1991 …2022

Research output per year

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Article
2019

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

Lee, K. J., Tieu, W., Blanco-Rodriguez, B., Paparella, A. S., Yu, J., Hayes, A., Feng, J., Marshall, A. C., Noll, B., Milne, R., Cini, D., Wilce, M. C. J., Booker, G. W., Bruning, J. B., Polyak, S. W. & Abell, A. D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 1990-1997 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis

Shah, N., Beckham, S. A., Wilce, J. A. & Wilce, M. C. J., 6 Apr 2018, In : Nucleic Acids Research. 46, 6, p. 3169-3186 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus

Paparella, A. S., Lee, K. J., Hayes, A. J., Feng, J., Feng, Z., Cini, D., Deshmukh, S., Booker, G. W., Wilce, M. C. J., Polyak, S. W. & Abell, A. D., 9 Feb 2018, In : ACS Infectious Diseases. 4, 2, p. 175-184 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

Lang, T., Lee, J. P. W., Elgass, K., Pinar, A. A., Tate, M. D., Aitken, E. H., Fan, H., Creed, S. J., Deen, N. S., Traore, D. A. K., Mueller, I., Stanisic, D., Baiwog, F. S., Skene, C., Wilce, M. C. J., Mansell, A., Morand, E. F. & Harris, J., 1 Dec 2018, In : Nature Communications. 9, 1, 15 p., 2223.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)
2017

Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target

Watson, G. M., Kulkarni, K., Sang, J., Ma, X., Gunzburg, M. J., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 22 Nov 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9349-9359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Structural analysis of variant of Helicobacter pylori MotB in its activated form, engineered as chimera of MotB and leucine zipper

Andrews, D. A., Nesmelov, Y. E., Wilce, M. C. & Roujeinikova, A., 1 Dec 2017, In : Scientific Reports. 7, 1, 12 p., 13435.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

TIA-1 RRM23 binding and recognition of target oligonucleotides

Waris, S., Garcia-Maurino, S. M., Sivakumaran, A., Beckham, S. A., Loughlin, F. E., Gorospe, M., Diaz-Moreno, I., Wilce, M. C. J. & Wilce, J. A., 5 May 2017, In : Nucleic Acids Research. 45, 8, p. 4944-4957 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)
2016

Structural basis of selective aromatic pollutant sensing by the effector binding domain of MopR, an NtrC family transcriptional regulator

Ray, S., Gunzburg, M. J., Wilce, M., Panjikar, S. & Anand, R., 19 Aug 2016, In : ACS Chemical Biology. 11, 8, p. 2357-2365 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7

Gunzburg, M. J., Kulkarni, K., Watson, G. M., Ambaye, N. D., Del Borgo, M. P., Brandt, R., Pero, S. C., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 3 Jun 2016, In : Scientific Reports. 6, 13 p., 27060.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)
2015

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

Selkrig, J. P., Belousoff, M. J., Headey, S. J., Heinz, E., Shiota, T., Shen, H-H., Beckham, S. A., Bamert, R. S., Phan, M-D., Schembri, M. A., Wilce, M. C., Scanlon, M. J., Strugnell, R. A. & Lithgow, T. J., 2015, In : Scientific Reports. 5, 12 p., 12905.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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19 Citations (Scopus)

Cooperative interplay of let-7 mimic and HuR with MYC RNA

Gunzburg, M. J., Sivakumaran, A., Pendini, N. R., Yoon, J-H., Gorospe, M., Wilce, M. C. J. & Wilce, J. A., 2015, In : Cell Cycle. 14, 17, p. 2729 - 2733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Cyclic peptides incorporating phosphotyrosine mimetics as potent and specific inhibitors of the Grb7 breast cancer target

Watson, G. M., Gunzburg, M. J., Ambaye, N. D., Lucas, W. S., Traore, D. A. K., Kulkarni, K. P., Cergol, K. M., Payne, R. J., Panjikar, S., Pero, S. C., Perlmutter, P., Wilce, M. C. & Wilce, J. A., 2015, In : Journal of Medicinal Chemistry. 58, 19, p. 7707 - 7718 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Improved synthesis of biotinol-5'-AMP: implications for antibacterial discovery

Tieu, W., Polyak, S. W., Paparella, A. S., Yap, M. Y., Soares da Costa, T. P., Ng, B., Wang, G., Lumb, R., Bell, J. M., Turnidge, J. D., Wilce, M. C., Booker, G. W. & Abell, A. D., 2015, In : ACS Medicinal Chemistry Letters. 6, 2, p. 216 - 220 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Nucleotide triphosphate promiscuity in mycobacterium tuberculosis dethiobiotin synthetase

Salaemae, W., Yap, M. Y., Wegener, K. L., Booker, G. W., Wilce, M. C. J. & Polyak, S. W., 2015, In : Tuberculosis. 95, 3, p. 259 - 266 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX

Headey, S. J., Sivakumaran, A., Adams, V., Lyras, D., Rood, J. I., Scanlon, M. & Wilce, M. C. J., 2015, In : Journal of Molecular Recognition. 28, 5, p. 316-324 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering

Close, D. W., Don Paul, C. B., Langan, P. S., Wilce, M. C. J., Traore, D. A. K., Halfmann, R., Rocha, R. C., Waldo, G. S., Payne, R. J., Rucker, J. B., Prescott, M. & Bradbury, A. R. M., 2015, In : Proteins: Structure, Function, and Bioinformatics. 83, 7, p. 1225 - 1237 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4

Moradi, S., Berry, R., Pymm, P. G., Hitchen, C. R., Beckham, S. A., Wilce, M. C. J., Walpole, N. G., Clements, C. S., Reid, H. H., Perugini, M. A., Brooks, A. G., Rossjohn, J. & Vivian, J. P., 2015, In : Journal of Biological Chemistry. 290, 16, p. 10460 - 10471 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

X-ray crystal structure and properties of phanta, a weakly fluorescent photochromic GFP-like protein

Don Paul, C. B., Traore, D. A. K., Olsen, S., Devenish, R. J., Close, D. W., Bell, T. D. M., Bradbury, A., Wilce, M. C. J. & Prescott, M., 2015, In : PLoS ONE. 10, 4, 23 p., e0123338.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)
2014

Dual roles of F123 in protein homodimerization and inhibitor binding to biotin protein ligase from Staphylococcus aureus

Soares da Costa, T. P., Yap, M. Y., Perugini, M. A., Wallace, J. C., Abell, A. D., Wilce, M. C., Polyak, S. W. & Booker, G. W., 2014, In : Molecular Microbiology. 91, 1, p. 110 - 120 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist

Ambaye, N. D., Gunzburg, M. J., Traore, D. A. K., Del Borgo, M. P., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 2014, In : Acta Crystallographica. Section F: Structural Biology Communications. 70, 2, p. 182 - 186 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

RNA recognition and stress granule formation by TIA proteins

Waris, S., Wilce, M. C. & Wilce, J. A., 2014, In : International Journal of Molecular Sciences. 15, 12, p. 23377 - 23388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)
12 Citations (Scopus)

Structure guided design of biotin protein ligase inhibitors for antibiotic discovery

Paparella, A. S., Soares da Costa, T. P., Yap, M. Y., Tieu, W., Wilce, M. C. J., Booker, G. W., Abell, A. D. & Polyak, S. W., 2014, In : Current Topics in Medicinal Chemistry. 14, 1, p. 4 - 20 17 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2013

Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

Beckham, S. A., Brouwer, J. M., Roth, A., Wang, D., Sadler, A. J., John, M., Jahn-Hofmann, K., Williams, B. R. G., Wilce, J. A. & Wilce, M. C. J., 2013, In : Nucleic Acids Research. 41, 5, p. 3436 - 3445 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Design, purification and characterization of a soluble variant of the integral membrane protein MotB for structural studies

