Projects per year
Personal profile
Biography
Dr Meiling Han is an ARC DECRA fellow (Jan 2023-Dec 2025) and a group leader focusing on the research in antimicrobial resistance at Monash Biomedicine Discovery Institute. She completed her PhD in antimicrobial systems pharmacology at Monash Institute of Pharmaceutical Science in 2018. As a 4-year early career researcher, she has supervised 7 students inlcuding 4 PhD, and secured numerous grants and awards such as the FMNHS Faculty Bridging Postdoctoral Fellowship (2018-2019), the AINSE Early Career Research Grant (2019-2021), and the Rod Rickards Fellowship from the Australian Academy of Sciences (2019). She was also appointed Vice Chair for the 2023 Gordon Research Seminar in Metabolomics (Italy). Moreover, she has also achieved a productive research output evidenced by over 50 peer-reviewed publications in high-impact journals (e.g., Nat Commun, Nat Microbiol, Adv Sci), with a total of >1500 citations (Google Scholar, Nov 2023).
Research interests
Dr Han's research has been focused on the relationship between antimicrobial resistance and the remodelling of bacterial membrane lipids and intracellular metabolites. Over the past 4 years, she has established an independent research program to characterise the chemical compositions and biological functions of essential bacterial lipids and intracellular metabolites using an integrative metabolomics/lpidomics and biophysical approach (e.g., neutron reflectometry). During this process she has established solid and extensive research skills in pharmacology and biochemistry, in particular, bacterial membrane lipidomics, an emerging field with only a handful of researchers in the world. Her research findings have enriched our knowledge of small molecules within bacteria and will inform the future discovery of much-needed antimicrobials.
Supervision interests
I am accepting PhD, Masters and Honours students, focusing on the research topics below. Please contact me if you are interetsed.
1. Deciphering bacterial membrane lipid remodelling and the interaction with membrane-targeting peptides
2. Targeting bacterial metabolic pathways and lipid biogenesis to combat antibiotic resistance
3. Investigating the impact of bacterial metabolites and lipids on host-pathogen interaction
Please check my lab website for details: https://www.monash.edu/discovery-institute/han-lab
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Antimicrobial drug resistance
- Metabolomics
- lipidomics
Collaborations and top research areas from the last five years
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A new mechanism of bacterial membrane defence against environmental stress
1/04/25 → 31/03/28
Project: Research
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Applying a pharmacometric approach to achieve personalised medicine in people with Alzheimer's disease
Jin, L. (Primary Chief Investigator (PCI)), Li, Q.-X. (Chief Investigator (CI)), Lin, W. (Chief Investigator (CI)) & Han, M. (Chief Investigator (CI))
1/01/24 → 31/12/26
Project: Research
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Bacterial membrane remodelling and the interaction with peptides
Australian Research Council (ARC)
1/01/23 → 6/04/26
Project: Research
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Interaction of monolaurin-containing microemulsions with Polymyxin B on Gram-negative model membrane
Shen, H., Han, M., Huang, X. & Wang, S.
13/11/22 → 20/11/22
Project: Research
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Charge interference - how does increase of lysyl-phosphatidylglycerols in Staphylococcus aureus lead to daptomycin resistance?
23/05/22 → 26/05/22
Project: Research
Research output
- 58 Article
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Advancing Nitrile-Aminothiol Strategy for Dual and Sequential Bioconjugation
Thombare, V. J., Wu, Y., Pamulapati, K., Han, M., Tailhades, J., Cryle, M. J., Roberts, K. D., Velkov, T., Li, J. & Patil, N. A., 19 Aug 2024, In: Chemistry - A European Journal. 30, 6, 10 p., e202401674.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Arginine catabolism is essential to polymyxin dependence in Acinetobacter baumannii
Han, M.-L. (Leading Author), Alsaadi, Y., Zhao, J., Zhu, Y., Lu, J., Jiang, X., Ma, W., Patil, N. A., Dunstan, R. A., Le Brun, A. P., Wickremasinghe, H., Hu, X., Wu, Y., Yu, H. H., Wang, J., Barlow, C. K., Bergen, P. J., Shen, H.-H., Lithgow, T. & Creek, D. J. & 2 others, , 23 Jul 2024, In: Cell Reports. 43, 7, 21 p., 114410.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Characterization of outer membrane vesicles released by clinical isolates of Neisseria gonorrhoeae
Dhital, S., Deo, P., Stuart, I., Huang, C., Zavan, L., Han, M.-L., Kaparakis-Liaskos, M., Ramm, G., Schittenhelm, R. B., Howden, B. & Naderer, T., Jun 2024, In: Proteomics. 24, 11, 13 p., 2300087.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Phage resistance in Klebsiella pneumoniae and bidirectional effects impacting antibiotic susceptibility
Nang, S. C., Lu, J., Yu, H. H., Wickremasinghe, H., Azad, M. A. K., Han, M., Zhao, J., Rao, G., Bergen, P. J., Velkov, T., Sherry, N., McCarthy, D. T., Aslam, S., Schooley, R. T., Howden, B. P., Barr, J. J., Zhu, Y. & Li, J., Jun 2024, In: Clinical Microbiology and Infection. 30, 6, p. 787-794 8 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
Polysaccharide-targeting lipid nanoparticles to kill gram-negative bacteria
Lai, X., Chow, S. H., Le Brun, A. P., Muir, B. W., Bergen, P. J., White, J., Yu, H. H., Wang, J., Danne, J., Jiang, J. H., Short, F. L., Han, M. L., Strugnell, R. A., Song, J., Cameron, N. R., Peleg, A. Y., Li, J. & Shen, H. H., 8 Feb 2024, In: Small. 20, 6, 13 p., 230502.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Prizes
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ASM Microbe Student and Postdoctoral Travel Award
Han, Meiling (Recipient), 2016
Prize: Prize (including medals and awards)
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BDI Research Accelerator Program
Han, Meiling (Recipient), Jun 2023
Prize: Prize (including medals and awards)
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Faculty Bridging Postdoctoral Fellowship
Han, Meiling (Recipient), 2018
Prize: Competitive Fellowships
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FMNHS Early Career Researcher Travel Grants
Han, Meiling (Recipient), 2022
Prize: Prize (including medals and awards)