Projects per year
Personal profile
Biography
Professor Matthew CJ Wilce studied for his degree at James Cook University and his PhD at Monash University. He held two postdoctoral positions in Structural Biology. Firstly with Professor Michael Parker, St Vincents Institute, and then with Professor Mitchell Guss and the late Professor Hans Freeman, Sydney University. Matthew then moved to the University of Western Australia to established Structural Biology/Macromolecular X-ray crystallography. Following this he took up an academic position at Monash University before being awarded a NHMRC fellowship and working fulltime on research.
His research focuses on Structural Biology and drug development for new anti-bacterials, and, the role of protein - RNA interactions in innate immunity in response to infection by viral pathogens.
His currently an NHMRC Senior Research Fellow.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Antibacterials
- Molecular Modeling
- Poliovirus
- Protein Nucleic Interactions
- RIG-I like Helicase - innate immunity
- Small Angle X-ray Scattering
- Structural Biology
- X-ray Crystallography
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Structural basis for ribosomal docking on a picornavirus type I IRES
Wilce, M., Wilce, J. & Semler, B. L.
1/01/19 → 31/12/22
Project: Research
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Discovery and Characterisation of Tick Evasins - Inhibitors of Chemokine-mediated Inflammation
Stone, M., Payne, R., Rothenberg, M., Canals, M. & Wilce, M.
1/01/18 → 31/12/21
Project: Research
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Characterisation of TIA proteins in RNA recognition and stress granule formation
Wilce, J., Gorospe, M. & Wilce, M.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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Defining Poly-C-binding protein/RNA complex antiviral targets.
Wilce, M., Semler, B. L. & Wilce, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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NHMRC Research Fellowship
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/19
Project: Research
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Tandem RNA binding sites induce self-association of the stress granule marker protein TIA-1
Loughlin, F. E., West, D. L., Gunzburg, M. J., Waris, S., Crawford, S. A., Wilce, M. C. J. & Wilce, J. A., 18 Mar 2021, In: Nucleic Acids Research. 49, 5, p. 2403-2417 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Engineering the Ovarian Hormones Inhibin A and Inhibin B to Enhance Synthesis and Activity
Goney, M. P., Wilce, M. C. J., Wilce, J. A., Stocker, W. A., Goodchild, G. M., Chan, K. L., Harrison, C. A. & Walton, K. L., Aug 2020, In: Endocrinology. 161, 8, 12 p., bqaa099.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Structure of the PCBP2/stem-loop IV complex underlying translation initiation mediated by the poliovirus type I IRES
Beckham, S. A., Matak, M. Y., Belousoff, M. J., Venugopal, H., Shah, N., Vankadari, N., Elmlund, H., Nguyen, J. H. C., Semler, B. L., Wilce, M. C. J. & Wilce, J. A., 20 Aug 2020, In: Nucleic Acids Research. 48, 14, p. 8006-8021 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus) -
Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads
Lee, K. J., Tieu, W., Blanco-Rodriguez, B., Paparella, A. S., Yu, J., Hayes, A., Feng, J., Marshall, A. C., Noll, B., Milne, R., Cini, D., Wilce, M. C. J., Booker, G. W., Bruning, J. B., Polyak, S. W. & Abell, A. D., 20 Sep 2019, In: ACS Chemical Biology. 14, 9, p. 1990-1997 8 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis
Shah, N., Beckham, S. A., Wilce, J. A. & Wilce, M. C. J., 6 Apr 2018, In: Nucleic Acids Research. 46, 6, p. 3169-3186 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile4 Citations (Scopus)
Activities
- 1 Patents
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Adelaide Research & Innovation Pty Ltd (External organisation)
Matthew Wilce (Inventor) & Min Yap (Inventor)
28 Mar 2013Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent