1984 …2019

Research output per year

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Research Output

2017

Melphalan modifies the bone microenvironment by enhancing osteoclast formation

Chai, R. C., McDonald, M. M., Terry, R. L., Kovačić, N., Down, J. M., Mohanty, S. T., Haffari, G., Xu, J., Gillespie, M. T., Rogers, M. J., Price, J. T., Croucher, P. I. & Quinn, J. M. W., 2017, In : Oncotarget. 8, 40, p. 68047-68058 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Urolithiasis is prevalent and associated with reduced bone mineral density in β-thalassaemia major

Wong, P., Milat, F., Fuller, P. J., Kerr, P. G., Doery, J. C. G., Oh, D. H., Jackson, D., Gillespie, M. T., Bowden, D. K., Pasricha, S-R. & Lau, K. K., Sep 2017, In : Internal Medicine Journal. 47, 9, p. 1064-1067 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2016

Bone disease in thalassemia: A molecular and clinical overview

Wong, P., Fuller, P. J., Gillespie, M. & Milat, F., Aug 2016, In : Endocrine Reviews. 37, 4, p. 320 - 346 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Deferasirox at therapeutic doses is associated with dose-dependent hypercalciuria

Wong, P., Polkinghorne, K., Kerr, P. G., Doery, J. C. G., Gillespie, M. T., Larmour, I., Fuller, P. J., Bowden, D. K. & Milat, F., 1 Apr 2016, In : Bone. 85, p. 55-58 4 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2015

Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model

Chen, P., Aguilar, O. A., Rahim, M. M. A., Allan, D. S. J., Fine, J., Kirkham, C. L., Ma, J., Tanaka, M., Tu, M., Wight, A., Kartsogiannis, V., Gillespie, M. T., Makrigiannis, A. P. & Carlyle, J. R., 2015, In : Journal of Immunology. 194, 6, p. 2909 - 2918 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Osteoclast formation elicited by interleukin-33 stimulation is dependent upon the type of osteoclast progenitor

Eeles, D., Hodge, J. M., Singh, P., Schuijers, J. A., Grills, B. L., Gillespie, M. T., Myers, D. E. & Quinn, J. M. W., 2015, In : Molecular and Cellular Endocrinology. 399, p. 259 - 266 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

RARγ is a negative regulator of osteoclastogenesis

Green, A. C., Poulton, I. J., Vrahnas, C., Hausler, K. D., Walkley, C. R., Wu, J. Y., Martin, T. J., Gillespie, M. T., Chandraratna, R. A. S., Quinn, J. M. W., Sims, N. A. & Purton, L. E., 2015, In : Journal of Steroid Biochemistry and Molecular Biology. 150, p. 46 - 53 8 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses

Rahim, M. M. A., Chen, P., Mottashed, A. N., Mahmoud, A. B., Thomas, M. J., Zhu, Q., Brooks, C. G., Kartsogiannis, V., Gillespie, M. T., Carlyle, J. R. & Makrigiannis, A. P., 2015, In : Blood. 125, 14, p. 2217 - 2227 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2014

Molecular stress-inducing compounds increase osteoclast formation in a heat shock factor 1 protein-dependent manner

Chai, R. C. C., Kouspou, M. M., Lang, B. J., Nguyen, C. H., van der Kraan, A. G., Vieusseux, J. L., Lim, R. C. C., Gillespie, M. T., Bnejamin, I. J., Quinn, J. M. W. & Price, J. T., 2014, In : Journal of Biological Chemistry. 289, 19, p. 13602 - 13614 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Thalassemia bone disease: a 19-year longitudinal analysis

Wong, P., Fuller, P. J., Gillespie, M. T., Kartsogiannis, V., Kerr, P. G., Doery, J. C. G., Paul, E., Bowden, D. K., Strauss, B. J. G. & Milat, F., 2014, In : Journal of Bone and Mineral Research. 29, S1, p. 2468 - 2473 6 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

The effect of gonadal status on body composition and bone mineral density in transfusion-dependent thalassemia

Wong, P., Fuller, P. J., Gillespie, M. T., Kartsogiannis, V., Milat, F., Bowden, D. K. & Strauss, B. J. G., 2014, In : Osteoporosis International. 25, 2, p. 597 - 604 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2013

HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors

van der Kraan, A. G., Chai, R. C. C., Singh, P., Lang, B. J., Wu, J., Gillespie, M. T., Price, J. T. & Quinn, J. M. W., 2013, In : Biochemical Journal. 451, 2, p. 235 - 244 10 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Prolonged hypocalcemia following denosumab therapy in metastatic hormone refractory prostate cancer

Milat, F., Goh, S. L., Gani, L. U., Suriadi, C., Gillespie, M. T., Teede, H. J. & Fuller, P. J., 2013, In : Bone. 55, 2, p. 305 - 308 4 p.

