20032019
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Research Output 2003 2019

2019

Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B. & Costa, M. W., Feb 2019, In : Molecular Metabolism. 20, p. 102-114 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

Anderson, D. J., Kaplan, D. I., Bell, K. M., Koutsis, K., Haynes, J. M., Mills, R. J., Phelan, D. G., Qian, E. L., Leitoguinho, A. R., Arasaratnam, D., Labonne, T., Ng, E. S., Davis, R. P., Casini, S., Passier, R., Hudson, J. E., Porrello, E. R., Costa, M. W., Rafii, A., Curl, C. L. & 9 othersDelbridge, L. M., Harvey, R. P., Oshlack, A., Cheung, M. M., Mummery, C. L., Petrou, S., Elefanty, A. G., Stanley, E. G. & Elliott, D. A., 10 Apr 2018, In : Nature Communications. 9, 1, 13 p., 1373.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

Furtado, M. B., Wilmanns, J. C., Chandran, A., Perera, J., Hon, O., Biben, C., Willow, T. J., Nim, H. T., Kaur, G., Simonds, S., Wu, Q., Willians, D., Salimova, E., Plachta, N., Denegre, J. M., Murray, S. A., Fatkin, D., Cowley, M., Pearson, J. T., Kaye, D. & 4 othersRamialison, M., Harvey, R. P., Rosenthal, N. A. & Costa, M. W., 23 Mar 2017, In : JCI Insight. 2, 6, p. e88271 18 p., e88271.

Research output: Contribution to journalArticleResearch

2016

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels

Furtado, M. B., Wilmanns, J., Chandran, A., Tonta, M. A., Biben, C., Eichenlaub, M. P., Coleman, H. A., Berger, S., Bouveret, R., Singh, R., Harvey, R. P., Ramialison, M. S. M., Pearson, J. T., Parkington, H. C., Rosenthal, N. A. & Da Costa, M. W., 2016, In : Differentiation. 91, 1-3, p. 29 - 41 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The cardiac fibroblast: Origin, identity and role in homeostasis and disease

Furtado, M. B., Costa, M. W. & Rosenthal, N. A., 1 Sep 2016, In : Differentiation. 92, 3, p. 93-101 9 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2015

CARFMAP: a curated pathway map of cardiac fibroblasts

Nim, H. T., Furtado, M. B., Costa, M. W., Kitano, H., Rosenthal, N. A. & Boyd, S. E., 2015, In : PLoS ONE. 10, 12, 16 p., e0143274.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

VISIONET: intuitive visualisation of overlapping transcription factor networks, with applications in cardiogenic gene discovery

Nim, H. T., Furtado, M. B., Da Costa, M., Rosenthal, N. A., Kitano, H. & Boyd, S. E., 2015, In : BMC Bioinformatics. 16, 1 (Art. No: 141), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair

Furtado, M. B., Da Costa, M., Pranoto, E. M. A., Salimova, E., Pinto, R. I. A., Lam, N. T., Park, A., Snider, P., Chandran, A., Harvey, R. P., Boyd, R. L., Conway, S., Pearson, J. T., Kaye, D. M. & Rosenthal, N. A., 2014, In : Circulation Research. 114, 9, p. 1422 - 1434 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Microarray profiling to analyse adult cardiac fibroblast identity

Furtado, M. B., Nim, H. T., Gould, J. A., Costa, M. W., Rosenthal, N. A. & Boyd, S. E., 2014, In : Genomics Data. 2, p. 345 - 350 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Effect of oxygen on cardiac differentiation in mouse iPS cells: role of hypoxia inducible factor-1 and Wnt/beta-catenin signaling

Medley, T. L., Furtado, M. B., Lam, N. T., Idrizi, R., Williams, D., Verma, P. J., Da Costa, M. & Kaye, D. M., 2013, In : PLoS ONE. 8, 11, 8 p., e80280.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy

Da Costa, M., Guo, G., Wolstein, O., Vale, M., Castro, M. L., Wang, L., Otway, R., Riek, P., Cochrane, N., Furtado, M. B., Semsarian, C., Weintraub, R., Yeoh, T., Hayward, C. S., Keogh, A., Macdonald, P., Feneley, M. P., Graham, R. M., Seidman, J. G., Seidman, C. E. & 3 othersRosenthal, N. A., Fatkin, D. & Harvey, R. P., 2013, In : Circulation: Cardiovascular Genetics. 6, 3, p. 238 - 247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Tools in Cancer Research

