Melanie Pritchard

Dr

19992017
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Research Output 1999 2017

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Article
2017
3 Citations (Scopus)

Modulation of Intersectin-1s Lung Expression Induces Obliterative Remodeling and Severe Plexiform Arteriopathy in the Murine Pulmonary Vascular Bed

Patel, M., Predescu, D., Bardita, C., Chen, J., Jeganathan, N., Pritchard, M., DiBartolo, S., Machado, R. & Predescu, S., 1 Mar 2017, In : American Journal of Pathology. 187, 3, p. 528-542 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
16 Citations (Scopus)

A syntenic cross species aneuploidy genetic screen links RCAN1 expression to β-cell mitochondrial dysfunction in type 2 diabetes

Peiris, H., Duffield, M. D., Fadista, J., Jessup, C. F., Kashmir, V., Genders, A. J., McGee, S. L., Martin, A. M., Saiedi, M., Morton, N., Carter, R., Cousin, M. A., Kokotos, A. C., Oskolkov, N., Volkov, P., Hough, T. A., Fisher, E. M. C., Tybulewicz, V. L. J., Busciglio, J., Coskun, P. E. & 12 others, Becker, A., Belichenko, P. V., Mobley, W. C., Ryan, M. T., Chan, J. Y., Laybutt, D. R., Coates, P. T., Yang, S., Ling, C., Groop, L., Pritchard, M. A. & Keating, D. J., 19 May 2016, In : PLoS Genetics. 12, 5, 24 p., 1006033.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
1 Citation (Scopus)

RCAN 1 and 3 proteins regulate thymic positive selection

Serrano-Candelas, E., Aleman-Muench, G. R., Sole-Sanchez, S., Aubareda, A., Martinez-Hoyer, S., Adan, J., Aranguren-Ibanez, A., Pritchard, M. A., Soldevila, G. & Perez-Riba, M., 2015, In : Biochemical and Biophysical Research Communications. 460, 2, p. 295-301 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
30 Citations (Scopus)

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks

Ling, K-H., Hewitt, C. A., Tan, K. L., Cheah, P-S., Vidyadaran, S., Lai, M-I., Lee, H. C., Simpson, K. M., Hyde, L., Pritchard, M. A., Smyth, G. K., Thomas, T. & Scott, H. S., 2014, In : BMC Genomics. 15, 1 (Art. No.: 624), p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells

Peiris, H., Dubach, D., Jessup, C. F., Unterweger, P., Raghupathi, R., Muyderman, H., Zanin, M. P., Mackenzie, K. D., Pritchard, M. A. & Keating, D. J., 2014, In : Oxidative Medicine and Cellular Longevity. 2014, (Art. No.: 520316), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

Role of metal ions in the cognitive decline of Down syndrome

Malakooti, N., Pritchard, M. A., Adlard, P. A. & Finkelstein, D. I., 2014, In : Frontiers in Aging Neuroscience. 6, Art. No.:136, p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome

Tan, K. L., Ling, K-H., Hewitt, C. A., Cheah, P. S., Simpson, K. M., Gordon, L., Pritchard, M. A., Smyth, G. K., Thomas, T. & Scott, H. S., 2014, In : Genomics Data. 2, p. 314 - 317 4 p.

Research output: Contribution to journalArticleOtherpeer-review

2013
15 Citations (Scopus)

RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity

Zanin, M. P., Mackenzie, K. D., Peiris, H., Pritchard, M. A. & Keating, D. J., 2013, In : Journal of Neurochemistry. 124, 3, p. 290 - 299 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Upregulation of RCAN1 causes Down syndrome-like immune dysfunction

Martin, K. R., Layton, D. S., Seach, N. L., Corlett, A. R. I., Barallobre, M-J., Arbones, M., Boyd, R. L., Scott, B. M. & Pritchard, M. A., 2013, In : Journal of Medical Genetics. 50, 7, p. 444 - 454 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
23 Citations (Scopus)

Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, {beta}-cell dysfunction, and diabetes

