Projects per year
Personal profile
Biography
Professor Matthew CJ Wilce studied for his degree at James Cook University and his PhD at Monash University. He held two postdoctoral positions in Structural Biology. Firstly with Professor Michael Parker, St Vincents Institute, and then with Professor Mitchell Guss and the late Professor Hans Freeman, Sydney University. Matthew then moved to the University of Western Australia to established Structural Biology/Macromolecular X-ray crystallography. Following this he took up an academic position at Monash University before being awarded a NHMRC fellowship and working fulltime on research.
His research focuses on Structural Biology and drug development for new anti-bacterials, and, the role of protein - RNA interactions in innate immunity in response to infection by viral pathogens.
His currently an NHMRC Senior Research Fellow.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Antibacterials
- Molecular Modeling
- Poliovirus
- Protein Nucleic Interactions
- RIG-I like Helicase - innate immunity
- Small Angle X-ray Scattering
- Structural Biology
- X-ray Crystallography
Network
Projects
- 24 Finished
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Structural basis for ribosomal docking on a picornavirus type I IRES
Wilce, M., Wilce, J. & Semler, B. L.
1/01/19 → 31/12/22
Project: Research
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Discovery and Characterisation of Tick Evasins - Inhibitors of Chemokine-mediated Inflammation
Stone, M., Payne, R., Rothenberg, M., Canals, M. & Wilce, M.
1/01/18 → 31/12/21
Project: Research
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Characterisation of TIA proteins in RNA recognition and stress granule formation
Wilce, J., Gorospe, M. & Wilce, M.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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Defining Poly-C-binding protein/RNA complex antiviral targets.
Wilce, M., Semler, B. L. & Wilce, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research
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NHMRC Research Fellowship
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/19
Project: Research
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Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability
Sturre, N. P., Colson, R. N., Shah, N., Watson, G. M., Yang, X., Wilce, M. C. J., Price, J. T. & Wilce, J. A., May 2022, In: Biomedicines. 10, 5, 12 p., 1145.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Genistein Targets STING-Driven Antiviral Responses
Ullah, T. R., Balka, K. R., Ambrose, R. L., Pépin, G., Wilce, M. C. J., Wilce, J. A., Thomas, B. J., De Nardo, D., Williams, B. R. G. & Gantier, M. P., Jul 2022, In: mBio. 13, 4, 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases
Bhusal, R. P., Aryal, P., Devkota, S. R., Pokhrel, R., Gunzburg, M. J., Foster, S. R., Lim, H. D., Payne, R. J., Wilce, M. C. J. & Stone, M. J., 1 Mar 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, 7 p., e2122105119.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Tandem RNA binding sites induce self-association of the stress granule marker protein TIA-1
Loughlin, F. E., West, D. L., Gunzburg, M. J., Waris, S., Crawford, S. A., Wilce, M. C. J. & Wilce, J. A., 18 Mar 2021, In: Nucleic Acids Research. 49, 5, p. 2403-2417 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access18 Citations (Scopus) -
Engineering the Ovarian Hormones Inhibin A and Inhibin B to Enhance Synthesis and Activity
Goney, M. P., Wilce, M. C. J., Wilce, J. A., Stocker, W. A., Goodchild, G. M., Chan, K. L., Harrison, C. A. & Walton, K. L., Aug 2020, In: Endocrinology. 161, 8, 12 p., bqaa099.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus)
Activities
- 1 Patents
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Adelaide Research & Innovation Pty Ltd (External organisation)
Matthew Wilce (Inventor) & Min Yap (Inventor)
28 Mar 2013Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent