Melinda Coughlan

Assoc Professor

  • Associate Professor (Research), Diabetes
20052020
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Personal profile

Biography

Biography

Associate Professor Melinda Coughlan has a BSc (Biology) with Honours in Human Nutrition from Deakin University, and a PhD in Obstetrics & Gynaecology from the University of Melbourne. Her PhD focused on mediators of inflammation and oxidative stress in the development of gestational diabetes (Mercy Hospital for Women). After completing her PhD, Melinda joined the Baker Heart Research Institute as a postdoctoral researcher in Prof Mark Cooper’s Diabetes Complications Division. In 2012, she became the Head of the Glycation, Nutrition and Metabolism Laboratory at the Baker IDI Heart and Diabetes Institute. In 2016, she was recruited to Monash University’s Central Clinical School to establish the Department of Diabetes. Associate Professor Coughlan holds a Career Development Fellowship from the JDRF and has research grants from the NHMRC.

Biography

Achievements and Awards

  • JDRF Career Development Award
  • Roche-Australian and New Zealand Society of Nephrology Senior Scientist Career Development Award
  • Australian Diabetes Society Skip Martin Early Career Fellowship
  • National Health and Medical Research Council of Australia (NHMRC) New Investigator Project Grant
  • Registered Nutritionist (Nutrition Society of Australia)

Research interests

Dietary factors in the initiation of diabetes and its complications:

  • Maillard reaction products/advanced glycation end-products (AGEs).
  • Dietary constituents and incretins (GLP-1).
  • Dietary AGEs and gut microbial ecology.

Mitochondrial health in diabetes:

  • Mapping the mitochondrial bioenergetic signature of individuals with diabetic kidney disease.
  • Investigating pathways of mitochondrial quality control.
  • Validation of mitochondria-targeted therapies in pre-clinical models.

Keywords

  • Diabetes
  • Diet and nutrition
  • mitochondria
  • advanced glycation end products
  • processed food
  • dietary modification

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Projects 2016 2020

Research Output 2005 2018

Open Access
Open Access
File

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Zhuang, A., Yap, F. Y., Bruce, C., Leung, C., Plan, M. R., Sullivan, M. A., Herath, C. B., McCarthy, D., Sourris, K. C., Kantharidis, P., Coughlan, M. T., Febbraio, M. A., Hodson, M. P., Watt, M. J., Angus, P., Schulz, B. L. & Forbes, J. M. 1 Dec 2017 In : Scientific Reports. 7, 1, 12292

Research output: Contribution to journalArticle

Open Access
File

NADPH oxidase Nox5 accelerates renal injury in diabetic nephropathy

Jha, J. C., Banal, C., Okabe, J., Gray, S. P., Hettige, T., Chow, B. S. M., Thallas-Bonke, V., Vos, L. D., Holterman, C. E., Coughlan, M. T., Power, D. A., Skene, A., Ekinci, E. I., Cooper, M. E., Touyz, R. M., Kennedy, C. R. & Jandeleit-Dahm, K. 1 Oct 2017 In : Diabetes. 66, 10, p. 2691-2703 13 p.

Research output: Contribution to journalArticle

Activities 2017 2017

  • 1 Membership of an advisory panel/policy group/ board

Australian Academy of Science (External organisation)

Coughlan, M. T. (Member)
1 Dec 201731 Dec 2020

Activity: Membership of an advisory panel/policy group/ board