Peiris, H., Raghupathi, R., Jessup, C. F., Zanin, M. P., Mohanasundaram, D., Mackenzie, K. D., Chataway, T., Clarke, J. N., Brealey, J., Coates, P. T., Pritchard, M. A. & Keating, D. J., 2012, In : Endocrinology. 153, 11, p. 5212 - 5221 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Over-expression of DSCR1 protects against post-ischemic neuronal injury

Brait, V. H., Martin, K. R., Corlett, A. R. I., Broughton, B. RS., Kim, H., Thundyil, J., Drummond, G. R., Arumugam, T. V., Pritchard, M. A. & Sobey, C. G., 2012, In : PLoS ONE. 7, 10, 8 p., e47841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
50 Citations (Scopus)

Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory

Martin, K., Corlett, A., Dubach, D., Mustafa, T., Coleman, H. A., Parkington, H. C., Merson, T. D., Bourne, J. A., Porta, S., Arbones, M. L., Finkelstein, D. I. & Pritchard, M. A., 2012, In : Human Molecular Genetics. 21, 13, p. 3025 - 3041 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
28 Citations (Scopus)

Do RCAN1 proteins link chronic stress with neurodegeneration?

Ermak, G., Pritchard, M., Dronjak, S., Nui, B. & Davies, K., 2011, In : FASEB Journal. 25, 10, p. 3306 - 3311 6 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Partially redundant functions of Adamts1 and Adamts4 in the perinatal development of the renal medulla

Boerboom, D., Lafond, J-F., Zheng, X., Lapointe, E., Mittaz, L., Boyer, A., Pritchard, M., Demayo, F., Mort, J., Drolet, R. & Richards, J., 2011, In : Developmental Dynamics. 240, 7, p. 1806 - 1814 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

The ADAMTS1 protease gene is required for mammary tumor growth and metastasis

Ricciardelli, C., Frewin, K., Tan, I., Williams, E., Opeskin, K., Pritchard, M., Ingman, W. & Russell, D., 2011, In : American Journal of Pathology. 179, 6, p. 3075 - 3085 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney

Lapinskas, E., Svobodova, S., Davis, I., Cebon, J., Hertzog, P. & Pritchard, M., 2011, In : Twin Research and Human Genetics. 14, 4, p. 316 - 322 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
81 Citations (Scopus)

ADAMTS1 cleavage of versican mediates essential structural remodeling of the ovarian follicle and cumulus-oocyte matrix during ovulation in mice

Brown, H. M., Dunning, K. R., Robker, R. L., Boerboom, D., Pritchard, M. A., Lane, M. & Russell, D. L., 2010, In : Biology of Reproduction. 83, 4, p. 549 - 557 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome

Hewitt, C. A., Ling, K. -H., Merson, T. D., Simpson, K. M., Ritchie, M. E., King, S. L., Pritchard, M. A., Smyth, G. K., Thomas, T., Scott, H. S. & Voss, A. K., 2010, In : PLoS ONE. 5, 7 (Art. No: e11561), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Transcript profiling of Elf5+/- mammary glands during pregnancy identifies novel targets of elf5

Chehab Rogers, R., van Seuningen, I., Gould, J. A., Hertzog, P. J., Naylor, M. J. & Pritchard, M. A., 2010, In : PLoS ONE. 5, 10 (e13150), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
22 Citations (Scopus)

Down syndrome and the genes of human chromosome 21: Current knowledge and future potentials

Pritchard, M. A., Reeves, R. H., Dierssen, M., Patterson, D. & Gardiner, K. J., 2008, In : Cytogenetic and Genome Research. 121, 1, p. 67 - 77 11 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

Keating, D. J., Dubach, D., Zanin, M. P., Yu, Y., Martin, K. R., Zhao, Y-F., Chen, C., Porta, S., Arbones, M. L., Mittaz, L. & Pritchard, M. A., 2008, In : Human Molecular Genetics. 17, 7, p. 1020 - 1030 11 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities

Yu, Y., Chu, P-Y., Bowser, D. N., Keating, D. J., Dubach, D., Harper, I. S., Tkalcevic, J., Finkelstein, D. I. & Pritchard, M. A., 2008, In : Human Molecular Genetics. 17, 21, p. 3281 - 3290 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation

Wu, J., Duan, R., Cao, H., Field, D., Newnham, C. M., Koehler, D. R., Zamel, N., Pritchard, M. A., Hertzog, P. J., Post, M., Tanswell, A. K. & Hu, J., 2008, In : Cell Research. 18, 6, p. 649 - 663 15 p.

