Projects per year
Personal profile
Biography
Dr Max Cryle is an EMBL Australia Group leader in the Victorian Node, based in the Department of Biochemistry and Molecular Biology at Monash University and an associate investigator at the Australian Research Council Centre of Excellence in Advanced Molecular Imaging. After obtaining his PhD in chemistry from the University of Queensland in 2006, he moved to the Max Planck Institute for Medical Research in Heidelberg as a Cross Disciplinary Fellow of the Human Frontiers Science Program. He was subsequently awarded funding from the German Research Foundation (Deutsche Forschungsgemeinschaft) to establish his own group to investigate glycopeptide antibiotic biosynthesis as part of the Emmy Noether program. His group works at the boundary of chemistry and biology, where they apply a multidisciplinary approach including synthetic chemistry, biochemistry, structural biology and enzyme catalysis. In 2016 he joined EMBL Australia to continue his research into understanding the biosynthesis of important natural antibiotics and developing new antimicrobial agents, with his work supported by an NHMRC Career Development Fellowship since 2018.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Antibiotics
- Biosynthesis
- Biological Chemistry
- Structural Biology
- Peptides
- Biochemistry
- Biocatalysis
- Enzymes
- Drug Resistance
Collaborations and top research areas from the last five years
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Engineering glycopeptide antibiotic biosynthesis to produce novel antibiotics
Cryle, M. (Primary Chief Investigator (PCI)), Hansen, M. (Chief Investigator (CI)), Ratnayake, M. (Chief Investigator (CI)) & Stegmann, E. (Chief Investigator (CI))
1/01/25 → 31/12/26
Project: Research
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Exploiting a novel dendritic cell regulatory pathway for developing unique immunotherapies
Lahoud, M. (Primary Chief Investigator (PCI)) & Cryle, M. (Chief Investigator (CI))
1/01/24 → 31/12/26
Project: Research
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ARC Centre of Excellence for Innovations in Peptide and Protein Science
Craik, D. J. (Primary Chief Investigator (PCI)), Payne, R. J. (Chief Investigator (CI)), Belov, K. (Chief Investigator (CI)), Jolliffe, K. A. (Chief Investigator (CI)), New, E. (Chief Investigator (CI)), Fairlie, D. P. (Chief Investigator (CI)), King, G. F. (Chief Investigator (CI)), Henriques, S. T. (Chief Investigator (CI)), Otting, G. (Chief Investigator (CI)), Malins, L. (Chief Investigator (CI)), Jackson, C. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Challis, G. (Chief Investigator (CI)), Colgrave, M. (Chief Investigator (CI)), Ploegh, H. (Partner Investigator (PI)), Baker, D. A. (Partner Investigator (PI)), Suga, H. (Partner Investigator (PI)), Davis, B. G. (Partner Investigator (PI)), Pentelute, B. (Partner Investigator (PI)), van der Donk, W. (Partner Investigator (PI)), Tavassoli, A. (Partner Investigator (PI)) & Savage, G. (Partner Investigator (PI))
23/12/20 → 21/01/28
Project: Research
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NHMRC Equipment Grant - Alpine Direct Electron Detector
Ramm, G. (Primary Chief Investigator (PCI)), Lithgow, T. (Chief Investigator (CI)), Davidovich, C. (Chief Investigator (CI)), Ellisdon, A. (Chief Investigator (CI)), Dunstone, M. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Gully, B. (Chief Investigator (CI)), Wong, W. (Chief Investigator (CI)), Coulibaly, F. (Chief Investigator (CI)) & Knott, G. (Chief Investigator (CI))
1/11/23 → 31/12/24
Project: Research
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Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R. (Primary Chief Investigator (PCI)), Davidovich, C. (Chief Investigator (CI)), Purcell, A. (Chief Investigator (CI)), Ellisdon, A. (Chief Investigator (CI)), Li, J. (Chief Investigator (CI)), Aguilar, M. (Chief Investigator (CI)), Cryle, M. (Chief Investigator (CI)), Stone, M. (Chief Investigator (CI)), Lithgow, T. (Chief Investigator (CI)) & Zhang, Q. (Chief Investigator (CI))
1/10/21 → 31/12/22
Project: Research
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Advancing Nitrile-Aminothiol Strategy for Dual and Sequential Bioconjugation
Thombare, V. J., Wu, Y., Pamulapati, K., Han, M., Tailhades, J., Cryle, M. J., Roberts, K. D., Velkov, T., Li, J. & Patil, N. A., 19 Aug 2024, In: Chemistry - A European Journal. 30, 6, 10 p., e202401674.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides
Treisman, M., Coe, L., Zhao, Y., Sasi, V. M., Gullick, J., Hansen, M. H., Ly, A., Leichthammer, V., Hess, C., Machell, D. L., Schittenhelm, R. B., Hooper, J., Jackson, C. J., Tailhades, J., De Voss, J. J. & Cryle, M. J., 28 Feb 2024, In: Organic Letters. 26, 9, p. 1828-1833 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
An in vitro assay to explore condensation domain specificity from non-ribosomal peptide synthesis
Ratnayake, M., Ho, Y. T. C., Jian, X. & Cryle, M. J., 2024, Methods in Enzymology: Siderophore and Related Natural Products Biosynthesis. Wencewicz, T. (ed.). Cambridge MA USA: Academic Press, Vol. 702. p. 89-119 31 p. (Methods in Enzymology; vol. 702).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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Enzyme engineering lets us play with new building blocks in non-ribosomal peptide synthesis
Ratnayake, M. S., Hansen, M. H. & Cryle, M. J., 2 May 2024, In: Structure. 32, 5, p. 520-522 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Reassignment of the Structure of a Tryptophan-Containing Cyclic Tripeptide Produced by the Biarylitide Crosslinking Cytochrome P450blt
Coe, L. J., Zhao, Y., Padva, L., Keto, A., Schittenhelm, R., Tailhades, J., Pierens, G., Krenske, E. H., Crüsemann, M., De Voss, J. J. & Cryle, M. J., 5 Jul 2024, In: Chemistry - A European Journal. 30, 38, 10 p., e202400988.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus)
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Evan Lo
Tailhades, J. (Supervisor) & Cryle, M. (Supervisor)
2025 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Jemma Gullick
Tailhades, J. (Supervisor) & Cryle, M. (Supervisor)
2024 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Komal Prasad
Tailhades, J. (Supervisor) & Cryle, M. (Supervisor)
2024 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Krishani Dave (Masters Student)
Payne, J. (Supervisor) & Cryle, M. (Supervisor)
2021Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Rachel Cass (Summer Scholarship)
Payne, J. (Supervisor) & Cryle, M. (Supervisor)
Nov 2021 → Feb 2022Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
Press/Media
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Faculty of Opinions recommendation
Payne, J., Cryle, M., Tailhades, J., Fulcher, A., Ellett, F., Irima, D., Kostoulias, X., Leung, R., Louch, S., Tran, A., Weber, S., Schittenhelm, R., Lieschke, G., Qin, C. H., Peleg, A. & Fu, T.
3/12/21
1 item of Media coverage
Press/Media: Article/Feature
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New article: Chemoattractant attachment boosts antibiotic efficacy
Payne, J. & Cryle, M.
28/10/21
1 item of Media coverage
Press/Media: Article/Feature
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