1990 …2024

Research output per year

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Personal profile


Professor Melissa C. Southey, BSc (Hons, Pathology) PhD (Medicine), GradDip (Law), is a molecular geneticist (FHGSA) and a Founding Fellow of the Faculty of Science, Royal College of Pathologists of Australasia (FFSc, RCPA). She is Chair of Precision Medicine, School of Clinical Sciences at Monash Health, Director of Monash University’s new Biobanking Victoria initiative, based at the Monash Health Translation Precinct and Research Director of the Monash Partners Comprehensive Cancer Consortium.

Professor Southey’s research program has a population-based focus that has been pivotal to the establishment of large genetic epidemiological research resources that are now being utilized to address key questions in cancer research.  Melissa is best known for her work with multiple-case cancer families and heritable risk factors that has provided the evidence base for best practice guidelines for the clinical management of individuals at high risk of the disease.

Professor Southey has led multidisciplinary teams in diagnostic and research settings in Australia and internationally, supported by programmatic awards from the European Commission, the National Institutes of Health (USA), NHMRC and The National Breast Cancer Foundation. She has co-authored more than 520 peer reviewed publications and has been namedin the Clarivate 2018 Highly Cited Researchers, ranking in the top 1% of researchers over the last 10 years.  She actively participates on a number of national and international scientific advisory, governance and editorial bodies.


Please see Southeylab.org

External positions

Honorary Professorial Fellow, University of Melbourne

1 Jan 2019 → …

Senior Honorary Research Associate, Cancer Council Victoria

1 Jan 2013 → …

Research area keywords

  • Precision Medicine
  • Oncology
  • Familial Cancer
  • Epidemiology
  • Genomics
  • Biobanking

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


Heritable methylation marks associated with colorectal cancer risk

Dowty, J. G., Buchanan, D. D., Winship, I., Waterland, R., Joo, J. H. E., Jenkins, M. & Southey, M.

Cancer Council Victoria


Project: Research

Research Output

Overall lack of replication of associations between dietary intake of folate and vitamin B-12 and DNA methylation in peripheral blood

Dugué, P-A., Chamberlain, J. A., Bassett, J. K., Hodge, A. M., Brinkman, M. T., Joo, J. H. E., Jung, C. H., Wong, E. M., Makalic, E., Schmidt, D. F., Hopper, J. L., Buchanan, D. D., English, D. R., Milne, R. L., Southey, M. C. & Giles, G. G., 1 Jan 2020, In : American Journal of Clinical Nutrition. 111, 1, p. 228-230 3 p.

Research output: Contribution to journalLetterOtherpeer-review

PALB2 Genetic Variants: Can Functional Assays Assist Translation?

Southey, M. C., Rewse, A. & Nguyen-Dumont, T., Apr 2020, In : Trends In Cancer. 6, 4, p. 263-265 3 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Palm reading and water divining: A cross-sectional study of the accuracy of palmar hyperlinearity and transepidermal water loss to identify individuals with a filaggrin gene null mutation

Lowe, A. J., Lee, B., Orchard, D., King, E., Abramson, M. J., Allen, K. J., Hui, J., Southey, M. C., Lodge, C. J. & Dharmage, S. C., 14 Feb 2020, (Accepted/In press) In : Journal of the American Academy of Dermatology. 3 p.

Research output: Contribution to journalLetterOtherpeer-review

Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility

Dugué, P-A., Jung, C-H., Joo, J. E., Wang, X., Wong, E. M., Makalic, E., Schmidt, D. F., Baglietto, L., Severi, G., Southey, M. C., English, D. R., Giles, G. G. & Milne, R. L., 2 Apr 2020, In : Epigenetics. 15, 4, p. 358-368 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

10-year performance of four models of breast cancer risk: a validation study

Terry, M. B., Liao, Y., Whittemore, A. S., Leoce, N., Buchsbaum, R., Zeinomar, N., Dite, G. S., Chung, W. K., Knight, J. A., Southey, M. C., Milne, R. L., Goldgar, D., Giles, G. G., McLachlan, S. A., Friedlander, M. L., Weideman, P. C., Glendon, G., Nesci, S., Andrulis, I. L., John, E. M. & 5 others, Phillips, K. A., Daly, M. B., Buys, S. S., Hopper, J. L. & MacInnis, R. J., 1 Apr 2019, In : The Lancet Oncology. 20, 4, p. 504-517 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)