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PhD projects

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20012025

Research activity per year

Personal profile

Biography

Professor Melinda Coughlan has a BSc (Biology) with Honours in Nutrition from Deakin University, and a PhD in Metabolism from the University of Melbourne. Her PhD focused on mediators of inflammation and oxidative stress in the development of gestational diabetes (Mercy Hospital for Women). After completing her PhD, Melinda joined the Baker Heart Research Institute as a postdoctoral researcher in Prof Mark Cooper’s Diabetes Complications Division. In 2012, she became the Head of the Glycation, Nutrition and Metabolism Laboratory at the Baker IDI Heart and Diabetes Institute. In Nov 2016, she was recruited to Monash University’s School of Translational Medicine as one of the key recruits to help establish the Department of Diabetes. Professor Coughlan has recently held a REDI Fellowship from the MRFF partnering with AstraZeneca Cambridge, and has research grants from the NHMRC, JDRF and Diabetes Australia.

Research interests

Dietary factors in the initiation of diabetes and its complications:

  • Incretin (GLP-1) pathway signaling
  • Advanced glycation end-products (AGEs)
  • Ultraprocessed foods and gut barrier function

Mitochondrial health in diabetes:

  • Mapping the mitochondrial bioenergetic signature of individuals with diabetic kidney disease
  • Validation of mitochondria-targeted therapies in pre-clinical models

Identification of novel targets of therapy for chronic kidney disease:

  • Multiomic profiling of human kidney biospecimens from subjects with diabetes and kidney disease
  • Complement pathway and disease pathogenesis

Biography

Achievements and Awards

  • Researcher Exchange and Development within Industry initiative Fellowship Program (REDI)- Medical Research Future Fund (MRFF)

  • JDRF Career Development Award

  • Nutrition Society of Australia Mid Career Research Award
  • Roche-Australian and New Zealand Society of Nephrology Senior Scientist Career Development Award
  • Australian Diabetes Society Skip Martin Early Career Fellowship
  • National Health and Medical Research Council of Australia (NHMRC) New Investigator Project Grant
  • Registered Nutritionist (Nutrition Society of Australia)

University Service

Bladder and Kidney Health Discovery Program Leadership Team. Theme Leader: Chronic Kidney Diseases. School of Translational Medicine June 2022- 

 

Chair of Graduate Research Milestone Committee. School of Translational Medicine. May 2022-

Monash teaching commitment

Honours Coordinator, Med4301 M3701, Bachelor of Medical Science, School of Translational Medicine (Alfred Health), Faculty of Medicine, Nursing and Health Sciences. 2024-

 

Monash teaching commitment

Unit Coordinator, TRM5007/TRM6007, Translational Research & Medicine for Metabolic Disorders, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences. 2023

Education/Academic qualification

Obstetrics & Gynaecology, PhD, Pro-inflammatory cytokines and oxidative stress in the pathophysiology of gestational diabetes mellitus., University of Melbourne

External positions

Member, National Committee for Nutrition, Australian Academy of Science

Mar 2108Dec 2023

Council Member, International Maillard Reaction Society (IMARS)

17 Feb 2025 → …

Board/Council Member , Australian and New Zealand Society of Nephrology

28 Aug 2022 → …

Adjunct Associate Professor, Monash Institute of Pharmaceutical Sciences

15 Aug 2022 → …

Member, Research Advisory Committee, Australian and New Zealand Society of Nephrology

Jul 2019Dec 2021

Honorary Baker Affiliate, Baker Heart and Diabetes Institute

16 Nov 2016 → …

Research area keywords

  • Diabetes
  • Diet and nutrition
  • mitochondria
  • advanced glycation end products
  • processed food
  • dietary modification
  • Kidney
  • Diabetic Nephropathy
  • Metabolism

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or