Research output: Contribution to journalArticleOther

15 Citations (Scopus)

PTHrP overexpression increases sensitivity of breast cancer cells to Apo2L/TRAIL

Cheung, V., Bouralexis, S. & Gillespie, M. T., 2013, In : PLoS ONE. 8, 6, 11 p., e66343.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures

Wong, P., Fuller, P. J., Gillespie, M. T., Kartsogiannis, V., Strauss, B. J. G., Bowden, D. K. & Milat, F., 2013, In : Osteoporosis International. 24, 7, p. 1965 - 1971 7 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)
2012

Membrane-bound receptor activator of NF{K}B ligand (RANKL) activity displayed by osteoblasts is differentially regulated by osteolytic factors

Singh, P., van der Kraan, A. G., Xu, J., Gillespie, M. T. & Quinn, J. M. W., 2012, In : Biochemical and Biophysical Research Communications. 422, 1, p. 48 - 53 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2011

Interleukin-33, a target of parathyroid hormone and oncostatin m, increases osteoblastic matrix mineral deposition and inhibits osteoclast formation in vitro

Saleh, H., Eeles, D., Hodge, J. M., Nicholson, G. C., Gu, R., Pompolo, S., Gillespie, M. T. & Quinn, J. M. W., May 2011, In : Endocrinology. 152, 5, p. 1911-1922 12 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment

Quach, J. M., Walker, E. C., Allan, E., Solano, M., Yokohama, A., Kato, S., Sims, N. A., Gillespie, M. T. & Martin, T. J., 11 Feb 2011, In : Journal of Biological Chemistry. 286, 6, p. 4186-4198 13 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)
2010

Calcitonin impairs the anabolic effect of PTH in young rats and stimulates expression of sclerostin by osteocytes

Gooi, J. H., Pompolo, S., Karsdal, M. A., Kulkarni, N. H., Kalajzic, I., McAhren, S. H. M., Han, B., Onyia, J. E., Ho, P. W. M., Gillespie, M. T., Walsh, N. C., Chia, L. Y., Quinn, J. M. W., Martin, T. J. & Sims, N. A., Jun 2010, In : Bone. 46, 6, p. 1486-1497 12 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Communication between ephrinB2 and ephb4 within the osteoblast lineage

Martin, T. J., Allan, E. H., Ho, P. W. M., Gooi, J. H., Quinn, J. M. W., Gillespie, M. T., Krasnoperov, V. & Sims, N. A., 2010, Osteoimmunology: Interactions of the Immune and Skeletal Systems II. Vol. 658. p. 51-60 10 p. (Advances in Experimental Medicine and Biology; vol. 658).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

58 Citations (Scopus)

Germline deletion of AMP-activated protein kinase β subunits reduces bone mass without altering osteoclast differentiation or function

Quinn, J. M. W., Tam, S., Sims, N. A., Saleh, H., McGregor, N. E., Poulton, I. J., Scott, J. W., Gillespie, M. T., Kemp, B. E. & Van Denderen, B. J. W., Jan 2010, In : FASEB Journal. 24, 1, p. 275-285 11 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice mice

Walker, E. C., McGregor, N. E., Poulton, I. J., Solano, M., Pompolo, S., Fernandes, T. J., Constable, M. J., Zhang, J. G., Nicola, N. A., Gillespie, M. T., John Martin, T. & Sims, N. A., 1 Feb 2010, In : Journal of Clinical Investigation. 120, 2, p. 582-592 11 p.