Andrews, D. A., Xie, M., Hughes, V., Wilce, M. C. & Roujeinikova, A., 6 Feb 2013, In : Journal of the Royal Society Interface. 10, 79, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Distinct binding properties of TIAR RRMs and linker region

Kim, H., Headey, S. J., Yoga, Y. M. K., Scanlon, M., Gorospe, M., Wilce, M. C. J. & Wilce, J. A., 2013, In : RNA Biology. 10, 4, p. 579 - 589 11 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Optimising in situ click chemistry: the screening and identification of biotin protein ligase inhibitors

Tieu, W., Soares da Costa, T. P., Yap, M. Y., Keeling, K. L., Wilce, M. C. J., Wallace, J. C., Booker, G. W., Polyak, S. W. & Abell, A. D., 2013, In : Chemical Science. 4, 9, p. 3533 - 3537 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

Phanta: A non-fluorescent photochromic acceptor for pcFRET

Don Paul, C. B., Kiss, C., Traore, D. A. K., Gong, L., Wilce, M. C. J., Devenish, R. J., Bradbury, A. & Prescott, M., 2013, In : PLoS ONE. 8, 9, 9 p., e75835.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Quinine binding by the cocaine-binding aptamer. Thermodynamic and hydrodynamic analysis of high-affinity binding of an off-target ligand

Reinstein, O., Yoo, M., Han, C., Palmo, T., Beckham, S. A., Wilce, M. C. J. & Johnson, P., 2013, In : Biochemistry. 52, 48, p. 8652 - 8662 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: An antibiotic target

Pendini, N. R., Yap, M. Y., Traore, D. A. K., Polyak, S. W., Cowieson, N. P., Abell, A. D., Booker, G. W., Wallace, J. C., Wilce, J. A. & Wilce, M. C. J., 2013, In : Protein Science. 22, 6, p. 762 - 773 12 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Structure of the N-terminal domain of human thioredoxin-interacting protein

Polekhina, G., Ascher, D. B., Kok, S. F., Beckham, S. A., Wilce, M. C. J. & Waltham, M., 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 3, p. 333 - 344 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Supramolecular self-assembly of N-acetyl-capped beta-peptides leads to nano- to macroscale fiber formation

Del Borgo, M. P., Mechler, A. I., Traore, D. A. K., Forsyth, C. M., Wilce, J. A., Wilce, M. C. J., Aguilar, M. I. & Perlmutter, P., 2013, In : Angewandte Chemie - International Edition. 52, 32, p. 8266 - 8270 5 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents

Ambaye, N. D., Gunzburg, M. J., Lim, R. C. C., Price, J. T., Wilce, M. C. J. & Wilce, J. A., 2013, In : ChemMedChem. 8, 2, p. 280 - 288 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2012

A green fluorescent protein containing a QFG tri-peptide chromophore: optical properties and X-Ray crystal structure

Battad, J., Traore, D. AK., Byres, E., Rossjohn, J., Devenish, R. J., Olsen, S., Wilce, M. C. & Prescott, M., 2012, In : PLoS ONE. 7, 10, 14 p., e47331.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Biotin analogues with antibacterial activity are potent inhibitors of biotin protein ligase

Soares da Costa, T. P., Tieu, W., Yap, M. Y., Zvarec, O., Bell, J. M., Turnidge, J. D., Wallace, J. C., Booker, G. W., Wilce, M. C. J., Abell, A. D. & Polyak, S. W., 14 May 2012, In : ACS Medicinal Chemistry Letters. 3, 6, p. 509-514 6 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Conformational stability studies of a stapled hexa-beta(3)-peptide library

Gopalan, R. D., Del Borgo, M. P., Bergman, Y. E., Unabia, S., Mulder, R. J., Wilce, M. C., Wilce, J. A., Aguilar, M. MI. & Perlmutter, P., 2012, In : Organic and Biomolecular Chemistry. 10, 9, p. 1802 - 1806 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides

Yoga, Y. M. K., Traore, D. AK., Sidiqi, M., Szeto, C., Pendini, N. R., Barker, A., Leedman, P., Wilce, J. A. & Wilce, M. C., 2012, In : Nucleic Acids Research. 40, 11, p. 5101 - 5114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity

