Matthew Watt

Professor

19992019
If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

 

Finding new ways to get healthy

Professor Matthew Watt leads an innovative research program that seeks to identify how defects of lipid metabolism and inter-tissue communication cause obesity-related disorders, and to use this information to discover novel targets that can be transitioned to clinical therapeutics. His team’s research strategy encompasses two major streams:

(1) Target identification- where protein expression is modulated in cultured cells and combined with discovery-based transcriptomic, proteomic and lipidomic approaches with targeted functional cell biology to unravel the regulation of biological functions (metabolism, endocrine function, energy metabolism).

(2) In vivo validation- involves the utilisation of mouse metabolic phenotyping and biochemical assessment of unique transgenic murine models to understand integrative biology systems. This is followed by pre-clinical studies in human tissues to demonstrate potential therapeutic efficacy.

Professor Watt has authored >120 peer-reviewed manuscripts and contributes to the discipline through his roles as National Secretary of the Australian Physiological Society and as a reviewing editor of the American Journal of Physiology (Endocrinology & Metabolism). 

Research area keywords

  • Adipose tissue biology
  • Skeletal muscle metabolism
  • Lipid metabolism
  • insulin resistance
  • Obesity
  • Type 2 Diabetes
  • Mice
  • Inter-tissue communication

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2008 2019

Research Output 1999 2019

Effect of Body Mass Index, Metabolic Health and Adipose Tissue Inflammation on the Severity of Non-alcoholic Fatty Liver Disease in Bariatric Surgical Patients: a Prospective Study

Ooi, G. J., Burton, P. R., Bayliss, J., Raajendiran, A., Earnest, A., Laurie, C., Kemp, W. W., McLean, C. A., Roberts, S. K., Watt, M. J. & Brown, W. A., Jan 2019, In : Obesity Surgery. 29, 1, p. 99–108 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues

Raajendiran, A., Ooi, G., Bayliss, J., O'Brien, P. E., Schittenhelm, R. B., Clark, A. K., Taylor, R. A., Rodeheffer, M. S., Burton, P. R. & Watt, M. J., 30 Apr 2019, In : Cell Reports. 27, 5, p. 1528-1540 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Febbraio, M. A., Reibe, S., Shalapour, S., Ooi, G. J., Watt, M. J. & Karin, M., 8 Jan 2019, In : Cell Metabolism. 29, 1, p. 18-26 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Watt, M. J., Clark, A. K., Selth, L. A., Haynes, V. R., Lister, N., Rebello, R., Porter, L. H., Niranjan, B., Whitby, S. T., Lo, J., Huang, C., Schittenhelm, R. B., Anderson, K. E., Furic, L., Wijayaratne, P. R., Matzaris, M., Montgomery, M. K., Papargiris, M., Norden, S., Febbraio, M. & 4 others, Risbridger, G. P., Frydenberg, M., Nomura, D. K. & Taylor, R. A., 6 Feb 2019, In : Science Translational Medicine. 11, 478, 12 p., eaau5758.

Research output: Contribution to journalArticleResearchpeer-review

Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury

Ow, C. P. C., Ngo, J. P., Ullah, M. M., Barsha, G., Meex, R. C., Watt, M. J., Hilliard, L. M., Koeners, M. P. & Evans, R. G., Nov 2018, In : American Journal of Physiology - Renal Physiology. 315, 5, p. F1358-F1369 12 p.

Research output: Contribution to journalArticleResearchpeer-review