Projects per year
Personal profile
Biography
Matthew works in the Centre for Genetic Diseases, Hudson Insitute of Medical Research, as an ARC Future Fellow and Research Group Leader.
Following the completion of his PhD in 2002, Dr McKenzie undertook his post-doctoral research in the laboratory of Professor Michael Duchen, University College London. Here he investigated how mitochondrial membrane potential, calcium handling and ATP generation are disrupted in mitochondrial disorders using state of the art confocal imaging techniques.
In 2004, Dr McKenzie returned to Australia to work in the laboratory of Professor Michael Ryan, La Trobe University, Melbourne (now at Monash University). During this time he was awarded an NHMRC Peter Doherty Fellowship, and subsequently an NHMRC Career Development Fellowship, to study the biogenesis of mitochondrial complex I and how inherited defects can disrupt this process.
In April 2011 Dr McKenzie was recruited to the Hudson Institute of Medical Research (formerly Monash Institute of Medical Research) as a Group Leader in the Centre for Genetic Diseases. His current research focuses on mitochondrial fatty acid b-oxidation (FAO) and how this metabolic pathway interacts with mitochondrial oxidative phosphorylation (OXPHOS). He was recently awarded a prestigious ARC Future Fellowship and is currently supported by the Australian Mitochondrial Disease Foundation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Mitochondrial Disease
- Fatty Acid Oxidation
- Oxidative Phosphorylation
- Protein Complex Assembly
Collaborations and top research areas from the last five years
Projects
- 8 Finished
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Improving oocyte mitochondrial DNA copy number to enhance female reproductive capacity
St John, J., McKenzie, M., Western, P., Rombauts, L., McLachlan, P. R. & Carmody, D. R.
1/01/18 → 31/12/20
Project: Research
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Mitochondrial Damage following Fetal Hypoxia or Birth Asphyxia: Using Creatine to Preserve Mitochondrial Function
Walker, D., McKenzie, M., Snow, R., Dickinson, H. & Ellery, S.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/21
Project: Research
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Mitochondrial Damage following Fetal Hypoxia or Birth Asphyxia: Using Creatine to Preserve Mitochondrial Function
Walker, D., McKenzie, M., Snow, R. & Dickinson, H.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 1/01/20
Project: Research
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Understanding how defects in mitochondrial sugar and fat metabolism cause mitochondrial disease
1/01/16 → 31/12/17
Project: Research
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Determining the Safety of Homologous Mitochondrial Transfer
St John, J., McKenzie, M., Walker, D., Wallace, M. & Black, M.
8/01/13 → 1/04/18
Project: Research
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Loss of mitochondrial fatty acid β-oxidation protein short-chain Enoyl-CoA hydratase disrupts oxidative phosphorylation protein complex stability and function
Burgin, H., Sharpe, A. J., Nie, S., Ziemann, M., Crameri, J. J., Stojanovski, D., Pitt, J., Ohtake, A., Murayama, K. & McKenzie, M., 13 Aug 2022, (Accepted/In press) In: FEBS Journal. 22 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
MicroRNA-101-3p Modulates Mitochondrial Metabolism via the Regulation of Complex II Assembly
Ziemann, M., Lim, S. C., Kang, Y., Samuel, S., Sanchez, I. L., Gantier, M., Stojanovski, D. & McKenzie, M., 30 Jan 2022, In: Journal of Molecular Biology. 434, 2, 16 p., 167361.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Mitochondrial Short-Chain Enoyl-CoA Hydratase Deficiency (ECHS1D)
Burgin, H., Murayama, K., Ohtake, A. & McKenzie, M., 8 Oct 2022, Genetic Syndromes: A Comprehensive Reference Guide. Resaei, N. (ed.). Switzerland: Springer, 5 p. 1343-1Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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Stimulating Mitochondrial Biogenesis with Deoxyribonucleosides Increases Functional Capacity in ECHS1-Deficient Cells
Burgin, H. J., Crameri, J. J., Stojanovski, D., Sanchez, M. I. G. L., Ziemann, M. & McKenzie, M., Oct 2022, In: International Journal of Molecular Sciences. 23, 20, 19 p., 12610.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
The Effects of in Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain
Muccini, A. M., Tran, N. T., Hale, N., McKenzie, M., Snow, R. J., Walker, D. W. & Ellery, S. J., 29 Jan 2022, In: Oxidative Medicine and Cellular Longevity. 2022, 19 p., 3255296.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)
Prizes
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Junior Investigator Award
McKenzie, Matthew (Recipient), 2008
Prize: Prize (including medals and awards)
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Junior Investigator Award, St. Vincent's Hospital Research Week
McKenzie, Matthew (Recipient), 2002
Prize: Prize (including medals and awards)
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Monash Research Accelerator Program
McKenzie, Matthew (Recipient), 1 Jan 2013
Prize: Prize (including medals and awards)
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Poster prize, 1st place
McKenzie, Matthew (Recipient), 2009
Prize: Prize (including medals and awards)
Activities
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PhD Thesis examination
Matthew McKenzie (Examiner)
9 Mar 2017 → 10 Mar 2017Activity: Examination types › Thesis Examination
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Masters' Thesis Examination
Matthew McKenzie (Examiner)
1 Nov 2017 → 10 Nov 2017Activity: Examination types › Thesis Examination
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Grant Reviewer
Matthew McKenzie (Fellow)
1 Apr 2017 → 20 May 2017Activity: External Academic Engagement › Grant review responsibilities
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Grant Review Panel
Matthew McKenzie (Fellow)
21 Aug 2017 → 25 Aug 2017Activity: External Academic Engagement › Peer review panel or committee
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PhD Thesis examination
Matthew McKenzie (Examiner)
6 Mar 2017 → 8 Mar 2017Activity: Examination types › Thesis Examination