Projects per year
Personal profile
Biography
Dr Max Cryle is an EMBL Australia Group leader in the Victorian Node, based in the Department of Biochemistry and Molecular Biology at Monash University and an associate investigator at the Australian Research Council Centre of Excellence in Advanced Molecular Imaging. After obtaining his PhD in chemistry from the University of Queensland in 2006, he moved to the Max Planck Institute for Medical Research in Heidelberg as a Cross Disciplinary Fellow of the Human Frontiers Science Program. He was subsequently awarded funding from the German Research Foundation (Deutsche Forschungsgemeinschaft) to establish his own group to investigate glycopeptide antibiotic biosynthesis as part of the Emmy Noether program. His group works at the boundary of chemistry and biology, where they apply a multidisciplinary approach including synthetic chemistry, biochemistry, structural biology and enzyme catalysis. In 2016 he joined EMBL Australia to continue his research into understanding the biosynthesis of important natural antibiotics and developing new antimicrobial agents, with his work supported by an NHMRC Career Development Fellowship since 2018.
Research area keywords
- Antibiotics
- Biosynthesis
- Biological Chemistry
- Structural Biology
- Peptides
- Biochemistry
- Biocatalysis
- Enzymes
- Drug Resistance
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
PROTACs as a novel therapeutic strategy to enable colorectal cancer precision medicine
Rosenbluh, S., Cryle, M. & Segelov, E.
1/01/19 → 31/12/20
Project: Research
Biosynthetic LEGO: enzymatic redesign to produce new vancomycin analogues
1/01/19 → 31/12/21
Project: Research
Characterisation of novel glycopeptide antibiotic biosyntheses pathways
1/02/17 → 31/01/19
Project: Research
Development of a bio-enabled synthesis for the Glycopeptide Antibiotics
Cryle, M. & De Voss, J.
Australian Research Council (ARC), Monash University, University of Queensland
1/01/17 → 31/12/19
Project: Research
Research Output
A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues
Tailhades, J., Zhao, Y., Ho, Y. T. C., Greule, A., Ahmed, I., Schoppet, M., Kulkarni, K., Goode, R. J. A., Schittenhelm, R. B., De Voss, J. J. & Cryle, M. J., 15 Apr 2020, (Accepted/In press) In : Angewandte Chemie - International Edition. 6 p.Research output: Contribution to journal › Article › Research › peer-review
1
Citation
(Scopus)
Exploring the Tetracyclization of Teicoplanin Precursor Peptides through Chemoenzymatic Synthesis
Zhao, Y., Goode, R. J. A., Schittenhelm, R. B., Tailhades, J. & Cryle, M. J., 7 Feb 2020, In : The Journal of Organic Chemistry. 85, 3, p. 1537-1547 11 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
Understanding the early stages of peptide formation during the biosynthesis of teicoplanin and related glycopeptide antibiotics
Kaniusaite, M., Tailhades, J., Kittilä, T., Fage, C. D., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 2 May 2020, (Accepted/In press) In : FEBS Journal. 23 p.Research output: Contribution to journal › Article › Research › peer-review
Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation
Lim Kam Sian, T. C. C., Indumathy, S., Halim, H., Greule, A., Cryle, M. J., Bowness, P., Rossjohn, J., Gras, S., Purcell, A. W. & Schittenhelm, R. B., 27 Dec 2019, In : The Journal of Biological Chemistry. 294, 52, p. 20185-20195 11 p.Research output: Contribution to journal › Article › Research › peer-review
A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics
Kaniusaite, M., Tailhades, J., Marschall, E. A., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 29 Aug 2019, In : Chemical Science. 10, 41, p. 9466-9482 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
4
Citations
(Scopus)
Activities
Aoife Kelly (Research in Action project)
Jennifer Payne (Supervisor), & Max Cryle (Supervisor)
Mar 2019 → Jun 2019
Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
Ye (Elaine) Jiang (Summer Scholarship)
Jennifer Payne (Supervisor), , Julien Tailhades (Supervisor), & Max Cryle (Supervisor)
Nov 2019 → Feb 2020
Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
Amy Tran (Winter Scholarship)
Jennifer Payne (Supervisor), & Max Cryle (Supervisor)
Jul 2018 → Aug 2018
Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), , Max Cryle (Member), , Kellie Tuck (Member), , Ana Traven (Member), , Thomas Naderer (Member), , Julian Rood (Member), , Dena Lyras (Member), , Anton Peleg (Member), , Mibel Aguilar (Member), , Fasseli Coulibaly (Member), , Sheena McGowan (Member), , Meredith Anne Okeeffe (Member), , Matthew Belousoff (Member), & Philip Heraud (Member)
1 Mar 2017 → 1 Jan 2019
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
(Honours)
Jennifer Payne (Supervisor), & Max Cryle (Supervisor)
2017
Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions