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Research output per year

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Personal profile

Biography

Biography

Associate Professor Melinda Coughlan has a BSc (Biology) with Honours in Human Nutrition from Deakin University, and a PhD in Obstetrics & Gynaecology from the University of Melbourne. Her PhD focused on mediators of inflammation and oxidative stress in the development of gestational diabetes (Mercy Hospital for Women). After completing her PhD, Melinda joined the Baker Heart Research Institute as a postdoctoral researcher in Prof Mark Cooper’s Diabetes Complications Division. In 2012, she became the Head of the Glycation, Nutrition and Metabolism Laboratory at the Baker IDI Heart and Diabetes Institute. In 2016, she was recruited to Monash University’s Central Clinical School to establish the Department of Diabetes. Associate Professor Coughlan holds a Career Development Fellowship from the JDRF and has research grants from the NHMRC.

Biography

Achievements and Awards

  • JDRF Career Development Award
  • Nutrition Society of Australia Mid Career Research Award
  • Roche-Australian and New Zealand Society of Nephrology Senior Scientist Career Development Award
  • Australian Diabetes Society Skip Martin Early Career Fellowship
  • National Health and Medical Research Council of Australia (NHMRC) New Investigator Project Grant
  • Registered Nutritionist (Nutrition Society of Australia)

Research interests

Dietary factors in the initiation of diabetes and its complications:

  • Maillard reaction products/advanced glycation end-products (AGEs).
  • Dietary constituents and incretins (GLP-1).
  • Dietary AGEs and gut microbial ecology.

Mitochondrial health in diabetes:

  • Mapping the mitochondrial bioenergetic signature of individuals with diabetic kidney disease.
  • Investigating pathways of mitochondrial quality control.
  • Validation of mitochondria-targeted therapies in pre-clinical models.

Research area keywords

  • Diabetes
  • Diet and nutrition
  • mitochondria
  • advanced glycation end products
  • processed food
  • dietary modification

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Projects

Research Output

Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility

Tan, S. M., Ziemann, M., Thallas-Bonke, V., Snelson, M., Kumar, V., Laskowski, A., Nguyen, T. V., Huynh, K., Clarke, M. V., Libianto, R., Baker, S. T., Skene, A., Power, D. A., MacIsaac, R. J., Henstridge, D. C., Wetsel, R. A., El-Osta, A., Meikle, P. J., Wilson, S. G., Forbes, J. M. & 4 others, Cooper, M. E., Ekinci, E. I., Woodruff, T. M. & Coughlan, M. T., 1 Jan 2020, In : Diabetes. 69, 1, p. 83-98 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart (Cardiovascular Drugs and Therapy, (2019), 33, 6, (669-674), 10.1007/s10557-019-06914-9)

Tate, M., Higgins, G. C., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garza, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. T. & Ritchie, R. H., 1 Apr 2020, In : Cardiovascular Drugs and Therapy. 34, 2, p. 223 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
1 Citation (Scopus)

Deficiency of Prebiotic Fiber and Insufficient Signaling through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease

Kaye, D. M., Shihata, W. A., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Coughlan, M. T., Phillips, S., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W. & 4 others, Spector, T. D., Valdes, A. M., Mackay, C. R. & Marques, F. Z., 28 Apr 2020, In : Circulation. 141, 17, p. 1393-1403 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Lindblom, R. S. J., Higgins, G. C., Nguyen, T. V., Arnstein, M., Henstridge, D. C., Granata, C., Snelson, M., Thallas-Bonke, V., Cooper, M. E., Forbes, J. M. & Coughlan, M. T., 29 Jan 2020, In : Clinical Science. 134, 2, p. 239-259 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy

Snelson, M., Tan, S. M., Higgins, G. C., Lindblom, R. S. J. & Coughlan, M. T., 1 Mar 2020, In : American Journal of Physiology-Renal Physiology. 318, 3, p. F835-F842 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

Nutrition Society of Australia Mid Career Research Award

Coughlan, Melinda (Recipient), 27 Nov 2018

Prize: Prize (including medals and awards)

Activities

  • 1 Committees and working groups
  • 1 Membership of an advisory panel/policy group/ board

Australian and New Zealand Society of Nephrology Research Advisory Committee

Melinda Coughlan (Fellow)

Jul 2019Jul 2021

Activity: External Academic EngagementCommittees and working groups

Australian Academy of Science (External organisation)

Melinda Coughlan (Member)

1 Dec 201731 Dec 2020

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board