Melanie Hutton

Dr

  • 19 Innovation Walk, Monash BDI

20102020

Research output per year

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Research Output

2020

A mouse model of Staphylococcus aureus small intestinal infection

Larcombe, S., Jiang, J-H., Hutton, M. L., Abud, H. E., Peleg, A. Y. & Lyras, D., 31 Jan 2020, In : Journal of Medical Microbiology. 69, 2, p. 290-297 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Repurposing auranofin as a Clostridioides difficile therapeutic

Hutton, M. L., Pehlivanoglu, H., Vidor, C. J., James, M. L., Thomson, M. J. & Lyras, D., Feb 2020, In : Journal of Antimicrobial Chemotherapy. 75, 2, p. 409-417 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain

Wehrhahn, M. C., Keighley, C., Kurtovic, J., Knight, D. R., Hong, S., Hutton, M. L., Lyras, D., Wang, Q., Leong, R., Borody, T., Edye, M. & Riley, T. V., 1 Feb 2019, In : Anaerobe. 55, p. 117-123 7 p.

Research output: Contribution to journalArticleOtherpeer-review

3 Citations (Scopus)

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model

Tague, A. J., Putsathit, P., Hutton, M. L., Hammer, K. A., Wales, S. M., Knight, D. R., Riley, T. V., Lyras, D., Keller, P. A. & Pyne, S. G., 15 May 2019, In : European Journal of Medicinal Chemistry. 170, p. 203-224 22 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., Dec 2019, In : Nature Microbiology. 4, p. 2237-2245 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Hyperimmune bovine colostrum reduces gastrointestinal carriage of uropathogenic Escherichia coli

Larcombe, S., Hutton, M. L. & Lyras, D., 1 Feb 2019, In : Human Vaccines & Immunotherapeutics. 15, 2, p. 508-513 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

In silico, in vitro and in vivo analysis of putative virulence factors identified in large clostridial toxin-negative, binary toxin- producing C. difficile strains

Androga, G. O., Knight, D. R., Hutton, M. L., Mileto, S. J., James, M. L., Evans, C., Lyras, D., Chang, B. J., Foster, N. F. & Riley, T. V., Dec 2019, In : Anaerobe. 60, 8 p., 102083.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

Diverse bacterial species contribute to antibiotic-associated diarrhoea and gastrointestinal damage

Larcombe, S., Hutton, M. L., Riley, T. V., Abud, H. E. & Lyras, D., Nov 2018, In : Journal of Infection. 77, 5, p. 417-426 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Intestinal colonization traits of pandemic multidrug-resistant Escherichia coli ST131

Sarkar, S., Hutton, M. L., Vagenas, D., Ruter, R., Schuller, S., Lyras, D., Schembri, M. A. & Totsika, M., 15 Sep 2018, In : Journal of Infectious Diseases. 218, 6, p. 979-990 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)
2017

A Helicobacter pylori homolog of eukaryotic flotillin is involved in cholesterol accumulation, epithelial cell responses and host colonization

Hutton, M. L., D'Costa, K., Rossiter, A. E., Wang, L., Turner, L., Steer, D. L., Masters, S. L., Croker, B. A., Kaparakis-Liaskos, M. & Ferrero, R. L., 6 Jun 2017, In : Frontiers in Cellular and Infection Microbiology. 7, 13 p., 219.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative

Hutton, M. L., Cunningham, B. A., Mackin, K. E., Lyon, S. A., James, M. L., Rood, J. I. & Lyras, D., 16 Jun 2017, In : Scientific Reports. 7, 1, 13 p., 3665.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Options for improving effectiveness of rotavirus vaccines in developing countries

Tissera, M. S., Cowley, D., Bogdanovic-Sakran, N., Hutton, M. L., Lyras, D., Kirkwood, C. D. & Buttery, J. P., 3 Apr 2017, In : Human Vaccines & Immunotherapeutics. 13, 4, p. 921-927 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)
2016

CdtR regulates TcdA and TcdB production in Clostridium difficile

Lyon, S. A., Hutton, M. L., Rood, J. I., Cheung, J. K. & Lyras, D., 14 Jul 2016, In : PLoS Pathogens. 12, 7, 19 p., e1005758.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
26 Citations (Scopus)

Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea

Larcombe, S., Hutton, M. L. & Lyras, D., Jun 2016, In : Trends in Microbiology. 24, 6, p. 463-476 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

36 Citations (Scopus)
2015

Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance

Johanesen, P. A., Mackin, K. E., Hutton, M. L., Awad, M. M., Larcombe, S., Amy, J. M. & Lyras, D., 2015, In : Genes. 6, 4, p. 1347 - 1360 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
35 Citations (Scopus)

Increased outer membrane vesicle formation in a Helicobacter pylori tolB mutant

Turner, L. J., Praszkier, J., Hutton, M. L., Steer, D. L., Ramm, G., Liaskos, M. & Ferrero, R. L., 2015, In : Helicobacter. 20, 4, p. 269 - 283 15 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)
2014

Small animal models for the study of Clostridium difficile disease pathogenesis

Hutton, M. L., Mackin, K. E., Chakravorty, A. & Lyras, D., 2014, In : FEMS Microbiology Letters. 352, 2, p. 140 - 149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)
2013

A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system

Gorrell, R. J., Guan, J. S., Xin, Y., Anoushiravani Tafreshi, M., Hutton, M. L., McGuckin, M. A., Ferrero, R. L. & Kwok, T., 2013, In : Cellular Microbiology. 15, 4, p. 554 - 570 17 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)
2012

The use of AlbuMAX II[R] as a blood or serum alternative for the culture of helicobacter pylori

Hutton, M., Liaskos, M. & Ferrero, R., 2012, In : Helicobacter. 17, 1, p. 68 - 76 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2010

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

Liaskos, M., Turnbull, L., Carneiro, L., Firth, S. D., Coleman, H. A., Parkington, H. C., Le Bourhis, L., Karrar, A., Viala, J., Mak, J., Hutton, M. L., Davies, J. K., Crack, P. J., Hertzog, P. J., Philpott, D., Girardin, S. E., Whitchurch, C. B. & Ferrero, R. L., 2010, In : Cellular Microbiology. 12, p. 372 - 385 13 p.

Research output: Contribution to journalArticleResearchpeer-review

186 Citations (Scopus)

Helicobacter pylori exploits cholesterol-rich microdomains for induction of NF-kappaB-dependent responses and peptidoglycan delivery in epithelial cells

Hutton, M., Liaskos, M., Turner, L., Cardona, A., Kwok, T. & Ferrero, R., 2010, In : Infection and Immunity. 78, 11, p. 4523 - 4531 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Innate immune initiators and effectors in Helicobacter pylori infection

Kaparakis, M., Allison, C., Hutton, M. & Ferrero, R., 2010, Helicobacter pylori in the 21st Century. Sutton, P. & Mitchell, H. M. (eds.). UK: CABI, p. 142 - 166 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review