Projects per year
Personal profile
Biography
Professor Melissa C. Southey, BSc (Hons, Pathology) PhD (Medicine), GradDip (Law), is a molecular geneticist (FHGSA) and a Founding Fellow of the Faculty of Science, Royal College of Pathologists of Australasia (FFSc, RCPA). She is Chair of Precision Medicine, School of Clinical Sciences at Monash Health, Director of Monash University’s new Biobanking Victoria initiative, based at the Monash Health Translation Precinct and Research Director of the Monash Partners Comprehensive Cancer Consortium.
Professor Southey’s research program has a population-based focus that has been pivotal to the establishment of large genetic epidemiological research resources that are now being utilized to address key questions in cancer research. Melissa is best known for her work with multiple-case cancer families and heritable risk factors that has provided the evidence base for best practice guidelines for the clinical management of individuals at high risk of the disease.
Professor Southey has led multidisciplinary teams in diagnostic and research settings in Australia and internationally, supported by programmatic awards from the European Commission, the National Institutes of Health (USA), NHMRC and The National Breast Cancer Foundation. She has co-authored more than 520 peer reviewed publications and has been namedin the Clarivate 2018 Highly Cited Researchers, ranking in the top 1% of researchers over the last 10 years. She actively participates on a number of national and international scientific advisory, governance and editorial bodies.
Biography
Please see Southeylab.org
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Professorial Fellow, University of Melbourne
1 Jan 2019 → …
Senior Honorary Research Associate, Cancer Council Victoria
1 Jan 2013 → …
Research area keywords
- Precision Medicine
- Oncology
- Familial Cancer
- Epidemiology
- Genomics
- Biobanking
Collaborations and top research areas from the last five years
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Classification of SMAD4 pathogenic variants
Rosenbluh, S. (Primary Chief Investigator (PCI)), Southey, M. (Chief Investigator (CI)), Buchanan, D. (Chief Investigator (CI)) & Thompson, B. A. (Chief Investigator (CI))
Australian Functional Genomics Network
1/02/25 → 1/02/26
Project: Research
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Integrating genetic and epigenetic data for prediction of prostate cancer aggressiveness and outcomes
Dugue, P.-A. (Primary Chief Investigator (PCI)), Southey, M. (Chief Investigator (CI)), Azad, A. (Chief Investigator (CI)), Giles, G. (Chief Investigator (CI)), Maclnnis, R. (Chief Investigator (CI)), Barlee, A. (Partner Investigator (PI)) & Cavill, S. (Partner Investigator (PI))
1/01/24 → 31/12/27
Project: Research
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The One Water Consortium
Henry, R. (Primary Chief Investigator (PCI)), McCarthy, D. (Chief Investigator (CI)), Barker, F. (Chief Investigator (CI)), Powell, D. (Chief Investigator (CI)), Southey, M. (Chief Investigator (CI)), Leder, K. (Chief Investigator (CI)), Cottam, D. (Partner Investigator (PI)), Crosbie, N. (Partner Investigator (PI)), Poon, R. (Partner Investigator (PI)) & Sprink, T. (Partner Investigator (PI))
Monash University, Environment Protection Authority (trading as EPA Victoria) , Melbourne Water Corporation (MWC) (trading as Melbourne Water) (Victoria), Department of Health (DH) (Victoria)
30/06/23 → 6/09/28
Project: Research
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Trial Integration of Polygenic Scores for Common Cancers into Standard Clinical Care
James, P. (Primary Chief Investigator (PCI)), Young, M. A. (Chief Investigator (CI)), Yanes, T. (Chief Investigator (CI)), Chenevix-Trench, G. (Chief Investigator (CI)), Fox, S. (Chief Investigator (CI)), Best, S. (Chief Investigator (CI)), Taylor, N. (Chief Investigator (CI)), Jackson, V. (Chief Investigator (CI)), Marfan, H. (Chief Investigator (CI)), Blackburn, J. (Chief Investigator (CI)), Willis, A. M. (Chief Investigator (CI)), Goranitis, I. (Chief Investigator (CI)), Terrill, B. N. (Chief Investigator (CI)), McLanders, M. (Chief Investigator (CI)) & Southey, M. (Chief Investigator (CI))
1/06/23 → 31/05/27
Project: Research
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Determination of “actionable vaccine targets” for breast cancer immunotherapy
Faridi, P. (Primary Chief Investigator (PCI)), Dolcetti, R. (Chief Investigator (CI)), Purcell, A. (Associate Investigator (AI)), Mazzieri, R. (Associate Investigator (AI)) & Southey, M. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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Body Size, Diet Quality, and Epigenetic Aging: Cross-Sectional and Longitudinal Analyses
Li, D. L., Hodge, A. M., Cribb, L., Southey, M. C., Giles, G. G., Milne, R. L. & Dugué, P. A., Apr 2024, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 79, 4, 10 p., glae026.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Breast and bowel cancers diagnosed in people ‘too young to have cancer’: A blueprint for research using family and twin studies
Hopper, J. L., Li, S., MacInnis, R. J., Dowty, J. G., Nguyen, T. L., Bui, M., Dite, G. S., Esser, V. F. C., Ye, Z., Makalic, E., Schmidt, D. F., Goudey, B., Alpen, K., Kapuscinski, M., Win, A. K., Dugué, P. A., Milne, R. L., Jayasekara, H., Brooks, J. D. & Malta, S. & 11 others, , Dec 2024, In: Genetic Epidemiology. 48, 8, p. 433-447 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Causation and familial confounding as explanations for the associations of polygenic risk scores with breast cancer: Evidence from innovative ICE FALCON and ICE CRISTAL analyses
Li, S., Dite, G. S., MacInnis, R. J., Bui, M., Nguyen, T. L., Esser, V. F. C., Ye, Z., Dowty, J. G., Makalic, E., Sung, J., Giles, G. G., Southey, M. C. & Hopper, J. L., Dec 2024, In: Genetic Epidemiology. 48, 8, p. 401-413 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Chen, Z., Guo, X., Tao, R., Huyghe, J. R., Law, P. J., Fernandez-Rozadilla, C., Ping, J., Jia, G., Long, J., Li, C., Shen, Q., Xie, Y., Timofeeva, M. N., Thomas, M., Schmit, S. L., Díez-Obrero, V., Devall, M., Moratalla-Navarro, F., Fernandez-Tajes, J. & Palles, C. & 185 others, , 26 Apr 2024, In: Nature Communications. 15, 1, 17 p., 3557.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Genetic and environmental causes of variation in an automated breast cancer risk factor based on mammographic textures
Ye, Z., Dite, G. S., Nguyen, T. L., MacInnis, R. J., Schmidt, D. F., Makalic, E., Al-Qershi, O. M., Nguyen-Dumont, T., Goudey, B., Stone, J., Dowty, J. G., Giles, G. G., Southey, M. C., Hopper, J. L. & Li, S., 1 Feb 2024, In: Cancer Epidemiology, Biomarkers and Prevention. 33, 2, p. 306-313 8 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)