Professor Matthew CJ Wilce studied for his degree at James Cook University and his PhD at Monash University. He held two postdoctoral positions in Structural Biology. Firstly with Professor Michael Parker, St Vincents Institute, and then with Professor Mitchell Guss and the late Professor Hans Freeman, Sydney University. Matthew then moved to the University of Western Australia to established Structural Biology/Macromolecular X-ray crystallography. Following this he took up an academic position at Monash University before being awarded a NHMRC fellowship and working fulltime on research.

His research focuses on Structural Biology and drug development for new anti-bacterials, and, the role of protein - RNA interactions in innate immunity in response to infection by viral pathogens.

His currently an NHMRC Senior Research Fellow.