Gunzburg, M. J., Ambaye, N. D., Del Borgo, M. P., Pero, S. C., Krag, D. N., Wilce, M. C. & Wilce, J. A., 2012, In : Journal of Molecular Recognition. 25, 1, p. 57 - 67 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Novel semiconducting biomaterials derived from a proline ester and tetracyanoquinodimethane identified by handpicked selection of individual crystals

Martin, L. L., Lu, J., Nafady, A., Le, T. H., Siriwardana, A. I., Qu, X., Traore, D. A. K., Wilce, M. C. J. & Bond, A. M., 2012, In : Australian Journal of Chemistry. 65, 7, p. 935 - 941 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective inhibition of biotin protein ligase from Staphylococcus aureus

Soares da Costa, T. P., Tieu, W., Yap, M. Y., Pendini, N. R., Polyak, S. W., Pedersen, D. S., Morona, R., Turnidge, J. D., Wallace, J. C., Wilce, M. C., Booker, G. W. & Abell, A. D., 2012, In : Journal of Biological Chemistry. 287, 21, p. 17823 - 17832 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Sequence requirements for RNA binding by HuR and AUF1

Barker, A., Epis, M. R., Porter, C. J., Hopkins, B. R., Wilce, M. C., Wilce, J. A., Giles, K. M. & Leedman, P. J., 2012, In : Journal of Biochemistry. 151, 4, p. 423 - 437 15 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Spontaneous redox synthesis of the charge transfer material TTF4[SVMo11O40]

Li, Q., Lu, J., Boas, J. F., Traore, D. A. K., Wilce, M. C. J., Huang, F., Martin, L. L., Ueda, T. & Bond, A. M., 2012, In : Inorganic Chemistry. 51, 23, p. 12929 - 12937 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structure, function and selective inhibition of bacterial acetyl-coa carboxylase

Polyak, S. W., Abell, A. D., Wilce, M. C. J., Zhang, L. & Booker, G. W., 2012, In : Applied Microbiology and Biotechnology. 93, 3, p. 983 - 992 10 p.

Research output: Contribution to journalArticleOther

41 Citations (Scopus)

Synthesis and conformation of fluorinated beta-peptidic compounds

Peddie, V., Butcher, R. J., Robinson, W. T., Wilce, M. C., Traore, D. A. K. & Abell, A. D., 2012, In : Chemistry - A European Journal. 18, 21, p. 6655 - 6662 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
17 Citations (Scopus)
2011

Benzopyrazine derivatives: a novel class of Growth Factor receptor bound protein 7 antagonists

Ambaye, N. D., Gunzburg, M. J., Lim, R. CC., Price, J. T., Wilce, M. CJ. & Wilce, J. A., 2011, In : Bioorganic & Medicinal Chemistry. 19, p. 693 - 701 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Different modes of interaction by TIAR and HuR with target RNA and DNA

Kim, H. S., Wilce, M. C. J., Yoga, Y., Pendini, N. R., Gunzburg, M. J., Cowieson, N., Wilson, G. M., Williams, B., Gorospe, M. & Wilce, J. A., 2011, In : Nucleic Acids Research. 39, 3, p. 1117 - 1130 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)

Engineering a structure switching mechanism into a steroid-binding aptamer and hydrodynamic analysis of the ligand binding mechanism

Reinstein, O., Neves, M., Saad, M., Boodram, S., Lombardo, S., Beckham, S., Brouwer, J., Audette, G., Groves, P., Wilce, M. & Johnson, P., 2011, In : Biochemistry. 50, 43, p. 9368 - 9376 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Identification of an mRNP complex regulating tumorigenesis at the translational elongation step

Hussey, G., Chaudhury, A., Dawson, A., Lindner, D., Knudsen, C., Wilce, M., Merrick, W. & Howe, P., 2011, In : Molecular Cell. 41, 4, p. 419 - 431 13 p.

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)