20032020

Research output per year

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Personal profile

Biography

Dr Max Cryle is an EMBL Australia Group leader in the Victorian Node, based in the Department of Biochemistry and Molecular Biology at Monash University and an associate investigator at the Australian Research Council Centre of Excellence in Advanced Molecular Imaging. After obtaining his PhD in chemistry from the University of Queensland in 2006, he moved to the Max Planck Institute for Medical Research in Heidelberg as a Cross Disciplinary Fellow of the Human Frontiers Science Program. He was subsequently awarded funding from the German Research Foundation (Deutsche Forschungsgemeinschaft) to establish his own group to investigate glycopeptide antibiotic biosynthesis as part of the Emmy Noether program. His group works at the boundary of chemistry and biology, where they apply a multidisciplinary approach including synthetic chemistry, biochemistry, structural biology and enzyme catalysis. In 2016 he joined EMBL Australia to continue his research into understanding the biosynthesis of important natural antibiotics and developing new antimicrobial agents, with his work supported by an NHMRC Career Development Fellowship since 2018.

Research area keywords

  • Antibiotics
  • Biosynthesis
  • Biological Chemistry
  • Structural Biology
  • Peptides
  • Biochemistry
  • Biocatalysis
  • Enzymes
  • Drug Resistance

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Projects

Research Output

A Chemoenzymatic Approach to the Synthesis of Glycopeptide Antibiotic Analogues

Tailhades, J., Zhao, Y., Ho, Y. T. C., Greule, A., Ahmed, I., Schoppet, M., Kulkarni, K., Goode, R. J. A., Schittenhelm, R. B., De Voss, J. J. & Cryle, M. J., 15 Apr 2020, (Accepted/In press) In : Angewandte Chemie - International Edition. 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Exploring the Tetracyclization of Teicoplanin Precursor Peptides through Chemoenzymatic Synthesis

Zhao, Y., Goode, R. J. A., Schittenhelm, R. B., Tailhades, J. & Cryle, M. J., 7 Feb 2020, In : The Journal of Organic Chemistry. 85, 3, p. 1537-1547 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Understanding the early stages of peptide formation during the biosynthesis of teicoplanin and related glycopeptide antibiotics

Kaniusaite, M., Tailhades, J., Kittilä, T., Fage, C. D., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 2 May 2020, (Accepted/In press) In : FEBS Journal. 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation

Lim Kam Sian, T. C. C., Indumathy, S., Halim, H., Greule, A., Cryle, M. J., Bowness, P., Rossjohn, J., Gras, S., Purcell, A. W. & Schittenhelm, R. B., 27 Dec 2019, In : The Journal of Biological Chemistry. 294, 52, p. 20185-20195 11 p.

Research output: Contribution to journalArticleResearchpeer-review

A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics

Kaniusaite, M., Tailhades, J., Marschall, E. A., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 29 Aug 2019, In : Chemical Science. 10, 41, p. 9466-9482 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Activities

  • 13 Non-HDR Supervisions
  • 1 Membership of industry collaboration/ network

Aoife Kelly (Research in Action project)

Jennifer Payne (Supervisor), & Max Cryle (Supervisor)

Mar 2019Jun 2019

Activity: Other Teaching Engagements and non-HDR SupervisionsNon-HDR Supervisions

Ye (Elaine) Jiang (Summer Scholarship)

Jennifer Payne (Supervisor), , Julien Tailhades (Supervisor), & Max Cryle (Supervisor)

Nov 2019Feb 2020

Activity: Other Teaching Engagements and non-HDR SupervisionsNon-HDR Supervisions

Amy Tran (Winter Scholarship)

Jennifer Payne (Supervisor), & Max Cryle (Supervisor)

Jul 2018Aug 2018

Activity: Other Teaching Engagements and non-HDR SupervisionsNon-HDR Supervisions

Monash Antimicrobial Resistance Group (Event)

Trevor Lithgow (Chair/Co-Chair), , Max Cryle (Member), , Kellie Tuck (Member), , Ana Traven (Member), , Thomas Naderer (Member), , Julian Rood (Member), , Dena Lyras (Member), , Anton Peleg (Member), , Mibel Aguilar (Member), , Fasseli Coulibaly (Member), , Sheena McGowan (Member), , Meredith Anne Okeeffe (Member), , Matthew Belousoff (Member), & Philip Heraud (Member)

1 Mar 20171 Jan 2019

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network

(Honours)

Jennifer Payne (Supervisor), & Max Cryle (Supervisor)

2017

Activity: Other Teaching Engagements and non-HDR SupervisionsNon-HDR Supervisions

Press / Media

Max Cryle talks: molecular machines

Max Cryle

1/09/17

1 Media contribution

Press/Media: Expert Comment