Meiling Han

Dr

20162019
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Research Output 2016 2019

2019

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel polymyxin combination with the antiretroviral zidovudine exerts synergistic killing against Ndm-producing multidrug-resistant klebsiella pneumoniae

Lin, Y-W., Rahim, N. A., Zhao, J., Han, M-L., Yu, H. H., Wickremasinghe, H., Chen, K., Wang, J., Paterson, D. L., Zhu, Y., Rao, G. G., Zhou, Q. T., Forrest, A., Velkov, T. & Li, J., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. 63, 4, 11 p., e02176-18.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-resistant Pseudomonas aeruginosa

Lin, Y-W., Han, M-L., Zhao, J., Zhu, Y., Rao, G., Forrest, A., Song, J., Kaye, K. S., Hertzog, P., Purcell, A., Creek, D., Zhou, T. Q., Velkov, T. & Li, J., 3 Oct 2019, In : Frontiers in Pharmacology. 10, 11 p., 1146.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

Jasim, R., Baker, M. A., Zhu, Y., Han, M., Schneider-Futschik, E. K., Hussein, M., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, (Accepted/In press) In : ACS Infectious Diseases. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.

Research output: Contribution to journalArticleResearchpeer-review

Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across 10 clinically relevant Gram-negative bacteria

Huang, J., Zhu, Y., Han, M., Li, M., Song, J., Velkov, T., Li, C. & Li, J., 1 Apr 2018, In : International Journal of Antimicrobial Agents. 51, 4, p. 586-593 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Lin, Y-W., Zhou, Q. T., Han, M-L., Chen, K., Onufrak, N. J., Wang, J., Turnidge, J. D., Howden, B. P., Forrest, A., Chan, H. K. & Li, J., 1 Feb 2018, In : Antimicrobial Agents and Chemotherapy. 62, 2, 9 p., e01790.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Emergence of high-level colistin resistance in an acinetobacter baumannii clinical isolate mediated by inactivation of the global regulator H-NS

Lucas, D. D., Crane, B., Wright, A., Han, M-L., Moffatt, J., Bulach, D., Gladman, S. L., Powell, D., Aranda, J., Seemann, T., Machado, D., Pacheco, T., Marques, T., Viveiros, M., Nation, R., Li, J., Harper, M. & Boyce, J. D., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 17 p., e02442-17.

Research output: Contribution to journalArticleResearchpeer-review

Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae

Nang, S. C., Morris, F. C., McDonald, M. J., Han, M., Wang, J., Strugnell, R. A., Velkov, T. & Li, J., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1604-1610 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa

Zhu, Y., Czauderna, T., Zhao, J., Klapperstueck, M., Mahamad Maifiah, M. H. B., Han, M-L., Lu, J., Sommer, B., Velkov, T., Lithgow, T., Song, J., Schreiber, F. & Li, J., 1 Apr 2018, In : GigaScience. 7, 4, 18 p., giy021.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lipidomic analysis of the outer membrane vesicles from paired polymyxin-susceptible and -resistant Klebsiella pneumoniae clinical isolates

Jasim, R., Han, M-L., Zhu, Y., Hu, X., Hussein, M. H., Lin, Y-W., Zhou, T. Q., Dong, C. Y. D., Li, J. & Velkov, T., 10 Aug 2018, In : International Journal of Molecular Sciences. 19, 8, 13 p., 2356.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mechanism-based pharmacokinetic/pharmacodynamic modeling of aerosolized colistin in a mouse lung infection model

Lin, Y-W., Zhou, Q. T., Han, M-L., Onufrak, N. J., Chen, K., Wang, J., Forrest, A., Chan, H-K. & Li, J., 1 Mar 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, 14 p., e01965-17.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Hussein, M., Han, M-L., Zhu, Y., Schneider-Futschik, E. K., Hu, X., Zhou, Q. T., Lin, Y-W., Anderson, D., Creek, D. J., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, In : Computational and Structural Biotechnology Journal. 16, p. 587-599 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Li, M., Yu, H. H., Zhou, Z., Creek, D. J., Zhang, J. & Li, J., 16 Nov 2018, In : Frontiers in Microbiology. 9, 12 p., 2776.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Polymyxin b in combination with enrofloxacin exerts synergistic killing against extensively drug-resistant pseudomonas aeruginosa

Lin, Y-W., Yu, H. H., Zhao, J., Han, M-L., Zhu, Y., Akter, J., Wickremasinghe, H., Walpola, H., Wirth, V., Rao, G. G., Forrest, A., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 13 p., e00028-18.

