19972020

Research output per year

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Personal profile

Biography

A/Prof McCormack’s research centers on understanding the role of master transcription factors in haematopoiesis and leukaemia. He completed his PhD at the University of Adelaide in the Laboratory of Prof. Tom Gonda, studying the role of activated cytokine signaling in myeloid leukaemia. In 1999 he commenced Postdoctoral studies at the MRC Laboratory of Molecular Biology, Cambridge, UK in the laboratory of Prof. Terence Rabbitts, where he commenced work on the role of the LMO2 oncogene in T-cell leukaemia. He helped to identify LMO2 as a common target of insertional mutagenesis during gene therapy, leading to publications in Science and New Engl J Med. 

In 2003 he returned to Australia at the Royal Melbourne Hospital where he continued to study the role of LMO2 and in 2010 made the key discovery that Lmo2 causes thymocyte self-renewal, published in Science.

He was appointed Laboratory Head at the Walter and Eliza Hall Institute in 2011 and in 2016 moved his research group to the Australian Centre for Blood Diseases, Monash University. He continues to study the role of transcription factors in T-cell leukaemia and has recently initiated a second research program to understand the role of homeobox transcription factors in myeloid leukaemia. His research has led to over 30 publications in high profile journals including Science, New Engl J Med, Cancer Cell, Genes Dev, J Clin Invest, Blood, Leukemia and Oncogene.

Links:

https://www.monash.edu/medicine/ccs/blood-disease/research/mccormack

 

Supervision interests

Current - 1 PhD, 2 Honours

Past - 1 PhD, 2 Honours

Research area keywords

  • Haematology
  • Leukaemia
  • Transcription factors
  • Epigenetics
  • T-cell Leukaemia

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Projects

Research Output

Androgens stimulate erythropoiesis through the DNA-binding activity of the androgen receptor in non-hematopoietic cells

McManus, J. F., Nguyen, N. Y. N., Davey, R. A., MacLean, H. E., Pomilio, G., McCormack, M. P., Chiu, W. S., Wei, A. H., Zajac, J. D. & Curtis, D. J., 20 Apr 2020, (Accepted/In press) In : European Journal of Haematology. 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Hhex regulates murine lymphoid progenitor survival independently of Stat5 and Cdkn2a

Jackson, J. T., O'Donnell, K., Light, A., Goh, W., Huntington, N. D., Tarlinton, D. M. & McCormack, M. P., 23 Feb 2020, (Accepted/In press) In : European Journal of Immunology. 13 p.

Research output: Contribution to journalArticleResearchpeer-review

PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia

McRae, H. M., Garnham, A. L., Hu, Y., Witkowski, M. T., Corbett, M. A., Dixon, M. P., May, R. E., Sheikh, B. N., Chiang, W., Kueh, A. J., Nguyen, T. A., Man, K., Gloury, R., Aubrey, B. J., Policheni, A., Di Rago, L., Alexander, W. S., Gray, D. H. D., Strasser, A., Hawkins, E. D. & 7 others, Wilcox, S., Gécz, J., Kallies, A., McCormack, M. P., Smyth, G. K., Voss, A. K. & Thomas, T., 18 Apr 2019, In : Blood. 133, 16, p. 1729-1741 13 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1

Shields, B. J., Slape, C. I., Vo, N., Jackson, J. T., Pliego-Zamora, A., Ranasinghe, H., Shi, W., Curtis, D. J. & McCormack, M. P., Aug 2019, In : Leukemia. 33, 8, p. 1868-1880 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Analysis of histone modifications in acute myeloid leukaemia using chromatin immunoprecipitation

Shields, B. J., Keniry, A., Blewitt, M. E. & McCormack, M. P., 1 Jan 2018, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). New York : Humana Press, p. 177-184 8 p. (Methods in Molecular Biology; vol. 1725).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)