hampe, J., Stadler, Z. K., Vodicka, P., Vodickova, L., Vymetalkova, V., Edlund, C. K., Gauderman, W. J., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S. J., van Duijnhoven, F., Feskens, E. J. M., Sakoda, L. C., Gago-Dominguez, M., Wolk, A., Pardini, B., FitzGerald, L. M., Lee, S. C., Ogino, S., Bien, S. A., Kooperberg, C., Li, C. I., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Yamaji, T., Sawada, N., Iwasaki, M., Le Marchand, L., Wu, A. H., Qu, C., McNeil, C. E., Coetzee, G., Hayward, C., Deary, I. J., Harris, S. E., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Lau, K. S., Zhao, H., Hsu, L., Cai, Q., Dunlop, M. G., Gruber, S. B., Houlston, R. S., Moreno, V., Casey, G., Peters, U., Tomlinson, I. & Zheng, W., 26 Apr 2024, In: Nature Communications. 15, 1, 17 p., 3557.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

4 Citations (Scopus)
Genetic and environmental causes of variation in an automated breast cancer risk factor based on mammographic textures
Ye, Z., Dite, G. S., Nguyen, T. L., MacInnis, R. J., Schmidt, D. F., Makalic, E., Al-Qershi, O. M., Nguyen-Dumont, T., Goudey, B., Stone, J., Dowty, J. G., Giles, G. G., Southey, M. C., Hopper, J. L. & Li, S., 1 Feb 2024, In: Cancer Epidemiology, Biomarkers and Prevention. 33, 2, p. 306-313 8 p.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Melissa Southey

Personal profile

Biography

Biography

Expertise related to UN Sustainable Development Goals

External positions

Research area keywords

Collaborations and top research areas from the last five years

Dive into details

Classification of SMAD4 pathogenic variants

Integrating genetic and epigenetic data for prediction of prostate cancer aggressiveness and outcomes

The One Water Consortium

Trial Integration of Polygenic Scores for Common Cancers into Standard Clinical Care

Determination of “actionable vaccine targets” for breast cancer immunotherapy

Body Size, Diet Quality, and Epigenetic Aging: Cross-Sectional and Longitudinal Analyses

Breast and bowel cancers diagnosed in people ‘too young to have cancer’: A blueprint for research using family and twin studies

Causation and familial confounding as explanations for the associations of polygenic risk scores with breast cancer: Evidence from innovative ICE FALCON and ICE CRISTAL analyses

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

Genetic and environmental causes of variation in an automated breast cancer risk factor based on mammographic textures

Melissa Southey

Personal profile

Biography

Biography

Expertise related to UN Sustainable Development Goals

External positions

Research area keywords

Collaborations and top research areas from the last five years

Projects

Research output