Projects per year
Personal profile
Biography
Dr Max Cryle is an EMBL Australia Group leader in the Victorian Node, based in the Department of Biochemistry and Molecular Biology at Monash University and an associate investigator at the Australian Research Council Centre of Excellence in Advanced Molecular Imaging. After obtaining his PhD in chemistry from the University of Queensland in 2006, he moved to the Max Planck Institute for Medical Research in Heidelberg as a Cross Disciplinary Fellow of the Human Frontiers Science Program. He was subsequently awarded funding from the German Research Foundation (Deutsche Forschungsgemeinschaft) to establish his own group to investigate glycopeptide antibiotic biosynthesis as part of the Emmy Noether program. His group works at the boundary of chemistry and biology, where they apply a multidisciplinary approach including synthetic chemistry, biochemistry, structural biology and enzyme catalysis. In 2016 he joined EMBL Australia to continue his research into understanding the biosynthesis of important natural antibiotics and developing new antimicrobial agents, with his work supported by an NHMRC Career Development Fellowship since 2018.
Keywords
- Antibiotics
- Biosynthesis
- Biological Chemistry
- Structural Biology
- Peptides
- Biochemistry
- Biocatalysis
- Enzymes
- Drug Resistance
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Projects 2016 2021
Biosynthetic LEGO: enzymatic redesign to produce new vancomycin analogues
1/01/19 → 31/12/21
Project: Research
PROTACs as a novel therapeutic strategy to enable colorectal cancer precision medicine
Rosenbluh, S., Cryle, M. & Segelov, E.
1/01/19 → 31/12/20
Project: Research
Development of a bio-enabled synthesis for the Glycopeptide Antibiotics
Cryle, M. & De Voss, J.
Australian Research Council (ARC), Monash University, The University of Queensland
1/01/17 → 31/12/19
Project: Research
Characterisation of novel glycopeptide antibiotic biosyntheses pathways
1/02/17 → 31/01/19
Project: Research
Research Output 2003 2019
Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain
Izoré, T., Tailhades, J., Hansen, M. H., Kaczmarski, J. A., Jackson, C. J. & Cryle, M. J., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 2913-2918 6 p.Research output: Contribution to journal › Article › Research › peer-review
Studying trans-acting enzymes that target carrier protein-bound amino acids during nonribosomal peptide synthesis
Greule, A., Charkoudian, L. K. & Cryle, M. J., 1 Jan 2019, Metabolons and Supramolecular Enzyme Assemblies. Schmidt-Dannert, C. & Quin, M. B. (eds.). Academic Press, p. 113-154 42 p. (Methods in Enzymology; vol. 617).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis
Schoppet, M., Peschke, M., Kirchberg, A., Wiebach, V., Süssmuth, R. D., Stegmann, E. & Cryle, M. J., 1 Jan 2019, In : Chemical Science. 10, 1, p. 118-133 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
An enhanced chemoenzymatic method for loading substrates onto carrier protein domains
Kittilä, T. & Cryle, M. J., 1 Jan 2018, In : Biochemistry and Cell Biology. 96, 3, p. 372-379 8 p.Research output: Contribution to journal › Article › Research › peer-review
A route to diastereomerically pure phenylglycine thioester peptides: Crucial intermediates for investigating glycopeptide antibiotic biosynthesis
Tailhades, J., Schoppet, M., Greule, A., Peschke, M., Brieke, C. & Cryle, M. J., 9 Feb 2018, In : Chemical Communications. 54, 17, p. 2146-2149 4 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Activities 2017 2017
- 1 Membership of industry collaboration/ network
Monash Biomedicine Discovery Institute (Organisational unit)
Trevor Lithgow (Inventor), Matthew James Belousoff (Member), Meredith Anne O'Keeffe (Member), Max Cryle (Member), Ana Traven (Member), John Dallas Boyce (Member), Julian Ian Rood (Member), Fasseli Joseph Coulibaly (Member), Anton Yariv Peleg (Member), Sheena McGowan (Member), Dena Lyras (Member), Philip Robert Heraud (Member)2017 → 2018
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network