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Research Output 2003 2019

2019

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

Izoré, T., Tailhades, J., Hansen, M. H., Kaczmarski, J. A., Jackson, C. J. & Cryle, M. J., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 2913-2918 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Studying trans-acting enzymes that target carrier protein-bound amino acids during nonribosomal peptide synthesis

Greule, A., Charkoudian, L. K. & Cryle, M. J., 1 Jan 2019, Metabolons and Supramolecular Enzyme Assemblies. Schmidt-Dannert, C. & Quin, M. B. (eds.). Academic Press, p. 113-154 42 p. (Methods in Enzymology; vol. 617).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis

Schoppet, M., Peschke, M., Kirchberg, A., Wiebach, V., Süssmuth, R. D., Stegmann, E. & Cryle, M. J., 1 Jan 2019, In : Chemical Science. 10, 1, p. 118-133 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

An enhanced chemoenzymatic method for loading substrates onto carrier protein domains

Kittilä, T. & Cryle, M. J., 1 Jan 2018, In : Biochemistry and Cell Biology. 96, 3, p. 372-379 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A route to diastereomerically pure phenylglycine thioester peptides: Crucial intermediates for investigating glycopeptide antibiotic biosynthesis

Tailhades, J., Schoppet, M., Greule, A., Peschke, M., Brieke, C. & Cryle, M. J., 9 Feb 2018, In : Chemical Communications. 54, 17, p. 2146-2149 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach

Brieke, C., Tarnawski, M., Greule, A. & Cryle, M. J., 1 Aug 2018, In : Journal of Inorganic Biochemistry. 185, p. 43-51 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathway to malonic acid-containing metabolites

Cryle, M. J., 1 Dec 2018, In : Nature Catalysis. 1, 12, p. 907-908 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade?

Schoppet, M., Tailhades, J., Kulkarni, K. & Cryle, M. J., 6 Jul 2018, In : Journal of Organic Chemistry. 83, 13, p. 7206-7214 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The many faces and important roles of protein-protein interactions during non-ribosomal peptide synthesis

Izoré, T. & Cryle, M. J., 1 Nov 2018, In : Natural Product Reports. 35, 11, p. 1120-1139 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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The Thioesterase Domain in Glycopeptide Antibiotic Biosynthesis Is Selective for Cross-Linked Aglycones

Peschke, M., Brieke, C., Heimes, M. & Cryle, M. J., 19 Jan 2018, In : ACS Chemical Biology. 13, 1, p. 110-120 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding biosynthetic protein-protein interactions

Ackerley, D. F., Challis, G. L. & Cryle, M. J., 1 Nov 2018, In : Natural Product Reports. 35, 11, p. 1118-1119 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

Greule, A., Stok, J. E., De Voss, J. J. & Cryle, M., 1 Aug 2018, In : Natural Product Reports. 35, 8, p. 757-791 35 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2017

Chlorinated Glycopeptide Antibiotic Peptide Precursors Improve Cytochrome P450-Catalyzed Cyclization Cascade Efficiency

Peschke, M., Brieke, C., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 7 Mar 2017, In : Biochemistry. 56, 9, p. 1239-1247 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Diversity of nature's assembly lines: Recent discoveries in non-ribosomal peptide synthesis

Payne, J. A. E., Schoppet, M., Hansen, M. H. & Cryle, M. J., 2017, In : Molecular BioSystems. 13, 1, p. 9-22 14 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis

Kittilä, T., Kittel, C., Tailhades, J., Butz, D., Schoppet, M., Büttner, A., Goode, R. J. A., Schittenhelm, R. B., Van Pee, K. H., Süssmuth, R. D., Wohlleben, W., Cryle, M. J. & Stegmann, E., 13 Jul 2017, In : Chemical Science. 8, 9, p. 5992-6004 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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P450 monooxygenase ComJ catalyses side chain phenolic cross-coupling during complestatin biosynthesis

