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Research Output 1997 2019

2019
4 Citations (Scopus)

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

McRae, H. M., Garnham, A. L., Hu, Y., Witkowski, M. T., Corbett, M. A., Dixon, M. P., May, R. E., Sheikh, B. N., Chiang, W., Kueh, A. J., Nguyen, T. A., Man, K., Gloury, R., Aubrey, B. J., Policheni, A., Di Rago, L., Alexander, W. S., Gray, D. H. D., Strasser, A., Hawkins, E. D. & 7 others, Wilcox, S., Gécz, J., Kallies, A., McCormack, M. P., Smyth, G. K., Voss, A. K. & Thomas, T., 18 Apr 2019, In : Blood. 133, 16, p. 1729-1741 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1

Shields, B. J., Slape, C. I., Vo, N., Jackson, J. T., Pliego-Zamora, A., Ranasinghe, H., Shi, W., Curtis, D. J. & McCormack, M. P., 1 Jan 2019, In : Leukemia. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
1 Citation (Scopus)

Analysis of histone modifications in acute myeloid leukaemia using chromatin immunoprecipitation

Shields, B. J., Keniry, A., Blewitt, M. E. & McCormack, M. P., 1 Jan 2018, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). New York : Humana Press, p. 177-184 8 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice

Jackson, J. T., Ng, A., Shields, B. J., Haupt, S. M., Haupt, Y. & McCormack, M. P., 27 Feb 2018, In : Blood Advances. 2, 4, p. 347-360 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Thymocyte self-renewal and oncogenic risk in immunodeficient mouse models: relevance for human gene therapy clinical trials targeting haematopoietic stem cell populations?

Ginn, S. L., McCormack, M. P. & Alexander, I. E., 1 Dec 2018, In : Mammalian Genome. 29, 11-12, p. 771-776 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017
5 Citations (Scopus)

Hhex Regulates Hematopoietic Stem Cell Self-Renewal and Stress Hematopoiesis via Repression of Cdkn2a

Jackson, J. T., Shields, B. J., Shi, W., Di Rago, L., Metcalf, D., Nicola, N. A. & Mccormack, M. P., Aug 2017, In : Stem Cells. 35, 8, p. 1948-1957 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Ginn, S. L., Hallwirth, C. V., Liao, S. H. Y., Teber, E. T., Arthur, J. W., Wu, J., Lee, H. C., Tay, S. S., Hu, M., Reddel, R. R., McCormack, M. P., Thrasher, A. J., Cavazzana, M., Alexander, S. I. & Alexander, I. E., 17 Mar 2017, In : Molecular Therapy - Nucleic Acids. 6, p. 1-14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016
11 Citations (Scopus)

Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a

Shields, B., Jackson, J. T., Metcalf, D., Shi, W., Huang, Q., Garnham, A. L., Glaser, S. P., Beck, D., Pimanda, J. E., Bogue, C. W., Smyth, G. K., Alexander, W. S. & McCormack, M. P., 1 Jan 2016, In : Genes and Development. 30, 1, p. 78-91 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
23 Citations (Scopus)

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, CS., Brown, FC., Collett, M., Saw, J., Chiu, SK., Sonderegger, SE., Lucas, SE., Alserihi, R., Chau, N., Toribio, ML., McCormack, MP., Chircop, M., Robinson, PJ., Jane, SM. & Curtis, DJ., 1 Oct 2016, In : Leukemia. 30, 10, p. 1993-2001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
16 Citations (Scopus)

A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis

Jackson, J. T., Nasa, C., Shi, W., Huntington, N. D., Bogue, C. W., Alexander, W. S. & McCormack, M. P., 29 Jan 2015, In : Blood. 125, 5, p. 803-814 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice

Shields, B., Alserihi, R., Nasa, C., Bogue, C., Alexander, W. S. & McCormack, M. P., 15 Apr 2015, In : Leukemia. 29, 4, p. 927-938 12 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Goossens, S., Radaelli, E., Blanchet, O., Durinck, K., Van der Meulen, J., Peirs, S., Taghon, T., Tremblay, C., Costa, M., Ghahremani, M. F., De Medts, J., Bartunkova, S., Haigh, K., Schwab, C., Farla, N., Pieters, T., Matthijssens, F., Roy, N. V., Best, J. A., Deswarte, K. & 24 others, Bogaert, P., Carmichael, C., Rickard, A. S., Suryani, S., Bracken, L. S., Alserihi, R., Cante-Barrett, K., Haenebalcke, L., Clappier, E., Rondou, P., Slowicka, K., Huylebroeck, D., Goldrath, A. W., Janzen, V., McCormack, M., Lock, R. B., Curtis, D. J., Harrison, C., Berx, G., Speleman, F. P., Meijerink, J. P. P., Soulier, J., Van Vlierberghe, P. & Haigh, J. J., 2015, In : Nature Communications. 6, p. 1 - 12 12 p., 5794.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013
26 Citations (Scopus)

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL

McCormack, M., Shields, B., Jackson, J., Nasa, C., Shi, W., Slater, N. J., Tremblay, C., Rabbitts, T. H. & Curtis, D. J., 2013, In : Blood. 122, 12, p. 2093 - 2103 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
150 Citations (Scopus)

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

McCormack, M., Young, L., Vasudevan, S., de Graaf, C., Codrington, R., Rabbitts, T., Jane, S. & Curtis, D., 2010, In : Science. 327, 12, p. 879 - 883 5 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The molecular basis of Lmo2-induced T-cell acute lymphoblastic leukemia

Curtis, D. J. & McCormack, M. P., 2010, In : Clinical Cancer Research. 16, 23, p. 5618 - 5623 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The thymus under siege: Lmo2 induces precancerous stem cells in a mouse model of T-ALL

McCormack, M. P. & Curtis, D. J., 2010, In : Cell Cycle. 9, 12, p. 2267 - 2268 2 p.

