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Personal profile

Biography

Dr Max Cryle is an EMBL Australia Group leader in the Victorian Node, based in the Department of Biochemistry and Molecular Biology at Monash University and an associate investigator at the Australian Research Council Centre of Excellence in Advanced Molecular Imaging. After obtaining his PhD in chemistry from the University of Queensland in 2006, he moved to the Max Planck Institute for Medical Research in Heidelberg as a Cross Disciplinary Fellow of the Human Frontiers Science Program. He was subsequently awarded funding from the German Research Foundation (Deutsche Forschungsgemeinschaft) to establish his own group to investigate glycopeptide antibiotic biosynthesis as part of the Emmy Noether program. His group works at the boundary of chemistry and biology, where they apply a multidisciplinary approach including synthetic chemistry, biochemistry, structural biology and enzyme catalysis. In 2016 he joined EMBL Australia to continue his research into understanding the biosynthesis of important natural antibiotics and developing new antimicrobial agents, with his work supported by an NHMRC Career Development Fellowship since 2018.

Research area keywords

  • Antibiotics
  • Biosynthesis
  • Biological Chemistry
  • Structural Biology
  • Peptides
  • Biochemistry
  • Biocatalysis
  • Enzymes
  • Drug Resistance

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Projects 2016 2021

Research Output 2003 2019

1 Citation (Scopus)

A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics

Kaniusaite, M., Tailhades, J., Marschall, E. A., Goode, R. J. A., Schittenhelm, R. B. & Cryle, M. J., 29 Aug 2019, In : Chemical Science. 10, 41, p. 9466-9482 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

Izoré, T., Tailhades, J., Hansen, M. H., Kaczmarski, J. A., Jackson, C. J. & Cryle, M. J., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 2913-2918 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Enzymatic Cascade to Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign

Tailhades, J., Zhao, Y., Schoppet, M., Greule, A., Goode, R. J. A., Schittenhelm, R. B., De Voss, J. J. & Cryle, M. J., 1 Nov 2019, In : Organic Letters. 21, 21, p. 8635-8640 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

Greule, A., Izoré, T., Iftime, D., Tailhades, J., Schoppet, M., Zhao, Y., Peschke, M., Ahmed, I., Kulik, A., Adamek, M., Goode, R. J. A., Schittenhelm, R. B., Kaczmarski, J. A., Jackson, C. J., Ziemert, N., Krenske, E. H., De Voss, J. J., Stegmann, E. & Cryle, M. J., 13 Jun 2019, In : Nature Communications. 10, 1, 15 p., 2613.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Studying trans-acting enzymes that target carrier protein-bound amino acids during nonribosomal peptide synthesis

Greule, A., Charkoudian, L. K. & Cryle, M. J., 1 Jan 2019, Metabolons and Supramolecular Enzyme Assemblies. Schmidt-Dannert, C. & Quin, M. B. (eds.). Academic Press, p. 113-154 42 p. (Methods in Enzymology; vol. 617).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Activities 2017 2017

  • 1 Membership of industry collaboration/ network

Monash Antimicrobial Resistance Group (Event)

Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member), Philip Heraud (Member)
1 Mar 2017

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network

Press / Media

Max Cryle talks: molecular machines

Max Cryle

1/09/17

1 Media contribution

Press/Media: Expert Comment