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nutrition and lifelong health in Drosophila.

19992020

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2020

Amino acid quality modifies the quantitative availability of protein for reproduction in Drosophila melanogaster

Ma, C., Mirth, C. K., Hall, M. D. & Piper, M. D. W., 1 Jan 2020, (Accepted/In press) In : Journal of Insect Physiology. 5 p., 104050.

Research output: Contribution to journalArticleResearchpeer-review

Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution

Yap, Y. W., Rusu, P. M., Chan, A. Y., Fam, B. C., Jungmann, A., Solon-Biet, S. M., Barlow, C. K., Creek, D. J., Huang, E., Schittenhelm, R. B., Morgan, B., Schmoll, D., Kiens, B., Piper, M. D. W., Heikenwälder, M., Simpson, S. J., Bröer, S., Andrikopoulos, S., Muller, O. J. & Rose, A. J., 9 Jun 2020, In : Nature Communications. 11, 13 p., 2894.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Sexual dimorphism in the nutritional requirement for adult lifespan in Drosophila melanogaster

Wu, Q., Yu, G., Cheng, X., Gao, Y., Fan, X., Yang, D., Xie, M., Wang, T., Piper, M. D. W. & Yang, M., Mar 2020, In : Aging Cell. 8 p., e13120.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control

Solon-Biet, S. M., Cogger, V. C., Pulpitel, T., Wahl, D., Clark, X., Gregoriou, G. C., Senior, A. M., Wang, Q-P., Brandon, A. E., Perks, R., O’Sullivan, J., Koay, Y. C., Bell-Anderson, K., Kebede, M., Yau, B., Atkinson, C., Svineng, G., Dodgson, T., Wali, J. A., Piper, M. D. W. & 7 others, Juricic, P., Partridge, L., Rose, A. J., Raubenheimer, D., Cooney, G. J., Couteur, D. G. L. & Simpson, S. J., 1 May 2019, In : Nature Metabolism. 1, 5, p. 532-545 14 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Sex-specific transcriptomic responses to changes in the nutritional environment

Camus, M. F., Piper, M. D. W. & Reuter, M., 22 Aug 2019, In : eLife. 8, 24 p., e47262.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transgenerational Obesity and Healthy Aging in Drosophila

Camilleri Carter, T-L., Dowling, D. K., Robker, R. & Piper, M., Oct 2019, In : Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 74, 10, p. 1582-1589 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)
2018

Drosophila as a model for ageing

Piper, M. D. W. & Partridge, L., Sep 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 9, p. 2707-2717 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction

Dobson, A. J., He, X., Blanc, E., Bolukbasi, E., Feseha, Y., Yang, M. & Piper, M. D. W., 1 Dec 2018, In : npj Aging and Mechanisms of Disease. 4, 1, 8 p., 5.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)
2017

2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling

Wu, Q., Lian, T., Fan, X., Song, C., Gaur, U., Mao, X., Yang, D., Piper, M. D. W. & Yang, M., 1 Oct 2017, In : Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 72, 10, p. 1334-1341 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Both overlapping and independent mechanisms determine how diet and insulin-ligand knockouts extend lifespan of Drosophila melanogaster

Zandveld, J., van den Heuvel, J., Zwaan, B. J. & Piper, M., 1 Dec 2017, In : npj Aging and Mechanisms of Disease. 3, 1, 4 p., 4.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Commensal bacteria and essential amino acids control food choice behavior and reproduction

Leitão-Gonçalves, R., Carvalho-Santos, Z., Francisco, A. P., Fioreze, G. T., Anjos, M., Baltazar, C., Elias, A. P., Itskov, P. M., Piper, M. D. W. & Ribeiro, C., 25 Apr 2017, In : PLoS Biology. 15, 4, 29 p., e2000862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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91 Citations (Scopus)

Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

Piper, M. D. W., Soultoukis, G. A., Blanc, E., Mesaros, A., Herbert, S. L., Juricic, P., He, X., Atanassov, I., Salmonowicz, H., Yang, M., Simpson, S. J., Ribeiro, C. & Partridge, L., 7 Mar 2017, In : Cell Metabolism. 25, 3, p. 610-621 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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52 Citations (Scopus)

Nutritional programming of lifespan by FOXO inhibition on sugar-rich diets

Dobson, A. J., Ezcurra, M., Flanagan, C. E., Summerfield, A. C., Piper, M., Gems, D. & Alic, N., 10 Jan 2017, In : Cell Reports. 18, 2, p. 299-306 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Sex and genotype effects on nutrient-dependent fitness landscapes in Drosophila melanogaster

Camus, M. F., Fowler, K., Piper, M. W. D. & Reuter, M., 20 Dec 2017, In : Proceedings of the Royal Society B: Biological Sciences. 284, 1869, 10 p., 20172237.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2016

Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila

Afschar, S., Toivonen, J. M., Hoffmann, J. M., Tain, L. S., Wieser, D., Finlayson, A. J., Driege, Y., Alic, N., Emran, S., Stinn, J., Froehlich, J., Piper, M. & Partridge, L., 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. 1321-1326 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)
2015

QuantiFly: Robust trainable software for automated Drosophila egg counting

Waithe, D., Rennert, P., Brostow, G. & Piper, M. D. W., 18 May 2015, In : PLoS ONE. 10, 5, 16 p., e0127659.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)
2014

A holidic medium for Drosophila melanogaster

Piper, M., Blanc, E., Leitao-Goncalves, R., Yang, M., He, X., Linford, N. J., Hoddinott, M. P., Hopfen, C., Soultoukis, G. A., Niemeyer, C., Kerr, F., Pletcher, S., Ribeiro, C. & Partridge, L., 1 Jan 2014, In : Nature Methods. 11, 1, p. 100-105 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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129 Citations (Scopus)

Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration

Emran, S., Yang, M., He, X., Zandveld, J. & Piper, M., May 2014, In : Aging. 6, 5, p. 390-398 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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34 Citations (Scopus)

Using Doubly-Labeled Water to Measure Energy Expenditure in an Important Small Ectotherm Drosophila melanogaster

Piper, M., Selman, C., Speakman, J. R. & Partridge, L., 20 Sep 2014, In : Journal of Genetics and Genomics. 41, 9, p. 505-512 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)
2013

Analysing variation in Drosophila aging across independent experimental studies: a meta-analysis of survival data

Ziehm, M., Piper, M. & Thornton, J., 2013, In : Aging Cell. 12, 5, p. 917 - 922 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)
2012

Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies

Alic, N., Hoddinott, M. P., Foley, A., Slack, C., Piper, M. & Partridge, L., 2012, In : PLoS ONE. 7, 9, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)
2011

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Burnett, C., Valentini, S., Cabreiro, F. G., Goss, M., Somogyvari, M., Piper, M., Hoddinott, M. P., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A-M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M. & 3 others, Soti, C., Partridge, L. & Gems, D., 2011, In : Nature. 477, 7365, p. 482 - 485 4 p.

Research output: Contribution to journalArticleResearchpeer-review

440 Citations (Scopus)

Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network

Partridge, L., Alic, N., Bjedov, I. & Piper, M., 2011, In : Experimental Gerontology. 46, 5, p. 376 - 381 6 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

Dietary restriction and aging: a unifying perspective

Piper, M., Partridge, L., Raubenheimer, D. & Simpson, S. J., 2011, In : Cell Metabolism. 14, 2, p. 154 - 160 7 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Dietary restriction delays ageing, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease

Kerr, F., Augustin, H., Piper, M., Gandy, C., Allen, M., Lovestone, S. & Partridge, L., 2011, In : Neurobiology of Aging. 32, 11, p. 1977 - 1989 13 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2010

Water-independent effects of dietary restriction in Drosophila

Piper, M., Wong, R., Grandison, R. C., Bass, T. M., Martinez, P. & Partridge, L., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 54 - 56 3 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2009

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

Grandison, R. C., Piper, M. & Partridge, L., 2009, In : Nature. 462, 7276, p. 1061 - 1064 4 p.

