Projects per year
Personal profile
Biography
Matthew Belousoff began his career as a structural biologist in 2008 as a post-doctoral fellow in the lab of Prof. Ada Yonath, doing X-ray crystallography on the bacterial ribosome. Since returning to Australia in 2011, he has been using single particle cryoEM as a tool for the development of new ribosomal interfering antibiotics. Since the beginning of 2019 he has joined the lab of Prof. Patrick Sexton where he is using cryoEM as a tool to explore the structure and function of G-coupled protein receptors.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Structure determination of GPCR heteromers
Sexton, P. (Primary Chief Investigator (PCI)), Wootten, D. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)) & Shepard, R. (Chief Investigator (CI))
27/07/23 → 26/07/27
Project: Research
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Structural characterization of GLP-1 peptide agonists in complex with GLP-1R and amylin-receptor antibody in complex with amylin receptors
Wootten, D. (Primary Chief Investigator (PCI)), Sexton, P. (Chief Investigator (CI)), Zhang, C. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)), Reedtz-Runge, S. (Partner Investigator (PI)) & Glendorf, T. (Partner Investigator (PI))
1/10/23 → 31/12/24
Project: Research
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Cryo correlative Focused Ion Beam, a new frontier in structural biology
Hanssen, E. (Primary Chief Investigator (PCI)), Ghosal, D. (Chief Investigator (CI)), McFadden, G. I. (Chief Investigator (CI)), Rouiller, I. (Chief Investigator (CI)), Parker, M. W. (Chief Investigator (CI)), Ivanova, E. P. (Chief Investigator (CI)), Wootten, D. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)), Lucet, I. (Partner Investigator (PI)), Czabotar, P. E. (Partner Investigator (PI)) & Bouwer, J. (Chief Investigator (CI))
17/04/23 → 16/04/24
Project: Research
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Structure and dynamics of class B1 G protein coupled receptors
Wootten, D. (Primary Chief Investigator (PCI)), Belousoff, M. (Chief Investigator (CI)) & Josephs, T. (Chief Investigator (CI))
ARC - Australian Research Council, Monash University – Internal School Contribution
2/01/23 → 31/12/25
Project: Research
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Development of approaches for inactive, antagonist bound GPCR structures determination
Wootten, D. (Primary Chief Investigator (PCI)), Sexton, P. (Chief Investigator (CI)), Belousoff, M. (Chief Investigator (CI)), Johnson, R. (Chief Investigator (CI)) & Han, S. (Chief Investigator (CI))
22/02/22 → 21/02/26
Project: Research
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Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation
Liang, Y. L., Belousoff, M. J., Zhao, P., Koole, C., Fletcher, M. M., Truong, T. T., Julita, V., Christopoulos, G., Xu, H. E., Zhang, Y., Khoshouei, M., Christopoulos, A., Danev, R., Sexton, P. M. & Wootten, D., 6 Feb 2020, In: Molecular Cell. 77, 3, p. 656-668.e5 18 p.Research output: Contribution to journal › Article › Research › peer-review
102 Link opens in a new tab Citations (Scopus) -
Activation of the GLP-1 receptor by a non-peptidic agonist
Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In: Nature. 577, 7790, p. 432-436 5 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile152 Link opens in a new tab Citations (Scopus) -
A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles
Chen, M. Z., Yuen, D., McLeod, V. M., Yong, K. W., Smyth, C. H., Herling, B. R., Payne, T. J., Fabb, S. A., Belousoff, M. J., Algarni, A., Sexton, P. M., Porter, C. J. H., Pouton, C. W. & Johnston, A. P. R., 4 Aug 2025, In: Nature Nanotechnology. 20, p. 1273–1284 21 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access49 Link opens in a new tab Citations (Scopus) -
Mode of Action and Mechanisms of Resistance to the Unusual Polyglycosylated Thiopeptide Antibiotic Persiathiacin A
Woodgate, J., Sumang, F. A., Salliss, M. E., Belousoff, M., Ward, A. C., Challis, G. L., Zenkin, N., Errington, J. & Dashti, Y., 11 Jan 2025, In: ACS Infectious Diseases. 11, 1, p. 155-163 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Prolonged signaling of backbone-modified glucagon‐like peptide‐1 analogues with diverse receptor trafficking
Cary, B. P., Hager, M. V., Mariam, Z., Morris, R. K., Belousoff, M. J., Deganutti, G., Sexton, P. M., Wootten, D. & Gellman, S. H., 8 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 14, 10 p., e2407574122.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Monash Antimicrobial Resistance Group (Event)
Lithgow, T. (Chair/Co-Chair), Cryle, M. (Member), Tuck, K. (Member), Traven, A. (Member), Naderer, T. (Member), Rood, J. (Member), Lyras, D. (Member), Peleg, A. (Member), Aguilar, M. (Member), Coulibaly, F. (Member), McGowan, S. (Member), Okeeffe, M. A. (Member), Belousoff, M. (Member) & Heraud, P. (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
Press/Media
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Key to ‘superbug’ antibiotic resistance discovered
Belousoff, M. J. & Lithgow, T.
10/05/17 → 19/05/18
12 items of Media coverage, 6 Media contributions
Press/Media: Research