Research output: Contribution to journalArticleResearchpeer-review

139 Citations (Scopus)

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

Oakes, S. R., Naylor, M. J., Asselin-Labat, M-L., Blazek, K. D., Gardiner-Garden, M., Hilton, H. N., Kazlauskas, M., Pritchard, M. A., Chodosh, L. A., Pfeffer, P. L., Lindeman, G. J., Visvader, J. E. & Ormandy, C. J., 2008, In : Genes and Development. 22, 5, p. 581 - 586 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
7 Citations (Scopus)

Multiplex ligation-dependent probe amplification (MLPA) genotyping assay for mouse models of down syndrome

Hewitt, C. A., Carmichael, C. L., Wilkins, E. J., Cannon, P. ZF., Pritchard, M. A. & Scott, H. S., 2007, In : Frontiers in Bioscience. 12, p. 3010 - 3016 7 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin

Davies, K. JA., Ermak, G., Rothermel, B. A., Pritchard, M. A., Heitman, J., Ahnn, J., Henrique-Silva, F., Crawford, D., Canaider, S., Strippoli, P., Carinci, P., Min, K-T., Fox, D. S., Cunningham, K. W., Bassel-Duby, R., Olson, E. N., Zhang, Z., Williams, R. S., Gerber, H-P., Perez-Riba, M. & 14 others, Seo, H., Cao, X., Klee, C. B., Redondo, J. M., Maltais, L. J., Bruford, E. A., Povey, S., Molkentin, J. D., McKeon, F. D., Duh, E. J., Crabtree, G. R., Cyert, M. S., de la Luna, S. & Estivill, X., 2007, In : FASEB Journal. 21, 12, p. 3023 - 3028 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

TGF-betaRII rescues development of small intestinal epithelial cells in Elf3-deficient mice

Flentjar, N. J., Chu, P-Y., Ng, A. Y. N., Johnstone, C. N., Heath, J. K., Ernst, M. R., Hertzog, P. J. & Pritchard, M. A., 2007, In : Gastroenterology. 132, p. 1410 - 1419 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
49 Citations (Scopus)

Alzheimer's disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN1

Keating, D. J., Chen, C. & Pritchard, M. A., 2006, In : Ageing Research Reviews. 5, 4, p. 388 - 401 14 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis

Brown, H. M., Dunning, K. R., Robker, R. L., Pritchard, M. A. & Russell, D. L., 2006, In : Developmental Biology. 300, 2, p. 699 - 709 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
81 Citations (Scopus)

ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo

Little, C. B., Mittaz, L., Belluoccio, D., Rogerson, F. M., Campbell, I. K., Meeker, C. T., Bateman, J. F., Pritchard, M. A. & Fosang, A. J., 2005, In : Arthritis and Rheumatism. 52, 5, p. 1461 - 1472 12 p.

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)

Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

Zhou, J., Chehab, R., Tkalcevic, J., Naylor, M. J., Harris, J., Wilson, T. J., Tsao, S. E., Tellis, I., Zavarsek, S., Xu, D., Lapinskas, E. J., Visvader, J., Lindeman, G. J., Thomas, R. S., Ormandy, C. J., Hertzog, P. J., Kola, I. & Pritchard, M. A., 2005, In : EMBO Journal. 24, 3, p. 635 - 644 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Neonatal calyceal dilation and renal fibrosis resulting from loss of Adamts-1 in mouse kidney is due to a developmental dysgenesis

Mittaz, L., Ricardo, S. D., Martinez, G., Kola, I., Kelly, D. J., Little, M. H., Hertzog, P. J. & Pritchard, M. A., 2005, In : Nephrology Dialysis Transplantation. 20, p. 419 - 423 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Report on the 'Expert Workshop on the Biology of Chromosome 21: towards Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C.