Research output: Contribution to journalArticleResearchpeer-review

440 Citations (Scopus)

Chemical changes in aging Drosophila melanogaster

Iqbal, A., Piper, M., Faragher, R. G. A., Naughton, D., Partridge, L. & Ostler, E., 2009, In : Age. 31, 4, p. 343 - 351 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Effect of a standardized dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster

Grandison, R. C., Wong, R., Bass, T. M., Partridge, L. & Piper, M., 2009, In : PLoS ONE. 4, 1, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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61 Citations (Scopus)

Quantification of food intake in Drosophila

Wong, R., Piper, M., Wertheim, B. & Partridge, L., 2009, In : PLoS ONE. 4, 6, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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136 Citations (Scopus)
2008

Diet and Aging

Piper, M. D. W. & Bartke, A., 6 Aug 2008, In : Cell Metabolism. 8, 2, p. 99-104 6 p.

Research output: Contribution to journalArticleResearchpeer-review

152 Citations (Scopus)

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Selman, C., Lingard, S., Choudhury, A. I., Batterham, R. L., Claret, M., Clements, M., Ramadani, F., Okkenhaug, K., Schuster, E., Blanc, E., Piper, M. D., Al-Qassab, H., Speakman, J. R., Carmignac, D., Robinson, I. C. A., Thornton, J. M., Gems, D., Partridge, L. & Withers, D. J., Mar 2008, In : The FASEB Journal. 22, 3, p. 807-818 12 p.

Research output: Contribution to journalArticleResearchpeer-review

352 Citations (Scopus)

Separating cause from effect: How does insulin/IGF signalling control lifespan in worms, flies and mice?

Piper, M. D. W., Selman, C., McElwee, J. J. & Partridge, L., Feb 2008, In : Journal of Internal Medicine. 263, 2, p. 179-191 13 p.

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)
2007

Evolutionary conservation of regulated longevity assurance mechanisms

McElwee, J. J., Schuster, E., Blanc, E., Piper, M. D., Thomas, J. H., Patel, D. S., Selman, C., Withers, D. J., Thornton, J. M., Partridge, L. & Gems, D., 5 Jul 2007, In : Genome Biology. 8, 7, R132.

Research output: Contribution to journalArticleResearchpeer-review

146 Citations (Scopus)

Optimization of dietary restriction protocols in Drosophila

Bass, T. M., Grandison, R. C., Wong, R., Martinez, P., Partridge, L. & Piper, M. D. W., Oct 2007, In : Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 62, 10, p. 1071-1081 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
168 Citations (Scopus)

Transcriptional responses of Saccharomyces cerevisiae to preferred and nonpreferred nitrogen sources in glucose-limited chemostat cultures

Boer, V. M., Tai, S. L., Vuralhan, Z., Arifin, Y., Walsh, M. C., Piper, M. D. W., De Winde, J. H., Pronk, J. T. & Daran, J. M., Jun 2007, In : FEMS Yeast Research. 7, 4, p. 604-620 17 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)
2006

Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice

Selman, C., Kerrison, N. D., Cooray, A., Piper, M. D. W., Lingard, S. J., Barton, R. H., Schuster, E. F., Blanc, E., Gems, D., Nicholson, J. K., Thornton, J. M., Partridge, L. & Withers, D. J., 27 Nov 2006, In : Physiological Genomics. 27, 3, p. 187-200 14 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)
2005

Calories do not explain extension of life span by dietary restriction in Drosophila

Mair, W., Piper, M. D. W. & Partridge, L., Jul 2005, In : PLoS Biology. 3, 7, p. 1305-1311 7 p.