Research output: Contribution to journalLetterOther

2009
37 Citations (Scopus)

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

Rank, G., Sutton, R., Marshall, V., Lundie, R. J., Caddy, J., Romeo, T., Fernandez, K. M., McCormack, M. P., Cooke, B. M., Foote, S. J., Crabb, B. S., Curtis, D. J., Hilton, D. J., Kile, B. T. & Jane, S. M., 2009, In : Blood. 113, 14, p. 3352 - 3362 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms

Siggins, S., Nguyen, N-Y., McCormack, M., Vasudevan, S., Vilani, R., Jane, S., Wainwright, B. & Curtis, D., 2009, In : Blood. 114, 5, p. 995 - 1004 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
23 Citations (Scopus)

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

Salmon, J., Slater, N., Hall, M., McCormack, M., Jane, S. & Curtis, D., 2007, In : Blood. 110, 10, p. 3573 - 3581 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
35 Citations (Scopus)

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

McCormack, M. P., Hall, M. A., Schoenwaelder, S. M., Zhao, Q., Ellis, S. L., Prentice, J. A., Clarke, A. J., Slater, N. J., Salmon, J. M., Jackson, S. P., Jane, S. M. & Curtis, D. J., 2006, In : Blood. 108, 7, p. 2248-2256 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
39 Citations (Scopus)

Functional but Abnormal Adult Erythropoiesis in the Absence of the Stem Cell Leukemia Gene

Hall, M., Slater, N., Begley, C., Salmon, J., Stekelenburg, L. J., McCormack, M., Jane, S. & Curtis, D., 2005, In : Molecular and Cellular Biology. 25, 15, p. 6355 - 6362 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
210 Citations (Scopus)

Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency

McCormack, M. P. & Rabbitts, T. H., 26 Feb 2004, In : New England Journal of Medicine. 350, 9, p. 913-922 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

49 Citations (Scopus)

LMO2 and gene therapy for severe combined immunodeficiency [7] (multiple letters)

Fischer, A., Hacein-Bey Abina, S., Thrasher, A., Von Kalle, C., Cavazzana-Calvo, M., Stone, B. D., Rabbitts, T. H. & McCormack, M. P., 10 Jun 2004, In : New England Journal of Medicine. 350, 24, p. 2526-2527 2 p.

Research output: Contribution to journalLetterOtherpeer-review

2003
110 Citations (Scopus)

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

Forster, A., Pannell, R., Drynan, L. F., McCormack, M., Collins, E. C., Daser, A. & Rabbitts, T. H., 1 May 2003, In : Cancer Cell. 3, 5, p. 449-458 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2564 Citations (Scopus)

LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., Sorensen, R., Forster, A., Fraser, P., Cohen, J. I., De Saint Basile, G., Alexander, I., Wintergerst, U., Frebourg, T., Aurias, A., Stoppa-Lyonnet, D. & 15 others, Romana, S., Radford-Weiss, I., Gross, F., Valensi, F., Delabesse, E., Macintyre, E., Sigaux, F., Soulier, J., Leiva, L. E., Wissler, M., Prinz, C., Rabbitts, T. H., Le Deist, F., Fischer, A. & Cavazzana-Calvo, M., 17 Oct 2003, In : Science. 302, 5644, p. 415-419 5 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

The LMO2 T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell Development

McCormack, M. P., Forster, A., Drynan, L., Pannell, R. & Rabbitts, T. H., 1 Dec 2003, In : Molecular and Cellular Biology. 23, 24, p. 9003-9013 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
16 Citations (Scopus)

Mouse models of human chromosomal translocations and approaches to cancer therapy

Rabbitts, T. H., Appert, A., Chung, G., Collins, E. C., Drynan, L., Forster, A., Lobato, M. N., McCormack, M. P., Pannell, R., Spandidos, A., Stocks, M. R., Tanaka, T. & Tse, E., 1 Jan 2001, In : Blood Cells, Molecules, and Diseases. 27, 1, p. 249-259 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
19 Citations (Scopus)

Novel murine myeloid cell lines that exhibit a differentiation switch in response to IL-3 or GM-CSF or to different constitutively active mutants of the GM-CSF receptor β subunit

McCormack, M. P. & Gonda, T. J., 1 Jan 2000, In : Blood. 95, 1, p. 120-127 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1999
14 Citations (Scopus)

Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common β subunit

McCormack, M. P. & Gonda, T. J., 2 Dec 1999, In : Oncogene. 18, 51, p. 7190-7199 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Activated mutants of the human gm-csf receptor β subunit cause myeloproliferative disorders and leukaemia in mice

McCormack, M. P., Jenkins, B. J. & Gonda, T. J., 1 Dec 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common β chain in transgenic mice

D'Andrea, R. J., Harrison-Findik, D., Butcher, C. M., Finnie, J., Blumbergs, P., Bartley, P., McCormack, M., Jones, K., Rowland, R., Gonda, T. J. & Vadas, M. A., 1 Dec 1998, In : Journal of Clinical Investigation. 102, 11, p. 1951-1960 10 p.

Research output: Contribution to journalArticleResearchpeer-review