Melinda Coughlan

Personal profile

Biography

Coughlan research group: www.med.monash.edu/cecs/diabetes/research/coughlan-group.html

Biography

Associate Professor Melinda Coughlan has a BSc (Biology) with Honours in Human Nutrition from Deakin University, and a PhD in Obstetrics & Gynaecology from the University of Melbourne. Her PhD focused on mediators of inflammation and oxidative stress in the development of gestational diabetes (Mercy Hospital for Women). After completing her PhD, Melinda joined the Baker Heart Research Institute as a postdoctoral researcher in Prof Mark Cooper’s Diabetes Complications Division. In 2012, she became the Head of the Glycation, Nutrition and Metabolism Laboratory at the Baker IDI Heart and Diabetes Institute. In 2016, she was recruited to Monash University’s Central Clinical School to establish the Department of Diabetes. Associate Professor Coughlan holds a Career Development Fellowship from the JDRF and has research grants from the NHMRC.

Biography

Achievements and Awards

JDRF Career Development Award
Nutrition Society of Australia Mid Career Research Award
Roche-Australian and New Zealand Society of Nephrology Senior Scientist Career Development Award
Australian Diabetes Society Skip Martin Early Career Fellowship
National Health and Medical Research Council of Australia (NHMRC) New Investigator Project Grant
Registered Nutritionist (Nutrition Society of Australia)

Research interests

Dietary factors in the initiation of diabetes and its complications:

Maillard reaction products/advanced glycation end-products (AGEs).
Dietary constituents and incretins (GLP-1).
Dietary AGEs and gut microbial ecology.

Mitochondrial health in diabetes:

Mapping the mitochondrial bioenergetic signature of individuals with diabetic kidney disease.
Investigating pathways of mitochondrial quality control.
Validation of mitochondria-targeted therapies in pre-clinical models.

Research area keywords

Diabetes
Diet and nutrition
mitochondria
advanced glycation end products
processed food
dietary modification

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Projects

1 Active
3 Finished

Investigating pathways of mitochondrial quality control in diabetic kidney disease

Coughlan, M., Cooper, M. E. & Devenish, R.

18/11/16 → 31/12/20

Project: Research

NHMRC Equipment Grant - Quanterix SIMOA HD-1 Analyser

Shultz, S., Kwan, P., Medcalf, R., O'Brien, T., Mitra, B., Coughlan, M., Jones, N., Van Der Walt, A., Butzkueven, H., Semple, B. & Hutton, E.

Monash University – Internal Department Contribution, Monash University – Internal Faculty Contribution, Novartis Pharmaceuticals Australia Ltd

1/01/19 → 31/12/19

Project: Research

Targeting the C5a-C5aR1 signalling axis in type 1 diabetic kidney disease

Coughlan, M.

1/01/18 → 31/12/18

Project: Research

JDRF Career Development Award - Mapping the mitochondrial signature of individuals with type 1 diabetes and nephropathy

Coughlan, M.

24/01/17 → 29/02/20

Project: Research

Research Output

55 Article
10 Review Article
2 Conference Paper
2 Comment / Debate
9 More

Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility

Tan, S. M., Ziemann, M., Thallas-Bonke, V., Snelson, M., Kumar, V., Laskowski, A., Nguyen, T. V., Huynh, K., Clarke, M. V., Libianto, R., Baker, S. T., Skene, A., Power, D. A., MacIsaac, R. J., Henstridge, D. C., Wetsel, R. A., El-Osta, A., Meikle, P. J., Wilson, S. G., Forbes, J. M. & 4 others, Cooper, M. E., Ekinci, E. I., Woodruff, T. M. & Coughlan, M. T., 1 Jan 2020, In : Diabetes. 69, 1, p. 83-98 16 p.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart (Cardiovascular Drugs and Therapy, (2019), 33, 6, (669-674), 10.1007/s10557-019-06914-9)

Tate, M., Higgins, G. C., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garza, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. T. & Ritchie, R. H., 1 Apr 2020, In : Cardiovascular Drugs and Therapy. 34, 2, p. 223 1 p.

Research output: Contribution to journal › Comment / Debate › Other › peer-review

Open Access

1 Citation (Scopus)

Deficiency of Prebiotic Fiber and Insufficient Signaling through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

Kaye, D. M., Shihata, W. A., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Coughlan, M. T., Phillips, S., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W. & 4 others, Spector, T. D., Valdes, A. M., Mackay, C. R. & Marques, F. Z., 28 Apr 2020, In : Circulation. 141, 17, p. 1393-1403 11 p.

Research output: Contribution to journal › Article › Research › peer-review