Projects per year
Personal profile
Biography
Matthew works in the Centre for Genetic Diseases, Hudson Insitute of Medical Research, as an ARC Future Fellow and Research Group Leader.
Following the completion of his PhD in 2002, Dr McKenzie undertook his post-doctoral research in the laboratory of Professor Michael Duchen, University College London. Here he investigated how mitochondrial membrane potential, calcium handling and ATP generation are disrupted in mitochondrial disorders using state of the art confocal imaging techniques.
In 2004, Dr McKenzie returned to Australia to work in the laboratory of Professor Michael Ryan, La Trobe University, Melbourne (now at Monash University). During this time he was awarded an NHMRC Peter Doherty Fellowship, and subsequently an NHMRC Career Development Fellowship, to study the biogenesis of mitochondrial complex I and how inherited defects can disrupt this process.
In April 2011 Dr McKenzie was recruited to the Hudson Institute of Medical Research (formerly Monash Institute of Medical Research) as a Group Leader in the Centre for Genetic Diseases. His current research focuses on mitochondrial fatty acid b-oxidation (FAO) and how this metabolic pathway interacts with mitochondrial oxidative phosphorylation (OXPHOS). He was recently awarded a prestigious ARC Future Fellowship and is currently supported by the Australian Mitochondrial Disease Foundation.
Research area keywords
- Mitochondrial Disease
- Fatty Acid Oxidation
- Oxidative Phosphorylation
- Protein Complex Assembly
Network
Projects
- 8 Finished
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Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity
St John, J., McKenzie, M., Western, P., Rombauts, L., McLachlan, P. R. & Carmody, D. R.
1/01/18 → 31/12/20
Project: Research
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Mitochondrial Damage following Fetal Hypoxia or Birth Asphyxia: Using Creatine to Preserve Mitochondrial Function
Walker, D., McKenzie, M., Snow, R., Dickinson, H. & Ellery, S.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/21
Project: Research
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Mitochondrial Damage following Fetal Hypoxia or Birth Asphyxia: Using Creatine to Preserve Mitochondrial Function
Walker, D., McKenzie, M., Snow, R. & Dickinson, H.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 1/01/20
Project: Research
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Understanding how defects in mitochondrial sugar and fat metabolism cause mitochondrial disease
1/01/16 → 31/12/17
Project: Research
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Determining the Safety of Homologous Mitochondrial Transfer
St John, J., McKenzie, M., Walker, D., Wallace, M. & Black, M.
8/01/13 → 1/04/18
Project: Research
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Integrating Mitochondrial Aerobic Metabolism into Ecology and Evolution
Koch, R. E., Buchanan, K. L., Casagrande, S., Crino, O., Dowling, D. K., Hill, G. E., Hood, W. R., McKenzie, M., Mariette, M. M., Noble, D. W. A., Pavlova, A., Seebacher, F., Sunnucks, P., Udino, E., White, C. R., Salin, K. & Stier, A., 1 Apr 2021, In: Trends in Ecology and Evolution. 36, 4, p. P321-332 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
24 Citations (Scopus) -
Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response
Lopez Sanchez, M. I. G., Ziemann, M., Bachem, A., Makam, R., Crowston, J. G., Pinkert, C. A., McKenzie, M., Bedoui, S. & Trounce, I. A., 2020, In: PLoS ONE. 15, 10, 16 p., e0239804.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Pioglitazone and deoxyribonucleoside combination treatment increases mitochondrial respiratory capacity in m.3243A>G MELAS cybrid cells
Burgin, H. J., Sanchez, M. I. G. L., Smith, C. M., Trounce, I. A. & McKenzie, M., Mar 2020, In: International Journal of Molecular Sciences. 21, 6, 17 p., 2139.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Understanding the role of OXPHOS dysfunction in the pathogenesis of ECHS1 deficiency
Burgin, H. J. & McKenzie, M., 1 Feb 2020, In: FEBS Letters. 594, 4, p. 590-610 21 p.Research output: Contribution to journal › Review Article › Research › peer-review
7 Citations (Scopus) -
Measurement of Mitochondrial Membrane Potential with the Fluorescent Dye Tetramethylrhodamine Methyl Ester (TMRM)
Creed, S. & McKenzie, M., 1 Jan 2019, In: Methods in Molecular Biology. 1928, p. 69-76 8 p.Research output: Contribution to journal › Article › Other › peer-review
25 Citations (Scopus)
Prizes
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Junior Investigator Award
McKenzie, Matthew (Recipient), 2008
Prize: Prize (including medals and awards)
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Junior Investigator Award, St. Vincent's Hospital Research Week
McKenzie, Matthew (Recipient), 2002
Prize: Prize (including medals and awards)
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Monash Research Accelerator Program
McKenzie, Matthew (Recipient), 1 Jan 2013
Prize: Prize (including medals and awards)
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Poster prize, 1st place
McKenzie, Matthew (Recipient), 2009
Prize: Prize (including medals and awards)
Activities
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Masters' Thesis Examination
Matthew McKenzie (Examiner)
1 Nov 2017 → 10 Nov 2017Activity: Examination types › Thesis Examination
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PhD Thesis examination
Matthew McKenzie (Examiner)
6 Mar 2017 → 8 Mar 2017Activity: Examination types › Thesis Examination
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Guest Lecturer
Matthew McKenzie (Fellow)
1 Sep 2017Activity: External Academic Engagement › External research and teaching
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Grant Reviewer
Matthew McKenzie (Fellow)
1 Apr 2017 → 20 May 2017Activity: External Academic Engagement › Grant review responsibilities
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Grant reviewer
Matthew McKenzie (Fellow)
27 Mar 2017 → 27 Apr 2017Activity: External Academic Engagement › Grant review responsibilities