Projects per year
Personal profile
Biography
Professor Matthew CJ Wilce studied for his degree at James Cook University and his PhD at Monash University. He held two postdoctoral positions in Structural Biology. Firstly with Professor Michael Parker, St Vincents Institute, and then with Professor Mitchell Guss and the late Professor Hans Freeman, Sydney University. Matthew then moved to the University of Western Australia to established Structural Biology/Macromolecular X-ray crystallography. Following this he took up an academic position at Monash University before being awarded a NHMRC fellowship and working fulltime on research.
His research focuses on Structural Biology and drug development for new anti-bacterials, and, the role of protein - RNA interactions in innate immunity in response to infection by viral pathogens.
His currently an NHMRC Senior Research Fellow.
Keywords
- Antibacterials
- Molecular Modeling
- Poliovirus
- Protein Nucleic Interactions
- RIG-I like Helicase - innate immunity
- Small Angle X-ray Scattering
- Structural Biology
- X-ray Crystallography
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Projects 2003 2022
Structural basis for ribosomal docking on a picornavirus type I IRES
Wilce, M. C. J., Wilce, J. A. & Semler, B.
1/01/19 → 31/12/22
Project: Research
Discovery and Characterisation of Tick Evasins - Inhibitors of Chemokine-mediated Inflammation
Stone, M. J., Payne, R., Rothenberg, M., Canals, M. & Wilce, M. C. J.
1/01/18 → 31/12/20
Project: Research
NHMRC Research Fellowship
National Health & Medical Research Council (NHMRC)
1/01/15 → 31/12/19
Project: Research
Defining Poly-C-binding protein/RNA complex antiviral targets.
Wilce, M. C. J., Semler, B. & Wilce, J. A.
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/18
Project: Research
Characterisation of TIA proteins in RNA recognition and stress granule formation
Wilce, J. A., Gorospe, M. & Wilce, M. C. J.
National Health & Medical Research Council (NHMRC)
1/01/16 → 31/12/18
Project: Research
Research Output 1991 2018
Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis
Shah, N., Beckham, S. A., Wilce, J. A. & Wilce, M. C. J., 6 Apr 2018, In : Nucleic Acids Research. 46, 6, p. 3169-3186 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus
Paparella, A. S., Lee, K. J., Hayes, A. J., Feng, J., Feng, Z., Cini, D., Deshmukh, S., Booker, G. W., Wilce, M. C. J., Polyak, S. W. & Abell, A. D., 9 Feb 2018, In : ACS Infectious Diseases. 4, 2, p. 175-184 10 p.Research output: Contribution to journal › Article › Research › peer-review
Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation
Lang, T., Lee, J. P. W., Elgass, K., Pinar, A. A., Tate, M. D., Aitken, E. H., Fan, H., Creed, S. J., Deen, N. S., Traore, D. A. K., Mueller, I., Stanisic, D., Baiwog, F. S., Skene, C., Wilce, M. C. J., Mansell, A., Morand, E. F. & Harris, J., 1 Dec 2018, In : Nature Communications. 9, 1, 15 p., 2223.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target
Watson, G. M., Kulkarni, K., Sang, J., Ma, X., Gunzburg, M. J., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 22 Nov 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9349-9359 11 p.Research output: Contribution to journal › Article › Research › peer-review
Structural analysis of variant of Helicobacter pylori MotB in its activated form, engineered as chimera of MotB and leucine zipper
Andrews, D. A., Nesmelov, Y. E., Wilce, M. C. & Roujeinikova, A., 1 Dec 2017, In : Scientific Reports. 7, 1, 12 p., 13435.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File