Personal profile
Biography
Professor Melinda Coughlan has a BSc (Biology) with Honours in Nutrition from Deakin University, and a PhD in Metabolism from the University of Melbourne. Her PhD focused on mediators of inflammation and oxidative stress in the development of gestational diabetes (Mercy Hospital for Women). After completing her PhD, Melinda joined the Baker Heart Research Institute as a postdoctoral researcher in Prof Mark Cooper’s Diabetes Complications Division. In 2012, she became the Head of the Glycation, Nutrition and Metabolism Laboratory at the Baker IDI Heart and Diabetes Institute. In Nov 2016, she was recruited to Monash University’s School of Translational Medicine as one of the key recruits to help establish the Department of Diabetes. Professor Coughlan has recently held a REDI Fellowship from the MRFF partnering with AstraZeneca Cambridge, and has research grants from the NHMRC, JDRF and Diabetes Australia.
Research interests
Dietary factors in the initiation of diabetes and its complications:
- Incretin (GLP-1) pathway signaling
- Advanced glycation end-products (AGEs)
- Ultraprocessed foods and gut barrier function
Mitochondrial health in diabetes:
- Mapping the mitochondrial bioenergetic signature of individuals with diabetic kidney disease
- Validation of mitochondria-targeted therapies in pre-clinical models
Identification of novel targets of therapy for chronic kidney disease:
- Multiomic profiling of human kidney biospecimens from subjects with diabetes and kidney disease
- Complement pathway and disease pathogenesis
Biography
Achievements and Awards
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Researcher Exchange and Development within Industry initiative Fellowship Program (REDI)- Medical Research Future Fund (MRFF)
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JDRF Career Development Award
- Nutrition Society of Australia Mid Career Research Award
- Roche-Australian and New Zealand Society of Nephrology Senior Scientist Career Development Award
- Australian Diabetes Society Skip Martin Early Career Fellowship
- National Health and Medical Research Council of Australia (NHMRC) New Investigator Project Grant
- Registered Nutritionist (Nutrition Society of Australia)
University Service
Bladder and Kidney Health Discovery Program Leadership Team. Theme Leader: Chronic Kidney Diseases. School of Translational Medicine June 2022-
Chair of Graduate Research Milestone Committee. School of Translational Medicine. May 2022-
Monash teaching commitment
Honours Coordinator, Med4301 M3701, Bachelor of Medical Science, School of Translational Medicine (Alfred Health), Faculty of Medicine, Nursing and Health Sciences. 2024-
Monash teaching commitment
Unit Coordinator, TRM5007/TRM6007, Translational Research & Medicine for Metabolic Disorders, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences. 2023
Education/Academic qualification
Obstetrics & Gynaecology, PhD, Pro-inflammatory cytokines and oxidative stress in the pathophysiology of gestational diabetes mellitus., University of Melbourne
External positions
Member, National Committee for Nutrition, Australian Academy of Science
Mar 2108 → Dec 2023
Council Member, International Maillard Reaction Society (IMARS)
17 Feb 2025 → …
Board/Council Member , Australian and New Zealand Society of Nephrology
28 Aug 2022 → …
Adjunct Associate Professor, Monash Institute of Pharmaceutical Sciences
15 Aug 2022 → …
Member, Research Advisory Committee, Australian and New Zealand Society of Nephrology
Jul 2019 → Dec 2021
Honorary Baker Affiliate, Baker Heart and Diabetes Institute
16 Nov 2016 → …
Research area keywords
- Diabetes
- Diet and nutrition
- mitochondria
- advanced glycation end products
- processed food
- dietary modification
- Kidney
- Diabetic Nephropathy
- Metabolism
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Understanding the metabolic landscape in the human kidney in diabetes
Coughlan, M. (Primary Chief Investigator (PCI)), Watt, M. J. (Associate Investigator (AI)), Stroud, D. A. (Associate Investigator (AI)), Ramm, G. (Associate Investigator (AI)), Schittenhelm, R. (Associate Investigator (AI)), Lazarou, M. (Associate Investigator (AI)), McLean, C. (Associate Investigator (AI)), Lawton, P. (Associate Investigator (AI)) & Ekinci, E. (Associate Investigator (AI))
1/01/24 → 31/12/28
Project: Research
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Targeting mitochondria in kidney diseases
Coughlan, M. (Primary Chief Investigator (PCI))
1/07/23 → 31/12/23
Project: Research
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Inhibiting Complement C5a Receptor1 to Improve Heart Function in Type 2 Diabetes
Sharma, A. (Primary Chief Investigator (PCI)), Coughlan, M. (Chief Investigator (CI)), Woodruff, T. M. (Chief Investigator (CI)) & Donner, D. (Chief Investigator (CI))
1/02/23 → 31/12/24
Project: Research
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Splice switching oligonucleotides for the treatment of chronic kidney disease
Thomas, M. (Primary Chief Investigator (PCI)), Wilton, S. (Chief Investigator (CI)), Wraight, C. (Chief Investigator (CI)), Pickering, R. (Chief Investigator (CI)), Cooper, M. (Associate Investigator (AI)), Coughlan, M. (Associate Investigator (AI)), Tesch, G. (Associate Investigator (AI)), Kitching, R. (Associate Investigator (AI)) & Jupp, B. (Associate Investigator (AI))
1/01/23 → 31/12/25
Project: Research
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Boosting regulatory T cells with kidney-targeted nanoparticles to treat diabetic kidney disease
Coughlan, M. (Primary Chief Investigator (PCI)), Ooi, J. (Chief Investigator (CI)), Tan, M. (Chief Investigator (CI)) & Gan, P. Y. (Chief Investigator (CI))
1/01/23 → 30/12/23
Project: Research
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Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes
Trambas, I. A., Bowen, L., Thallas-Bonke, V., Snelson, M., Sourris, K. C., Laskowski, A., Tauc, M., Rubera, I., Zheng, G., Harris, D. C. H., Kantharidis, P., Shimizu, T., Cooper, M. E., Tan, S. M. & Coughlan, M. T., May 2025, In: Redox Biology. 82, 8 p., 103601.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Dietary resistant starch enhances immune health of the kidney in diabetes via promoting microbially-derived metabolites and dampening neutrophil recruitment
Snelson, M., Deliyanti, D., Tan, S. M., Drake, A. M., de Pasquale, C., Kumar, V., Woodruff, T. M., Wilkinson-Berka, J. L. & Coughlan, M. T., 20 Jun 2024, In: Nutrition and Diabetes. 14, 1, 9 p., 46.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
Does the expression of glucagon-like peptide-1 receptor on bone marrow derived cells influence the onset and progression of diabetic kidney disease?
Sourris, K. C., Bertuzzo Veiga, C., Kantharidis, P., Rosado, C., Bose, M., Dimitropoulos, A., Xu, Y., Coughlan, M. T., Aziz, M., Morgan, P., Drucker, D. J., Murphy, A. J., Jandeleit-Dahm, K. A. M. & Cooper, M. E., Sept 2024, In: Diabetologia. 67, S1, p. S106 1 p., OP198.Research output: Contribution to journal › Meeting Abstract › peer-review
Open AccessFile -
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation
Sourris, K. C., Ding, Y., Maxwell, S. S., Al-Sharea, A., Kantharidis, P., Mohan, M., Rosado, C., Penfold, S., Haase, C. G., Xu, Y., Forbes, J. M., Crawford, S. A., Ramm, G., Harcourt, B. E., Jandeleit-Dahm, K. A. M., Advani, A., Murphy, A. J., Timmermann, D. B., Karihaloo, A. & Knudsen, L. B. & 4 others, , Jan 2024, In: Kidney International. 105, 1, p. 132-149 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access116 Link opens in a new tab Citations (Scopus) -
The AMPK activator ATX-304 alters cellular metabolism to protect against cisplatin-induced acute kidney injury
Katerelos, M., Gleich, K., Harley, G., Loh, K., Oakhill, J. S., Kemp, B. E., de Souza, D. P., Narayana, V. K., Coughlan, M. T., Laskowski, A., Ling, N. X. Y., Murray-Segal, L., Brink, R., Lee, M., Power, D. A. & Mount, P. F., Jun 2024, In: Biomedicine & Pharmacotherapy. 175, 13 p., 116730.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus)
Prizes
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Australian Diabetes Society (ADS) Skip Martin Early Career Fellowship
Coughlan, M. (Recipient), 2010
Prize: Competitive Fellowships
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JDRF-Australian Type 1 Diabetes Clinical Research Network Career Development Award
Coughlan, M. (Recipient), 2016
Prize: Competitive Fellowships
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Nutrition Society of Australia Mid Career Research Award
Coughlan, M. (Recipient), 27 Nov 2018
Prize: Prize (including medals and awards)
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Nutrition Society of Australia Mid Career Travel Award
Coughlan, M. (Recipient), 2017
Prize: Prize (including medals and awards)
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Researcher Exchange and Development within Industry (REDI) Fellowship
Coughlan, M. (Recipient), 1 Jul 2023
Prize: Competitive Fellowships
Activities
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Member, Council of the International Maillard Reaction Society
Coughlan, M. (Fellow)
17 Feb 2025Activity: External Academic Engagement › Committees and working groups
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Honours Supervision (BMedSc): Isambard Knox-Johnson
Coughlan, M. (Supervisor)
2025Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Diabetes (Journal)
Coughlan, M. (Editorial board member)
2024Activity: Publication peer-review and editorial work types › Editorial responsibility
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Honours Supervision (BMedSc): Dietary fibre as an adjunct therapy for reducing kidney injury in diabetes
Coughlan, M. (Supervisor) & Sharma, A. (Supervisor)
2023Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Bladder and Kidney Health Discovery Program Leadership Team- Theme Leader: Chronic Kidney Diseases
Coughlan, M. (Fellow)
2023 → …Activity: External Academic Engagement › Committees and working groups
Press/Media
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Can supplements lower blood sugar levels and improve diabetes? Here's what the science says
12/12/24
1 Media contribution
Press/Media: Expert Comment
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Ten News Melbourne interview- New Founds Benefits of Ozempic for Kidney & Heart Disease
12/12/23
1 Media contribution
Press/Media: Profile/Interview
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7NEWS interview- Surprise health benefits linked to weight-loss drug
12/12/23
1 Media contribution
Press/Media: Profile/Interview
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Radio Interview- Joy FM Drive Program- Processed foods
8/04/21
1 Media contribution
Press/Media: Profile/Interview