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Research Output 2001 2019

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Article

Nutritional supplements for diabetes: Preface

Coughlan, M. T., 1 Apr 2018, In : Journal of Nutrition and Intermediary Metabolism.

Research output: Contribution to journalArticleOther

Obesity associated advanced glycation end products within the human uterine cavity adversely impact endometrial function and embryo implantation competence

Antoniotti, G. S., Coughlan, M., Salamonsen, L. A. & Evans, J., 1 Apr 2018, In : Human Reproduction. 33, 4, p. 654-665 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

Borg, D. J., Yap, F. Y. T., Keshvari, S., Simmons, D. G., Gallo, L. A., Fotheringham, A. K., Zhuang, A., Slattery, R. M., Hasnain, S. Z., Coughlan, M. T., Kantharidis, P. & Forbes, J. M., 2 Jan 2018, In : Islets. 10, 1, p. 10-24 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Zhuang, A., Yap, F. Y., Bruce, C., Leung, C., Plan, M. R., Sullivan, M. A., Herath, C. B., McCarthy, D., Sourris, K. C., Kantharidis, P., Coughlan, M. T., Febbraio, M. A., Hodson, M. P., Watt, M. J., Angus, P., Schulz, B. L. & Forbes, J. M., 1 Dec 2017, In : Scientific Reports. 7, 1, 12292.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NADPH oxidase Nox5 accelerates renal injury in diabetic nephropathy

Jha, J. C., Banal, C., Okabe, J., Gray, S. P., Hettige, T., Chow, B. S. M., Thallas-Bonke, V., Vos, L. D., Holterman, C. E., Coughlan, M. T., Power, D. A., Skene, A., Ekinci, E. I., Cooper, M. E., Touyz, R. M., Kennedy, C. R. & Jandeleit-Dahm, K., 1 Oct 2017, In : Diabetes. 66, 10, p. 2691-2703 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Can targeting the incretin pathway dampen RAGE-mediated events in diabetic nephropathy?

Sourris, K. C., Yao, H., Jerums, G., Cooper, M. E., Ekinci, E. I. & Coughlan, M. T., 1 Sep 2016, In : Current Drug Targets. 17, 11, p. 1252-1264 13 p.

Research output: Contribution to journalArticleOtherpeer-review

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

Coughlan, M. T., Higgins, G. C., Nguyen, T-V., Penfold, S. A., Thallas-Bonke, V., Tan, S. M., Ramm, G., Van Bergen, N. J., Henstridge, D. C., Sourris, K. C., Harcourt, B. E., Trounce, I. A., Robb, P. M., Laskowski, A., McGee, S. L., Genders, A. J., Walder, K., Drew, B. G., Gregorevic, P., Qian, H. & 13 othersThomas, M. C., Jerums, G., Macisaac, R. J., Skene, A., Power, D. A., Ekinci, E. I., Wijeyeratne, X. W., Gallo, L. A., Herman-Edelstein, M., Ryan, M. T., Cooper, M. E., Thorburn, D. R. & Forbes, J. M., Apr 2016, In : Diabetes. 65, 4, p. 1085-1098 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Coughlan, M. T., Nguyen, T. V., Penfold, S. A., Higgins, G. C., Thallas-Bonke, V., Tan, S. M., Van Bergen, N. J., Sourris, K. C., Harcourt, B. E., Thorburn, D. R., Trounce, I. A., Cooper, M. E. & Forbes, J. M., 1 May 2016, In : Clinical Science. 130, 9, p. 711-720 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Effect of diet-derived advanced glycation end products on inflammation

Kellow, N. J. & Coughlan, M. T., 2015, In : Nutrition Reviews. 73, 11 (nuv030), p. 737 - 759 23 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

Forbes, J. M., Sourris, K., De Courten, M. P. J., Dougherty, S. L., Chand, V., Lyons, J., Bertovic, D. A., Coughlan, M. T., Schlaich, M. P., Soldatos, G., Cooper, M. E., Straznicky, N., Kingwell, B. A. & de Courten, B., 2014, In : Amino Acids. 46, 2, p. 321 - 326 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials

Kellow, N., Coughlan, M. T. & Reid, C. M., 2014, In : British Journal of Nutrition. 111, 7, p. 1147 - 1161 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

Higgins, G. C. & Coughlan, M. T., 2014, In : British Journal of Pharmacology. 171, 8, p. 1917 - 1942 26 p.

