Personal profile
Research area keywords
- Clostridium difficile
- mouse models
- pathogenesis
- industry collaboration
- Pre-clinical studies
- gut infections
- AMR
- In vitro and In vivo drug testing
- Therapeutics for gut infections
- infection and immunity
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Testing the stability and efficacy of the C. difficile clinical colostrum product
Lyras, D. (Primary Chief Investigator (PCI)) & Hutton, M. (Chief Investigator (CI))
28/11/23 → 28/05/26
Project: Research
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Bridge and BridgeTech Industry Fellowship
Hutton, M. (Primary Chief Investigator (PCI))
31/07/23 → 6/11/23
Project: Research
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The role of host proteases in exacerbating enteric infectious disease
Lyras, D. (Primary Chief Investigator (PCI)), Srikhanta, Y. (Chief Investigator (CI)), Awad, M. (Chief Investigator (CI)) & Hutton, M. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/21 → 31/12/24
Project: Research
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Developing protocols for testing the efficacy of colostrum against COVID-19
Lyras, D. (Primary Chief Investigator (PCI)) & Hutton, M. (Chief Investigator (CI))
1/10/20 → 31/10/20
Project: Research
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Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile
Cun, W. Y., Bate, C. E., Srikhanta, Y. N., Hutton, M. L., Webb, C. T., Revitt-Mills, S. A., Lyras, D., McGowan, S., Yu, H., Keller, P. A. & Pyne, S. G., 11 Jan 2024, In: Journal of Medicinal Chemistry. 67, 1, p. 450–466 17 p.Research output: Contribution to journal › Article › Research › peer-review
5 Link opens in a new tab Citations (Scopus) -
Gut Microbial Perturbation and Host Response Induce Redox Pathway Upregulation along the Gut–Liver Axis during Giardiasis in C57BL/6J Mouse Model
Karpe, A. V., Hutton, M. L., Mileto, S. J., James, M. L., Evans, C., Ghodke, A. B., Shah, R. M., Metcalfe, S. S., Liu, J. W., Walsh, T., Lyras, D., Palombo, E. A. & Beale, D. J., Jan 2023, In: International Journal of Molecular Sciences. 24, 2, 17 p., 1636.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Link opens in a new tab Citations (Scopus) -
A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections
Blaskovich, M. A. T., Hansford, K. A., Butler, M. S., Ramu, S., Kavanagh, A. M., Jarrad, A. M., Prasetyoputri, A., Pitt, M. E., Huang, J. X., Lindahl, F., Ziora, Z. M., Bradford, T., Muldoon, C., Rajaratnam, P., Pelingon, R., Edwards, D. J., Zhang, B., Amado, M., Elliott, A. G. & Zuegg, J. & 33 others, , 14 Sept 2022, In: Science Translational Medicine. 14, 662, 16 p., eabj2381.Research output: Contribution to journal › Article › Research › peer-review
14 Link opens in a new tab Citations (Scopus) -
Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection
Mileto, S. J., Hutton, M. L., Walton, S. L., Das, A., Ioannidis, L. J., Ketagoda, D., Quinn, K. M., Denton, K. M., Hansen, D. S. & Lyras, D., 1 Jan 2022, In: Gut Microbes. 14, 1, 18 p., e2117504.Research output: Contribution to journal › Article › Research › peer-review
Open Access18 Link opens in a new tab Citations (Scopus) -
Cationic peptidomimetic amphiphiles having a n-aryl- or n-naphthyl-1,2,3-triazole core structure targeting clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo c. difficile infection model
Mahadari, M. K., Jennepalli, S., Tague, A. J., Putsathit, P., Hutton, M. L., Hammer, K. A., Knight, D. R., Riley, T. V., Lyras, D., Keller, P. A. & Pyne, S. G., Aug 2021, In: Antibiotics. 10, 8, 17 p., 913.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Link opens in a new tab Citations (Scopus)
Prizes
Activities
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PCT/AU2018/051007 (Event)
Srikhanta, Y. (Inventor), Hutton, M. (Inventor), Awad, M. (Inventor), Singleton, J. (Inventor), Drinkwater, N. (Inventor), McGowan, S. (Inventor) & Lyras, D. (Inventor)
14 Sept 2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Antimicrobial Agents and Chemotherapy (Journal)
Hutton, M. (Peer reviewer)
2017 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
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Frontiers in Cellular and Infection Microbiology (Journal)
Hutton, M. (Editorial board member)
2017 → 2020Activity: Publication peer-review and editorial work types › Editorial responsibility
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Victorian Infection & Immunity Network Young Investigator Symposium 2016
Hutton, M. (Organiser)
2016 → …Activity: Participating in or organising an event types › Contribution to conference
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Faculty of Medicine, Nursing and Health Sciences Early Career Research Symposium
Hutton, M. (Organiser)
2015 → …Activity: Participating in or organising an event types › Contribution to conference