Research output: Contribution to journalArticleResearchpeer-review

132 Citations (Scopus)
2009

Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment

McKinstry, W. J., Polekhina, G., Diefenbach-Jagger, H., Sato, K., Onuma, E., Gillespie, M. T., Martin, T. J. & Parker, M. W., 2009, In : Acta Crystallographica. Section F: Structural Biology Communications. 65, Pt 4, p. 336 - 338 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor

McKinstry, W. J., Polekhina, G., Diefenbach-Jagger, H., Ho, P. W. M., Sato, K., Onuma, E., Gillespie, M. T., Martin, T. J. & Parker, M. W., 2009, In : Journal of Biological Chemistry. 284, 23, p. 15557 - 15563 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The chemokine cxcll is a novel target gene of parathyroid hormone (PTH)/PTH-related protein in committed osteoblasts

Onan, D., Allan, E. H., Quinn, J. M. W., Gooi, J. H., Pompolo, S., Sims, N. A., Gillespie, M. T. & Martin, T. J., May 2009, In : Endocrinology. 150, 5, p. 2244-2253 10 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2008

BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells

Susperregui, A. R. G., Viñals, F., Ho, P. W. M., Gillespie, M. T., Martin, T. J. & Ventura, F., 1 Jul 2008, In : Journal of Cellular Physiology. 216, 1, p. 144-152 9 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling

Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M. W., Gillespie, M. T., Martin, T. J. & Sims, N. A., 1 Dec 2008, In : Journal of Bone and Mineral Research. 23, 12, p. 2025-2032 8 p.

Research output: Contribution to journalArticleResearchpeer-review

107 Citations (Scopus)

EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts

Allan, E. H., Häusler, K. D., Wei, T., Gooi, J. H., Quinn, J. M. W., Crimeen-Irwin, B., Pompolo, S., Sims, N. A., Gillespie, M. T., Onyia, J. E. & Martin, T. J., 1 Aug 2008, In : Journal of Bone and Mineral Research. 23, 8, p. 1170-1181 12 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

IL-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice

Quinn, J. M. W., Sims, N. A., Saleh, H., Mirosa, D., Thompson, K., Bouralexis, S., Walker, E. C., Martin, T. J. & Gillespie, M. T., 1 Jan 2008, In : Journal of Immunology. 181, 8, p. 5720-5729 10 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo

Kartsogiannis, V., Sims, N. A., Quinn, J. M. W., Ly, C., Cipetić, M., Poulton, I. J., Walker, E. C., Saleh, H., McGregor, N. E., Wallace, M. E., Smyth, M. J., Martin, T. J., Zhou, H., Kong, W. N. & Gillespie, M. T., 7 Nov 2008, In : Journal of Biological Chemistry. 283, 45, p. 30850-30860 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2007

Impact of cytokines and T lymphocytes upon osteoclast differentiation and function

Gillespie, M. T., 21 Mar 2007, In : Arthritis Research and Therapy. 9, 2, 3 p., 103.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
54 Citations (Scopus)

Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro

Nakamura, A., Ly, C., Cipetic, M., Sims, N. A., Vieusseux, J., Kartsogiannis, V., Bouralexis, S., Saleh, H., Zhou, H., Price, J. T., Martin, T. J., Ng, K. W., Gillespie, M. T. & Quinn, J. M. W., 2007, In : Bone. 40, 2, p. 305 - 315 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2006

Inflammation-Induced Bone Loss: Can it Be Prevented?

Romas, E. & Gillespie, M. T., 1 Nov 2006, In : Rheumatic Disease Clinics of North America. 32, 4, p. 759-773 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

58 Citations (Scopus)

Mechanisms involved in skeletal anabolic therapies

Martin, T. J., Quinn, J. M. W., Gillespie, M. T., Ng, K. W., Karsdal, M. A. & Sims, N. A., 1 Jan 2006, In : Annals of the New York Academy of Sciences. 1068, 1, p. 458-470 13 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Osteoprotegerin overexpression by breast cancer cells enhances orthotopic and osseous tumor growth and contrasts with that delivered therapeutically

Fisher, J. L., Thomas-Mudge, R. J., Elliott, J., Hards, D. K., Sims, N. A., Slavin, J., Martin, T. J. & Gillespie, M. T., 1 Apr 2006, In : Cancer Research. 66, 7, p. 3620-3628 9 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)
2005

Effects of parathyroid hormone on Wnt signaling pathway in bone

Kulkarni, N. H., Halladay, D. L., Miles, R. R., Gilbert, L. M., Frolik, C. A., Calvin, R. J. S., Martin, T. J., Gillespie, M. T. & Onyia, J. E., 15 Aug 2005, In : Journal of Cellular Biochemistry. 95, 6, p. 1178-1190 13 p.