Research output: Contribution to journalArticleResearchpeer-review

Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy

Thallas-Bonke, V., Jha, J. C., Gray, S. P., Barit, D., Haller, H., Schmidt, H. H. H. W., Coughlan, M. T., Cooper, M. E., Forbes, J. M. & Jandeleit-Dahm, K. A. M., 2014, In : Physiological Reports. 2, 11, 13 p., e12192.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

Fukami, K., Yamagishi, S., Coughlan, M. T., Harcourt, B. E., Kantharidis, P., Thallas-Bonke, V., Okuda, S., Cooper, M. E. & Forbes, J. M., 2014, In : Diabetology and Metabolic Syndrome. 6, p. 1 - 9 9 p., 86.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013

Advanced glycation end products augment experimental hepatic fibrosis

Goodwin, M., Herath, C. B., Zhiyuan, J., Leung, C., Coughlan, M. T., Forbes, J. M. & Angus, P. W., 2013, In : Journal of Gastroenterology and Hepatology. 28, 2, p. 369 - 376 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease

Forbes, J. M., Ke, B-X., Nguyen, T. V., Henstridge, D. C., Penfold, S. A., Laskowski, A., Sourris, K., Groschner, L. N., Cooper, M., Thorburn, D. R. & Coughlan, M. T., 2013, In : Antioxidants and Redox Signaling. 19, 4, p. 331-343 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucose homeostasis can be differentially modulated by varying individual components of a western diet

Forbes, J. M., Cowan, S. P., Andrikopoulos, S., Morley, A. L., Ward, L. C., Walker, K. Z., Cooper, M. & Coughlan, M. T., 2013, In : Journal of Nutritional Biochemistry. 24, 7, p. 1251 - 1257 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content

Thallas-Bonke, V., Coughlan, M. T., Tan, A., Harcourt, B. E., Morgan, P. E., Davies, M. J., Bach, L. A., Cooper, M. & Forbes, J. M., 2013, In : Nephrology. 18, 1, p. 47 - 56 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Advanced glycation end products as environmental risk factors for the development of type 1 diabetes

Yap, F., Kantharidis, P., Coughlan, M. T., Slattery, R. M. & Forbes, J. M., 2012, In : Current Drug Targets. 13, 4, p. 526 - 540 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

Sourris, K. C., Harcourt, B. E., Tang, P., Morley, A., Huynh, K., Penfold, S. A., Coughlan, M. T., Cooper, M. E., Nguyen, T-V., Ritchie, R. H. & Forbes, J. M., 2012, In : Free Radical Biology and Medicine. 52, 3, p. 716 - 723 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Advanced glycation end products are direct modulators of beta-cell function

Coughlan, M. T., Yap, F., Tong, D., Andrikopoulos, S., Gasser, A., Thallas-Bonke, V., Webster, D., Miyazaki, J., Kay, T., Slattery, R., Kaye, D., Drew, B., Kingwell, B., Fourlanos, S., Groop, P-H., Harrison, L., Knip, M. & Forbes, J., 2011, In : Diabetes. 60, 10, p. 2523 - 2532 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man

Coughlan, M. T., Patel, S. K., Jerums, G., Penfold, S. A., Nguyen, T. V., Sourris, K. C., Panagiotopoulos, S., Srivastava, P. M., Cooper, M. E., Burrell, L. M., MacIsaac, R. J. & Forbes, J. M., Oct 2011, In : American Journal of Nephrology. 34, 4, p. 347-355 9 p.

Research output: Contribution to journalArticleResearchpeer-review

MiR-200a prevents renal fibrogenesis through repression of TGF-β2 expression

Wang, B., Koh, P., Winbanks, C., Coughlan, M. T., McClelland, A., Watson, A., Jandeleit-Dahm, K., Burns, W. C., Thomas, M. C., Cooper, M. E. & Kantharidis, P., Jan 2011, In : Diabetes. 60, 1, p. 280-287 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

Forbes, J., Soderlund, J., Yap, F., Knip, M., Andrikopoulos, S., Ilonen, J., Simell, O., Veijola, R., Sourris, K., Coughlan, M. T., Forsblom, C., Slattery, R. M., Grey, S., Wessman, M., Yamamoto, H., Bierhaus, A., Cooper, M. & Groop, P., 2011, In : Diabetologia. 54, 5, p. 1032 - 1042 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted reduction of advanced glycation improves renal function in obesity

Harcourt, B., Sourris, K., Coughlan, M. T., Walker, K., Dougherty, S., Andrikopoulos, S., Morley, A., Thallas-Bonke, V., Chand, V., Penfold, S., De Courten, M. P. J., Thomas, M., Kingwell, B., Bierhaus, A., Cooper, M., de Courten, B. & Forbes, J., 2011, In : Kidney International. 80, 2, p. 190 - 198 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes

Coughlan, M. T. & Forbes, J. M., 2011, In : American Journal of Nephrology. 34, 1, p. 9 - 17 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase

Soro-Paavonen, A., Zhang, W. Z., Venardos, K., Coughlan, M. T., Harris, E., Tong, D. C. K., Brasacchio, D., Paavonen, K., Chin-Dusting, J., Cooper, M. E., Kaye, D., Thomas, M. C. & Forbes, J. M., Apr 2010, In : Journal of Hypertension. 28, 4, p. 780-788 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse

Chew, P., Yuen, D., Stefanovic, N., Pete, J., Coughlan, M. T., Jandeleit-Dahm, K., Thomas, M., Rosenfeldt, F., Cooper, M. & De Haan, J. B., 2010, In : Diabetes. 59, 12, p. 3198-3207 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy

Penfold, S. A., Coughlan, M. T., Patel, S. K., Srivastava, P. M., Sourris, K. C., Steer, D., Webster, D., Thomas, M. C., MacIsaac, R. J., Jerums, G., Burrell, L. M., Cooper, M. E. & Forbes, J. M., 2010, In : Kidney International. 78, 3, p. 287 - 295 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy

Tan, A., Sourris, K. C., Harcourt, B. E., Thallas-Bonke, V., Penfold, S. A., Andrikopoulos, S., Thomas, M. C., O'Brien, R. C., Bierhaus, A., Cooper, M., Forbes, J. M. & Coghlan, M. T., 2010, In : American Journal of Physiology - Renal Physiology. 298, 3, p. F763 - F770 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy

Thallas-Bonke, V., Coughlan, M. T., Bach, L., Cooper, M. & Forbes, J., 2010, In : American Journal of Nephrology. 32, 1, p. 73 - 82 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor

Sourris, K. C., Morley, A. L., Koitka, A., Samuel, P., Coughlan, M. T., Penfold, S. A., Thomas, M. C., Bierhaus, A., Nawroth, P. P., Yamamoto, H., Allen, T. J., Walther, T., Hussain, T., Cooper, M. & Forbes, J. M., 2010, In : Diabetologia. 53, p. 2442 - 2451 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Rage-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes

Coughlan, M. T., Thorburn, D. R., Penfold, S. A., Laskowski, A., Harcourt, B. E., Sourris, K. C., Tan, A. L. Y., Fukami, K., Thallas-Bonke, V., Nawroth, P. P., Brownlee, M., Bierhaus, A., Cooper, M. E. & Forbes, J. M., Apr 2009, In : Journal of the American Society of Nephrology. 20, 4, p. 742-752 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: Health In Men Study