Research output: Contribution to journalArticleResearchpeer-review

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance

Han, M-L., Velkov, T., Zhu, Y., Roberts, K. D., Le Brun, A. P., Chow, S. H., Gutu, A. D., Moskowitz, S. M., Shen, H-H. & Li, J., 19 Jan 2018, In : ACS Chemical Biology. 13, 1, p. 121-130 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria

Velkov, T., Gallardo-Godoy, A., Swarbrick, J. D., Blaskovich, M. A. T., Elliott, A. G., Han, M., Thompson, P. E., Roberts, K. D., Huang, J. X., Becker, B., Butler, M. S., Lash, L. H., Henriques, S. T., Nation, R. L., Sivanesan, S., Sani, M. A., Separovic, F., Mertens, H., Bulach, D., Seemann, T. & 3 othersOwen, J., Li, J. & Cooper, M. A., 19 Apr 2018, In : Cell Chemical Biology. 25, 4, p. 380-391 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

A fresh shine on cystic fibrosis inhalation therapy: Antimicrobial synergy of polymyxin B in combination with silver nanoparticles

Jasim, R., Schneider, E. K., Han, M., Azad, M. A. K., Hussein, M., Nowell, C., Baker, M. A., Wang, J., Li, J. & Velkov, T., 1 Apr 2017, In : Journal of Biomedical Nanotechnology. 13, 4, p. 447-457 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401

Galea, C. A., Han, M., Zhu, Y., Roberts, K., Wang, J., Thompson, P. E., Li, J. & Velkov, T., 26 May 2017, In : Journal of Natural Products. 80, 5, p. 1264-1274 11 p.

Research output: Contribution to journalArticleResearchpeer-review

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators

Hussein, M. H., Schneider, E. K., Elliott, A. G., Han, M., Reyes-Ortega, F., Morris, F., Blastovich, M. A. T., Jasim, R., Currie, B. J., Mayo, M., Baker, M., Cooper, M. A., Li, J. & Velkov, T., 1 Jul 2017, In : Microbial Drug Resistance. 23, 5, p. 640-650 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

Han, M. L., Shen, H. H., Hansford, K. A., Schneider, E. K., Sivanesan, S., Roberts, K. D., Thompson, P. E., Le Brun, A. P., Zhu, Y., Sani, M-A., Separovic, F., Blaskovich, M. A. T., Baker, M. A., Moskowitz, S. M., Cooper, M. A., Li, J. & Velkov, T., 11 Aug 2017, In : ACS Infectious Diseases. 3, 8, p. 606-619 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin

Schneider, E. K., Huang, J. X., Carbone, V., Han, M., Zhu, Y., Nang, S., Khoo, K. K., Mak, J., Cooper, M. A., Li, J. & Velkov, T., 1 Feb 2017, In : ACS Infectious Diseases. 3, 3, p. 249-258 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

An "unlikely" pair: the antimicrobial synergy of polymyxin B in combination with the cystic fibrosis transmembrane conductance regulator drugs KALYDECO and ORKAMBI

Schneider, E. K., Azad, M. A. K., Han, M-L., Zhou, Q. T., Wang, J., Huang, J. X., Cooper, M. A., Doi, Y., Baker, M. A., Bergen, P. J., Li, J. & Velkov, T., 8 Jul 2016, In : ACS Infectious Diseases. 2, 7, p. 478-488 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Maifiah, M. H. M., Cheah, S-E., Johnson, M. D., Han, M., Boyce, J. D., Thamlikitkul, V., Forrest, A., Kaye, K. S., Hertzog, P., Purcell, A. W., Song, J., Velkov, T., Creek, D. J. & Li, J., 29 Feb 2016, In : Scientific Reports. 6, 17 p., 22287.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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