Matthew Watt



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Finding new ways to get healthy

Professor Matthew Watt leads an innovative research program that seeks to identify how defects of lipid metabolism and inter-tissue communication cause obesity-related disorders, and to use this information to discover novel targets that can be transitioned to clinical therapeutics. His team’s research strategy encompasses two major streams:

(1) Target identification- where protein expression is modulated in cultured cells and combined with discovery-based transcriptomic, proteomic and lipidomic approaches with targeted functional cell biology to unravel the regulation of biological functions (metabolism, endocrine function, energy metabolism).

(2) In vivo validation- involves the utilisation of mouse metabolic phenotyping and biochemical assessment of unique transgenic murine models to understand integrative biology systems. This is followed by pre-clinical studies in human tissues to demonstrate potential therapeutic efficacy.

Professor Watt has authored >120 peer-reviewed manuscripts and contributes to the discipline through his roles as National Secretary of the Australian Physiological Society and as a reviewing editor of the American Journal of Physiology (Endocrinology & Metabolism). 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 7 - Affordable and Clean Energy

Research area keywords

  • Adipose tissue biology
  • Skeletal muscle metabolism
  • Lipid metabolism
  • insulin resistance
  • Obesity
  • Type 2 Diabetes
  • Mice
  • Inter-tissue communication


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