1991 …2022

Research output per year

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Personal profile


Professor Matthew CJ Wilce studied for his degree at James Cook University and his PhD at Monash University. He held two postdoctoral positions in Structural Biology. Firstly with Professor Michael Parker, St Vincents Institute, and then with Professor Mitchell Guss and the late Professor Hans Freeman, Sydney University. Matthew then moved to the University of Western Australia to established Structural Biology/Macromolecular X-ray crystallography. Following this he took up an academic position at Monash University before being awarded a NHMRC fellowship and working fulltime on research.

His research focuses on Structural Biology and drug development for new anti-bacterials, and, the role of protein - RNA interactions in innate immunity in response to infection by viral pathogens.

His currently an NHMRC Senior Research Fellow.

Research area keywords

  • Antibacterials
  • Molecular Modeling
  • Poliovirus
  • Protein Nucleic Interactions
  • RIG-I like Helicase - innate immunity
  • Small Angle X-ray Scattering
  • Structural Biology
  • X-ray Crystallography

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Research Output

Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis

Shah, N., Beckham, S. A., Wilce, J. A. & Wilce, M. C. J., 6 Apr 2018, In : Nucleic Acids Research. 46, 6, p. 3169-3186 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus

Paparella, A. S., Lee, K. J., Hayes, A. J., Feng, J., Feng, Z., Cini, D., Deshmukh, S., Booker, G. W., Wilce, M. C. J., Polyak, S. W. & Abell, A. D., 9 Feb 2018, In : ACS Infectious Diseases. 4, 2, p. 175-184 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

Lang, T., Lee, J. P. W., Elgass, K., Pinar, A. A., Tate, M. D., Aitken, E. H., Fan, H., Creed, S. J., Deen, N. S., Traore, D. A. K., Mueller, I., Stanisic, D., Baiwog, F. S., Skene, C., Wilce, M. C. J., Mansell, A., Morand, E. F. & Harris, J., 1 Dec 2018, In : Nature Communications. 9, 1, 15 p., 2223.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)

Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target

Watson, G. M., Kulkarni, K., Sang, J., Ma, X., Gunzburg, M. J., Perlmutter, P., Wilce, M. C. J. & Wilce, J. A., 22 Nov 2017, In : Journal of Medicinal Chemistry. 60, 22, p. 9349-9359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Structural analysis of variant of Helicobacter pylori MotB in its activated form, engineered as chimera of MotB and leucine zipper

Andrews, D. A., Nesmelov, Y. E., Wilce, M. C. & Roujeinikova, A., 1 Dec 2017, In : Scientific Reports. 7, 1, 12 p., 13435.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)