Research output: Contribution to journalArticleResearchpeer-review

310 Citations (Scopus)

Counting the calories: The role of specific nutrients in extension of life span by food restriction

Piper, M. D. W., Mair, W. & Partridge, L., May 2005, In : Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 60, 5, p. 549-555 7 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Dietary restriction in Drosophila

Partridge, L., Piper, M. D. W. & Mair, W., Sep 2005, In : Mechanisms of Ageing and Development. 126, 9 SPEC. ISS., p. 938-950 13 p.

Research output: Contribution to journalArticleResearchpeer-review

227 Citations (Scopus)

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J. & Partridge, L., 22 Feb 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 8, p. 3105-3110 6 p.

Research output: Contribution to journalArticleResearchpeer-review

509 Citations (Scopus)
2004

Directed Evolution of Pyruvate Decarboxylase-Negative Saccharomyces cerevisiae, Yielding a C2-Independent, Glucose-Tolerant, and Pyruvate-Hyperproducing Yeast

Van Maris, A. J. A., Geertman, J. M. A., Vermeulen, A., Groothuizen, M. K., Winkler, A. A., Piper, M. D. W., Van Dijken, J. P. & Pronk, J. T., Jan 2004, In : Applied and Environmental Microbiology. 70, 1, p. 159-166 8 p.

Research output: Contribution to journalArticleResearchpeer-review

147 Citations (Scopus)

Identification of a Novel One-carbon Metabolism Regulon in Saccharomyces cerevisiae

Gelling, C. L., Piper, M. D. W., Hong, S. P., Kornfeld, G. D. & Dawes, I. W., 20 Feb 2004, In : The Journal of Biological Chemistry. 279, 8, p. 7072-7081 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Prolonged Maltose-Limited Cultivation of Saccharomyces cerevisiae Selects for Cells with Improved Maltose Affinity and Hypersensitivity

Jansen, M. L. A., Daran-Lapujade, P., De Winde, J. H., Piper, M. D. W. & Pronk, J. T., Apr 2004, In : Applied and Environmental Microbiology. 70, 4, p. 1956-1963 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)
2003

Comparative genotyping of the Saccharomyces cerevisiae laboratory strains S288C and CEN.PK113-7D using oligonucleotide microarrays

Daran-Lapujade, P., Daran, J. M., Kötter, P., Petit, T., Piper, M. D. W. & Pronk, J. T., Dec 2003, In : FEMS Yeast Research. 4, 3, p. 259-269 11 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Hap4p overexpression in glucose-grown Saccharomyces cerevisiae induces cells to enter a novel metabolic state.

Lascaris, R., Bussemaker, H. J., Boorsma, A., Piper, M., van der Spek, H., Grivell, L. & Blom, J., 2003, In : Genome Biology. 4, 1

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae

Vuralhan, Z., Morais, M. A., Tai, S. L., Piper, M. D. W. & Pronk, J. T., 1 Aug 2003, In : Applied and Environmental Microbiology. 69, 8, p. 4534-4541 8 p.

Research output: Contribution to journalArticleResearchpeer-review

131 Citations (Scopus)

The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur

Boer, V. M., De Winde, J. H., Pronk, J. T. & Piper, M. D. W., 31 Jan 2003, In : The Journal of Biological Chemistry. 278, 5, p. 3265-3274 10 p.

Research output: Contribution to journalArticleResearchpeer-review

238 Citations (Scopus)
2002

Regulation of the yeast glycine cleavage genes is responsive to the availability of multiple nutrients

Piper, M. D. W., Hong, S. P., Eißing, T., Sealey, P. & Dawes, I. W., 2002, In : FEMS Yeast Research. 2, 1, p. 59-71 13 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Reproducibility of oligonucleotide microarray transcriptome analyses. An interlaboratory comparison using chemostat cultures of Saccharomyces cerevisiae

Piper, M. D. W., Daran-Lapujade, P., Bro, C., Regenberg, B., Knudsen, S., Nielsen, J. & Pronk, J. T., 4 Oct 2002, In : The Journal of Biological Chemistry. 277, 40, p. 37001-37008 8 p.

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)