Costa, M. W. & Rosenthal, N., 22 Oct 2013, Abeloff's Clinical Oncology. Niederhuber, J. E., Armitage, J. O., Tepper, J. E., Doroshow, J. H. & Kastan, M. B. (eds.). 5th ed. Philadelphia PA USA: Academic Press, p. 2-21.e1

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy

Kaur, G., Costa, M., Nefzger, C., Silva, J., Fierro-Gonzalez, J. C., Polo, J. M., Bell, T. D. M. & Plachta, N., 2013, In : Nature Communications. 4, 1637, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2012

Cardiac systolic dysfunction in doxorubicin-challenged rats is associated with upregulation of MuRF2 and MuRF3 ligases

da Silva, M. G., Mattos, E., Camacho-Pereira, J., Domitrovic, T., Galina, A., Costa, M. & Kurtenbach, E., 2012, In : Experimental and Clinical Cardiology. 17, 3, p. 101 - 109 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5

Da Costa, M., Lee, S., Furtado, M., Xin, L., Sparrow, D., Martinez, C., Dunwoodie, S., Kurtenbach, E., Mohun, T., Rosenthal, N. & Harvey, R., 2011, In : PLoS ONE. 6, 9, 13 p., e24812.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

GATA4 mutations in 357 unrelated patients with congenital heart malformation

Butler, T., Esposito, G., Blue, G., Cole, A., Da Costa, M. W., Waddell, L., Walizada, G., Sholler, G., Kirk, E., Feneley, M., Harvey, R. & Winlaw, D., 2010, In : Genetic Testing and Molecular Biomarkers. 14, 6, p. 797 - 802 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Conformational stability and DNA binding specificity of the cardiac T-box transcription factor Tbx20

Macindoe, I., Glockner, L., Vukasin, P., Stennard, F. A., Costa, M. W., Harvey, R. P., Mackay, J. P. & Sunde, M., 2009, In : Journal of Molecular Biology. 389, 3, p. 606 - 618 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular analysis of PRKAG2, LAMP2, and NKX2-5 genes in a cohort of 125 patients with accessory atrioventricular connection

Esposito, G., Grutter, G., Drago, F., Da Costa, M., De Santis, A., Bosco, G., Marino, B., Bellacchio, E., Lepri, F., Harvey, R., Sarkozy, A. & Dallapiccola, B., 2009, In : American Journal of Medical Genetics Part A. 149A, 7, p. 1574 - 1577 4 p.

Research output: Contribution to journalLetterOther

2008

BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4

Furtado, M. B., Solloway, M., Jones, V., Da Costa, M. W., Biben, C., Wolstein, O., Preis, J., Sparrow, D., Saga, Y., Dunwoodie, S., Robertson, E., Tam, P. & Harvey, R., 2008, In : Genes and Development. 22, 21, p. 3037 - 3049 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Mutations in crdiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy

Kirk, E., Sunde, M., Da Costa, M., Rankin, S., Wolstein, O., Castro, M., Butler, T., Huyn, C., Guo, G., Otway, R., Mackay, J., Waddell, L., Cole, A., Hayward, C., Keogh, A., Macdonald, P., Griffiths, L., Fatkin, D., Sholler, G., Zorn, A. & 3 othersFeneley, M., Winlaw, D. & Harvey, R., 2007, In : American Journal of Human Genetics. 81, 2, p. 280 - 291 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery

Elliott, D. A., Solloway, M. J., Wise, N., Biben, C., Costa, M. W., Furtado, M. B., Lange, M., Dunwoodie, S. & Harvey, R. P., 2006, In : Development. 133, 7, p. 1311 - 1322 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation

Stennard, F. A., Costa, M. W., Lai, D., Biben, C., Furtado, M. B., Solloway, M. J., McCulley, D. J., Leimena, C., Preis, J. I., Dunwoodie, S., Elliott, D. A., Prall, O. WJ., Black, B. L., Fatkin, D. & Harvey, R. P., 2005, In : Development. 132, 10, p. 2451 - 2462 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5

Linhares, V. LF., Almeida, N. AS., Menezes, D. C., Elliott, D. A., Lai, D., Beyer, E. C., Campos de Carvalho, A. C. & Costa, M. W., 2004, In : Cardiovascular Research. 64, 3, p. 402 - 411 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

Stennard, F. A., Costa, M. W., Elliott, D. A., Rankin, S., Haast, S. JP., Lai, D., McDonald, L. PA., Niederreither, K., Dolle, P., Bruneau, B. G., Zorn, A. M. & Harvey, R. P., 2003, In : Developmental Biology. 262, 2, p. 206 - 224 19 p.

Research output: Contribution to journalArticleResearchpeer-review