Mollo, A., von Krusenstiern, A. N., Bulos, J. A., Ulrich, V., Åkerfeldt, K. S., Cryle, M. J. & Charkoudian, L. K., 12 Jul 2017, In : RSC Advances. 7, 56, p. 35376-35384 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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SNaPe: A versatile method to generate multiplexed protein fusions using synthetic linker peptides for in vitro applications

Ulrich, V. & Cryle, M. J., Jan 2017, In : Journal of Peptide Science. 23, 1, p. 16-27 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Uncovering protein–protein interactions through a team-based undergraduate biochemistry course

Cookmeyer, D. L., Winesett, E. S., Kokona, B., Huff, A. R., Aliev, S., Bloch, N. B., Bulos, J. A., Evans, I. L., Fagre, C. R., Godbe, K. N., Khromava, M., Konstantinovsky, D. M., Lafrance, A. E., Lamacki, A. J., Parry, R. C., Quinn, J. M., Thurston, A. M., Tsai, K. J. S., Mollo, A., Cryle, M. J. & 2 othersFairman, R. & Charkoudian, L. K., 1 Nov 2017, In : PLoS Biology. 15, 11, 13 p., e2003145.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934

Ulrich, V., Brieke, C. & Cryle, M. J., 27 Dec 2016, In : Beilstein Journal of Organic Chemistry. 12, p. 2849-2864 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Capturing the Structure of the Substrate Bound Condensation Domain

Kittila, T. & Cryle, M. J., 17 Mar 2016, In : Chemistry and Biology. 23, 3, p. 315-316 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Catalytic promiscuity of glycopeptide N-methyltransferases enables bio-orthogonal labelling of biosynthetic intermediates

Brieke, C., Yim, G., Peschke, M., Wright, G. D. & Cryle, M. J., Nov 2016, In : Chemical Communications. 52, 94, p. 13679-13682 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis?

Brieke, C., Maier, T., Schroter, M. & Cryle, M. J., 2016, In : MedChemComm. 7, 1, p. 132 - 140 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Facile Synthetic Access to Glycopeptide Antibiotic Precursor Peptides for the Investigation of Cytochrome P450 Action in Glycopeptide Antibiotic Biosynthesis

Brieke, C., Kratzig, V., Peschke, M. & Cryle, M. J., 2016, Nonribosomal Peptide and Polyketide Biosynthesis: Methods and Protocols. Evans, B. S. (ed.). 1st ed. New York NY USA: Humana Press, p. 85-102 18 p. (Methods in Molecular Biology: Springer Protocols; vol. 1401).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

F-O-G ring formation in glycopeptide antibiotic biosynthesis is catalysed by OxyE

Peschke, M., Brieke, C. & Cryle, M. J., 18 Oct 2016, In : Scientific Reports. 6, 9 p., 35584.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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More than just recruitment: The X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

Ulrich, V., Peschke, M., Brieke, C. & Cryle, M. J., Oct 2016, In : Molecular BioSystems. 12, 10, p. 2992-3004 13 p.

Research output: Contribution to journalArticleResearchpeer-review

New structural data reveal the motion of carrier proteins in nonribosomal peptide synthesis

Kittila, T., Mollo, A., Charkoudian, L. K. & Cryle, M. J., 16 Aug 2016, In : Angewandte Chemie - International Edition. 55, 34, p. 9834-9840 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Online pyrophosphate assay for analyzing adenylation domains of nonribosomal peptide synthetases

Kittila, T., Schoppet, M. & Cryle, M. J., 1 Apr 2016, In : ChemBioChem. 17, 7, p. 576-584 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the selectivity of β-hydroxylation reactions in non-ribosomal peptide synthesis using analytical ultracentrifugation

Kokona, B., Winesett, E. S., von Krusenstiern, A. N., Cryle, M. J., Fairman, R. & Charkoudian, L. K., 15 Feb 2016, In : Analytical Biochemistry. 495, p. 42-51 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of the P450 oxygenation cascade involved in glycopeptide antibiotic biosynthesis

Peschke, M., Haslinger, K., Brieke, C., Reinstein, J. & Cryle, M. J., 23 May 2016, In : Journal of the American Chemical Society. 138, 21, p. 6746-6753 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of OxyAtei : Completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade

Haslinger, K. & Cryle, M. J., Feb 2016, In : FEBS Letters. 590, 4, p. 571-581 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis

Peschke, M., Gonsior, M., Sussmuth, R. D. & Cryle, M. J., 1 Dec 2016, In : Current Opinion in Structural Biology. 41, p. 46-53 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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2015

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

Brieke, C., Kratzig, V., Haslinger, K., Winkler, A. & Cryle, M. J., 2015, In : Organic and Biomolecular Chemistry. 13, 7, p. 2012 - 2021 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis

Brieke, C., Peschke, M., Haslinger, K. & Cryle, M. J., 2015, In : Angewandte Chemie - International Edition. 54, 52, p. 15715 - 15719 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

Al Toma, R. S., Brieke, C., Cryle, M. J. & Sussmuth, R. D., 2015, In : Natural Product Reports. 32, 8, p. 1207 - 1235 29 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis

Haslinger, K., Redfield, C. & Cryle, M. J., 2015, In : Proteins: Structure, Function, and Bioinformatics. 83, 4, p. 711 - 721 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis

Zhang, A., Zhang, T., Hall, E. A., Hutchinson, S., Cryle, M. J., Wong, L-L. L., Zhou, W. & Bell, S. G., 2015, In : Molecular BioSystems. 11, 3, p. 869 - 881 13 p.

Research output: Contribution to journalArticleResearchpeer-review

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

Haslinger, K., Peschke, M., Brieke, C., Maximowitsch, E. & Cryle, M. J., 2015, In : Nature. 521, 7550, p. 105 - 109 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

A facile Fmoc solid phase synthesis strategy to access epimerization-prone biosynthetic intermediates of glycopeptide antibiotics

Brieke, C. & Cryle, M. J., 2014, In : Organic Letters. 16, p. 2454 - 2457 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis

Haslinger, K., Maximowitsch, E., Brieke, C., Koch, A. & Cryle, M. J., 2014, In : ChemBioChem. 15, 18, p. 2719 - 2728 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative transformations of amino acids and peptides catalysed by Cytochromes P450

Cryle, M. J., Brieke, C. & Haslinger, K., 1 Jan 2014, Amino Acids, Peptides and Proteins. Farkas, E. & Ryadnov, M. (eds.). UK: The Royal Society of Chemistry, p. 1-36 36 p. (Amino Acids, Peptides and Proteins; vol. 38).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

The structure of a transient complex of a nonribosomal peptide synthetase and a cytochrome P450 monooxygenase

Haslinger, K., Brieke, C., Uhlmann, S., Sieverling, L., Sussmuth, R. D. & Cryle, M. J., 2014, In : Angewandte Chemie - International Edition. 53, 32, p. 8518 - 8522 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Cytochrome p450sky interacts directly with the nonribosomal peptide synthetase to generate three amino acid precursors in skyllamycin biosynthesis

Uhlmann, S., Sussmuth, R. D. & Cryle, M., 2013, In : ACS Chemical Biology. 8, 11, p. 2586 - 2596 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inner-shell multiple ionization of polyatomic molecules with an intense x-ray free-electron laser studied by coincident ion momentum imaging

Erk, B., Rolles, D., Foucar, L., Rudek, B., Epp, S. W., Cryle, M. J., Bostedt, C., Schorb, S., Bozek, J. D., Rouzee, A., Hundertmark, A., Marchenko, T., Simon, M., Filsinger, F., Christensen, L., De, S., Trippel, S., Kupper, J., Stapelfeldt, H., Wada, S. & 8 othersUeda, K., Swiggers, M., Messerschmidt, M., Schroter, C. D., Moshammer, R., Schlichting, I., Ullrich, J. & Rudenko, A., 2013, In : Journal of Physics B: Atomic, Molecular and Optical Physics. 46, Article #164031, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Ultrafast charge rearrangement and nuclear dynamics upon inner-shell multiple ionization of small polyatomic molecules