Norman, P. E., Davis, W. A., Coughlan, M. T., Forbes, J. M., Golledge, J. & Davis, T. M. E., Sep 2009, In : Journal of Vascular Surgery. 50, 3, p. 626-631 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs

Tikellis, C., Thomas, M. C., Harcourt, B. E., Coughlan, M. T., Pete, J., Bialkowski, K., Tan, A., Bierhaus, A., Cooper, M. E. & Forbes, J. M., Aug 2008, In : American Journal of Physiology - Endocrinology and Metabolism. 295, 2, p. 323-330 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway

Thallas-Bonke, V., Thorpe, S. R., Coughlan, M. T., Fukami, K., Yap, F., Sourris, K. C., Penfold, S. A., Bach, L. A., Cooper, M. E. & Forbes, J. M., 2008, In : Diabetes. 57, 2, p. 460 - 469 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress as a major culprit in kidney disease in diabetes

Forbes, J. M., Coughlan, M. T. & Cooper, M. E., 2008, In : Diabetes. 57, 6, p. 1446 - 1454 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes

Soro-Paavonen, A., Watson, A. M. D., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., Thomas, M., Forbes, J. M., Nawroth, P. P., Bierhaus, A., Cooper, M. E. & Jandeleit-Dahm, K. A., 1 Sep 2008, In : Diabetes. 57, 9, p. 2461-2469 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties

Hoang, A., Murphy, A. J., Coughlan, M. T., Thomas, M. C., Forbes, J. M., O'Brien, R., Cooper, M. E., Chin-Dusting, J. P. F. & Sviridov, D., 1 Aug 2007, In : Diabetologia. 50, 8, p. 1770-1779 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: Synergy or redundancy?

Coughlan, M. T., Thallas-Bonke, V., Pete, J., Long, D. M., Gasser, A., Tong, D. C. K., Arnstein, M., Thorpe, S. R., Cooper, M. E. & Forbes, J. M., 1 Feb 2007, In : Endocrinology. 148, 2, p. 886-895 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes

Coughlan, M. T., Forbes, J. M. & Cooper, M. E., 1 Aug 2007, In : Kidney International. 72, SUPPL. 106, p. S54-S60 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Can advanced glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?

Coughlan, M. T., Cooper, M. E. & Forbes, J. M., 1 Jan 2005, In : Annals of the New York Academy of Sciences. 1043, p. 750-758 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Interactions between renin angiotensin system and advanced glycation in the kidney

Thomas, M. C., Tikellis, C., Burns, W. C., Bialkowski, K., Cao, Z. M., Coughlan, M. T., Jandeleit-Dahm, K., Cooper, M. E. & Forbes, J. M., 1 Dec 2005, In : Journal of the American Society of Nephrology. 16, 10, p. 2976-2984 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Altered placental oxidative stress status in gestational diabetes mellitus

Coughlan, M. T., Vervaart, P. P., Permezel, M., Georgiou, H. M. & Rice, G. E., 1 Jan 2004, In : Placenta. 25, 1, p. 78-84 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Repression of oxidant-induced nuclear factor-κB activity mediates placental cytokine responses in gestational diabetes

Coughlan, M. T., Permezel, M., Georgiou, H. M. & Rice, G. E., 1 Jul 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 7, p. 3585-3594 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Glucose-induced release of tumour necrosis factor-alpha from human placental and adipose tissues in gestational diabetes mellitus

Coughlan, M. T., Oliva, K., Georgiou, H. M., Permezel, J. M. H. & Rice, G. E., 1 Dec 2001, In : Diabetic Medicine. 18, 11, p. 921-927 7 p.

Research output: Contribution to journalArticleResearchpeer-review