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Personal profile

Biography

Matthew works in the Centre for Genetic Diseases, Hudson Insitute of Medical Research, as an ARC Future Fellow and Research Group Leader.



Following the completion of his PhD in 2002, Dr McKenzie undertook his post-doctoral research in the laboratory of Professor Michael Duchen, University College London. Here he investigated how mitochondrial membrane potential, calcium handling and ATP generation are disrupted in mitochondrial disorders using state of the art confocal imaging techniques.

In 2004, Dr McKenzie returned to Australia to work in the laboratory of Professor Michael Ryan, La Trobe University, Melbourne (now at Monash University). During this time he was awarded an NHMRC Peter Doherty Fellowship, and subsequently an NHMRC Career Development Fellowship, to study the biogenesis of mitochondrial complex I and how inherited defects can disrupt this process.

In April 2011 Dr McKenzie was recruited to the Hudson Institute of Medical Research (formerly Monash Institute of Medical Research) as a Group Leader in the Centre for Genetic Diseases. His current research focuses on mitochondrial fatty acid b-oxidation (FAO) and how this metabolic pathway interacts with mitochondrial oxidative phosphorylation (OXPHOS). He was recently awarded a prestigious ARC Future Fellowship and is currently supported by the Australian Mitochondrial Disease Foundation.

Keywords

  • Mitochondrial Disease
  • Fatty Acid Oxidation
  • Oxidative Phosphorylation
  • Protein Complex Assembly

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Projects 2011 2020

Research Output 1999 2018

Loss of the Mitochondrial Fatty Acid β-Oxidation Protein Medium-Chain Acyl-Coenzyme A Dehydrogenase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function

Lim, S. C., Tajika, M., Shimura, M., Carey, K. T., Stroud, D. A., Murayama, K., Ohtake, A. & McKenzie, M., 1 Dec 2018, In : Scientific Reports. 8, 1, 17 p., 153.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mitochondrial DNA haplotypes induce differential patterns of DNA methylation that result in differential chromosomal gene expression patterns

Lee, W. T., Sun, X., Tsai, T-S., Johnson, J. L., Gould, J. A., Garama, D. J., Gough, D. J., McKenzie, M., Trounce, I. A. & St John, J. C., 1 Jan 2017, In : Cell Death Discovery. 3, 11 p., 17062.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Monocytes and dendritic cells are the primary sources of interleukin 37 in human immune cells

Rudloff, I., Cho, S. X., Lao, J. C., Ngo, D., McKenzie, M., Nold-Petry, C. A. & Nold, M. F., 1 Apr 2017, In : Journal of leukocyte biology. 101, 4, p. 901-911 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Simultaneous measurement of mitochondrial calcium and mitochondrial membrane potential in live cells by fluorescent microscopy

McKenzie, M., Lim, S. C. & Duchen, M. R., 24 Jan 2017, In : Journal of Visualized Experiments. 2017, 119, 6 p., e55166.

Research output: Contribution to journalArticleOtherpeer-review

AarF domain containing kinase 3 (ADCK3) mutant cells display signs of oxidative stress, defects in mitochondrial homeostasis and lysosomal accumulation

Cullen, J. K., Murad, N. A., Yeo, A., McKenzie, M., Ward, M., Chong, K. L., Schieber, N. L., Parton, R. G., Lim, Y. C., Wolvetang, E., Maghzal, G. J., Stocker, R. & Lavin, M. F., 11 Feb 2016, In : PLoS ONE. 11, 2, 28 p., e0148213.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

Junior Investigator Award

Matthew McKenzie (Recipient), 2008

Prize: Prize (including medals and awards)

Junior Investigator Award, St. Vincent's Hospital Research Week

Matthew McKenzie (Recipient), 2002

Prize: Prize (including medals and awards)

Monash Research Accelerator Program

Matthew McKenzie (Recipient), 1 Jan 2013

Prize: Prize (including medals and awards)

Poster prize, 1st place

Matthew McKenzie (Recipient), 2009

Prize: Prize (including medals and awards)

Activities 1998 2017

PhD Thesis examination

Matthew McKenzie (Examiner)
6 Mar 20178 Mar 2017

Activity: Examination typesThesis Examination

Grant reviewer

Matthew McKenzie (Fellow)
27 Mar 201727 Apr 2017

Activity: External Academic EngagementGrant review responsibilities

Guest Lecturer

Matthew McKenzie (Fellow)
1 Sep 2017

Activity: External Academic EngagementExternal research and teaching

Grant reviewer

Matthew McKenzie (Reviewer)
28 Feb 201710 Mar 2017

Activity: External Academic EngagementGrant review responsibilities

Grant Reviewer

Matthew McKenzie (Fellow)
1 Apr 201720 May 2017

Activity: External Academic EngagementGrant review responsibilities