Projects per year
Personal profile
Biography
Dr Max Cryle is an EMBL Australia Group leader in the Victorian Node, based in the Department of Biochemistry and Molecular Biology at Monash University and an associate investigator at the Australian Research Council Centre of Excellence in Advanced Molecular Imaging. After obtaining his PhD in chemistry from the University of Queensland in 2006, he moved to the Max Planck Institute for Medical Research in Heidelberg as a Cross Disciplinary Fellow of the Human Frontiers Science Program. He was subsequently awarded funding from the German Research Foundation (Deutsche Forschungsgemeinschaft) to establish his own group to investigate glycopeptide antibiotic biosynthesis as part of the Emmy Noether program. His group works at the boundary of chemistry and biology, where they apply a multidisciplinary approach including synthetic chemistry, biochemistry, structural biology and enzyme catalysis. In 2016 he joined EMBL Australia to continue his research into understanding the biosynthesis of important natural antibiotics and developing new antimicrobial agents, with his work supported by an NHMRC Career Development Fellowship since 2018.
Research area keywords
- Antibiotics
- Biosynthesis
- Biological Chemistry
- Structural Biology
- Peptides
- Biochemistry
- Biocatalysis
- Enzymes
- Drug Resistance
Network
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Parallel Extended HDX system (Trajan Scientific and Medical)
Schittenhelm, R., Davidovich, C., Purcell, A., Ellisdon, A., Li, J., Aguilar, M., Cryle, M., Stone, M., Lithgow, T. & Zhang, Q.
1/10/21 → 31/12/22
Project: Research
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Understanding peptide bond formation in non-ribosomal peptide biosynthesis
1/01/21 → 31/12/23
Project: Research
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ARC Centre of Excellence for Innovations in Peptide and Protein Science
Craik, D. J., Payne, R., Belov, K., Jolliffe, K. A., New, E., Fairlie, D., King, G. F., Henriques, S. T., Otting, G., Malins, L., Jackson, C., Cryle, M., Challis, G., Colgrave, M., Ploegh, H., Baker, D. A., Suga, H., Davis, B. G., Pentelute, B., van der Donk, W., Tavassoli, A. & Savage, G.
23/12/20 → 23/12/27
Project: Research
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PROTACs as a novel therapeutic strategy to enable colorectal cancer precision medicine
Rosenbluh, S., Cryle, M. & Segelov, E.
1/01/19 → 31/12/20
Project: Research
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Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus
Payne, J. A. E., Tailhades, J., Ellett, F., Kostoulias, X., Fulcher, A. J., Fu, T., Leung, R., Louch, S., Tran, A., Weber, S. A., Schittenhelm, R. B., Lieschke, G. J., Qin, C. H., Irima, D., Peleg, A. Y. & Cryle, M. J., Dec 2021, In: Nature Communications. 12, 1, 15 p., 6157.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Chemical probes reveal the timing of early chlorination in vancomycin biosynthesis
Leng, D. J., Greule, A., Cryle, M. J. & Tosin, M., 4 Mar 2021, In: Chemical Communications. 57, 18, p. 2293-2296 4 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Communication Breakdown: Dissecting the COM Interfaces between the Subunits of Nonribosomal Peptide Synthetases
Fage, C. D., Kosol, S., Jenner, M., Öster, C., Gallo, A., Kaniusaite, M., Steinbach, R., Staniforth, M., Stavros, V. G., Marahiel, M. A., Cryle, M. J. & Lewandowski, J. R., 3 Sep 2021, In: ACS Catalysis. 11, 17, p. 10802-10813 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Molecular basis for control of antibiotic production by a bacterial hormone
Zhou, S., Bhukya, H., Malet, N., Harrison, P. J., Rea, D., Belousoff, M. J., Venugopal, H., Sydor, P. K., Styles, K. M., Song, L., Cryle, M. J., Alkhalaf, L. M., Fülöp, V., Challis, G. L. & Corre, C., 18 Feb 2021, In: Nature. 590, 7846, p. 463–467 16 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Staphylococcus aureus entanglement in self-assembling β-peptide nanofibres decorated with vancomycin
Payne, J. A. E., Kulkarni, K., Izore, T., Fulcher, A. J., Peleg, A. Y., Aguilar, M. I., Cryle, M. J. & Del Borgo, M. P., 7 May 2021, In: Nanoscale Advances. 3, 9, p. 2607-2616 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
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Krishani Dave (Masters Student)
Jennifer Payne (Supervisor) & Max Cryle (Supervisor)
2021Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Rachel Cass (Summer Scholarship)
Jennifer Payne (Supervisor) & Max Cryle (Supervisor)
Nov 2021 → Feb 2022Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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MONASH UNIVERSITY (Organisational unit)
Jennifer Payne (Inventor), Max Cryle (Inventor), Anton Peleg (Inventor) & Julien Tailhades (Inventor)
23 Apr 2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent (Provisional)
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Aoife Kelly (Research in Action project)
Jennifer Payne (Supervisor) & Max Cryle (Supervisor)
Mar 2019 → Jun 2019Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
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Ye (Elaine) Jiang (Summer Scholarship)
Jennifer Payne (Supervisor), Julien Tailhades (Supervisor) & Max Cryle (Supervisor)
Nov 2019 → Feb 2020Activity: Other Teaching Engagements and non-HDR Supervisions › Non-HDR Supervisions
Press / Media
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Faculty of Opinions recommendation
Jennifer Payne, Max Cryle, Julien Tailhades, Alex Fulcher, Felix Ellett, Daniel Irima, Xenia Kostoulias, Ryan Leung, Steph Louch, Amy Tran, Severin Weber, Ralf Schittenhelm, Graham Lieschke, Chengxue Helena Qin, Anton Peleg & Ting Fu
3/12/21
1 item of Media coverage
Press/Media: Article/Feature
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New article: Chemoattractant attachment boosts antibiotic efficacy
28/10/21
1 item of Media coverage
Press/Media: Article/Feature
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