Projects per year
Personal profile
Biography
Dr Max Cryle is an EMBL Australia Group leader in the Victorian Node, based in the Department of Biochemistry and Molecular Biology at Monash University and an associate investigator at the Australian Research Council Centre of Excellence in Advanced Molecular Imaging. After obtaining his PhD in chemistry from the University of Queensland in 2006, he moved to the Max Planck Institute for Medical Research in Heidelberg as a Cross Disciplinary Fellow of the Human Frontiers Science Program. He was subsequently awarded funding from the German Research Foundation (Deutsche Forschungsgemeinschaft) to establish his own group to investigate glycopeptide antibiotic biosynthesis as part of the Emmy Noether program. His group works at the boundary of chemistry and biology, where they apply a multidisciplinary approach including synthetic chemistry, biochemistry, structural biology and enzyme catalysis. In 2016 he joined EMBL Australia to continue his research into understanding the biosynthesis of important natural antibiotics and developing new antimicrobial agents, with his work supported by an NHMRC Career Development Fellowship since 2018.
Research area keywords
- Antibiotics
- Biosynthesis
- Biological Chemistry
- Structural Biology
- Peptides
- Biochemistry
- Biocatalysis
- Enzymes
- Drug Resistance
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being -
SDG 7 Affordable and Clean Energy
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Engineering enzymes for controlled peptide modification
Cryle, M. (Primary Chief Investigator (PCI)) & Garcia-Borràs, M. (Partner Investigator (PI))
ARC - Australian Research Council
18/05/26 → 17/05/29
Project: Research
-
Engineering glycopeptide antibiotic biosynthesis to produce novel antibiotics
Cryle, M. (Primary Chief Investigator (PCI)), Hansen, M. (Chief Investigator (CI)), Ratnayake, M. (Chief Investigator (CI)) & Stegmann, E. (Chief Investigator (CI))
1/01/25 → 31/12/26
Project: Research
-
Exploiting a novel dendritic cell regulatory pathway for developing unique immunotherapies
Lahoud, M. (Primary Chief Investigator (PCI)) & Cryle, M. (Chief Investigator (CI))
1/01/24 → 31/12/26
Project: Research
-
ARC Centre of Excellence for Innovations in Peptide and Protein Science
Craik, D. (Primary Chief Investigator (PCI)), Payne, R. J. (Chief Investigator (CI)), Belov, K. (Chief Investigator (CI)), Jolliffe, K. A. (Chief Investigator (CI)), New, E. (Chief Investigator (CI)), Fairlie, D. (Chief Investigator (CI)), King, G. F. (Chief Investigator (CI)), Henriques, S. T. (Chief Investigator (CI)), Otting, G. (Chief Investigator (CI)), Malins, L. (Chief Investigator (CI)), Jackson, C. J. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Challis, G. (Chief Investigator (CI)), Colgrave, M. (Chief Investigator (CI)), Ploegh, H. (Partner Investigator (PI)), Baker, D. A. (Partner Investigator (PI)), Suga, H. (Partner Investigator (PI)), Davis, B. G. (Partner Investigator (PI)), Pentelute, B. (Partner Investigator (PI)), van der Donk, W. (Partner Investigator (PI)), Tavassoli, A. (Partner Investigator (PI)) & Savage, G. (Partner Investigator (PI))
23/12/20 → 21/01/28
Project: Research
-
NHMRC Equipment Grant - Alpine Direct Electron Detector
Ramm, G. (Primary Chief Investigator (PCI)), Lithgow, T. (Chief Investigator (CI)), Davidovich, C. (Chief Investigator (CI)), Ellisdon, A. (Chief Investigator (CI)), Dunstone, M. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Gully, B. (Chief Investigator (CI)), Wong, W. (Chief Investigator (CI)), Coulibaly, F. (Chief Investigator (CI)) & Knott, G. (Chief Investigator (CI))
1/11/23 → 31/12/24
Project: Research
-
Cyclic natural product oligomers: diversity and (bio)synthesis of macrocycles
Zhang, S., Fan, S., He, H., Zhu, J., Murray, L., Liang, G., Ran, S., Zhu, Y. Z., Cryle, M. J., He, H. Y. & Zhang, Y., 7 Jan 2025, In: Chemical Society Reviews. 54, 1, p. 396-464 69 p.Research output: Contribution to journal › Review Article › Research › peer-review
21 Link opens in a new tab Citations (Scopus) -
Ribosomal pentapeptide nitration for non-ribosomal peptide antibiotic precursor biosynthesis
Padva, L., Zimmer, L., Gullick, J., Zhao, Y., Sasi, V. M., Schittenhelm, R. B., Jackson, C. J., Cryle, M. J. & Crüsemann, M., 12 Jun 2025, In: Chem. 11, 6, 13 p., 102438.Research output: Contribution to journal › Article › Research › peer-review
Open Access17 Link opens in a new tab Citations (Scopus) -
SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss
Xi, X. (Leading Author), Liu, L., Tuano, N., Tailhades, J., Mouradov, D., Steen, J., Sieber, O., Cryle, M., Nguyen-Dumont, T., Segelov, E. & Rosenbluh, J. (Leading Author), 15 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 15, 12 p., e2409677122.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Teicoplanin Nonribosomal Peptide Synthetase Is Unable to Incorporate Alpha-Ketoacid Building Blocks
Ratnayake, M. S., Jian, X., Tailhades, J., Challis, G. L., Hansen, M. H., Lewandowski, J. R. & Cryle, M. J., 6 Jun 2025, In: Biochemistry. 64, 9, p. 2039−2053 15 p.Research output: Contribution to journal › Article › Research › peer-review
2 Link opens in a new tab Citations (Scopus) -
The Biarylitides: Understanding the Structure and Biosynthesis of a Fascinating Class of Cytochrome P450 Modified RiPP Natural Products
Padva, L., Gullick, J., Coe, L. J., Hansen, M. H., De Voss, J. J., Crüsemann, M. & Cryle, M. J., 1 Apr 2025, In: ChemBioChem. 26, 7, 25 p., e202400916.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access19 Link opens in a new tab Citations (Scopus)
-
Evan Lo
Tailhades, J. (Supervisor) & Cryle, M. (Supervisor)
2025 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
-
Jemma Gullick
Tailhades, J. (Supervisor) & Cryle, M. (Supervisor)
2024 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
-
Komal Prasad
Tailhades, J. (Supervisor) & Cryle, M. (Supervisor)
2024 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
-
Rachel Cass (Summer Scholarship)
Payne, J. (Supervisor) & Cryle, M. (Supervisor)
Nov 2021 → Feb 2022Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
-
Krishani Dave (Masters Student)
Payne, J. (Supervisor) & Cryle, M. (Supervisor)
2021Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
Press/Media
-
Faculty of Opinions recommendation
Payne, J., Cryle, M., Tailhades, J., Fulcher, A., Ellett, F., Irima, D., Kostoulias, X., Leung, R., Louch, S., Tran, A., Weber, S., Schittenhelm, R., Lieschke, G., Qin, C. H., Peleg, A. & Fu, T.
3/12/21
1 item of Media coverage
Press/Media: Article/Feature
-
New article: Chemoattractant attachment boosts antibiotic efficacy
Payne, J. & Cryle, M.
28/10/21
1 item of Media coverage
Press/Media: Article/Feature
-