Gardiner, K. J., Davisson, M. T., Pritchard, M. A., Patterson, D., Groner, Y., Crnic, L. S., Antonarakis, S. E. & Mobley, W., 2005, In : Cytogenetic and Genome Research. 108, 4, p. 269 - 277 9 p.

Research output: Contribution to journalArticleOther

2004
126 Citations (Scopus)

Adamts-1 is essential for the development and function of the urogenital system

Mittaz, L., Russell, D. L., Wilson, T. J., Brasted, M., Tkalcevic, J., Salamonsen, L. A., Hertzog, P. J. & Pritchard, M. A., 2004, In : Biology of Reproduction. 70, 4, p. 1096 - 1105 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands

Lapinskas, E. J., Palmer, J., Ricardo, S. D., Hertzog, P. J., Hammacher, A. & Pritchard, M. A., 2004, In : Histochemistry and Cell Biology. 122, 6, p. 521 - 526 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Tissue-specific overexpression of the HSA21 gene GABP Implications for DS

O'leary, D., Pritchard, M. A., Xu, D., Kola, I., Hertzog, P. J. & Ristevski, S., 2004, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1739, p. 81 - 87 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Tissue-specific overexpression of the HSA21 gene GABPα: Implications for DS

O'Leary, D. A., Pritchard, M. A., Xu, D., Kola, I., Hertzog, P. J. & Ristevski, S., 24 Dec 2004, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1739, 1, p. 81-87 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2003
37 Citations (Scopus)

An altered antioxidant balance occurs in Down syndrome fetal organs: implications for the "gene dosage effect" hypothesis

De Haan-Klein, J. B., Susil, B., Pritchard, M. A. & Kola, I., 2003, In : Journal of Neural Transmission. 67, Suppl, p. 67 - 83 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
109 Citations (Scopus)

Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium

Ng, A. Y-N., Waring, P., Ristevski, S., Wang, C., Wilson, T. J., Pritchard, M. A., Hertzog, P. J. & Kola, I., 2002, In : Gastroenterology. 122, p. 1455 - 1466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Clinical and cytogenetic characterisation of a patient with Down syndrome resulting from a 21q22.1->qter duplication

Nadal, M., Vigo, C. G., Melaragno, M. I., Andrade, J. A. D., Alonso, L. G., Brunoni, D., Pritchard, M. A. & Estivill, X., 2001, In : Journal of Medical Genetics. 38, 1, p. 73 - 76 4 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis

Casas, C., Martinez, S., Pritchard, M. A., Fuentes, J. J., Nadal, M., Guimera, J., Florez, J., Arbones, M., Soriano, E., Estivill, X. & Alcantara, S., 2001, In : Mechanisms of Development. 101, p. 289 - 292 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

The mouse brain transcriptome by SAGE: Differences in gene expression between P30 brains of the partical trisomy 16 mouse model of down syndrom (Ts65Dn) and normals

Chrast, R., Scott, H. S., Papasavvas, M. P., Rossier, C., Antonarakis, E. S., Barras, C., Davisson, M. T., Schmidt, C., Estivill, X., Dierssen, M., Pritchard, M. A. & Antonarakis, S. E., 2000, In : Genome Research. 10, 12, p. 2006 - 2021 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Animal models of Down syndrome

Kola, I. & Pritchard, M., 1999, In : Molecular Medicine Today. p. 276 - 277 2 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

The "gene dosage effect" hypothesis versus the "amplified developmental instability" hypothesis in Down syndrome

Pritchard, M. & Kola, I., 1999, In : Journal of Neural Transmission. p. 293 - 303 11 p.

Research output: Contribution to journalArticleResearchpeer-review