Projects per year
Personal profile
Biography
Dr Meiling Han is an ARC DECRA fellow commencing in 2023 and is doing her research in antimicrobial resistance at Monash Biomedicine Discovery Institute. She completed her PhD in antimicrobial systems pharmacology at Monash Institute of Pharmaceutical Science in 2018. As a 3-year early career researcher, she has supervised 3 PhD, one master’s and one honours students, and secured numerous grants and awards such as the FMNHS Faculty Bridging Postdoctoral Fellowship (2018-2019), the AINSE Early Career Research Grant (2019-2021), and the Rod Rickards Fellowship from the Australian Academy of Sciences (2019). She was also appointed as Vice Chair for the 2023 Gordon Research Seminar in Metabolomics (Italy). Moreover, she has also achieved a productive research output evidenced by 49 peer-reviewed publications (13 first author, 2 corresponding author) in high-impact journals (e.g., Nat Commun, Nat Microbiol, Adv Sci), with a total of >1100 citations (Google Scholar, Sep 2022).
Research interests
Dr Han's research has been focused on the relationship between antimicrobial resistance and the remodelling of membrane lipids in Gram-negative bacteria. Over the past 3 years, she has established an independent research program to characterise the chemical compositions and biological functions of essential bacterial lipids and intracellular metabolites using an integrative metabolomics/lpidomics and biophysical approach (e.g., neutron reflectometry). During this process she has established solid and extensive research skills in pharmacology and biochemistry, in particular, bacterial membrane lipidomics, an emerging field with only a handful of researchers in the world. Her research findings have enriched our knowledge of small molecules within bacteria and will inform the future discovery of much-needed antimicrobials.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
-
Bacterial membrane remodelling and the interaction with peptides
Australian Research Council (ARC)
1/01/23 → 31/12/25
Project: Research
-
Interaction of monolaurin-containing microemulsions with Polymyxin B on Gram-negative model membrane
Shen, H., Han, M., Huang, X. & Wang, S.
13/11/22 → 20/11/22
Project: Research
-
Charge interference - how does increase of lysyl-phosphatidylglycerols in Staphylococcus aureus lead to daptomycin resistance?
23/05/22 → 26/05/22
Project: Research
-
Targeting Life-threatening ‘superbug’ Pseudomonas aeruginosa: A Systems and Computational Approach
2/12/19 → 20/12/19
Project: Research
-
Investigate the interaction of novel antimicrobial lipid-based nanoparticle systems with Gram-positive mutant membrane models using neutron reflectometry
Shen, H., Ding, Y., Han, M. & Lim, C. X.
22/10/19 → 24/10/19
Project: Research
Research output
- 49 Article
-
An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug-Resistant Pseudomonas aeruginosa
Jiang, X., Han, M., Tran, K., Patil, N. A., Ma, W., Roberts, K. D., Xiao, M., Sommer, B., Schreiber, F., Wang, L., Velkov, T. & Li, J., 28 Jul 2022, In: Journal of Medicinal Chemistry. 65, 14, p. 10001-10013 13 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
A polytherapy based approach to combat antimicrobial resistance using cubosomes
Lai, X., Han, M-L., Ding, Y., Chow, S. H., Le Brun, A. P., Wu, C-M., Bergen, P. J., Jiang, J., Hsu, H-Y., Muir, B. W., White, J., Song, J., Li, J. & Shen, H-H., Dec 2022, In: Nature Communications. 13, 1, 12 p., 343.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
Roberts, K. D., Zhu, Y., Azad, M. A. K., Han, M. L., Wang, J., Wang, L., Yu, H. H., Horne, A. S., Pinson, J. A., Rudd, D., Voelcker, N. H., Patil, N. A., Zhao, J., Jiang, X., Lu, J., Chen, K., Lomovskaya, O., Hecker, S. J., Thompson, P. E., Nation, R. L., & 4 others , 2022, In: Nature Communications. 13, 1, 15 p., 1625.Research output: Contribution to journal › Article › Research › peer-review
Open Access22 Citations (Scopus) -
Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination
Han, M-L., Nang, S. C., Lin, Y-W., Zhu, Y., Yu, H. H., Wickremasinghe, H., Barlow, C. K., Creek, D. J., Crawford, S., Rao, G., Dai, C., Barr, J. J., Chan, K., Turner Schooley, R., Velkov, T. & Li, J., 2022, In: Computational and Structural Biotechnology Journal. 20, p. 485-495 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages
Kho, Z. Y., Azad, M. A. K., Han, M-L., Zhu, Y., Huang, C., Schittenhelm, R. B., Naderer, T., Velkov, T., Selkrig, J., Zhou, Q. T. & Li, J., 1 Mar 2022, In: PLoS Pathogens. 18, 3, p. e1010308 25 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
Prizes
-
ASM Microbe Student and Postdoctoral Travel Award
Han, Meiling (Recipient), 2016
Prize: Prize (including medals and awards)
-
Faculty Bridging Postdoctoral Fellowship
Han, Meiling (Recipient), 2018
Prize: Competitive Fellowships
-
FMNHS Early Career Researcher Travel Grants
Han, Meiling (Recipient), 2022
Prize: Prize (including medals and awards)
-
France and Europe EMCR Mobility Grants, Australian Academy of Science
Han, Meiling (Recipient), 2019
Prize: Prize (including medals and awards)
-
Monash Biomedicine Discovery Institute Travel Award
Han, Meiling (Recipient), 2018
Prize: Prize (including medals and awards)