Research output: Contribution to journalArticleResearchpeer-review

165 Citations (Scopus)

Interleukin-11 receptor signaling is required for normal bone remodeling

Sims, N., Jenkins, B., Nakamura, A., Quinn, J. M. W., Li, R., Gillespie, M., Ernst, M., Robb, L. & Martin, T., 2005, In : Journal of Bone and Mineral Research. 20, 7, p. 1093 - 1102 10 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Modulation of osteoclast formation

Quinn, J. M. W. & Gillespie, M. T., 18 Mar 2005, In : Biochemical and Biophysical Research Communications. 328, 3, p. 739-745 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

81 Citations (Scopus)

The heat shock protein 90 inhibitor, 17-allylamino-17- demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line

Price, J. T., Quinn, J. M. W., Sims, N. A., Vieusseux, J. L., Waldeck, K., Docherty, S. E., Myers, D., Nakamura, A., Waltham, M., Gillespie, M. T. & Thompson, E. W., 2005, In : Cancer Research. 65, 11, p. 4929 - 4938 10 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)
2004

Characterization of sugar binding by osteoclast inhibitory lectin

Gange, C. T., Quinn, J. M. W., Zhou, H., Kartsogiannis, V., Gillespie, M. T. & Ng, K. W., 9 Jul 2004, In : Journal of Biological Chemistry. 279, 28, p. 29043-29049 7 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., Ernst, M. & Martin, T. J., 1 Jan 2004, In : Journal of Clinical Investigation. 113, 3, p. 379-389 11 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts

Yun, S. H., Zhou, H., Myers, D., Quinn, J. M. W., Atkins, G. J., Ly, C., Gange, C., Kartsogiannis, V., Elliott, J., Kostakis, P., Zannettino, A. C. W., Cromer, B., Mckinstry, W. J., Findlay, D. M., Gillespie, M. T. & Kong, W. N., 1 Jan 2004, In : Journal of Bone and Mineral Research. 19, 1, p. 89-99 11 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation

Lai, F. P. L., Cole-Sinclair, M., Cheng, W. J., Quinn, J. M. W., Gillespie, M. T., Sentry, J. W. & Schneider, H. G., 1 Jul 2004, In : British Journal of Haematology. 126, 2, p. 192-201 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Osteopenia in Siah1a mutant mice

Frew, I. J., Sims, N. A., Quinn, J. M. W., Walkley, C. R., Purton, L. E., Bowtell, D. D. L. & Gillespie, M. T., 9 Jul 2004, In : Journal of Biological Chemistry. 279, 28, p. 29583-29588 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation

Häusler, K. D., Horwood, N. J., Chuman, Y., Fisher, J. L., Ellis, J., Martin, T. J., Rubin, J. S. & Gillespie, M. T., 1 Nov 2004, In : Journal of Bone and Mineral Research. 19, 11, p. 1873-1881 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
107 Citations (Scopus)

Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis

Sims, N. A., Green, J. R., Glatt, M., Schlict, S., Martin, T. J., Gillespie, M. T. & Romas, E., 1 Jul 2004, In : Arthritis and Rheumatism. 50, 7, p. 2338-2346 9 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)
2003

Differentiation potential of a mouse bone marrow stromal cell line

Allan, E. H., Ho, P. W. M., Umezawa, A., Hata, J. I., Makishima, F., Gillespie, M. T. & Martin, T. J., 1 Sep 2003, In : Journal of Cellular Biochemistry. 90, 1, p. 158-169 12 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Generation and analysis of Siah2 mutant mice

Frew, I. J., Hammond, V. E., Dickins, R. A., Quinn, J. M. W., Walkley, C. R., Sims, N. A., Schnall, R., Della, N. G., Holloway, A. J., Digby, M. R., Janes, P. W., Tarlinton, D. M., Purton, L. E., Gillespie, M. T. & Bowtell, D. D. L., 2003, In : Molecular and Cellular Biology. 23, 24, p. 9150 - 9161 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Interleukin-18 is a novel mitogen of osteogenic and chondrogenic cells

Cornish, J., Gillespie, M. T., Callon, K. E., Horwood, N. J., Moseley, J. M. & Reid, I. R., 1 Apr 2003, In : Endocrinology. 144, 4, p. 1194-1201 8 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Parathyroid hormone-related protein (PTHrP): a nucleocytoplasmic shuttling protein with distinct paracrine and intracrine roles

Jans, D. A., Thomas, R. J. & Gillespie, M. T., 2003, Vitamins and Hormones. Litwack, G. (ed.). 66 ed. San Diego USA: Academic Press, p. 345 - 384 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

42 Citations (Scopus)