Erk, B., Rolles, D., Foucar, L., Rudek, B., Epp, S. W., Cryle, M. J., Bostedt, C., Schorb, S., Bozek, J. D., Rouzee, A., Hundertmark, A., Marchenko, T., Simon, M., Filsinger, F., Christensen, L., De, S., Trippel, S., Kupper, J., Stapelfeldt, H., Wada, S. & 8 othersUeda, K., Swiggers, M., Messerschmidt, M., Schroter, C. D., Moshammer, R., Schlichting, I., Ullrich, J. & Rudenko, A., 2013, In : Physical Review Letters. 110, 5, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Coulomb explosion imaging of small organic molecules at LCLS

Erk, B., Rudenko, A., Rolles, D., Rudek, B., Foucar, L., Epp, S. W., Cryle, M., Schlichting, I., Bostedt, C., Schorb, S., Bozek, J. D., Rouzee, A., Hundertmark, A., Marchenko, T., Simon, M., Filsinger, F., Christensen, L., Ganesh, S., Trippel, S., Wada, S. & 3 othersUeda, K., Dieter Schroeter, C. & Ullrich, J., 2012, In : Journal of Physics: Conference Series. 388, PART 2, 022108.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3)-catalysed oxidation of cyclopropyl fatty acids

Cryle, M. J., Hayes, P. Y. & De Voss, J. J., 2012, In : Chemistry - A European Journal. 18, 50, p. 15994 - 15999 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Femtosecond free-electron laser x-ray diffraction data sets for algorithm development

Kassemeyer, S., Steinbrener, J., Lomb, L., Hartmann, E., Aquila, A. L., Barty, A., Martin, A. V., Hampton, C. Y., Bajt, S., Barthelmess, M., Barends, T. R. M., Bostedt, C., Bott, M., Bozek, J. D., Coppola, N., Cryle, M. J., DePonte, D. P., Doak, R. B., Epp, S. W., Erk, B. & 42 othersFleckenstein, H., Foucar, L., Graafsma, H., Gumprecht, L., Hartmann, A., Hartmann, R., Hauser, G., Hirsemann, H., Homke, A., Holl, P., Jonsson, O., Kimmel, N., Krasniqi, F., Liang, M., Maia, F. R. N. C., Marchesini, S., Nass, K., Reich, C., Rolles, D., Rudek, B., Rudenko, A., Schmidt, C., Schulz, J., Shoeman, R. L., Sierra, R. G., Soltau, H., Spence, J. C. H., Starodub, D., Stellato, F., Stern, S., Stier, G., Svenda, M., Weidenspointner, G., Weierstall, U., White, T. A., Wunderer, C., Frank, M., Chapman, H. N., Ullrich, J., Struder, L., Bogan, M. J. & Schlichting, I., 2012, In : Optics Express. 20, 4, p. 4149 - 4158 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

Carrier protein substrates in cytochrome P450-catalysed oxidation

Cryle, M. J., 2011, In : Metallomics. 3, 4, p. 323 - 326 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural characterization of CYP165D3, a cytochrome P450 involved in phenolic coupling in teicoplanin biosynthesis

Cryle, M. J., Staaden, J. & Schlichting, I., 2011, In : Archives of Biochemistry and Biophysics. 507, 1, p. 163 - 173 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Selectivity in a barren landscape: the P450(BioI)-ACP complex

Cryle, M. J., 2010, In : Biochemical Society Transactions. 38, 4, p. 934 - 939 6 p.

Research output: Contribution to journalArticleResearchpeer-review